Crucial role of acetaldehyde in alcohol activation of the mesolimbic dopamine system

Annals of the New York Academy of Sciences

Volumn 1139, Issue , 2008, Pages 307-317

  Diana, Marco ^a   Peana, Alessandra Tiziana ^a   Sirca, Donatella ^a   Lintas, Alessandra ^a   Melis, Miriam ^b   Enrico, Paolo ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Acetaldehyde; Conditioned place preference; Ethanol; Microdialysis; Nucleus accumbens; Patch clamp; Rat

Indexed keywords

ACETALDEHYDE; ALCOHOL; CATALASE; DOPAMINE;

ADOLESCENT; ALCOHOL ABUSE; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; BIOTRANSFORMATION; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; MALE; MESOLIMBIC DOPAMINERGIC SYSTEM; MOTIVATION; NERVE CONDUCTION; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; RAT; REWARD; VENTRAL TEGMENTUM;

RATTUS;

EID: 53549110021     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1432.009     Document Type: Conference Paper

References (39)

1. Goodwin, D.W. & W.F. Gabrielli. 1997. In Substance Abuse: A Comprehensive Textbook. J.H. Lowinson, P. Ruiz, R.B. Millman, J.G. Langrod, Eds. : 142 148. Williams & Wilkins. Baltimore, MD.
2. Baraona, E., A. Yokoyama, H. Ishii, et al. 1991. Lack of alcohol dehydrogenase isoenzyme activities in the stomach of Japanese subjects. Life Sci. 49 : 1929 1934.
3. Gill, K., Z. Amit & B.R. Smith. 1996. The regulation of alcohol consumption in rats: the role of alcohol-metabolizing enzymes-catalase and aldehyde dehydrogenase. Alcohol 13 : 347 353.
4. Suh, J.J., H.M. Pettinati, K.M. Kampman & C.P. O'Brien. 2006. The status of disulfiram: a half of a century later. J. Clin. Psychopharmacol. 26 : 290 302.
5. Quertemont, E. & P. De Witte. 2001. Conditioned stimulus preference after acetaldehyde but not ethanol injections. Pharmacol. Biochem. Behav. 68 : 449 454.
6. Smith, B.R., Z. Amit & J. Splawinsky. 1984. Conditioned place preference induced by intraventricular infusions of acetaldehyde. Alcohol 1 : 193 195.
7. Amit, Z. & B.R. Smith. 1985. A multi-dimensional examination of the positive reinforcing properties of acetaldehyde. Alcohol 2 : 367 370.
8. Rodd-Henricks, Z.A., R.L. Bell, K.A. Kuc, et al. 2002. The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats. Pharmacol. Biochem. Behav. 72 : 55 64.
9. Quertemont, E., S. Tambour & E. Tirelli. 2005. The role of acetaldehyde in the neurobehavioral effects of ethanol: a comprehensive review of animal studies. Prog. Neurobiol. 75 : 247 274.
10. Foddai, M., G. Dosia, S. Spiga & M. Diana. 2004. Acetaldehyde increases dopaminergic neuronal activity in the VTA. Neuropsychopharmacology 29 : 530 536.
11. Tupala, E. & J. Tiihonen. 2004. Dopamine and alcoholism: neurobiological basis of ethanol abuse. Prog. Neuropsychopharmacol. Biol. Psychiatry 28 : 1221 1247.
12. Girault, J.A. & P. Greengard. 2004. The neurobiology of dopamine signaling. Arch. Neurol. 61 : 641 644.
13. Melis, M., S. Spiga & M. Diana. 2005. The dopamine hypothesis of drug addiction: hypodopaminergic state. Int. Rev. Neurobiol. 63 : 101 154.
14. Kienast, T. & A. Heinz. 2006. Dopamine and the diseased brain. CNS Neurol. Disord. Drug. Targets 5 : 109 131.
15. Nagasawa, H.T., D.J. Goon & E.G. De Master. 1978. 2,5,5-Trimethylthiazolidine-4-carboxylic acid, a D(-)-penicillamine-directed pseudometabolite of ethanol: detoxication mechanism for acetaldehyde. J. Med. Chem. 21 : 1274 1279.
16. Font, L., C.M. Aragon & M. Miquel. 2006. Voluntary ethanol consumption decreases after the inactivation of central acetaldehyde by d-penicillamine. Behav. Brain. Res. 171 : 78 86.
17. Font, L., C.M. Aragon & M. Miquel. 2006. Ethanol-induced conditioned place preference, but not aversion, is blocked by treatment with D-penicillamine, an inactivation agent for acetaldehyde. Psychopharmacology (Berl.) 184 : 56 64.
