Effects of temperature on the p53-DNA binding interactions and their dynamical behavior: Comparing the wild type to the R248Q mutant

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Barakat, Khaled ^a,b   Issack, Bilkiss B ^a,c   Stepanova, Maria ^a,c   Tuszynski, Jack ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b FAYOUM UNIVERSITY   (Egypt)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN P53; MUTANT PROTEIN; WATER;

ARTICLE; BINDING AFFINITY; CLUSTER ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; HYDROGEN BOND; MOLECULAR DYNAMICS; MUTANT; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; PROTEIN STRUCTURE; SIMULATION; TEMPERATURE SENSITIVITY; WILD TYPE; CHEMISTRY; CONFORMATION; GENETICS; HUMAN; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; TEMPERATURE; THERMODYNAMICS;

BASE SEQUENCE; DNA; HUMANS; HYDROGEN BONDING; MOLECULAR DYNAMICS SIMULATION; MUTANT PROTEINS; MUTATION; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE; THERMODYNAMICS; TUMOR SUPPRESSOR PROTEIN P53; WATER;

EID: 81155134495     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027651     Document Type: Article

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