Antidepressant-like effect of extract from Polygala paniculata: Involvement of the monoaminergic systems

Pharmaceutical Biology

Volumn 49, Issue 12, 2011, Pages 1277-1285

  Bettio, Luis E B ^a   MacHado, Daniele G ^a   Cunha, Mauricio P ^a   Capra, Juliano C ^a   Missau, Fabiana C ^a   Santos, Adair R S ^a   Pizzolatti, Moacir G ^a   Rodrigues, Ana Lúcia S ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Antidepressant; Dopamine; Forced swimming test; Noradrenaline; Serotonin

Indexed keywords

8 BROMO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL; ALPHA 2 ADRENERGIC RECEPTOR; ANTIDEPRESSANT AGENT; BETA ADRENERGIC RECEPTOR; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; FLUOXETINE; KETANSERIN; PLANT EXTRACT; POLYGALA PANICULATA EXTRACT; PROPRANOLOL; SEROTONIN 2A RECEPTOR; SULPIRIDE; UNCLASSIFIED DRUG; YOHIMBINE;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ANTIDEPRESSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; FEMALE; FORCED SWIMMING TEST; IMMOBILIZATION; MOLECULAR INTERACTION; MONOAMINERGIC SYSTEM; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; POLYGALA PANICULATA; POLYGALACEAE; SEROTONINERGIC SYSTEM; TREATMENT DURATION;

ADRENERGIC ANTAGONISTS; ANIMALS; ANTIDEPRESSIVE AGENTS; BIOGENIC MONOAMINES; DOPAMINE; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; IMMOBILITY RESPONSE, TONIC; MICE; MOTOR ACTIVITY; NOREPINEPHRINE; PLANT EXTRACTS; POLYGALA; SEROTONIN; SEROTONIN ANTAGONISTS; SWIMMING;

ANIMALIA; MUS; POLYGALA PANICULATA; POLYGALACEAE;

EID: 81155123348     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2011.621958     Document Type: Article

References (73)

