Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and β cell dysfunction

Steroids

Volumn 76, Issue 14, 2011, Pages 1575-1581

  Baudrand, Rene ^a   Campino, Carmen ^a   Carvajal, Cristian A ^a   Olivieri, Oliviero ^b   Guidi, Giancesare ^b   Faccini, Giovanni ^b   Sateler, Javiera ^a   Cornejo, Javiera ^c   Martin, Betty San ^c   Dominguez, Jose M ^a   Cerda, Jaime ^a   Mosso, Lorena M ^a   Owen, Gareth I ^a   Kalergis, Alexis M ^a   Fardella, Carlos E ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSITY OF VERONA   (Italy)

^c UNIVERSITY OF CHILE   (Chile)

Author keywords

11 Hydroxysteroid dehydrogenase; Adiponectin; Glucocorticoid metabolites; Insulin resistance; Metabolic syndrome

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADIPOCYTOKINE; ADIPOKINETIC HORMONE; ADIPONECTIN; GLUCOCORTICOID;

ANTHROPOMETRIC PARAMETERS; ARTICLE; CONTROLLED STUDY; CUSHING SYNDROME; DYSLIPIDEMIA; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PHENOTYPE; URINE LEVEL;

ADIPONECTIN; ADULT; FEMALE; GLUCOCORTICOIDS; HUMANS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LIPID METABOLISM; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY;

EID: 81155128682     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.09.010     Document Type: Article

References (42)

