Methotrexate: An effective agent for treating cancer and building careers. The polyglutamate era

Stem Cells

Volumn 14, Issue 1, 1996, Pages 29-32

  Schilsky, Richard L ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

5 ethynyluracil; 5 fluorouracil; Leucovurin; Methotrexate; Polyglutamate; Stereoisomers

Indexed keywords

5 ETHYNYLURACIL; DIHYDROFOLATE REDUCTASE; DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; FOLINIC ACID; METHOTREXATE; METHOTREXATE POLYGLUTAMATE; THYMIDYLATE SYNTHASE;

AREA UNDER THE CURVE; BREAST CANCER; CANCER CHEMOTHERAPY; CELL VIABILITY; COLORECTAL CANCER; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DEVELOPMENT; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG UPTAKE; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; REVIEW;

EID: 0030032030     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.140029     Document Type: Review

References (10)

1. Schilsky RL, Bailey BD, Chabner BA. Characteristics of membrane transport of methotrexate by cultured human breast cancer cells. Biochem Pharmacol 1981;30:1537-1542.
2. Schilsky RL, Bailey BD, Chabner BA. Methotrexate polyglutamate synthesis by cultured human breast cancer cells. Proc Natl Acad Sci USA 1980;77:2919-2922.
3. Jolivet J, Schilsky RL. High-pressure liquid chromatography analysis of methotrexate polyglutamates in cultured human breast cancer cells. Biochem Pharmacol 1981;30:1387-1390.
4. Jolivet J, Schilsky RL, Bailey BD et al. The synthesis and retention of methotrexate polyglutamates in cultured human breast cancer cells. Ann NY Acad Sci 1982;397:184-192.
5. Jolivet J, Schilsky RL, Bailey BD et al. Synthesis retention and biologic activity of methotrexate polyglutamates in cultured human breast cancer cells. J Clin Invest 1982;70:351-360.
6. Choi KE, Schilsky RL. Resolution of the stereoisomers of leucovorin and 5-methyltetrahydrofolate by chiral high performance liquid chromatography. Anal Biochem 1988;168:398-404.
7. Schilsky RL, Ratain MJ. Clinical pharmacokinetics of high dose leucovorin calcium after intravenous and oral administration. J Natl Cancer Inst 1990;82:1411-1415.
8. Schilsky R, Burns H, Khor SP et al. A pharmacokinetic study of 5-ethynyluracil plus 5-fluorouracil in cancer patients with solid tumors. Proc Fifth Int Congress Anticancer Chemother. Paris, France. February. 1995.
9. Khor SP, Lucas S, Schilsky R et al. A phase I/pharmacokinetic study of 5-ethynyluracil plus 5-fluorouracil in cancer patients with solid tumors. Proc Am Assoc Cancer Res 1995;36:241a.
10. Burris H, Schilsky R, Fields S et al. Initial phase I trial of the dihydropyrimidine dehydrogenase inactivator 5-ethynyluracil (776C85) plus 5-fluorouracil. Proc Am Soc Clin Oncol 1995;14:171a.