Pyrazolone-based anaplastic lymphoma kinase (ALK) inhibitors: Control of selectivity by a benzyloxy group

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 24, 2011, Pages 7261-7264

  Tripathy, Rabindranath ^a   McHugh, Robert J ^a   Ghose, Arup K ^a   Ott, Gregory R ^a   Angeles, Thelma S ^a   Albom, Mark S ^a   Huang, Zeck ^a   Aimone, Lisa D ^a   Cheng, Mangeng ^a   Dorsey, Bruce D ^a  

^a CEPHALON INC   (United States)

Author keywords

ALCL; ALK; NMP ALK; Pyrazolone; VEGFR2

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; ANAPLASTIC LYMPHOMA KINASE INHIBITOR; CRIZOTINIB; HETEROCYCLIC COMPOUND; PROTEIN TYROSINE KINASE INHIBITOR; PYRAZOLONE; THIAZOLE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; AUTOPHOSPHORYLATION; CROSS REACTION; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; ENTROPY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME METABOLISM; MOLECULAR DOCKING; NONHUMAN; PROTEIN BINDING; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; ENZYME ACTIVATION; INDOLES; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRAZOLONES; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

RATTUS;

EID: 81255190719     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.055     Document Type: Article

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