1. V.G. Athyros, E.S. Ganotakis, M. Elisaf, and D.P. Mikhailidis The prevalence of the metabolic syndrome using the National Cholesterol Educational Program and International Diabetes Federation definitions Curr Med Res Opin 21 2005 1157 1159 (Pubitemid 41140717)
2. J.W. Tomlinson, and P.M. Stewart Mechanisms of disease: selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome Nat Clin Pract Endocrinol Metab 1 2005 92 99
3. J.W. Tomlinson, E.A. Walker, I.J. Bujalska, N. Draper, G.G. Lavery, and M.S. Cooper 11Beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response Endocr Rev 25 2004 831 866 (Pubitemid 39366049)
4. A. Swali, E.A. Walker, G.G. Lavery, J.W. Tomlinson, and P.M. Stewart 11Beta-hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets Diabetologia 51 2008 2003 2011
5. R. Andrew, D.I. Phillips, and B.R. Walker Obesity and gender influence cortisol secretion and metabolism in man J Clin Endocrinol Metab 83 1998 1806 1809 (Pubitemid 28501063)
6. B.R. Walker Cortisol - cause and cure for metabolic syndrome? Diabet Med 23 2006 1281 1288 (Pubitemid 44787789)
7. P. Anagnostis, V.G. Athyros, K. Tziomalos, A. Karagiannis, and D.P. Mikhailidis Clinical review: the pathogenetic role of cortisol in the metabolic syndrome: a hypothesis J Clin Endocrinol Metab 94 2009 2692 2701
8. C. Campino, C.A. Carvajal, J. Cornejo, B.S. Martin, O. Olivieri, and G. Guidi 11Beta-hydroxysteroid dehydrogenase type-2 and type-1 (11beta-HSD2 and 11beta-HSD1) and 5beta-reductase activities in the pathogenia of essential hypertension Endocrine 37 2009 106 114
9. L. Alberti, A. Girola, L. Gilardini, A. Conti, S. Cattaldo, and G. Micheletto Type 2 diabetes and metabolic syndrome are associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese subjects Int J Obes (Lond) 31 2007 1826 1831 (Pubitemid 350174630)
10. D.H. van Raalte, D.M. Ouwens, and M. Diamant Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options? Eur J Clin Invest 39 2009 81 93
11. A. Krikorian, and M. Khan Is metabolic syndrome a mild form of Cushing's syndrome? Rev Endocr Metab Disord 11 2010 141 145
12. H.L. Bradlow, B. Zumoff, D.K. Fukushima, L. Hellman, and T.F. Gallagher Biotransformations of the C-20-dihydro metabolites of cortisol in man J Clin Endocrinol Metab 34 1972 997 1002
13. M. Bose, B. Olivan, and B. Laferrere Stress and obesity: the role of the hypothalamic-pituitary-adrenal axis in metabolic disease Curr Opin Endocrinol Diabetes Obes 16 2009 340 346
14. Baudrand R, Dominguez JM, Carvajal CA, Riquelme A, Campino C, Macchiavello S, et al. Overexpression of hepatic 5alpha-reductase and 11beta-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyperinsulinemia in morbidly obese patients. Metabolism. doi:10.1016/j.metabol.2011.05.001.
15. B. Zumoff, C. Monder, and H.L. Bradlow Studies in the biotransformation of cortisol to the cortoic acids in man. II. The central role of tetrahydrocortisol and tetrahydrocortisone as intermediates J Clin Endocrinol Metab 44 1977 647 650 (Pubitemid 8088096)
16. H.L. Bradlow, B. Zumoff, T.F. Gallagher, and L. Hellman Tetrahydrocortisol metabolism in man Steroids 12 3 1968 303 308
17. S.M. Grundy, J.I. Cleeman, S.R. Daniels, K.A. Donato, R.H. Eckel, and B.A. Franklin Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement Circulation 112 2005 2735 2752 (Pubitemid 41532612)
18. C.A. Aguilar-Salinas, E.G. Garcia, L. Robles, D. Riano, D.G. Ruiz-Gomez, and A.C. Garcia-Ulloa High adiponectin concentrations are associated with the metabolically healthy obese phenotype J Clin Endocrinol Metab 93 2008 4075 4079
19. Y. Song, J.E. Manson, L. Tinker, B.V. Howard, L.H. Kuller, and L. Nathan Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the Women's Health Initiative Observational Study Diabetes Care 30 2007 1747 1752 (Pubitemid 47036347)
20. P. Krall, C. Carvajal, E. Ortiz, C. Munoz, J.L. Garrido, and L. Mosso Urinary free cortisol is not a biochemical marker of hypertension Am J Hypertens 20 2007 459 465 (Pubitemid 46441749)
21. J.W. Tomlinson, J. Finney, B.A. Hughes, S.V. Hughes, and P.M. Stewart Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss Diabetes 57 2008 1536 1543
22. J.W. Tomlinson, J. Finney, C. Gay, B.A. Hughes, S.V. Hughes, and P.M. Stewart Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity Diabetes 57 2008 2652 2660
23. R. Basu, A. Basu, M. Grudzien, P. Jung, P. Jacobson, and M. Johnson Liver is the site of splanchnic cortisol production in obese nondiabetic humans Diabetes 58 2009 39 45
24. K. Mussig, T. Remer, A. Haupt, B. Gallwitz, A. Fritsche, and H.U. Haring 11Beta-hydroxysteroid dehydrogenase 2 activity is elevated in severe obesity and negatively associated with insulin sensitivity Obesity (Silver Spring) 16 2008 1256 1260 (Pubitemid 351770515)
25. J.E. Yun, J.W. Sull, H.Y. Lee, E. Park, S. Kim, and J. Jo Serum adiponectin as a useful marker for metabolic syndrome in type 2 diabetic patients Diabetes Metab Res Rev 25 2009 259 265
26. A. Shankar, S. Marshall, and J. Li The association between plasma adiponectin level and hypertension Acta Cardiol 63 2008 160 165 (Pubitemid 351548700)
27. M. Calvani, A. Scarfone, L. Granato, E.V. Mora, G. Nanni, and M. Castagneto Restoration of adiponectin pulsatility in severely obese subjects after weight loss Diabetes 53 2004 939 947 (Pubitemid 38436605)
28. N. Ashizawa, M. Takagi, S. Seto, S. Suzuki, and K. Yano Serum adiponectin and leptin in a patient with Cushing's syndrome before and after adrenalectomy Intern Med 46 2007 383 385 (Pubitemid 46585478)
29. A. Veilleux, C. Rheaume, M. Daris, V. Luu-The, and A. Tchernof Omental adipose tissue type 1 11 beta-hydroxysteroid dehydrogenase oxoreductase activity, body fat distribution, and metabolic alterations in women J Clin Endocrinol Metab 94 2009 3550 3557
30. J.H. Shi, W.H. Du, X.Y. Liu, Y.P. Fan, X.L. Hu, and H.Y. Zhou Glucocorticoids decrease serum adiponectin level and WAT adiponectin mRNA expression in rats Steroids 75 2010 853 858
31. M. Sundbom, C. Kaiser, E. Bjorkstrand, V.M. Castro, C. Larsson, and G. Selen Inhibition of 11betaHSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAy mice BMC Pharmacol 8 2008 3
32. R. Baudrand, C.A. Carvajal, A. Riquelme, M. Morales, N. Solis, and M. Pizarro Overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients Obes Surg 20 2010 77 83
33. B. Davani, N. Portwood, G. Bryzgalova, M.K. Reimer, T. Heiden, and C.G. Ostenson Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells develop diabetes Diabetes 53 Suppl. 1 2004 S51 S59
34. H. Masuzaki, J. Paterson, H. Shinyama, N.M. Morton, J.J. Mullins, and J.R. Seckl A transgenic model of visceral obesity and the metabolic syndrome Science 294 2001 2166 2170 (Pubitemid 33150673)
35. T.C. Friedman, G. Mastorakos, T.D. Newman, N.M. Mullen, E.G. Horton, and R. Costello Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM Endocr J 43 1996 645 655 (Pubitemid 126447899)
36. J. O'Connell, L. Lynch, A. Hogan, T.J. Cawood, and D. O'Shea Preadipocyte factor-1 is associated with metabolic profile in severe obesity J Clin Endocrinol Metab 96 2011 E680 E684
37. A.D. Karelis, M. Faraj, J.P. Bastard, D.H. St.-Pierre, M. Brochu, and D. Prud'homme The metabolically healthy but obese individual presents a favorable inflammation profile J Clin Endocrinol Metab 90 2005 4145 4150 (Pubitemid 41058189)
38. B.S. Mohammed, S. Cohen, D. Reeds, V.L. Young, and S. Klein Long-term effects of large-volume liposuction on metabolic risk factors for coronary heart disease Obesity (Silver Spring) 16 2008 2648 2651
39. N.M. Morton, J.M. Paterson, H. Masuzaki, M.C. Holmes, B. Staels, and C. Fievet Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice Diabetes 53 2004 931 938 (Pubitemid 38436604)
40. C. Mattsson, R.M. Reynolds, K. Simonyte, T. Olsson, and B.R. Walker Combined receptor antagonist stimulation of the hypothalamic-pituitary-adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men J Clin Endocrinol Metab 94 2009 1347 1352
41. R. Basu, R.J. Singh, A. Basu, E.G. Chittilapilly, C.M. Johnson, and G. Toffolo Splanchnic cortisol production occurs in humans: evidence for conversion of cortisone to cortisol via the 11-beta hydroxysteroid dehydrogenase (11beta-hsd) type 1 pathway Diabetes 53 2004 2051 2059 (Pubitemid 38970754)
42. R.H. Stimson, J. Andersson, R. Andrew, D.N. Redhead, F. Karpe, and P.C. Hayes Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans Diabetes 58 2009 46 53