Effect of opioid receptor blockade on acetaldehyde self-administration and ERK phosphorylation in the rat nucleus accumbens

Alcohol

Volumn 45, Issue 8, 2011, Pages 773-783

  Peana, Alessandra T ^a   Muggironi, Giulia ^a   Fois, Giulia R ^a   Zinellu, Manuel ^a   Vinci, Stefania ^b   Acquas, Elio ^b  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

ACD self administration; ACD elicited ERK activation; Ethanol; Naloxonazine; Naltrexone; Nucleus accumbens

Indexed keywords

ACETALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; NALOXONAZINE; NALTREXONE; OPIATE ANTAGONIST; SACCHARIN;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRINKING BEHAVIOR; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUCLEUS ACCUMBENS; RAT; RECEPTOR BLOCKING; SENSITIVITY AND SPECIFICITY;

ACETALDEHYDE; ANIMALS; ENZYME ACTIVATION; ETHANOL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MALE; NALOXONE; NALTREXONE; NARCOTIC ANTAGONISTS; NUCLEUS ACCUMBENS; PHOSPHORYLATION; RATS; RATS, WISTAR; RECEPTORS, OPIOID; RECEPTORS, OPIOID, MU; REINFORCEMENT (PSYCHOLOGY); SACCHARIN; SELF ADMINISTRATION;

RATTUS; RATTUS NORVEGICUS;

EID: 81055156274     PISSN: 07418329     EISSN: 18736823     Source Type: Journal    
DOI: 10.1016/j.alcohol.2011.06.003     Document Type: Article

References (73)

