Physical crosslinking modulates sustained drug release from recombinant silk-elastinlike protein polymer for ophthalmic applications

Journal of Controlled Release

Volumn 156, Issue 2, 2011, Pages 186-194

  Teng, Weibing ^a   Cappello, Joseph ^a   Wu, Xiaoyi ^a,b  

^a University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Antimicrobial assay; Ophthalmic material; Optical transparency; Silk elastinlike protein polymer; Sustained drug release

Indexed keywords

ANTI-MICROBIAL ACTIVITY; CIPROFLOXACIN; COATING TREATMENT; CROSSLINKS; DRUG RELEASE; DRUG-LOADED FILMS; EQUILIBRIUM SWELLING; FILM CASTING; FIRST-ORDER; FTIR; MATERIAL CANDIDATE; METHANOL VAPORS; OPHTHALMIC DRUG DELIVERY; OPTICAL TRANSPARENCY; PHYSICAL CROSSLINKING; PHYSICS-BASED MODELS; POLYMER COATING; POLYMER NETWORKS; PROTEIN FILMS; PROTEIN POLYMERS; RELEASE KINETICS; RELEASE RATE; SILK-ELASTINLIKE PROTEIN POLYMERS; SOLUBLE FRACTION; SUSTAINED DRUG RELEASE;

ANTIBIOTICS; DRUG DELIVERY; ETHANOL; METHANOL; MICROORGANISMS; PLASTIC COATINGS; POLYMERS; PROTEINS; RAMAN SPECTROSCOPY; SILK; SURFACE ROUGHNESS;

POLYMER FILMS;

ALCOHOL; CIPROFLOXACIN; METHANOL; POLYMER; RECOMBINANT SILK ELASTINLIKE PROTEIN POLYMER; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONTACT ANGLE; CROSS LINKING; DRUG RELEASE; DRUG SOLUBILITY; DRUG TRANSPORT; ESCHERICHIA COLI; HYDROPHOBICITY; INFRARED SPECTROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; RAMAN SPECTROMETRY; SIMULATION; SUSTAINED DRUG RELEASE;

ANTI-INFECTIVE AGENTS; CIPROFLOXACIN; DELAYED-ACTION PREPARATIONS; OPHTHALMIC SOLUTIONS; RECOMBINANT FUSION PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPECTRUM ANALYSIS, RAMAN;

EID: 81255127365     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.07.036     Document Type: Article

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