C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells

European Journal of Pharmacology

Volumn 672, Issue 1-3, 2011, Pages 30-37

  Brognara, Eleonora ^a   Lampronti, Ilaria ^a   Breveglieri, Giulia ^a   Accetta, Alessandro ^b   Corradini, Roberto ^b   Manicardi, Alex ^b   Borgatti, Monica ^a   Canella, Alessandro ^a   Multineddu, Chiara ^a   Marchelli, Rosangela ^b   Gambari, Roberto ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

Beta thalassemia; Chronic myelogenous leukemia; Erythroid differentiation; Isoorotic acid derivative; Tumor growth

Indexed keywords

(5 IODOURACIL 1 YL)ACETIC ACID; 1 OCTYL 5 URACIL CARBOXYLIC ACID (1 OCTYLISOOROTIC ACID); 1 OCTYL THYMINE; 1,3 DIOCTYLTHYMINE; 3 BENZOYL 1 METHYLURACIL; 3 BENZOYLURACIL; 5 AZIDOMETHYLURACIL; 5 URACIL CARBOXYLIC ACID(METHYL ISOOROTATE); [1 (CARBOXYMETHYL)THYMINE] (THYMIN 1 YL)ACETIC ACID; ETHYL (5 AMINOMETHYLURACIL 1 YL)ACETIC ACID; ETHYL (5 AZIDOMETHYLURACIL 1 YL)ACETIC ACID; ETHYL [5 [N (2 NAPHTHYLCARBOXYL)AMINOMETHYL]URACIL 1 YL]ACETIC ACID; GAMMA GLOBIN; N BENZYL 1 OCTYL 5 URACIL CARBOXAMIDE; N BUTYL 1 METHYL 5 URACIL CARBOXAMIDE; NITROGEN; TERT BUTYL (5 AZIDOMETHYLURACIL 1 YL)ACETIC ACID; TERT BUTYL (5 IODOURACIL 1 YL)ACETIC ACID; THYMINE; THYMINE DERIVATIVE; UNCLASSIFIED DRUG; URACIL; URACIL DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN K 562; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; ERYTHROID CELL; GAMMA GLOBIN GENE; GENE; GENE ACTIVATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BETA-GLOBINS; CELL DIFFERENTIATION; CELL PROLIFERATION; ERYTHROID CELLS; GAMMA-GLOBINS; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC; URACIL;

EID: 81255160660     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.09.024     Document Type: Article

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