Adhesion molecules as determinants of disease: From molecular biology to surgical research

British Journal of Surgery

Volumn 83, Issue 5, 1996, Pages 588-601

  Menger, M D ^a   Vollmar, B ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; IMMUNOGLOBULIN; INTEGRIN; MEMBRANE RECEPTOR; RECEPTOR; SELECTIN;

ANGIOGENESIS; ATHEROSCLEROSIS; CANCER; CELL ADHESION; CELL COMMUNICATION; CELL MIGRATION; COMPLICATION; GRAFT REJECTION; HUMAN; INFLAMMATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; SEPSIS; SHOCK; SURGERY; THROMBOSIS;

CELL ADHESION MOLECULES; DISEASE; HUMANS; SURGICAL PROCEDURES, OPERATIVE;

EID: 0029978607     PISSN: 00071323     EISSN: None     Source Type: Journal    
DOI: 10.1002/bjs.1800830506     Document Type: Review

References (229)

1. Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992; 69: 11-25.
2. Smyth SS, Joneckis CC, Parise LV. Regulation of vascular integrins. Blood 1993; 81: 2827-43.
3. Albelda SM. Biology of disease. Role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab Invest 1993; 68: 4-17.
4. x) is responsible for distinct adhesive properties of carcinoma cells. Cell 1989; 57: 59-69.
5. 6) identified in epithelial cells using the polymerase chain reaction. J Biol Chem 1990; 265: 11 502-7.
6. Hemler ME. VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu Rev Immunol 1990; 8: 365-400.
7. 4 integrins in vivo. J Clin Invest 1994; 94: 1722-8.
8. 7) identified in leukocytes. J Biol Chem 1991; 266: 11 009-16.
9. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994; 84: 2068-101.
10. 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 1995; 80: 413-22.
11. Albelda SM, Buck CA. Integrins and other cell adhesion molecules. FASEB J 1990; 4: 2868-80.
12. Elices MJ, Osborn L, Takada Y et al. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 1990; 60: 577-84.
13. 4 integrin counter-receptor on stimulated endothelium. J Exp Med 1992; 175: 1433-42.
14. van Kooyk Y, ven de Wiel-van Kemenade E, Weder P, Huijbens RJF, Figdor CG. Lymphocyte function-associated antigen 1 dominates very late antigen 4 in binding of activated T cells to endothelium. J Exp Med 1993; 177: 185-90.
15. Carlos T, Kovach N, Schwartz B et al. Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1. Blood 1991; 77: 2266-71.
16. Jonjic N, Jilek P, Bernasconi S et al. Molecules involved in the adhesion and cytotoxicity of activated monocytes on endothelial cells. J Immunol 1992; 148: 2080-3.
17. Bochner BS, Luscinskas FW, Gimbrone MA et al. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J Exp Med 1991; 173: 1553-7.
18. Schleimer RP, Sterbinsky SA, Kaiser J et al. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol 1992; 148: 1086-92.
19. Allavena P, Paganin C, Martin-Padura I et al. Molecules and structures involved in the adhesion of natural killer cells to vascular endothelium. J Exp Med 1991; 173: 439-48.
20. Arnaout MA. Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood 1990; 75: 1037-50.
21. Carlos TM, Harlan JM. Membrane proteins involved in phagocyte adherence to endothelium. Immunol Rev 1990; 114:5-28.
22. de Fougerolles AR, Springer TA. Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes. J Exp Med 1992; 175: 185-90.
23. Smith CW, Marlin SD, Rothlein R, Toman C, Anderson DC. Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J Clin Invest 1989; 83: 2008-17.
24. Lo SK, van Seventer GA, Levin SM, Wright SD. Two leukocyte receptors (CD11a/CD18 and CD11b/CD18) mediate transient adhesion to endothelium by binding to different ligands. J Immunol 1989; 143: 3325-9.
25. Arnaout MA, Lanier LL, Faller DV. Relative contribution of the leukocyte molecules Mo 1, LFA-1, and p 150/95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue- and stimulus-specific. J Cell Physiol 1988; 137: 305-9.
26. Mentzer SJ, Crimmins MAV, Burakoff SJ, Faller DV. Alpha and beta subunits of the LFA-1 membrane molecule are involved in human monocyte-endothelial cell adhesion. J Cell Physiol 1987; 130: 410-15.
27. Dustin ML, Springer TA. Lymphocyte function-associated molecule-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells. J Cell Biol 1988; 107: 321-31.
28. Shimizu Y, Newman W, Gopal TV et al. Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions. J Cell Biol 1991; 113: 1203-12.
29. 2 integrin CR3 (CD11b/CD18). Proc Natl Acad Sci USA 1994; 91: 10 680-4.
30. Hynes RO. Integrins: a family of cell surface receptors. Cell 1987; 48: 549-54.
31. Phillips DR, Charo IF, Parise LV, Fitzgerald LA. The platelet membrane glycoprotein IIb-IIIa complex. Blood 1988; 71: 831-43.