1. Barnes NM, Sharp T. (1999). A review of central 5-HT receptors and their function. Neuropharmacology, 38, 1083-1152.
2. Beaulieu JM. (2011). A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci, 36, 110011.
3. Berrocoso E, Rojas-Corrales MO, Mico JA. (2006). Diferential role of 5-HT1A and 5-HT1B receptors on the antinociceptive and antidepressant efect of tramadol in mice. Psychopharmacology (Berl), 188, 111-118.
4. Berton O, Nestler EJ. (2006). New approaches to antidepressant drug discovery: Beyond monoamines. Nat Rev Neurosci, 7, 137-151.
5. Bilia AR, Gallori S, Vincieri FF. (2002). St. John's wort and depression: Efcacy, safety and tolerability-an update. Life Sci, 70, 3077-3096.
6. Borsini F, Meli A. (1988). Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology (Berl), 94, 147-160.
7. Borsini F, Cesana R, Vidi A, Mennini T. (1991). Evidence that imipramine activates 5-HT1C receptor function. Eur J Pharmacol, 203, 359-363.
8. Brocardo PS, Budni J, Kaster MP, Santos AR, Rodrigues AL. (2008). Folic acid administration produces an antidepressant-like efect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology, 54, 464-473.
9. Calixto JB. (2005). Twenty-fve years of research on medicinal plants in Latin America: A personal view. J Ethnopharmacol, 100, 131-134.
10. Cardoso CC, Lobato KR, Binfaré RW, Ferreira PK, Rosa AO, Santos AR, Rodrigues AL. (2009). Evidence for the involvement of the monoaminergic system in the antidepressant-like efect of magnesium. Prog Neuropsychopharmacol Biol Psychiatry, 33, 235-242.
11. Cervellati R, Innocenti G, Dall'Acqua S, Costa S, Sartini E. (2004). Polyphenols from Polygala spp. and their antioxidant activity. Chem Biodivers, 1, 415-425.
12. Chiodo LA, Antelman SM. (1980). Repeated tricyclics induce a progressive dopamine autoreceptor subsensitivity independent of daily drug treatment. Nature, 287, 451-454.
13. Chung IW, Moore NA, Oh WK, O'Neill MF, Ahn JS, Park JB, Kang UG, Kim YS. (2002). Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efcacy. Pharmacol Biochem Behav, 71, 191-195.
14. Coppen A. (1967). Te biochemistry of afective disorders. Br J Psychiatry, 113, 1237-1264.
15. Cristiano R, Pizzolatti MG, Delle Monache F, Rezende CM, Branco A. (2003). Two xanthones from Polygala paniculata and confrmation of the 1-hydroxy-2,3,5-trimethoxy-xanthone at trace level by HRGC-MS. Z Naturforsch, C, J Biosci, 58, 490-494.
16. Croft H, Settle EJr, Houser T, Batey SR, Donahue RM, Ascher JA. (1999). A placebo-controlled comparison of the antidepressant efcacy and efects on sexual functioning of sustained-release bupropion and sertraline. Clin Ter, 21, 643-658.
17. Cryan JF, Markou A, Lucki I. (2002). Assessing antidepressant activity in rodents: Recent developments and future needs. Trends Pharmacol Sci, 23, 238-245.
18. Cryan JF, Valentino RJ, Lucki I. (2005). Assessing substrates underlying the behavioral efects of antidepressants using the modifed rat forced swimming test. Neurosci Biobehav Rev, 29, 547-569.
19. Dailly E, Chenu F, Renard CE, Bourin M. (2004). Dopamine, depression and antidepressants. Fundam Clin Pharmacol, 18, 601-607.
20. D'Aquila PS, Collu M, Gessa GL, Serra G. (2000). Te role of dopamine in the mechanism of action of antidepressant drugs. Eur J Pharmacol, 405, 365-373.
21. Dhingra D, Kumar V. (2008). Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice. Indian J Pharmacol, 40, 175-179.
22. Dhingra D, Sharma A. (2006). Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests. Prog Neuropsychopharmacol Biol Psychiatry, 30, 449-454.
23. Dhir A, Kulkarni SK. (2007). Efect of addition of yohimbine (alpha-2-receptor antagonist) to the antidepressant activity of fuoxetine or venlafaxine in the mouse forced swim test. Pharmacology, 80, 239-243.
24. Duarte FS, Marder M, Hoeller AA, Duzzioni M, Mendes BG, Pizzolatti MG, De Lima TC. (2008). Anticonvulsant and anxiolytic-like efects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: In vitro and in vivo interactions with benzodiazepine binding sites. Psychopharmacology (Berl), 197, 351-360.
25. Duman RS, Malberg J, Nakagawa S, D'Sa C. (2000). Neuronal plasticity and survival in mood disorders. Biol Psychiatry, 48, 732-739.
26. Dunlop BW, Nemerof CB. (2007). Te role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry, 64, 327-337.
