Uncoupling protein-2 deficient mice are not protected against warm ischemia/reperfusion injury of the liver

Journal of Surgical Research

Volumn 171, Issue 2, 2011, Pages 742-748

  Le Minh, Khoi ^a,b   Berger, Andreas ^a   Eipel, Christian ^a   Kuhla, Angela ^a   Minor, Thomas ^c   Stegemann, Judith ^c   Vollmar, Brigitte ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b HUE UNIVERSITY   (Viet Nam)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

ATP; hepatic energy charge; hepatic microcirculation; interleukin 6; reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINOTRANSFERASE; INTERLEUKIN 6; UNCOUPLING PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOENERGY; CONTROLLED STUDY; ENERGY; FLUORESCENCE MICROSCOPY; INFLAMMATION; INTRAVITAL FLUORESCENCE MICROSCOPY; LEUKOCYTE ADHERENCE; LIVER ISCHEMIA; LIVER PERFUSION; LIVER SINUSOID; MICROCIRCULATION; MORPHOMETRICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY; SHAM PROCEDURE; WILD TYPE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ENERGY METABOLISM; INTERLEUKIN-6; ION CHANNELS; LIVER DISEASES; MALE; MICE; MICE, KNOCKOUT; MICROCIRCULATION; MITOCHONDRIAL PROTEINS; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; TEMPERATURE;

EID: 81155128201     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2010.04.028     Document Type: Article

References (35)

1. T.L. Husted, and A.B. Lentsch The role of cytokines in pharmacological modulation of hepatic ischemia/reperfusion injury Curr Pharm Des 12 2006 2867
2. I.H. Chaudry Cellular mechanisms in shock and ischemia and their correction Am J Physiol 245 1983 R117
3. H. Jaeschke Mechanisms of reperfusion injury after warm ischemia of the liver J Hepatobiliary Pancreat Surg 5 1998 402
4. C. Eipel, M. Glanemann, and A.K. Nuessler Ischemic preconditioning impairs liver regeneration in extended reduced-size livers Ann Surg 241 2005 477
5. J. Jaeschke II Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions Am J Physiol Gastrointest Liver Physiol 290 2006 G1083
6. S. Arii, K. Teramoto, and T. Kawamura Current progress in the understanding of and therapeutic strategies for ischemia and reperfusion injury of the liver J Hepatobiliary Pancreat Surg 10 2003 189
7. C. Fleury, M. Neverova, and S. Collins Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia Nat Genet 15 1997 269
8. D. Ricquier, and F. Bouillaud Mitochondrial uncoupling proteins: From mitochondria to the regulation of energy balance J Physiol 529 2000 3
9. R.E. Gimeno, M. Dembski, and X. Weng Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis Diabetes 46 1997 900
10. A. Ngre-Salvayre, C. Hirtz, and G. Carrera A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation FASEB J 11 1997 809
11. S. Rousset, M.C. Alves-Guerra, and J. Mozo The biology of mitochondrial uncoupling proteins Diabetes 53 2004 S130
12. D. Arsenijevic, H. Onuma, and C. Pecqueur Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production Nat Genet 26 2000 435
13. F. Goglia, and V.P. Skulachev A function for novel uncoupling proteins: Antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet FASEB J 17 2003 1585
14. G. Serviddio, F. Bellanti, and R. Tamborra Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischemia-reperfusion injury Gut 57 2008 957
15. C.D. Wan, C.Y. Wang, and T. Liu Alleviation of ischemia/reperfusion injury in ob/ob mice by inhibiting UCP-2 expression in fatty liver World J Gastroenterol 14 2008 590
16. K. Le Minh, A. Kuhla, and K. Abshagen Uncoupling protein-2 deficiency provides protection in a murine model of endotoxemic acute liver failure Crit Care Med 37 2009 215
17. B. Vollmar, J. Glasz, and R. Leiderer Hepatic microcirculatory perfusion failure is a determinant for liver dysfunction in warm ischemia-reperfusion Am J Pathol 145 1994 1421
18. B. Vollmar, S. Richter, and M.D. Menger Leukocyte stasis in hepatic sinusoids Am J Physiol 270 1996 G798
19. P. Olschewski, G. Hunold, and C. Eipel Improved microcirculation by low-viscosity histidine-tryptophan-ketoglutarate graft flush and subsequent cold storage in University of Wisconsin solution: Results of an orthotopic rat liver transplantation model Transpl Int 21 2008 1175
20. M. Kravos, and I. Malesic Kinetics and isoforms of serum glutamate dehydrogenase in alcoholics Alcohol Alcohol 43 2008 281
21. T. Minor, A. Hachenberg, and R. Tolba Fibrinolytic preflush upon liver retrieval from non-heart beating donors to enhance post-preservation viability and energetic recovery upon reperfusion Transplantation 71 2001 1792
22. D.E. Atkinson The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers Biochemistry 7 1968 4030
23. H. Jaeschke Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning Am J Physiol Gastrointest Liver Physiol 284 2003 G15
24. Z.P. Evans, J.D. Ellett, and M.G. Schmidt Mitochondrial uncoupling protein-2 mediates steatotic liver injury following ischemia/reperfusion J Biol Chem 283 2008 8573
25. Y. Shang, Y. Liu, and L. Du Targeted expression of uncoupling protein 2 to mouse liver increases the susceptibility to lipopolysaccharide/galactosamine- induced acute liver injury Hepatology 50 2009 1204
26. B. Vollmar, M.D. Menger, and J. Glasz Impact of leukocyte-endothelial cell interaction in hepatic ischemia-reperfusion injury Am J Physiol 267 1994 G786
27. B. Vollmar, and M.D. Menger The hepatic microcirculation: Mechanistic contributions and therapeutic targets in liver injury and repair Physiol Rev 89 2009 1269
28. M.D. Menger, and B. Vollmar Adhesion molecules as determinants of disease: From molecular biology to surgical research Br J Surg 83 1996 588
29. J.W. Ryu, K.H. Hong, and J.H. Maeng Overexpression of uncoupling protein 2 in THP1 monocytes inhibits β2 integrin-mediated firm adhesion and transendothelial migration Arterioscler Thromb Vasc Biol 24 2004 864
30. D.Q. Liu, Y.L. Guo, and Z. Bian Uncoupling protein-2 negatively regulates polymorphonuclear leukocytes chemotaxis via modulating [Ca2+] influx Arterioscler Thromb Vasc Biol 30 2010 575
31. K.D. Chavin, S. Yang, and H.Z. Lin Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion J Biol Chem 274 1999 5692
32. D. Brealey, M. Brand, and I. Hargreaves Association between mitochondrial dysfunction and severity and outcome of septic shock Lancet 360 2002 219
33. S. Rousset, Y. Emre, and O. Join-Lambert The uncoupling protein 2 modulates the cytokine balance in innate immunity Cytokine 35 2006 135
34. Y. Bai, H. Onuma, and X. Bai Persistent nuclear factor-κ B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production J Biol Chem 280 2005 19062
35. Y. Liang, Y. Zhou, and P. Shen NF-κB and its regulation on the immune system Cell Mol Immunol 1 2004 343