32. 3 integrins (GPIIb-IIIa) and the expression of P-selectin and procoagulant activity. J Exp Med 1993; 178: 579-87.
33. 1 subunit on certain cell lines. J Biol Chem 1989; 264: 6529-35.
34. Holzmann B, McIntyre BW, Weissman IL. Identification of a murine Peyer's patch-specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4 α. Cell 1989; 56: 37-46.
35. 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993; 74: 185-95.
36. 7 on the human B cell line JY. J Biol Chem 1992; 267: 8366-70.
37. P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. J Cell Biol 1992; 117: 179-89.
38. 4 integrins on human B lymphocytes. J Immunol 1993; 151: 2471-83.
39. 1. J Exp Med 1995; 182: 345-55.
40. Springer TA. Adhesion receptors of the immune system. Nature 1990; 346: 425-34.
41. Marlin SD, Springer TA. Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 1987; 51: 813-19.
42. Diamond MS, Staunton DE, Marlin SD, Springer TA. Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation. Cell 1991; 65: 961-71.
43. Staunton DE, Dustin ML, Springer TA. Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. Nature 1989; 339: 61-4.
44. Diacovo TG, deFougerolles AR, Bainton DF, Springer TA. A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2. J Clin Invest 1994; 94: 1243-51.
45. Fawcett J, Holness CLL, Needham LA et al. Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. Nature 1992; 360: 481-4.
46. Campanero MR, del Pozo MA, Arroyo AG et al. ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway. J Cell Biol 1993; 123: 1007-16.
47. Osborn L, Hession C, Tizard R et al. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 1989; 59: 1203-11.
48. Hession C, Tizard R, Vassallo C et al. Cloning of an alternate form of vascular cell adhesion molecule-1 (VCAM1). J Biol Chem 1991; 266: 6682-5.
49. Cybulsky MI, Fries JWU, Williams AJ et al. Alternative splicing of human VCAM-1 in activated vascular endothelium. Am J Pathol 1991; 138: 815-20.
50. Bevilacqua MP, Nelson RM, Mannori G, Cecconi O. Endothelial-leukocyte adhesion molecules in human disease. Annu Rev Med 1994; 45: 361-78.
51. Newman PJ, Berndt MC, Gorski J et al. PECAM-1 (CD31): cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 1990; 247: 1219-22.
52. Stockinger H, Gadd SJ, Eher R et al. Molecular characterization and functional analysis of the leukocyte surface protein Cd31. J Immunol 1990; 145: 3889-97.
53. Albelda SM, Muller WA, Buck CA, Newman PJ. Molecular and cellular properties of PECAM-1 (EndoCAM/CD31): a novel vascular cell-cell adhesion molecule. J Cell Biol 1991; 114: 1059-68.
54. Simmons DL, Walker C, Power C, Pigott R. Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen. J Exp Med 1990; 171: 2147-52.
55. Muller WA, Weigl SA, Deng X, Phillips DM. PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 1993; 178: 449-60.
56. Streeter PR, Berg EL, Rouse BTN, Bargatze RF, Butcher EC. A tissue-specific endothelial cell molecule involved in lymphocyte homing. Nature 1988; 331: 41-6.
57. Nakache M, Berg EL, Streeter PR, Butcher EC. The mucosal vascular addressin is a tissue-specific endothelial cell adhesion molecule for circulating lymphocytes. Nature 1989; 337: 179-81.
58. 1. Nature 1993; 363: 461-4.
59. Berg EL, McEvoy LM, Berlin C, Bargatze RF, Butcher EC. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Nature 1993; 366: 695-8.
60. Cunningham BA, Hemperly JJ, Murray BA, Prediger EA, Brackenbury R, Edelman GM. Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation and alternative RNA splicing. Science 1987; 236: 799-806.
61. Moos M, Tacke R, Scherer H, Teplow D, Früh K, Schachner M. Neural adhesion molecule L1 is a member of the immunoglobulin superfamily with binding domains similar to fibronectin. Nature 1988; 334: 701-3.
62. Walsh FS, Skaper SD, Doherty P. Cell adhesion molecule (NCAM and N-cadherin)-dependent neurite outgrowth is modulated by gangliosides. Prog Brain Res 1994; 101: 113-18.
63. Lemmon V, Farr KL, Lagenaur C. L1-mediated axon outgrowth occurs via a homophilic binding mechanism. Neuron 1989; 2: 1597-603.
64. Doherty P, Fruns M, Seaton P et al. A threshold effect of the major isoforms of NCAM on neurite outgrowth. Nature 1990; 343: 464-6.
65. 2+ channels. Cell 1991; 67: 21-33.
66. Kuhn TB, Stoeckli ET, Condrau MA, Rathjen FG, Sonderegger P. Neurite outgrowth on immobilized axonin-1 is mediated by a heterophilic interaction with L1(G4). J Cell Biol 1992; 115: 1113-26.
67. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991; 251: 1451-5.
68. Patel JD, Gumbiner BM. Cell-cell recognition. Zipping together a cell adhesion interface. Nature 1995; 374: 306-7.
69. Wagner G. E-cadherin: a distant member of the immunoglobulin superfamily. Science 1995; 267: 342.
70. Overduin M, Harvey TS, Bagby S et al. Solution structure of the epithelial cadherin domain responsible for selective cell adhesion. Science 1995; 267: 386-9.
71. Takeichi M. Cadherins: a molecular family important in selective cell-cell adhesion. Annu Rev Biochem 1990; 59: 237-52.
72. Gumbiner B, Simons K. A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide. J Cell Biol 1986; 102: 457-68.
73. Volk T, Geiger B. A-CAM: A 135-kD receptor of intercellular adherence junction. I. Immunoelectron microscopic localization and biochemical studies. J Cell Biol 1986; 103: 1441-50.
74. Matsunaga M, Hatta K, Nagafuchi A, Takeichi M. Guidance of optic nerve fibres by N-cadherin adhesion molecules. Nature 1988; 334: 62-4.
75. Doherty P, Walsh FS. Neurite guidance molecules. Curr Opin Cell Biol 1989; 1: 1102-6.
76. 2+-dependent cell-cell adhesion molecule expressed in the retina. Neuron 1991; 7: 69-79.
77. Detrick RJ, Dickey D, Kintner CR. The effects of N-cadherin misexpression on morphogenesis in Xenopus embryos. Neuron 1990; 4: 493-506.
78. Shimoyama Y, Hirohashi S, Hirano S et al. Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res 1989; 49: 2128-33.
79. Edelman GM, Crossin KL. Cell adhesion molecules: implications for a molecular histology. Annu Rev Biochem 1991; 60: 155-90.
80. Edelman GM. Adhesion and counteradhesion: morphogenetic functions of the cell surface. Prog Brain Res 1994; 101: 1-14.
81. Lasky LA. Selectins: interpreters of cell-specific carbohydrate information during inflammation. Science 1992; 258: 964-9.
82. Tedder TF, Steeber DA, Chen A, Engel P. The selectins: vascular adhesion molecules. FASEB J 1995; 9: 866-73.
83. Paulson JC. Carbohydrate ligands of leukocyte adhesion molecules and their therapeutic potential. Prog Brain Res 1994; 101: 179-84.
84. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994; 76: 301-14.
85. Rosen SD, Bertozzi CR. The selectins and their ligands. Curr Opin Cell Biol 1994; 6: 663-73.
86. Shimizu Y, Shaw S. Cell adhesion. Mucins in the main stream. Nature 1993; 366: 630-1.
87. Baumheter S, Singer MS, Henzel W et al. Binding of L-selectin to the vascular sialomucin CD34. Science 1993; 262: 436-8.
88. Ley K, Tedder GF, Kansas GS. L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin. Blood 1993; 82: 1632-8.
89. Kishimoto TK, Jutila MA, Berk EL, Butcher EC. Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 1989; 245: 1238-41.
90. Gearing AJH, Newman W. Circulating adhesion molecules in disease. Immunol Today 1993; 14: 506-12.
91. Steegmaier M, Levinovitz A, Isenmann S et al. The E-selectin ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Nature 1995; 373: 615-20.
92. Sako D, Chang XJ, Barone KM et al. Expression cloning of a functional glycoprotein ligand for P-selectin. Cell 1993; 75: 1179-86.
93. Bevilacqua MP, Stengelin S, Gimbrone MA Jr, Seed B. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 1989; 243: 1160-5.
94. Moore KL, Patel KD, Bruehl RE et al. P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin. J Cell Biol 1995; 128: 661-71.
95. Granger DN, Kubes P. The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J Leukoc Biol 1994; 55: 662-75.
96. Doré M, Korthuis RJ, Granger DN, Entman ML, Smith CW. P-selectin mediates spontaneous leukocyte rolling in vivo. Blood 1993; 82: 1308-16.
97. Ley K, Bullard DC, Arbonés ML et al. Sequential contribution of L- and P-selectin to leukocyte rolling in vivo. J Exp Med 1995; 181: 669-75.
98. Mayadas TN, Johnson RC, Rayburn H, Hynes RO, Wagner DD. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 1993; 74: 541-54.
99. Dunlop LC, Skinner MP, Bendall LJ et al. Characterization of GMP-140 (P-selectin) as a circulating plasma protein. J Exp Med 1992; 175: 1147-50.
100. Marks RM, Todd RF III, Ward PA. Rapid induction of neutrophil-endothelial adhesion by endothelial complement fixation. Nature 1989; 339: 314-17.
101. Languino LR, Plescia J, Duperray A et al. Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway. Cell 1993; 73: 1423-34.
