Effects of formoterol and salmeterol on the production of Th1- and Th2-related chemokines by monocytes and bronchial epithelial cells

European Respiratory Journal

Volumn 31, Issue 6, 2008, Pages 1313-1321

  Hung, C H ^a,b,c   Chu, Y T ^b   Hua, Y M ^d   Hsu, S H ^c   Lin, C S ^c   Chang, H C ^c   Lee, M S ^b   Jong, Y J ^a,b,c  

^a Department of Otorhinolaryngology Head and Neck Surgery   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

2 adrenoreceptor agonist; Bronchial epithelial cells; Bronchodilators; CC chemokines; Macrophage; Monocyte

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; BUDESONIDE; FLUTICASONE; FORMOTEROL; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MACROPHAGE DERIVED CHEMOKINE; SALMETEROL; THYMUS AND ACTIVATION REGULATED CHEMOKINE; ADAM PROTEIN; ADAM11 PROTEIN, HUMAN; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CCL17 PROTEIN, HUMAN; CHEMOKINE; CXCL10 PROTEIN, HUMAN; DRUG DERIVATIVE; ETHANOLAMINE DERIVATIVE; SALBUTAMOL; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; ASTHMA; BRONCHUS MUCOSA; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; EPITHELIUM CELL; HUMAN; HUMAN CELL; MONOCYTE; MONOTHERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; BRONCHUS; CELL LINE; CYTOLOGY; MACROPHAGE; METABOLISM; PHYSIOLOGY;

ADAM PROTEINS; ADRENERGIC BETA-AGONISTS; ALBUTEROL; BRONCHI; CELL LINE; CHEMOKINE CCL17; CHEMOKINE CXCL10; CHEMOKINES; EPITHELIAL CELLS; ETHANOLAMINES; HUMANS; MACROPHAGES; TH1 CELLS; TH2 CELLS; TUMOR SUPPRESSOR PROTEINS;

EID: 49649109576     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00121406     Document Type: Article

References (30)

1. Barnes PJ, Chung KF, Page CP. Inflammatory mediators of asthma: an update. Pharmacol Rev 1998; 50: 515-596.
2. Robinson D, Hamid Q, Bentley A, Ying S, Kay AB, Durham SR. Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol 1993; 92: 313-324.
3. Busse WW, Lemanske RF Jr. Asthma. N Engl J Med 2001; 344: 350-362.
4. Siveke JT, Hamann A. T helper 1 and T helper 2 cells respond differentially to chemokines. J Immunol 1998; 160: 550-554.
5. Medoff BD, Sauty A, Tager AM, et al. IFN-γ-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol 2002; 168: 5278-5286.
6. Brightling CE, Ammit AJ, Kaur D, et al. The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med 2005; 171: 1103-1108.
7. Imai T, Nagira M, Takagi S, et al. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol 1999; 11: 81-88.
8. Hung CH, Li CY, Lai YS, Hsu PC, Hua YM, Yang KD. Discrepant clinical responses and blood chemokine profiles between two non-steroidal anti-inflammatory medications for children with mild persistent asthma. Pediatr Allergy Immunol 2005; 16: 306-309.
9. Bloemen PG, van den Tweel MC, Henricks PA, et al. Increased cAMP levels in stimulated neutrophils inhibit their adhesion to human bronchial epithelial cells. Am J Physiol 1997; 272: L580-L587.
10. Whelan CJ, Johnson M, Vardey CJ. Comparison of the anti-inflammatory properties of formoterol, salbutamol and salmeterol in guinea-pig skin and lung. Br J Pharmacol 1993; 110: 613-618.
11. Shinkai N, Takasuna K, Takayama S. Inhibitory effects of formoterol on lipopolysaccharide-induced premature delivery through modulation of proinflammatory cytokine production in mice. Reproduction 2003; 125: 199-203.
12. Korn SH, Jerre A, Brattsand R. Effects of formoterol and budesonide on GM-CSF and IL-8 secretion by triggered human bronchial epithelial cells. Eur Respir J 2001; 17: 1070-1077.
13. Sekut L, Champion BR, Page K, Menius JA Jr, Connolly KM. Anti-inflammatory activity of salmeterol: down-regulation of cytokine production. Clin Exp Immunol 1995; 99: 461-466.
14. 2-agonists: inhibition of TNF-α release from human mast cells. J Allergy Clin Immunol 1997; 100: 825-831.
15. Wallin A, Sandström T, Söderberg M, et al. The effects of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma. Am J Respir Crit Care Med 1999; 159: 79-86.
16. 2-agonists and corticosteroids. Eur Respir J 2002; 19: 182-191.
17. Sekiya T, Miyamasu M, Imanishi M, et al. Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells. J Immunol 2000; 165: 2205-2213.
18. Hamalainen HK, Tubman JC, Vikman S, et al. Identification and validation of endogenous reference genes for expression profiling of T helper cell differentiation by quantitative real-time RT-PCR. Anal Biochem 2001; 299: 63-70.
19. Panina-Bordignon P, Papi A, Mariani M, et al. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest 2001; 107: 1357-1364.
20. Liu AH. Endotoxin exposure in allergy and asthma: reconciling a paradox. J Allergy Clin Immunol 2002; 109: 379-392.
21. van Schayck CP, Cloosterman SG, Hofland ID, van Herwaarden CL, van Weel C. How detrimental is chronic use of bronchodilators in asthma and chronic obstructive pulmonary disease? Am J Respir Crit Care Med 1995; 151: 1317-1319.
22. McIvor RA, Pizzichini E, Turner MO, Hussack P, Hargreave FE, Sears MR. Potential masking effects of salmeterol on airway inflammation in asthma. Am J Respir Crit Care Med 1998; 158: 924-930.
23. 2-receptor agonist, attenuates lipopolysaccharide-induced lung inflammation in mice. Am J Physiol Lung Cell Mol Physiol 2004; 286: L1122-L1128.
24. 2-adrenoceptor-mediated responses by salmeterol and formoterol. Br J Pharmacol 2004; 141: 163-171.
25. 2-agonists and budesonide on interleukin-1β and leukotriene B4 secretion: studies of human monocytes and alveolar macrophages. J Asthma 1998; 35: 565-573.
26. 2-adrenergic agonists in COPD. Chest 2001; 120: 258-270.
27. Hart LA, Krishnan VL, Adcock IM, Barnes PJ, Chung KF. Activation and localization of transcription factor, nuclear factor-κB, in asthma. Am J Respir Crit Care Med 1998; 158: 1585-1592.
28. Takahashi N, Tetsuka T, Uranishi H, Okamoto T. Inhibition of the NF-κB transcriptional activity by protein kinase A. Eur J Biochem 2002; 269: 4559-4565.
29. Moon EY, Pyo S. Lipopolysaccharide stimulates Epac1-mediated Rap1/NF-κB pathway in Raw 264.7 murine macrophages. Immunol Lett 2007; 110: 121-125.
30. Ghadially H, Ross XL, Kerst C, Dong J, Reske-Kunz AB, Ross R. Differential regulation of CCL22 gene expression in murine dendritic cells and B cells. J Immunol 2005; 174: 5620-5629.