1. Acquas E., Meloni M., Di Chiara G. Blockade of delta-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release. Eur. J. Pharmacol. 1993, 230:239-241.
2. Acquas E., Pisanu A., Spiga S., Plumitallo A., Zernig G., Di Chiara G. Differential effects of intravenous R, S-(+/-)-3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and its S(+)- and R(-)-enantiomers on dopamine transmission and extracellular signal regulated kinase phosphorylation (pERK) in the rat nucleus accumbens shell and core. J. Neurochem. 2007, 102:121-132.
3. Altshuler H.L., Phillips P.E., Feinhandler D.A. Alteration of ethanol self-administration by naltrexone. Life Sci. 1980, 26:679-688.
4. Arias C., Molina J.C., Spear N.E. Differential role of micro, delta and kappa opioid receptors in ethanol-mediated locomotor activation and ethanol intake in preweanling rats. Physiol. Behav. 2010, 99:348-354.
5. Arnold J.M., Roberts D.C.S. A critique of fixed ratio and progressive ratio schedules used to examine the neural substrates of drug reinforcement. Pharmacol. Biochem. Behav. 1997, 57:441-447.
6. Benjamin D., Grant E.R., Pohorecky L.A. Naltrexone reverses ethanol-induced dopamine release in the nucleus accumbens in awake, freely moving rats. Brain Res. 1993, 621:137-140.
7. Besheer J., Faccidomo S., Grondin J.J.M., Hodge C.W. Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats. Alcohol. Clin. Exp. Res. 2008, 32:209-221.
8. Brown Z.W., Amit Z., Rockman G.E. Intraventricular self-administration of acetaldehyde, but not ethanol, in naïve laboratory rats. Psychopharmacology 1979, 64:271-276.
9. 1or δ opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats. Neuropsychopharmacology 2002, 27:391-399.
10. Cippitelli A., Bilbao A., Gorriti M.A., Navarro M., Massi M., Piomelli D., et al. The anandamide transport inhibitor AM404 reduces ethanol self-administration. Eur. J. Neurosci. 2007, 26:476-486.
11. Cunningham C.L., Henderson C.M., Bormann N.M. Extinction of ethanol-induced conditioned place preference and conditioned place aversion: effects of naloxone. Psychopharmacology 1998, 139:62-70.
12. Davidson D., Amit Z. Naltrexone blocks acquisition of voluntary ethanol intake in rats. Alcohol. Clin. Exp. Res. 1997, 21:677-683.
13. Devine D.P., Leone P., Pocock D., Wise R.A. Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies. J. Pharmacol. Exp. Ther. 1993, 266:1236-1246.
14. Dhawan B.N., Cesselin F., Raghubir R., Reisine T., Bradley P.B., Portoghese P.S., et al. International Union of Pharmacology. XII. Classification of opioid receptors. Pharmacol. Rev. 1996, 48:567-592.
15. Diana M., Peana A.T., Sirca D., Lintas A., Melis M., Enrico P. Crucial role of acetaldehyde in alcohol activation of the mesolimbic dopamine system. Ann. N. Y. Acad. Sci. 2008, 1139:307-317.
16. Di Chiara G., Acquas E., Tanda G. Ethanol as a neurochemical surrogate of conventional reinforcers: the dopamine-opioid link. Alcohol 1996, 13:13-17.
17. Di Chiara G., Bassareo V., Fenu S., De Luca M.A., Spina L., Cadoni C., et al. Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology 2004, (47 Suppl 1):227-241.
18. Di Chiara G., North R.A. Neurobiology of opiate abuse. Trends Pharmacol. Sci. 1992, 13:185-193.
19. Economidou D., Mattioli L., Cifani C., Perfumi M., Massi M., Cuomo V., et al. Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats. Psychopharmacology 2006, 183:394-403.
20. Enrico P., Sirca D., Mereu M., Peana A.T., Lintas A., Golosio A., et al. Acetaldehyde sequestering prevents ethanol-induced stimulation of mesolimbic dopamine transmission. Drug Alcohol Depend. 2009, 100:265-271.
21. Faccidomo S., Besheer J., Stanford P.C., Hodge C.W. Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway. Psychopharmacology 2009, 204:135-147.
22. Foddai M., Dosia G., Spiga S., Diana M. Acetaldehyde increases dopaminergic neuronal activity in the VTA. Neuropsychopharmacology 2004, 29:530-536.
23. Font L., Aragon C.M., Miquel M. Ethanol-induced conditioned place preference, but not aversion, is blocked by treatment with D-penicillamine, an inactivation agent for acetaldehyde. Psychopharmacology 2006, 184:56-64.