27. Elhwuegi AS. (2004). Central monoamines and their role in major depression. Prog Neuropsychopharmacol Biol Psychiatry, 28, 435-451.
28. Englander MT, Dulawa SC, Bhansali P, Schmauss C. (2005). How stress and fuoxetine modulate serotonin 2C receptor pre-mRNA editing. J Neurosci, 25, 648-651.
29. Farina M, Franco JL, Ribas CM, Meotti FC, Missau FC, Pizzolatti MG, Dafre AL, Santos AR. (2005). Protective efects of Polygala paniculata extract against methylmercury-induced neurotoxicity in mice. J Pharm Pharmacol, 57, 1503-1508.
30. Gambarana C, Ghiglieri O, Tagliamonte A, D'Alessandro N, de Montis MG. (1995). Crucial role of D1 dopamine receptors in mediating the antidepressant efect of imipramine. Pharmacol Biochem Behav, 50, 147-151.
31. Gurevich I, Englander M T, Adlersberg M, Siegal NB, Schmauss C. (2002). Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission. J Neurosci, 22, 10529-10532.
32. Hall CS. (1934). Emotional behavior in the rat: I. Defecation and urination as measures of individual diferences in emotionality. J Comp Psychol, 18, 385-403.
33. Hall CS. (1936). Emotional behavior in the rat III. Te relationship between emotionality and ambulatory activity. J Comp Psychol, 22, 345-52.
34. Herrera-Ruiz M, García-Beltrán Y, Mora S, Díaz-Véliz G, Viana GS, Tortoriello J, Ramírez G. (2006). Antidepressant and anxiolytic efects of hydroalcoholic extract from Salvia elegans. J Ethnopharmacol, 107, 53-58.
35. Jope RS, Roh MS. (2006). Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions. Curr Drug Targets, 7, 1421-1434.
36. Kaster MP, Santos AR, Rodrigues AL. (2005). Involvement of 5-HT1A receptors in the antidepressant-like efect of adenosine in the mouse forced swimming test. Brain Res Bull, 67, 53-61.
37. Kaster MP, Raupp I, Binfaré RW, Andreatini R, Rodrigues AL. (2007). Antidepressant-like efect of lamotrigine in the mouse forced swimming test: Evidence for the involvement of the noradrenergic system. Eur J Pharmacol, 565, 119-124.
38. Lapa Fda R, Gadotti VM, Missau FC, Pizzolatti MG, Marques MC, Dafré AL, Farina M, Rodrigues AL, Santos AR. (2009). Antinociceptive properties of the hydroalcoholic extract and the favonoid rutin obtained from Polygala paniculata L. in mice. Basic Clin Pharmacol Toxicol, 104, 306-315.
39. Lapa Fda R, Freitas CS, Baggio CH, Missau FC, Pizzolatti MG, Santos AR, Marques MC. (2007). Gastroprotective activity of the hydroalcoholic extract obtained from Polygala paniculata L. in rats. J Pharm Pharmacol, 59, 1413-1419.
40. Lee HJ, Ban JY, Koh SB, Seong NS, Song KS, Bae KW, Seong YH. (2004). Polygalae radix extract protects cultured rat granule cells against damage induced by NMDA. Am J Chin Med, 32, 599-610.
41. Machado DG, Kaster MP, Binfaré RW, Dias M, Santos AR, Pizzolatti MG, Brighente IM, Rodrigues AL. (2007). Antidepressant-like efect of the extract from leaves of Schinus molle L. in mice: Evidence for the involvement of the monoaminergic system. Prog Neuropsychopharmacol Biol Psychiatry, 31, 421-428.
42. Machado DG, Bettio LE, Cunha MP, Santos AR, Pizzolatti MG, Brighente IM, Rodrigues AL. (2008). Antidepressant-like efect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: Evidence for the involvement of the serotonergic and noradrenergic systems. Eur J Pharmacol, 587, 163-168.
43. Machado DG, Bettio LE, Cunha MP, Capra JC, Dalmarco JB, Pizzolatti MG, Rodrigues AL. (2009). Antidepressant-like efect of the extract of Rosmarinus ofcinalis in mice: Involvement of the monoaminergic system. Prog Neuropsychopharmacol Biol Psychiatry, 33, 642-650.
44. Mancinelli A, D'Aranno V, Stasi MA, Lecci A, Borsini F, Meli A. (1991). Efect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat. Pharmacol Res, 23, 47-50.
45. McGarry H, Pirotta M, Hegarty K, Gunn J. (2007). General practitioners and St. John's Wort: A question of regulation or knowledge? Complement Ter Med, 15, 142-148.
46. McKinney WTJr, Bunney WEJr. (1969). Animal model of depression. I. Review of evidence: Implications for research. Arch Gen Psychiatry, 21, 240-248.
47. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. (2002). Neurobiology of depression. Neuron, 34, 13-25.
48. Newall AC, Anderson AL, Phillipson DJ. (1996). Herbal Medicines: A Guide for Health-care Professionals, 3rd edn. London: Te Pharmaceutical Press.
