Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: Part 2

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 24, 2011, Pages 7287-7290

  Brumfield, Stephanie ^a   Matasi, Julius J ^a   Tulshian, Deen ^a   Czarniecki, Michael ^a   Greenlee, William ^a   Garlisi, Charles ^a   Qiu, Hongchen ^a   Devito, Kristine ^a   Chen, Shu Cheng ^a   Sun, Yongliang ^a   Bertorelli, Rosalia ^a   Ansell, Justin ^a   Geiss, William ^b   Le, Van Duc ^b   Martin, Gregory S ^b   Vellekoop, Samuel A ^b   Haber, James ^b   Allard, Melissa L ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ALBANY MOLECULAR RESEARCH INC   (United States)

Author keywords

Inflammatory pain; Neuropathic pain; P2X7; Purine derivatives

Indexed keywords

GABAPENTIN; NAPROXEN; PREGABALIN; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2X7 RECEPTOR ANTAGONIST; PURINERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN; PAIN; STRUCTURE ACTIVITY RELATION;

ANIMALS; HUMANS; PAIN; PURINERGIC P2X RECEPTOR ANTAGONISTS; PURINES; RATS; RECEPTORS, PURINERGIC P2X7; STRUCTURE-ACTIVITY RELATIONSHIP;

RODENTIA;

EID: 81255152299     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.037     Document Type: Article

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