24. Font L., Aragon C.M., Miquel M. Voluntary ethanol consumption decreases after the inactivation of central acetaldehyde by d-penicillamine. Behav. Brain Res. 2006, 171:78-86.
25. Froehlich J.C., Harts J., Lumeng L., Li T.K. Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference. Pharmacol. Biochem. Behav. 1990, 35:385-390.
26. Gonzales R.A., Weiss F. Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens. J. Neurosci. 1998, 18:10663-10671.
27. Herz A. Endogenous opioid systems and alcohol addiction. Psychopharmacology 1997, 129:99-111.
28. Hubbell C.L., Czirr S.A., Hunter G.A., Beaman C.M., Le Cann N.C., Reid L.D. Consumption of ethanol solution is potentiated by morphine and attenuated by naloxone persistently across repeated daily administrations. Alcohol 1986, 3:39-54.
29. Hubbell C.L., Marglin S.H., Spitalnic S.J., Abelson M.L., Wild K.D., Reid L.D. Opioidergic, serotonergic, and dopaminergic manipulations and rats' intake of a sweetened alcoholic beverage. Alcohol 1991, 8:355-367.
30. Hyytiä P., Sinclair J.D. Responding for oral ethanol after naloxone treatment by alcohol-preferring AA rats. Alcohol. Clin. Exp. Res. 1993, 17:631-636.
31. Ibba F., Vinci S., Spiga S., Peana A.T., Assaretti A.R., Spina L., et al. Ethanol-induced extracellular signal regulated kinase: role of dopamine D1 receptors. Alcohol. Clin. Exp. Res. 2009, 33:858-867.
32. Johnson N., Pasternak G.W. Binding of [3H]naloxonazine to rat brain membranes. Mol. Pharmacol. 1984, 26:477-483.
33. Kapur J.N., Sahoo P.K., Wong K.C. A new method for gray-level picture thresholding using the entropy of the histogram. Computer Vision. Graph. Image Process. 1985, 29:273-285.
34. Katner S.N., Weiss F. Ethanol-associated olfactory stimuli reinstate ethanol-seeking behavior after extinction and modify extracellular dopamine levels in the nucleus accumbens. Alcohol. Clin. Exp. Res. 1999, 23:1751-1760.
35. Kornet M., Goosen C., Van Ree J.M. Effect of naltrexone on alcohol consumption during chronic alcohol drinking and after a period of imposed abstinence in free-choice drinking rhesus monkeys. Psychopharmacology 1991, 104:367-376.
36. Lê A.D., Poulos C.X., Harding S., Watchus J., Juzytsch W., Shaham Y. Effects of naltrexone and fluoxetine on alcohol self-administration and reinstatement of alcohol seeking induced by priming injections of alcohol and exposure to stress. Neuropsychopharmacology 1999, 21:435-444.
37. Leriche M., Méndez M., Zimmer L., Bérod A. Acute ethanol induces Fos in GABAergic and non-GABAergic forebrain neurons: a double-labeling study in the medial prefrontal cortex and extended amygdala. Neuroscience 2008, 153:259-267.
38. Ling G.S., Simantov R., Clark J.A., Pasternak G.W. Naloxonazine actions in vivo. Eur. J. Pharmacol. 1986, 129:33-38.
39. Markou A., Weiss F., Gold L.H., Caine S.B., Schulteis G., Koob G.F. Animal models of drug craving. Psychopharmacology 1993, 112:163-182.
40. McBride W.J., Li T.K., Deitrich R.A., Zimatkin S., Smith B.R., Rodd-Henricks Z.A. Involvement of acetaldehyde in alcohol addiction. Alcohol. Clin. Exp. Res. 2002, 26:114-119.
41. Melis M., Enrico P., Peana A.T., Diana M. Acetaldehyde mediates alcohol activation of the mesolimbic dopamine system. Eur. J. Neurosci. 2007, 26:2824-2833.
42. Mhatre M., Holloway F. Micro1-opioid antagonist naloxonazine alters ethanol discrimination and consumption. Alcohol 2003, 29:109-116.
43. Middaugh L.D., Bandy A.L. Naltrexone effects on ethanol consumption and response to ethanol conditioned cues in C57BL/6 mice. Psychopharmacology 2000, 151:321-327.
44. Myers W.D., Ng K.T., Singer G. Intravenous self-administration of acetaldehyde in the rat as a function of schedule, food deprivation and photoperiod. Pharmacol. Biochem. Behav. 1982, 17:807-811.
45. Myers W.D., Ng K.T., Singer G. Effects of naloxone and buprenorphine on intravenous acetaldehyde self-injection in rats. Physiol. Behav. 1984, 33:449-455.
46. Naranjo C.A., Sellers E.M. Serotonin uptake inhibitors attenuate ethanol intake in problem drinkers. Recent Dev. Alcohol. 1989, 7:255-266.
47. O'Brien C.P., Volpicelli L.A., Volpicelli J.R. Naltrexone in the treatment of alcoholism: a clinical review. Alcohol 1996, 13:35-39.
