Runx2: of bone and stretch

International Journal of Biochemistry and Cell Biology

Volumn 40, Issue 9, 2008, Pages 1659-1663

  Ziros, Panos G ^a   Basdra, Efthimia K ^b   Papavassiliou, Athanasios G ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Bone remodelling; Mechanotransduction; Osteoblast; Osteogenesis; Runx2

Indexed keywords

TRANSCRIPTION FACTOR RUNX2;

BONE REMODELING; CELL DIFFERENTIATION; CELL MATURATION; CLEIDOCRANIAL DYSPLASIA; GENE EXPRESSION REGULATION; GENE MUTATION; HOMEOSTASIS; HUMAN; NONHUMAN; OSTEOBLAST; SHORT SURVEY; SIGNAL TRANSDUCTION;

ANIMALS; BONE AND BONES; BONE DISEASES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; GENE EXPRESSION REGULATION; HUMANS; MECHANOTRANSDUCTION, CELLULAR; STRESS, MECHANICAL;

MUS;

EID: 45149127389     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2007.05.024     Document Type: Short Survey

References (30)

1. Ducy P., and Karsenty G. Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol. Cell. Biol. 15 (1995) 1858-1869
2. Ducy P., Starbuck M., Priemel M., Shen J., Pinero G., Geoffroy V., et al. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev. 13 (1999) 1025-1036
3. Ducy P., Zhang R., Geoffroy V., Ridall A.L., and Karsenty G. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 89 (1997) 747-754
4. Franceschi R.T., and Xiao G. Regulation of the osteoblast-specific transcription factor Runx2: Responsiveness to multiple signal transduction pathways. J. Cell. Biochem. 88 (2003) 446-454
5. Geoffroy V., Ducy P., and Karsenty G. A PEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element. J. Biol. Chem. 270 (1995) 30973-30979
6. Geoffroy V., Kneissel M., Fournier B., Boyde A., and Matthias P. High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage. Mol. Cell. Biol. 22 (2002) 6222-6233
7. Huang G., Shigesada K., Ito K., Wee H.J., Yokomizo T., and Ito Y. Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. EMBO J. 20 (2001) 723-733
8. Inada M., Yasui T., Nomura S., Miyake S., Deguchi K., Himeno M., et al. Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev. Dynamics 214 (1999) 279-290
9. Kanno T., Takahashi T., Tsujisawa T., Ariyoshi W., and Nishihara T. Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts. J. Cell. Biochem. 101 (2008) 1266-1277
10. Kim I.S., Otto F., Zabel B., and Mundlos S. Regulation of chondrocyte differentiation by Cbfa1. Mech. Dev. 80 (1999) 159-170
11. Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89 (1997) 755-764
12. Levanon D., Negreanu V., Bernstein Y., Bar-Am I., Avivi L., and Groner Y. AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Genomics 23 (1994) 425-432
13. Li Y.L., and Xiao Z.S. Advances in Runx2 regulation and its isoforms. Med. Hypotheses 68 (2007) 169-175
14. Liu W., Toyosawa S., Furuich T., Kanatani N., Yoshida C., Liu Y., et al. Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J. Cell Biol. 155 (2001) 157-166
15. Merriman H.L., van Wijnen A.J., Hiebert S., Bidwell J.P., Fey E., Lian J., et al. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family: Interactions with the osteocalcin gene promoter. Biochemistry 34 (1995) 13125-13132
16. Ogawa E., Maruyama M., Kagoshima H., Inuzuka M., Lu J., Satake M., et al. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 6859-6863
17. Otto F., Kanegane H., and Mundlos S. Mutations in the RUNX2 gene in patients with cleidocranial dysplasia. Hum. Mutat. 19 (2002) 209-216
18. Otto F., Thornell A.P., Crompton T., Denzel A., Gilmour K.C., Rosewell I.R., et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89 (1997) 765-771
19. Pratap J., Lian J.B., Javed A., Barnes G.L., van Wijnen A.J., Stein J.L., et al. Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone. Cancer Metastasis Rev. 25 (2006) 589-600
20. Salingcarnboriboon R., Tsuji K., Komori T., Nakashima K., Ezura Y., and Noda M. Runx2 is a target of mechanical unloading to alter osteoblastic activity and bone formation in vivo. Endocrinology 147 (2006) 2296-2305
21. Schroeder T.M., Jensen E.D., and Westendorf J.J. Runx2: A master organizer of gene transcription in developing and maturing osteoblasts. Birth Defects Res. C. Embryo Today 75 (2005) 213-225
22. Thirunavukkarasu K., Mahajan M., McLarren K.W., Stifani S., and Karsenty G. Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta. Mol. Cell. Biol. 18 (1998) 4197-4208
23. Turner C.H. Bone strength: current concepts. Ann. N. Y. Acad. Sci. 1068 (2006) 429-446
24. Wang S.W., and Speck N.A. Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers. Mol. Cell. Biol. 12 (1992) 89-102
25. Westendorf J.J. Transcriptional co-repressors of Runx2. J. Cell. Biochem. 98 (2006) 54-64
26. Xiao Z.S., Hjelmeland A.B., and Quarles L.D. Selective deficiency of the "bone-related" Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis. J. Biol. Chem. 279 (2004) 20307-20313
27. Zeng C., McNeil S., Pockwinse S., Nickerson J., Shopland L., Lawrence J.B., et al. Intranuclear targeting of AML/CBFalpha regulatory factors to nuclear matrix-associated transcriptional domains. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 1585-1589
28. Zhang Y.W., Bae S.C., Takahashi E., and Ito Y. The cDNA cloning of the transcripts of human PEBP2alphaA/CBFA1 mapped to 6p12.3-p21.1, the locus for cleidocranial dysplasia. Oncogene 15 (1997) 367-371
29. Ziros P.G., Georgakopoulos T., Habeos I., Basdra E.K., and Papavassiliou A.G. Growth hormone attenuates the transcriptional activity of Runx2 by facilitating its physical association with Stat3beta. J. Bone Miner. Res. 19 (2004) 1892-1904
30. Ziros P.G., Gil A.-P., Georgakopoulos T., Habeos I., Kletsas D., and Basdra E.K., Papavassiliou A.G. The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells. J. Biol. Chem. 277 (2002) 23934-23941