102. Elices MJ, Tsai V, Strahl D et al. Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature. J Clin Invest 1994; 93: 405-16.
103. Salmi M, Jalkanen S. A 90-kilodalton endothelial cell molecule mediating lymphocyte binding in humans. Science 1992; 257: 1407-9.
104. Airas L, Salmi M, Jalkanen S. Lymphocyte-vascular adhesion protein-2 is a novel 70-kDa molecule involved in lymphocyte adhesion to vascular endothelium. J Immunol 1993; 151: 4228-38.
105. Anderson DC, Springer TA. Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Annu Rev Med 1987; 38: 175-94.
106. Etzioni A, Frydman M, Pollack S et al. Recurrent severe infections caused by a novel leukocyte adhesion deficiency. N Engl J Med 1992; 327: 1789-92.
107. Bruijn JA, de Heer E. Adhesion molecules in renal diseases. Lab Invest 1995; 72: 387-94.
108. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991; 67: 1033-6.
109. 2-integrin-mediated neutrophil adhesion at physiological shear rates in vivo. Am J Physiol 1992; 263: H1034-44.
110. Vollmar B, Glasz J, Senkel A, Menger MD, Messmer K. Role of leukocytes in the initial hepatic microvascular response to endotoxemia. Zentralbl Chir 1993; 118: 691-6.
111. Essani NA, McGuire GM, Manning MA, Jaeschke H. Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cells during endotoxemia. Biochem Biophys Res Commun 1995; 211: 74-82.
112. Engelberts I, Samyo SK, Leeuwenberg JFM, van der Linden CJ, Buurman WA. A role for ELAM-1 in the pathogenesis of MOF during septic shock. J Surg Res 1992; 53: 136-44.
113. Redl H, Dinges HP, Buurman WA et al. Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic/hypovolemic shock in the baboon. Am J Pathol 1991; 139: 461-6.
114. Essani NA, Fisher MA, Farhood A, Manning AM, Smith CW, Jaeschke H. Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology 1995; 21: 1632-9.
115. Chang HR, Vesin C, Grau GE et al. Respective role of polymorphonuclear leukocytes and their integrins (CD-11/18) in the local or systemic toxicity of lipopolysaccharide. J Leukoc Biol 1993; 53: 636-9.
116. Jaeschke H, Farhood A, Smith CW. Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism. Am J Physiol 1991; 261: G1051-6.
117. Harris NR, Russell JM, Granger DN. Mediators of endotoxin-induced leukocyte adhesion in mesenteric postcapillary venules. Circ Shock 1994; 43: 155-60.
118. Vollmar B, Senkel A, Menger MD. In vivo evidence that intercellular adhesion molecule-1 does not mediate endotoxin-induced hepatic leukocyte-endothelial cell interaction. J Hepatol 1995; 23: 613-16.
119. Xu H, Gonzalo JA, St Pierre Y et al. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med 1994; 180: 95-109.
120. Bogen S, Pak J, Garifallou M, Deng X, Muller WA. Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo. J Exp Med 1994; 179: 1059-64.
121. Engelberts I, van Hoof SCJ, Samyo SK, Buurman WA, van der Linden CJ. Generalized inflammation during peritonitis evidenced by intracutaneous E-selectin expression. Clin Immunol Immunopathol 1992; 65: 330-4.
122. Yang H, Vora DK, Targan SR, Toyoda H, Beaudet AL, Rotter JI. Intercellular adhesion molecule 1 gene associations with immunologic subsets of inflammatory bowel disease. Gastroenterology 1995; 109: 440-8.
123. Podolsky DK, Lobb R, King N et al. Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody. J Clin Invest 1993; 92: 372-80.
124. Menger MD, Steiner D, Messmer K. Microvascular ischemia-reperfusion injury in striated muscle: significance of 'no-reflow'. Am J Physiol 1992; 263: H1892-900.
125. Vollmar B, Glasz J, Leiderer R, Post S, Menger MD. Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion. Am J Pathol 1994; 145: 1421-31.
126. Menger MD, Pelikan S, Steiner D, Messmer K. Microvascular ischemia-reperfusion injury in striated muscle: significance of 'reflow-paradox'. Am J Physiol 1992; 263: H1901-6.
127. Granger DN. Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol 1988; 255: H1269-75.
128. Granger DN, Benoit JN, Suzuki M, Grisham MB. Leukocyte adherence to venular endothelium during ischemia-reperfusion. Am J Physiol 1989; 257: G683-8.
129. Vollmar B, Menger MD, Glasz J, Leiderer R, Messmer K. Impact of leukocyte-endothelial cell interaction in hepatic ischemia-reperfusion injury. Am J Physiol 1994; 267: G786-93.
130. Vollmar B, Lang G, Menger MD, Messmer K. Hypertonic hydroxyethyl-starch restores hepatic microvascular perfusion in hemorrhagic shock. Am J Physiol 1994; 266: H1927-34.
