Diagnosis and management of pernicious anemia

Current Gastroenterology Reports

Volumn 13, Issue 6, 2011, Pages 518-524

  Annibale, Bruno ^a   Lahner, Edith ^a   Fave, Gianfranco Delle ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Atrophic gastritis; Autoimmune gastritis; Cobalamin deficiency; Gastric autoimmunity; Helicobacter pylori infection; Intrinsic factor autoantibodies; Parietal cell autoantibodies; Pernicious anemia; Vitamin B 12 deficiency

Indexed keywords

AUTOANTIBODY; COBALAMIN; CYANOCOBALAMIN; GASTRIN; INTRINSIC FACTOR; PARIETAL CELL ANTIBODY; PEPSINOGEN I; THYROXINE;

ACHLORHYDRIA; ARTICLE; CANCER RISK; CLINICAL FEATURE; DISEASE ASSOCIATION; DRUG MEGADOSE; EARLY DIAGNOSIS; GASTRITIS; HISTOPATHOLOGY; HUMAN; IRON DEFICIENCY ANEMIA; PATIENT MONITORING; PERNICIOUS ANEMIA; SCHILLING TEST; SENSITIVITY AND SPECIFICITY; SEROLOGY; STOMACH ADENOCARCINOMA; STOMACH CARCINOID;

ACHLORHYDRIA; ANEMIA, PERNICIOUS; CARCINOID TUMOR; HUMANS; STOMACH NEOPLASMS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 81255161456     PISSN: 15228037     EISSN: 1534312X     Source Type: Journal    
DOI: 10.1007/s11894-011-0225-5     Document Type: Article

References (57)