48. O'Malley S.S., Jaffe A.J., Chang G., Schottenfeld R.S., Meyer R.E., Rounsaville B. Naltrexone and coping skills therapy for alcohol dependence. A controlled study. Arch. Gen. Psychiatry 1992, 49:881-887.
49. Oswald L.M., Wand G.S. Opioids and alcoholism. Physiol. Behav. 2004, 81:339-358.
50. Pastor R., Aragon C.M. The role of opioid receptor subtypes in the development of behavioral sensitization to ethanol. Neuropsychopharmacology 2006, 31:1489-1499.
51. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 1998, Academic Press, Sydney.
52. Peana A.T., Assaretti A.R., Muggironi G., Enrico P., Diana M. Reduction of ethanol-derived acetaldehyde induced motivational properties by L-cysteine. Alcohol. Clin. Exp. Res. 2009, 33:43-48.
53. Peana A.T., Enrico P., Assaretti A.R., Pulighe E., Muggironi G., Nieddu M., et al. Key role of ethanol-derived acetaldehyde in the motivational properties induced by intragastric ethanol: a conditioned place preference study in the rat. Alcohol Clin. Exp. Res. 2008, 32:249-258.
54. Peana A.T., Muggironi G., Calvisi G., Enrico P., Mereu M., Nieddu M., et al. L-cysteine reduces oral ethanol self-administration and reinstatement of ethanol-drinking behavior in rats. Pharmacol. Biochem. Behav. 2010, 94:431-437.
55. Peana A.T., Muggironi G., Diana M. Acetaldehyde-reinforcing effects; a study on oral self-administration behavior. Front. Psychiatry 2010, 16:23.
56. Quertemont E., De Witte P. Conditioned stimulus preference after acetaldehyde but not ethanol injections. Pharmacol. Biochem. Behav. 2001, 68:449-454.
57. Quertemont E., Tambour S., Tirelli E. The role of acetaldehyde in the neurobehavioral effects of ethanol: a comprehensive review of animal studies. Prog. Neurobiol. 2005, 75:247-274.
58. Richardson N.R., Roberts D.C. Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy. J. Neurosci. Methods 1996, 66:1-11.
59. Rodd-Henricks Z.A., Melendez R.I., Zaffaroni A., Goldstein A., McBride W.J., Lu T.K. The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats. Pharmacol. Biochem. Behav. 2002, 72:55-64.
60. Samson H.H., Doyle T.F. Oral ethanol self-administration in the rat: effect of naloxone. Pharmacol. Biochem. Behav. 1985, 22:91-99.
61. Sellers E.M., Higgins G.A., Sobell M.B. 5-HT and alcohol abuse. Trends Pharmacol. Sci. 1992, 13:69-75.
62. Sirca D., Enrico P., Mereu M., Peana A.T., Diana M. L-cysteine prevents ethanol-induced stimulation of mesolimbic dopamine transmission. Alcohol. Clin. Exp. Res. 2011, 35:862-869.
63. Smith B.R., Amit Z., Splawinsky J. Conditioned place preference induced by intraventricular infusions of acetaldehyde. Alcohol 1984, 1:193-195.
64. Spina L., Longoni R., Vinci S., Ibba F., Peana A.T., Muggironi G., et al. Role of dopamine D1 receptors and extracellular signal regulated kinase in the motivational properties of acetaldehyde as assessed by place preference conditioning. Alcohol. Clin. Exp. Res. 2010, 34:607-616.
65. Takayama S., Uyeno E.T. Intravenous self-administration of ethanol and acetaldehyde by rats. Yakubutsu Seishin Kodo 1985, 5:329-334.
66. Valjent E., Corvol J.C., Pages C., Besson M.J., Maldonado R., Caboche J. Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. J. Neurosci. 2000, 20:8701-8709.
67. Valjent E., Pages C., Herve D., Girault J.A., Caboche J. Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain. Eur. J. Neurosci. 2004, 19:1826-1836.
68. Vinci S., Ibba F., Longoni R., Spina L., Spiga S., Acquas E. Acetaldehyde elicits ERK phosphorylation in the rat nucleus accumbens and extended amygdala. Synapse 2010, 64:916-927.
69. Volpicelli J.R., Alterman A.I., Hayashida M., O'Brien C.P. Naltrexone in the treatment of alcohol dependence. Arch. Gen. Psychiatry 1992, 49:876-880.
70. Weiss F., Lorang M.T., Bloom F.E., Koob G.F. Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J. Pharmacol. Exp. Ther. 1993, 267:250-258.
71. Weiss F., Maldonado-Vlaar C.S., Parsons L.H., Kerr T.M., Smith D.L., Ben-Shahar O. Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:4321-4326.
72. Weiss F., Mitchiner M., Bloom F.E., Koob G.F. Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide. Psychopharmacology 1990, 101:178-186.
73. Williams J.T., Christie M.J., Manzoni O. Cellular and synaptic adaptations mediating opioid dependence. Physiol. Rev. 2001, 81:299-343.