131. Jaeschke H, Farhood A, Smith CW. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J 1990; 4: 3355-9.
132. Barroso-Aranda J, Schmid-Schönbein GW, Zweifach BW, Engler RL. Granulocytes and no-reflow phenomenon in irreversible hemorrhagic shock. Circ Res 1988; 63: 437-47.
133. Vedder NB, Winn RK, Rice CL, Chi EY, Arfors KE, Harlan JM. A monoclonal antibody to the adherence-promoting leukocyte glycoprotein, CD18, reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits. J Clin Invest 1988; 81: 939-44.
134. Vedder NB, Fouty BW, Winn RK, Harlan JM, Rice CL. Role of neutrophils in generalized reperfusion injury associated with resuscitation from shock. Surgery 1989; 106: 509-16.
135. Vedder NB, Winn RK, Rice CL, Chi EY, Arfors KE, Harlan JM. Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuates reperfusion injury in the rabbit ear. Proc Natl Acad Sci USA 1990; 87: 2643-6.
136. Nakano H, Kuzume M, Namatame K, Yamaguchi M, Kumada K. Efficacy of intraportal injection of anti-ICAM-1 monoclonal antibody against liver cell injury following warm ischemia in the rat. Am J Surg 1995; 170: 64-6.
137. Nolle D, Vestweber D, Hecht R, Meßmer K. Monoclonal antibodies to L- and P-selectin reduce postischemic reperfusion injury in striated muscle. Langenbecks Arch Chir Forum 1995; 95: 399-403.
138. Nolte D, Hecht R, Schmid P et al. Role of Mac-1 and ICAM-1 in ischemia-reperfusion injury in a microcirculation model of BALB/C-mice. Am J Physiol 1994; 267: H1320-8.
139. Vollmar B, Glasz J, Menger MD, Messmer K. Leukocytes contribute to hepatic ischemia/reperfusion injury via intercellular adhesion molecule-1-mediated venular adherence. Surgery 1995; 117: 195-200.
140. Hansell P, Borgström P, Arfors KE. Pressure-related capillary leukostasis following ischemia-reperfusion and hemorrhagic shock. Am J Physiol 1993; 265: H381-8.
141. Patel KD, Zimmerman GA, Prescott SM, McEver RP, McIntyre TM. Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils. J Cell Biol 1991; 112: 749-59.
142. Bargatze RF, Kurk S, Butcher EC, Jutila MA. Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cells. J Exp Med 1994; 180: 1785-92.
143. Menger MD, Vollmar B, Glasz J, Post S, Messmer K. Microcirculatory manifestations of hepatic ischemia/reperfusion injury. Progress In Applied Microcirculation 1993; 19: 106-24.
144. Marzi I, Knee J, Bühren V, Menger M, Trentz O. Reduction by superoxide dismutase of leukocyte-endothelial adherence after liver transplantation. Surgery 1992; 111: 90-7.
145. Post S, Palma P, Rentsch M, Gonzalez AP, Menger MD. Differential impact of Carolina rinse and University of Wisconsin solutions on microcirculation, leukocyte adhesion, Kupffer cell activity, and biliary excretion after liver transplantation. Hepatology 1993; 18: 1490-7.
146. Post S, Rentsch M, Gonzalez AP, Palma P, Otto G, Menger MD. Effects of Carolina rinse and adenosine rinse on microvascular perfusion and intrahepatic leukocyte-endothelial interaction after liver transplantation in the rat. Transplantation 1993; 55: 972-7.
147. Monden K, Arii S, Ishiguro S et al. Involvement of ICAM-1 expression on sinusoidal endothelial cell and neutrophil adherence in the reperfusion injury of cold-preserved livers. Transplant Proc 1995; 27: 759-61.
148. Land W, Schneeberger H, Schleibner S et al. The beneficial effect of human recombinant superoxide dismutase on both acute and chronic rejection events in recipients of cadaveric renal transplants. Transplantation 1994; 57: 211-17.
149. Halloran PF, Broski AP, Batiuk TD, Madrenas J. The molecular immunology of acute rejection: an overview. Transplant Immunol 1993; 1: 3-27.
150. Heemann UW, Tullius SG, Azuma H, Kupiec-Weglinsky J, Tilney NL. Adhesion molecules and transplantation. Ann Surg 1994; 219: 4-12.
151. Ferran C, Peuchmaur M, Desruennes M et al. Implications of de novo ELAM-1 and VCAM-1 expression in human cardiac allograft rejection. Transplantation 1993; 55: 605-9.
152. Herskowitz A, Mayne AE, Willoughby SB, Kanter K, Ansari AA. Patterns of myocardial cell adhesion molecule expression in human endomyocardial biopsies after cardiac transplantation. Induced ICAM-1 and VCAM-1 related to implantation and rejection. Am J Pathol 1994; 145: 1082-94.