49. Nöldner M, Schötz K. (2002). Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test. Planta Med, 68, 577-580.
50. O'Neill MF, Conway MW. (2001). Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice. Neuropsychopharmacology, 24, 391-398.
51. Páez-Pereda M. (2005). New drug targets in the signaling pathways activated by antidepressants. Prog Neuropsychopharmacol Biol Psychiatry, 29, 1010-1016.
52. Papakostas GI. (2006). Dopaminergic-based pharmacotherapies for depression. Eur Neuropsychopharmacol, 16, 391-402.
53. Park CH, Choi SH, Koo JW, Seo JH, Kim HS, Jeong SJ, Suh YH. (2002). Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11. J Neurosci Res, 70, 484-492.
54. Piato AL, Rizon LP, Martins BS, Nunes DS, Elisabetsky E. (2009). Antidepressant profle of Ptychopetalum olacoides Bentham (Marapuama) in mice. Phytother Res, 23, 519-524.
55. Porsolt RD, Bertin A, Jalfre M. (1977). Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ter, 229, 327-336.
56. Posser T, Kaster MP, Baraúna SC, Rocha JB, Rodrigues AL, Leal RB. (2009). Antidepressant-like efect of the organoselenium compound ebselen in mice: Evidence for the involvement of the monoaminergic system. Eur J Pharmacol, 602, 85-91.
57. Randrup A, Munkvad I, Fog R, Gerlach J, Molander L, Kjellberg B, ScheelKruger J. (1975). Mania, depression and brain dopamine. Curr Dev Psychopharmacol, 2, 205-48.
58. Redrobe JP, Bourin M. (1997). Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test. Eur J Pharmacol, 325, 129-135.
59. Rodrigues AL, da Silva GL, Mateussi AS, Fernandes ES, Miguel OG, Yunes RA, Calixto JB, Santos AR. (2002). Involvement of monoaminergic system in the antidepressant-like efect of the hydroalcoholic extract of Siphocampylus verticillatus. Life Sci, 70, 1347-1358.
60. Rosa AO, Kaster MP, Binfaré RW, Morales S, Martín-Aparicio E, Navarro-Rico ML, Martinez A, Medina M, García AG, López MG, Rodrigues AL. (2008). Antidepressant-like efect of the novel thiadiazolidinone NP031115 in mice. Prog Neuropsychopharmacol Biol Psychiatry, 32, 1549-1556.
61. Ruiu S, Marchese G, Saba PL, Gessa GL, Pani L. (2000). Te 5-HT2 antagonist ritanserin blocks dopamine re-uptake in the rat frontal cortex. Mol Psychiatry, 5, 673-677.
62. Schildkraut JJ, Gordon EK, Durell J. (1965). Catecholamine metabolism in afective disorders. I. Normetanephrine and VMA excretion in depressed patients treated with imipramine. J Psychiatr Res, 3, 213-228.
63. Takamori K, Yoshida S, Okuyama S. (2001). Repeated treatment with imipramine, fuvoxamine and tranylcypromine decreases the number of escape failures by activating dopaminergic systems in a rat learned helplessness test. Life Sci, 69, 1919-1926.
64. Taylor C, Fricker AD, Devi LA, Gomes I. (2005). Mechanisms of action of antidepressants: From neurotransmitter systems to signaling pathways. Cell Signal, 17, 549-557.
65. Wang H, Gao J, Kou J, Zhu D, Yu B. (2008). Anti-infammatory activities of triterpenoid saponins from Polygala japonica. Phytomedicine, 15, 321-326.
66. Weihs KL, Settle ECJr, Batey SR, Houser TL, Donahue RM, Ascher JA. (2000). Bupropion sustained release versus paroxetine for the treatment of depression in the elderly. J Clin Psychiatry, 61, 196-202.
67. Wong ML, Licinio J. (2001). Research and treatment approaches to depression. Nat Rev Neurosci, 2, 343-351.
68. World Health Organization. (2001). Te World Health Report- Mental Health: New Understanding. New Hope.
69. Wu JF, Chen SB, Gao JC, Song HL, Wu LJ, Chen SL, Tu PF. (2007). Antioxidants and a new dihydroisocoumarins from Polygala hongkongensis Hemsl. Nat Prod Res, 21, 580-584.
70. Yalcin I, Aksu F, Belzung C. (2005). Efects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol. Eur J Pharmacol, 514, 165-174.
71. Yamada J, Sugimoto Y. (2001). Efects of 5-HT(2) receptor antagonists on the anti-immobility efects of imipramine in the forced swimming test with mice. Eur J Pharmacol, 427, 221-225.
72. Zhang HT, Whisler LR, Huang Y, Xiang Y, O'Donnell JM. (2009). Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like efects of desipramine on behavior. Neuropsychopharmacology, 34, 1067-1077.
73. Zhang ZJ. (2004). Terapeutic efects of herbal extracts and constituents in animal models of psychiatric disorders. Life Sci, 75, 1659-1699.