1. Toh BH, Gleeson PA, Whittingham S, van Driel IR. Autoimmune gastritis and pernicious anemia. In: Rose NR, Mackay IR, editors. The Autoimmune diseases, 3rd edition. Academic Press; 1998. 459-76.
2. Bergman MP, Faller G, D'Elios MM, et al. Gastric autoimmunity. In: Mobley HLT, Mendz GL, Hazell SL, editors. Helicobacter pylori: physiology and genetics. Washington: ASM Press; 2001. Chapter 36.
3. CEM De Block IH De Leeuw LF Van Gaal 2008 Autoimmune gastritis in type 1 diabetes. A clinically oriented review J Clin Endocrinol Metab 93 363 71 18029461 10.1210/jc.2007-2134 (Pubitemid 351240803)
4. E Lahner M Centanni G Agnello, et al. 2008 Occurrence and risk factors for autoimmune thyroid disease in patients with atrophic body gastritis Am J Med 121 136 41 18261502 10.1016/j.amjmed.2007.09.025 (Pubitemid 351210633)
5. B Ungar JD Mathwes BD Tait DC Cowling 1981 HLA-DR patterns in pernicious anaemia BMJ 282 768 770 6783164 10.1136/bmj.282.6266.768 1:CAS:528: DyaL3MXkt1amt7w%3D (Pubitemid 11136470)
6. A Amedei MP Bergman BJ Appelmelk, et al. 2003 Molecular mimicry between Helicobacter pylori antigens and H+, K+ -ATPase in human gastric autoimmunity J Exp Med 198 1147 1156 14568977 10.1084/jem.20030530 1:CAS:528: DC%2BD3sXosVGqt7w%3D (Pubitemid 37323380)
7. E Lahner M Spoletini R Buzzetti, et al. 2010 HLA-DRB1*03 and DRB1*04 are associated with atrophic body gastritis in an Italian population Dig Liver Dis 42 854 9 20627832 10.1016/j.dld.2010.04.011 1:CAS:528:DC%2BC3cXhsVGisbvP This study shows that genotypes overlapping with those reported in other autoimmune diseases are associated with autoimmune gastritis, suggesting a common immunological cluster and supporting the role of a genetic susceptibility for autoimmunity in PA
8. MM Fernando CR Stevens EM Walsh, et al. 2008 Defining the role of the MCH in autoimmunity: a review and pooled analysis PloS Genet 4 e1000024 18437207 10.1371/journal.pgen.1000024 (Pubitemid 351656688)
9. Babior BM. Erythrocyte disorders: anemias related to disturbance of DNA synthesis (megaloblastic anemias). In: Williams JW, Beutler E, Erslev AJ, Lichtman MA, editors. Hematology. 4th ed. New York: McGraw-Hill; 1998. p. 453-81.
10. SF Werder 2010 Cobalamin deficiency, hyperhomocysteinemia and dementia Neuropsychiatr Dis Treat 6 159 95 20505848 10.2147/NDT.S6564 1:CAS:528:DC%2BC3cXlvF2ku7s%3D
11. GS Eisenbarth PA Gottlieb 2004 Autoimmune polyendocrine syndromes N Engl J Med 350 2068 2079 15141045 10.1056/NEJMra030158 1:CAS:528:DC%2BD2cXktVGitLc%3D (Pubitemid 38596558)
12. B Annibale E Lahner R Negrini, et al. 2005 Lack of specific association between gastric autoimmunity hallmarks and clinical presentations of atrophic body gastritis World J Gastroenterol 11 5351 57 16149145 (Pubitemid 41410305)
13. C Tosetti V Stangellini A Tucci, et al. 2000 Gastric emptying and dyspeptic symptoms in patients with nonautoimmune fundic atrophic gastritis Dig Dis Sci 45 252 257 10711434 10.1023/A:1005439905134 1:STN:280: DC%2BD3c7nsVGktA%3D%3D (Pubitemid 30133882)
14. B Annibale E Lahner C Bordi, et al. 2000 Role of Helicobacter pylori infection in pernicious anaemia Dig Liver Dis 32 756 762 11215554 10.1016/S1590-8658(00)80351-5 1:STN:280:DC%2BD3Mvnt1Clsw%3D%3D (Pubitemid 32098072)
15. M Marignani G Delle Fave S Mecarocci, et al. 1999 High prevalence of atrophic body gastritis in patients with unexplained microcytic and macrocytic anaemia Am J Gastroenterol 84 766 772 (Pubitemid 29124879)
16. M Centanni L Gargano G Canettieri, et al. 2006 Thyroxine in goiter, Helicobacter pylori, and chronic gastritis N Engl J Med 354 1787 95 16641395 10.1056/NEJMoa043903 1:CAS:528:DC%2BD28XjvVWhtL4%3D
17. RD Friedlander 1934 Racial factor in pernicious anaemia Am J Med Sci 187 634 10.1097/00000441-193405000-00007
18. R Carmel 1996 Prevalence of undiagnosed pernicious anemia in the elderly Arch Intern Med 156 1097 100 8638997 10.1001/archinte.156.10.1097 1:STN:280:DyaK283isVyjtQ%3D%3D (Pubitemid 26158066)
19. R Carmel CS Johnson 1978 Racial patterns in pernicious anemia: early age at onset and increased frequency of intrinsic-factor antibody in black women N Engl J Med 298 647 650 628388 10.1056/NEJM197803232981203 1:STN:280: DyaE1c7htl2ntg%3D%3D (Pubitemid 8293665)