153. Ardehali A, Laks H, Drinkwater DC, Ziv E, Drake TA. Vascular cell adhesion molecule-1 is induced on vascular endothelia and medial smooth muscle cells in experimental cardiac allograft vasculopathy. Circulation 1995; 92: 450-6.
154. Steinhoff G, Behrend M, Schrader B, Pichlmayr R. Intercellular immune adhesion molecules in human liver transplants: overview on expression patterns of leukocyte receptor and ligand molecules. Hepatology 1993; 18: 440-53.
155. Bacchi CE, Marsh CL, Perkins JD et al. Expression of vascular cell adhesion molecule (VCAM-1) in liver and pancreas allograft rejection. Am J Pathol 1993; 142: 579-91.
156. Brockmeyer C, Ulbrecht M, Schendel DJ et al. Distribution of cell adhesion molecules (ICAM-1, VCAM-1, ELAM-1) in renal tissue during allograft rejection. Transplantation 1993; 55: 610-15.
157. Fuggle SV, Sanderson JB, Gray DWR, Richardson A, Morris PJ. Variation in expression of endothelial adhesion molecules in pretransplant and transplanted kidneys-correlation with intragraft events. Transplantation 1993; 55: 117-23.
158. Meduri G, Groudev S, Charpentier B. Adhesion molecule expression in acute humoral and acute cellular rejection of renal grafts. Transplant Proc 1995; 27: 1674.
159. Quan D, Grant DR, Zhong RZ, Zhang Z, Garcia BM, Jevnikar AM. Altered gene expression of cytokine, ICAM-1, and class II molecules precedes mouse intestinal allograft rejection. Transplantation 1994; 58: 808-16.
160. Nakakura EK, McCabe SM, Zheng B et al. A non-lymphocyte-depleting monoclonal antibody to the adhesion molecule LFA-1 (CD11a) prevents sensitization to alloantigens and effectively prolongs the survival of heart allografts. Transplant Proc 1993; 25: 809-12.
161. Isobe M, Yagita H, Okumura K, Ihara A. Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science 1992; 255: 1125-7.
162. Orosz CG, Ohye RG, Pelletier RP et al. Treatment with anti-vascular cell adhesion molecule 1 monoclonal antibody induces long-term murine cardiac allograft acceptance. Transplantation 1993; 56: 453-60.
163. Yang H, Issekutz TB, Wright JR Jr. Prolongation of rat islet allograft survival by treatment with monoclonal antibodies against VLA-4 and LFA-1. Transplantation 1995; 60: 71-6.
164. Zeng Y, Gage A, Montag A, Rothlein R, Thistlethwaite JR, Bluestone JA. Inhibition of transplant rejection by pretreatment of xenogeneic pancreatic islet cells with anti-ICAM-1 antibodies. Transplantation 1994; 58: 681-9.
165. Miwa S, Kawasaki S, Makuuchi M et al. Role of ICAM-1 and LFA-1 in a cardiac xenograft rejection model. Transplant Proc 1995; 27: 111-12.
166. Schowengerdt KO, Zhu JY, Stepkowski SM, Tu Y, Entman ML, Ballantyne CM. Cardiac allograft survival in mice deficient in intercellular adhesion molecule-1. Circulation 1995; 92: 82-7.
167. Stepkowski SM, Tu Y, Condon TP, Bennett CF. Induction of transplantation tolerance by treatment with ICAM-1 antisense oligonucleotides and anti-LFA-1 monoclonal antibodies. Transplant Proc 1995; 27: 113.
168. Haug CE, Colvin RB, Delmonico FL et al. A phase I trial of immunosuppression with anti-ICAM-1 (CD54) mAb in renal allograft recipients. Transplantation 1993; 55: 766-73.
169. Hourmant M, Le Mauff B, Le Meur Y et al. Administration of an anti-CD11a monoclonal antibody in recipients of kidney transplantation. A pilot study. Transplantation 1994; 58: 377-80.
170. Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992; 267: 10 931-4.
171. Gamble JR, Matthias LJ, Meyer G et al. Regulation of in vitro capillary tube formation by anti-integrin antibodies. J Cell Biol 1993; 121: 931-43.
172. Brooks PC, Clark RA, Cheresh DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994; 264: 569-71.
173. Nguyen M, Strubel NA, Bischoff J. A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis. Nature 1993; 365: 267-9.
174. Koch AE, Halloran MM, Haskell CJ, Shah MR, Polverini PJ. Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature 1995; 376: 517-19.
175. Luscinskas FW, Lawler J. Integrins as dynamic regulators of vascular function. FASEB J 1994; 8: 929-38.
176. Juhasz I, Murphy GF, Yan HC, Herlyn M, Albelda SM. Regulation of extracellular matrix proteins and integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo. Am J Pathol 1993; 143: 1458-69.
177. Ross R. Pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362: 801-9.
178. Steinberg D. Modified forms of low-density lipoprotein and atherosclerosis. J Intern Med 1993; 233: 227-32.
179. Lehr HA, Seemüller J, Hübner C, Menger MD, Messmer K. Oxidized LDL-induced leukocyte/endothelium interaction in vivo involves the receptor for platelet-activating factor. Arterioscler Thromb 1993; 13: 1013-18.