18. Font, L., M. Miquel & C.M. Aragon. 2005. Prevention of ethanol-induced behavioral stimulation by D-penicillamine: a sequestration agent for acetaldehyde. Alcohol Clin. Exp. Res. 29 : 1156 1164.
19. Ward, R.J., C. Colantuoni, A. Dahchour, et al. 1997. Acetaldehyde-induced changes in monoamine and amino acid extracellular microdialysate content of the nucleus accumbens. Neuropharmacology 36 : 225 232.
20. Waller, M.B., W.J. McBride, L. Lumeng & T.K. Li. 1982. Effects of intravenous ethanol and of 4-methylpyrazole on alcohol drinking in alcohol-preferring rats. Pharmacol. Biochem. Behav. 17 : 763 768.
21. Imperato, A. & G. Di Chiara. 1986. Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J. Pharmacol. Exp. Ther. 239 : 219 228.
22. Boileau, I., J.M. Assaad, R.O. Pihl, et al. 2003. Alcohol promotes dopamine release in the human nucleus accumbens. Synapse 49 : 226 231.
23. Ford, C.P., G.P. Mark & J.T. Williams. 2006. Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location. J. Neurosci. 26 : 2788 2797.
24. Grace, A.A. & S.P. Onn. 1989. Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro. J. Neurosci. 9 : 3463 3481.
25. Isse, T., K. Matsuno, T. Oyama, et al. 2005. Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages. Alcohol Clin. Exp. Res. 29 : 1959 1964.
26. Brodie, M.S., S.A. Shefner & T. Dunwiddie. 1990. Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res. 508 : 65 69.
27. Okamoto, T., M.T. Harnett & H. Morikawa. 2006. Hyperpolarization- activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice. J. Neurophysiol. 95 : 619 626.
28. Zimatkin, S.M. & K.O. Lindros. 1996. Distribution of catalase in rat brain: aminergic neurons as possible targets for ethanol effects. Alcohol Alcohol 31 : 167 174.
29. Hung, H.C. & E.H. Lee. 1998. MPTP produces differential oxidative stress and antioxidative responses in the nigrostriatal and mesolimbic dopaminergic pathways. Free Rad. Biol. Med. 24 : 76 84.
30. Gessa, G.L., F. Muntoni, M. Collu, et al. 1985. Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res. 348 : 201 203.
31. Brodie, M.S. & S.B. Appel. 1998. The effects of ethanol on dopaminergic neurons of the ventral tegmental area studied with intracellular recording in brain slices. Alcohol Clin. Exp. Res. 22 : 236 244.
32. Brodie, M.S., C. Pesold & S.B. Appel. 1999. Ethanol directly excites dopaminergic ventral tegmental area reward neurons. Alcohol Clin. Exp. Res. 23 : 1848 1852.
33. Di Chiara, G. & V. Bassareo. 2007. Reward system and addiction: what dopamine does and doesn't do. Curr. Opin. Pharmacol. 7 : 69 76.
34. Sanchis-Segura, C., M. Miquel, M. Correa & C.M. Aragon. 1999. The catalase inhibitor sodium azide reduces ethanol-induced locomotor activity. Alcohol 19 : 37 42.
35. Sanchis-Segura, C., M. Miquel, M. Correa & C.M. Aragon. 1999. Cyanamide reduces brain catalase and ethanol-induced locomotor activity: is there a functional link? Psychopharmacology (Berl.) 144 : 83 89.
36. Escarabajal, D., M. Miquel & C.M. Aragon. 2000. A psychopharmacological study of the relationship between brain catalase activity and ethanol-induced locomotor activity in mice. J. Stud. Alcohol 61 : 493 498.
37. Arizzi-LaFrance, M.N., M. Correa, C.M. Aragon & J.D. Salamone. 2006. Motor stimulant effects of ethanol injected into the substantia nigra pars reticulata: importance of catalase-mediated metabolism and the role of acetaldehyde. Neuropsychopharmacology 31 : 997 1008.
38. Pianezza, M.L., E.M. Sellers & R.F. Tyndale. 1998. Nicotine metabolism defect reduces smoking. Nature 393 : 750.
39. Kreek, M.J., G. Bart, C. Lilly, et al. 2005. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol. Rev. 57 : 1 26.