20. AB Pedersen J Mosbeck 1969 Morbidity of pernicious anemia Acta Med Scand 185 449 5808646 10.1111/j.0954-6820.1969.tb07363.x 1:STN:280: DyaF1M3osVemtw%3D%3D
21. C Hershko A Ronson M Souroujon, et al. 2006 Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion Blood 107 1673 1679 16239424 10.1182/blood-2005-09-3534 1:CAS:528:DC%2BD28XhsFemtb4%3D (Pubitemid 43242408)
22. R Carmel JM Weiner CS Johnson 1987 Iron deficiency occurs frequently in patients with pernicious anemia JAMA 257 1081 1083 3806900 10.1001/jama.257.8. 1081 1:STN:280:DyaL2s7htlWmsw%3D%3D (Pubitemid 17031500)
23. WHO/UNICEF/UNU. Iron deficiency anemia: assessment, prevention, and control. Geneva: World Health Organization; 2001. WHO/NHD/01.3.
24. Lee EL, Feldman M. Gastritis and other gastropathies. In: Feldman M, Friedman LS, Sleisenger MH, editors. Sleisenger and Fordtran's gastrointestinal and liver disease: pathophysiology, diagnosis, management. 7th ed. Philadelphia: Saunders; 2002. p. 810-27.
25. M Kekki IM Samloff K Varis T Ihamäki 1991 Serum pepsinogen I and serum gastrin in the screening of severe atrophic corpus gastritis Scand J Gastroenterol 186 suppl 109 116 10.3109/00365529109103997 1:STN:280: DyaK387gtFSmsw%3D%3D
26. H Väänänen M Vauhkone T Helske, et al. 2003 Non-endoscopic diagnosis of atrophic gastritis with a blood test. Correlation between gastric histology and serum levels of gastrin-17 and pepsinogen I: a multicentre study Eur J Gastroenterol Hepatol 15 885 891 12867799 10.1097/00042737-200308000-00009 (Pubitemid 36904458)
27. MF Dixon RM Genta JH Yardley P Correa 1996 Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994 Am J Surg Pathol 20 1161 81 8827022 10.1097/00000478-199610000-00001 1:STN:280:DyaK28visVGlsg%3D%3D (Pubitemid 26336840)
28. E Lahner B Annibale 2009 Pernicous anemia: new insights from a gastroenterological point of view World J Gastroenterol 15 5121 8 19891010 10.3748/wjg.15.5121 1:CAS:528:DC%2BD1MXhsVSju73K
29. E Lahner GL Norman C Severi, et al. 2009 Reassessment of intrinsic factor and parietal cell autoantibodies in atrophic gastritis with respect to cobalamin deficiency Am J Gastroenterol 104 2071 9 19491828 10.1038/ajg.2009.231 1:CAS:528:DC%2BD1MXps1WqtLY%3D This study highlights the diagnostic accuracy of the combined assessment of intrinsic factor and parietal cell autoantibodies for the diagnosis of pernicious anemia
30. D Cattan 2011 Pernicious anemia: what are the acutal diagnostic criteria? World J Gastroenterol 17 543 4 21274387 10.3748/wjg.v17.i4.543
31. Toh BH, Alderuccio F. Parietal cell and intrinsic factor autoantibodies. In: Shoenfeld Y, Gershwin ME, Meroni PL, editors. Autoantibodies. 2nd ed. Amsterdam: Elsevier; 2007. p. 479-86.
32. B Ungar S Whittingham CM Francis 1967 Pernicious anaemia: incidence and significance of circulating antibodies to intrinsic factor and parietal cells Aus Ann Med 16 226 229 1:STN:280:DyaF1c%2FktFegtg%3D%3D
33. RJL Davidson HI Atrah HF Sewell 1989 Longitudinal study of circulating antibodies in pernicious anemia J Clin Pathol 42 1092 5 2584410 10.1136/jcp.42.10.1092 1:STN:280:DyaK3c%2Fmt1Gktg%3D%3D (Pubitemid 19255624)
34. R Carmel 1992 Reassessment of the relative prevalence of antibodies to gastric parietal cell and to intrinsic factor in patients with pernicious anaemia: influence of patient age and race Clin Exp Immunol 89 74 77 1628426 10.1111/j.1365-2249.1992.tb06880.x 1:STN:280:DyaK38zjtFaqug%3D%3D
35. B Annibale R Negrini P Caruana, et al. 2001 Two-thirds of atrophic body gastritis patients have evidence of Helicobacter pylori infection Helicobacter 6 225 233 11683925 10.1046/j.1083-4389.2001.00032.x 1:STN:280: DC%2BD3MngvVKlsg%3D%3D (Pubitemid 32843606)
36. R Carmel GI Perez-Perez MJ Blaser 1994 Helicobacter pylori infection and food-cobalamin malabsorption Dig Dis Sci 39 309 14 8313813 10.1007/BF02090202 1:STN:280:DyaK2c7kslyqsQ%3D%3D (Pubitemid 24073605)
37. H Cohen WM Weinstein R Carmel 2000 Heterogeneity of gastric histology and function in food cobalamin malabsorption: absence of atrophic gastritis and achlorhydria in some patients with severe malabsorption Gut 47 638 45 11034579 10.1136/gut.47.5.638 1:STN:280:DC%2BD3M%2FjvVSguw%3D%3D
38. 12 deficiency Dtsch Arztebl Int 105 680 5 19623286