180. Lehr HA, Kröber M, Hübner C et al. Stimulation of leukocyte/endothelium interaction by oxidized low-density lipoprotein in hairless mice. Involvement of CD11b/CD18 adhesion receptor complex. Lab Invest 1993; 68: 388-95.
181. Kume N, Cybulsky MI, Gimbrone MA Jr. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arteria endothelial cells. J Clin Invest 1992; 90: 1138-44.
182. Cybulsky MI, Gimbrone MA Jr. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 1991; 251: 788-91.
183. Li H, Cybulsky MI, Gimbrone MA Jr, Libby P. An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb 1993; 13: 197-204.
184. Poston RN, Haskard DO, Coucher JR, Gall NP, Johnson-Tidey RR. Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am J Pathol 1992; 140: 665-73.
185. van der Wal AC, Das PK, Tigges AJ, Becker AE. Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions. Am J Pathol 1992; 141: 1427-33.
186. Printseva OY, Peclo MM, Gown AM. Various cell types in human atherosclerotic lesions express ICAM-1. Further immunocytochemical and immunochemical studies employing monoclonal antibody 10F3. Am J Pathol 1992; 140: 889-96.
187. Gerrity RG. The role of the monocyte in atherogenesis. I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol 1981; 103: 181-90.
188. Gray JL, Shankar R. Down regulation of CD11b and CD18 expression in atherosclerotic lesion-derived macrophages. Am Surg 1995; 61: 674-9.
189. Furie B, Furie BC. The molecular basis of platelet and endothelial cell interaction with neutrophils and monocytes: role of P-selectin and the P-selectin ligand, PSGL-1. Thromb Haemost 1995; 74: 224-7.
190. Cerletti C, Evangelista V, Molino M, de Gaetano G. Platelet activation by polymorphonuclear leukocytes: role of cathepsin G and P-selectin. Thromb Haemost 1995; 74: 218-23.
191. Hawiger J. Mechanisms involved in platelet vessel wall interaction. Thromb Haemost 1995; 74: 369-72.
192. Beumer S, IJsseldijk MJW, de Groot PG, Sixma JJ. Platelet adhesion to fibronectin in flow: dependence on surface concentration and shear rate, role of platelet membrane glycoproteins GP IIb/IIIa and VLA-5, and inhibition by heparin. Blood 1994; 84: 3724-33.
193. Kotzé HF, Badenhorst PN, Lamprecht S et al. Prolonged inhibition of acute arterial thrombosis by high dosing of a monoclonal anti-platelet glycoprotein IIb/IIIa antibody in a baboon model. Thromb Haemost 1995; 74: 751-7.
194. 2 in reocclusion after thrombolysis. Thromb Haemost 1995; 73: 683-8.
195. Tschoepe D, Driesch E, Schwippert B, Nieuwenhuis KH, Gries FA. Exposure of adhesion molecules on activated platelets in patients with newly diagnosed IDDM is not normalized by near-normoglycemia. Diabetes 1995; 44: 890-4.
196. Becker K-F, Höfler H. Frequent somatic allelic inactivation of the E-cadherin gene in gastric carcinomas. J Natl Cancer Inst 1995; 87: 1082-4.
197. Birchmeier W, Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochem Biophys Acta 1994; 1198: 11-26.
198. Pizarro A, Gamallo C, Benito N et al. Differential patterns of placental and epithelial cadherin expression in basal cell carcinoma and in the epidermis overlying tumours. Br J Cancer 1995; 72: 327-32.
199. Dorudi S, Hanby AM, Poulsom R, Northover J, Hart IR. Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome. Br J Cancer 1995; 71: 614-16.
200. Tözeren A, Kleinman HK, Grant DS, Morales D, Mercurio AM, Byers SW. E-selectin-mediated dynamic interactions of breast- and colon-cancer cells with endothelial-cell monolayers. Int J Cancer 1995; 60: 426-31.
201. Ye C, Kiriyama K, Mistuoka C et al. Expression of E-selectin on endothelial cells of small veins in human colorectal cancer. Int J Cancer 1995; 61: 455-60.
202. Schadendorf D, Heidel J, Gawlik C, Suter L, Czarnetzki BM. Association with clinical outcome of expression of VLA-4 in primary cutaneous malignant melanoma as well as P-selectin and E-selectin on intratumoral vessels. J Natl Cancer Inst 1995; 87: 366-71.
203. x-positive mucins present in colon, colon carcinoma, and sera of patients with colorectal cancer. Cancer Res 1995; 55: 928-33.
204. a expression and tumour progression in melanoma. Cancer Res 1995; 55: 1748-51.
205. Johnson JP. Cell adhesion molecules of the immunoglobulin supergene family and their role in malignant transformation and progression to metastatic disease. Cancer Metastasis Rev 1991; 10: 11-22.
206. Obiri NI, Tandon N, Puri RK. Up-regulation of intercellular adhesion molecule 1 (ICAM-1) on human renal cell carcinoma cells by interleukin-4. Int J Cancer 1995; 61: 635-42.
207. Huang YW, Richardson JA, Vitetta ES. Anti-CD54 (ICAM-1) has antitumor activity in SCID mice with human myeloma cells. Cancer Res 1995; 55: 610-16.
208. Piali L, Fichtel A, Terpe HJ, Imhof BA, Gisler RH. Endothelial vascular cell adhesion molecule 1 expression is suppressed by melanoma and carcinoma. J Exp Med 1995; 181: 811-16.
209. García-Barcini M, Bidaurrazaga I, Neaud V et al. Variations in the expression of cell-adhesion molecules on liver-associated lymphocytes and peripheral-blood lymphocytes in patients with and without liver metastasis. Int J Cancer 1995; 61: 475-9.
210. Gui GPH, Wells CA, Browne PD et al. Integrin expression in primary breast cancer and its relation to axillary nodal status. Surgery 1995; 117: 102-8.
211. 1 laminin receptor. Int J Cancer 1991; 49: 168-72.
212. 5 are related to tumor progression in situ but not to metastatic capacity of cell lines in nude mice. Int J Cancer 1995; 61: 491-6.
213. McGregor BC, McGregor JL, Weiss LM et al. Presence of cytoadhesins (IIb-IIIa-like glycoproteins) on human metastatic melanomas but not on benign melanocytes. Am J Clin Pathol 1989; 92: 495-9.
214. Nierodzik ML, Klepfish A, Karpatkin S. Role of platelets, thrombin, integrin IIb-IIIa, fibronectin and von Willebrand factor on tumour adhesion in vitro and metastasis in vivo. Thromb Haemost 1995; 74: 282-90.
215. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994; 79: 1157-64.
216. Walz DA. Thrombospondin as a mediator of cancer cell adhesion in metastasis. Cancer Metastasis Rev 1992; 11: 313-24.
217. Incardona F, Lewalle JM, Morandi V et al. Thrombospondin modulates human breast adenocarcinoma cell adhesion to human vascular endothelial cells. Cancer Res 1995; 55: 166-73.
218. Honn KV, Tang DG, Crissman JD. Platelets and cancer metastasis: a causal relationship? Cancer Metastasis Rev 1992; 11: 325-51.
219. Harmon GD, Senagore AJ, Kilbride MJ, Warzynski MJ. Interleukin-6 response to laparoscopic and open colectomy. Dis Colon Rectum 1994; 37: 754-9.
220. Fiebig E, Ley K, Arfors K-E. Rapid leukocyte accumulation by 'spontaneous' rolling and adhesion in the exteriorized rabbit mesentery. Int J Microcirc Clin Exp 1991; 10: 127-44.
221. Dreyer WJ, Michael LH, Millman EE, Berens KL. Neutrophil activation and adhesion molecule expression in a canine model of open heart surgery with cardiopulmonary bypass. Cardiovasc Res 1995; 29: 775-81.
222. Menger MD, Lehr HA. Scope and perspectives of intravital microscopy - bridge over from in vitro to in vivo. Immunol Today 1993; 14: 519-22.
223. Lang T, Krams SM, Villanueva JC, Cox K, So S, Martinez OM. Differential patterns of circulating intercellular adhesion molecule-1 (cICAM-1) and vascular cell adhesion molecule-1 (cVCAM-1) during liver allograft rejection. Transplantation 1995; 59: 584-9.
224. Adams DH, Mainolfi E, Elias E, Neuberger JM, Rothlein R. Detection of circulating intercellular adhesion molecule-1 after liver transplantation - evidence of local release within the liver during graft rejection. Transplantation 1993; 55: 83-7.
225. Bechtel U, Scheuer R, Landgraf R, König A, Feucht HE. Assessment of soluble adhesion molecules (sICAM-1, sVCAM-1, sELAM-1) and complement cleavage products (sC4d, sC5b-9) in urine. Clinical monitoring of renal allograft recipients. Transplantation 1994; 58: 905-11.
226. Briscoe DM, Yeung AC, Schoen EL et al. Predictive value of inducible endothelial cell adhesion molecule expression for acute rejection of human cardiac allografts. Transplantation 1995; 59: 204-11.
227. Cosimi AB. Progress in monoclonal antibodies in clinical transplantation. Transplant Proc 1994; 26: 1943-4.
228. Cosimi AB, Conti D, Delmonico FL et al. In vivo effects of monoclonal antibody to ICAM-1 (CD54) in nonhuman primates with renal allografts. J Immunol 1990; 144: 4604-12.
229. Clark EA, Brugge JS. Integrins and signal transduction pathways: the road taken. Science 1995; 268: 233-9.