39. AM Hvas E Nexo 2006 Diagnosis and treatment of vitamin B12 deficiency-an update Haematologica 91 1506 12 17043022 1:CAS:528:DC%2BD28XhtlSltb%2FP (Pubitemid 44736117)
40. RK Pruthi A Tefferi 1994 Pernicious anemia revisited Mayo Clin Proc 69 144 50 8309266 1:STN:280:DyaK2c7kt1ensg%3D%3D (Pubitemid 24054751)
41. P Bastrup-Madsed I Helleberg-Rasmussen S Norregaard, et al. 1983 Long term therapy of pernicious anemia with the depot cobalamin preparation betolvex Scand J Haematol 31 57 62 10.1111/j.1600-0609.1983.tb02137.x (Pubitemid 13073355)
42. JN Hathcock GJ Troendle 1991 Oral cobalamin for treatment of pernicious anemia? JAMA 265 96 7 1984131 10.1001/jama.265.1.96 1:STN:280: DyaK3M%2FntlKhsA%3D%3D
43. FA Lederle 1991 Oral cobalamin for pernicious anemia. Medicine's best kept secret? JAMA 265 94 5 2064638 10.1001/jama.265.1.94 1:STN:280: DyaK3M%2FntlKhsw%3D%3D
44. E Andrès N Dali-Youcef T Vogel, et al. 2009 Oral cobalamin (vitamin B(12)) treatment. An update Int J Lab Hematol 31 1 8 19032377 10.1111/j.1751-553X.2008.01115.x
45. P Correa 1992 Human gastric carcinogenesis: a multistep and multifactorial process Cancer Res 52 673 5
46. M-S Wu C-J Chen J-T Lin 2005 Host-environment interactions: their impact on progression from gastric inflammation to carcinogenesis and on development of new approaches to prevent and treat gastric cancer Cancer Epidemiol Biomarkers Prev 14 1878 1882 16103430 10.1158/1055-9965.EPI-04-0792 (Pubitemid 41161193)
47. SM Sjoblom P Sipponen M Miettinen, et al. 1988 Gastroscopic screening for gastric carcinoids and carcinoma in pernicious anemia Endoscopy 20 52 6 3383791 10.1055/s-2007-1018130 1:STN:280:DyaL1c3lsVKquw%3D%3D (Pubitemid 18086226)
48. B Annibale C Azzoni VD Corleto, et al. 2001 Atrophic body gastritis patients with enterochromaffin-like cell dysplasia are at increased risk for the development of type I gastric carcinoid Eur J Gastroenterol Hepatol 13 1449 56 11742193 10.1097/00042737-200112000-00008 1:STN:280:DC%2BD3MjgtV2lsg%3D%3D (Pubitemid 33151497)
49. A Kokkola S-M Sjöblom R Haapiainen, et al. 1998 The risk of gastric carcinoma and carcinoid tumours in patients with pernicious anaemia Scand J Gastroenterol 33 88 92 9489914 10.1080/00365529850166266 1:STN:280: DyaK1c7kvFGmug%3D%3D (Pubitemid 28114075)
50. Vannella L, Sbrozzi-Vanni A, Lahner E, et al. Development of type I gastric carcinoid in patients with chronic atrophic gastritis. Aliment Pharmacol Ther. 2011. doi: 10.1111/j.1365-2036.2011.04659.x [Epub ahead of print].
51. N Uemura S Okamoto S Yamamoto, et al. 2001 Helicobacter pylori and the development of gastric cancer N Engl J Med 345 784 89 11556297 10.1056/NEJMoa001999 1:STN:280:DC%2BD3MrgslCqtA%3D%3D
52. G Eisenbrand B Adam M Peter, et al. 1984 Formation of nitrite in gastric juice of patients with various gastric disorders after ingestion of a standard dose of nitrate- a possible risk factor for gastric carcinogenesis IARC Sci Publ 963 68
53. B Annibale G Capurso E Lahner, et al. 2003 Concomitant alterations in intragastric pH and ascorbic acid concentration in patients with Helicobacter pylori gastritis and associated iron deficiency anaemia Gut 52 496 501 12631657 10.1136/gut.52.4.496 1:CAS:528:DC%2BD3sXjtVKltLs%3D (Pubitemid 36363399)
54. LW Schafer DE Larson LJ Melton 3rd, et al. 1985 Risk of development of gastric carcinoma in patients with pernicious anemia: a population-based study in Rochester, Minnesota Mayo Clin Proc 60 444 8 4010342 1:STN:280: DyaL2M3jvFWnuw%3D%3D (Pubitemid 15249992)
55. E Lahner C Bordi MS Cattaruzza, et al. 2005 Long-term follow-up in atrophic body gastritis patients: atrophy and intestinal metaplasia are persistent lesions irrespective of Helicobacter pylori infection Aliment Pharmacol Ther 22 471 81 16128686 10.1111/j.1365-2036.2005.02582.x 1:STN:280:DC%2BD2Mvosl2mtw%3D%3D (Pubitemid 41248115)
56. L Vannella E Lahner J Osborn, et al. 2010 Risk factors for progression to gastric neoplastic lesions in patients with atrophic gastritis Aliment Pharmacol Ther 31 1042 50 20175768 1:STN:280:DC%2BC3c3pt1WmsQ%3D%3D
57. E Lahner P Caruana G D'Ambra, et al. 2001 First endoscopic-histologic follow-up in patients with body-predominant atrophic gastritis: when should it be done? Gastrointest Endosc 53 443 8 11275884 10.1067/mge.2001.112189 1:STN:280:DC%2BD3M7oslSjuw%3D%3D (Pubitemid 33586752)