Nafamostat mesilate, a potent tryptase inhibitor, modulates periodontitis in rats

Clinical Oral Investigations

Volumn 15, Issue 6, 2011, Pages 967-973

  Holzhausen, Marinella ^a,c   Balejo, Rodrigo D P ^b   Lara, Guilherme M ^b   Cortelli, Sheila C ^b   Saad, Wilson A ^b   Cortelli, José R ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF TAUBATÉ   (Brazil)

^c Cidade Universitaria   (Brazil)

Author keywords

Alveolar bone loss; Periodontal diseases; Rats; Tryptases

Indexed keywords

EID: 81055147533     PISSN: 14326981     EISSN: 14363771     Source Type: Journal    
DOI: 10.1007/s00784-010-0463-1     Document Type: Article

References (44)

1. Williams RC (1990) Periodontal disease. N Engl J Med 322: 373-382.
2. Schenkein HA (2006) Host responses in maintaining periodontal health and determining periodontal disease. Periodontology 2000(40): 77-93.
3. Schwartz EM, Krimperfort P, Berns A, Verma IM (1997) Immunological defects in mice with a targeted disruption in Bcl-3. Genes Dev 11: 187-197.
4. Reynolds JJ, Meikle MC (1997) Mechanisms of connective tissue matrix destruction in periodontitis. Periodontology 2000(14): 144-157.
5. Loos BG, Tjoa S (2005) Host-derived diagnostic markers for periodontitis: do they exist in gingival crevice fluid? J Periodontol 39: 53-72.
6. Emberry G, Waddington R (1994) Gingival crevicular fluid: biomarkers of peridontal tissue activity. Adv Dent Res 8: 329-336.
7. Steinsvoll S, Helgeland K, Schenck K (2004) Mast cells-a role in periodontal diseases? J Clin Periodontol 31: 413-419.
8. Batista AC, Rodini CO, Lara VS (2005) Quantification of mast cells in different stages of human periodontal disease. Oral Dis 11: 249-254.
9. Steinsvoll S, Halstensen TS, Schenck K (1999) Extensive expression of TGF-beta1 in chronically-inflamed periodontal tissue. J Clin Periodontol 26: 366-373.
10. Gunhan M, Bostanci H, Gunhan O, Demiriz M (1991) Mast cells in periodontal disease. Ann Dent 50: 25-29.
11. Kennett CN, Cox SW, Eley BM, Osman IA (1993) Comparative histochemical and biochemical studies of mast cell tryptase in human gingiva. J Periodontol 64: 870-877.
12. Eley BM, Cox SW (1992) Correlation of gingival crevicular fluid proteases with clinical and radiological measurements of periodontal attachment loss. J Dent 20: 90-99.
13. Eley BM, Cox SW (1992) Cathepsin B/L-, elastase-, tryptase-, trypsin- and dipeptidyl peptidase IV-like activities in gingival crevicular fluid: correlation with clinical parameters in untreated chronic periodontitis patients. J Periodontal Res 27: 62-69.
14. Eley BM, Cox SW (1992) Cathepsin B/L-, elastase-, tryptase-, trypsin- and dipeptidyl peptidase IV-like activities in gingival crevicular fluid: a comparison of levels before and after periodontal surgery in chronic periodontitis patients. J Periodontol 63: 412-417.
15. Cox SW, Eley BM (1992) Cathepsin B/L-, elastase-, tryptase-, trypsin- and dipeptidyl peptidase IV-like activities in gingival crevicular fluid. A comparison of levels before and after basic periodontal treatment of chronic periodontitis patients. J Clin Periodontol 19: 333-339.
16. Nakano S, Mishiro T, Takahara S, Yokoi H, Hamada D, Yukata K et al (2007) Distinct expression of mast cell tryptase and protease activated receptor-2 in synovia of rheumatoid arthritis and osteoarthritis. Clin Rheumatol 26: 1284-1292.
17. Yoshida N, Isozaki Y, Takagi T, Takenaka S, Uchikawa R, Arizono N et al (2006) Review article: anti-tryptase therapy in inflammatory bowel disease. Aliment Pharmacol 1(suppl4): 249-255.
18. He S, Walls AF (1997) Human mast cell tryptase: a stimulus of microvascular leakage and mast cell activation. Eur J Pharmacol 328: 89-97.
19. He S, Peng Q, Walls AF (1997) Potent induction of a neutrophil and eosinophil-rich infiltrate in vivo by human mast cell tryptase: selective enhancement of eosinophil recruitment by histamine. J Immunol 159: 6216-6225.
20. Frungieri MB, Weidinger S, Meineke V, Kohn FM, Mayerhofer A (2002) Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma: possible relevance to human fibrotic disorders. Proc Natl Acad Sci 99: 15072-15077.
21. Lohi J, Harvima I, Keski-Oja J (1992) Pericellular substrates of human mast cell tryptase: 72, 000 dalton gelatinase and fibronectin. J Cell Biochem 50: 337-349.
22. Isozaki Y, Yoshida N, Kuroda M, Handa O, Takagi T, Kokura S et al (2006) Anti-tryptase treatment using nafamostat mesilate has a therapeutic effect on experimental colitis. Scand J Gastroenterol 41: 944-953.
23. Chen CL, Wang SD, Zeng ZY, Lin KJ, Kao ST, Tani T et al (2006) Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J Allergy Clin Immunol 118: 105-112.
24. Holzhausen M, Rossa C Jr, Marcantonio E Jr, Nassar PO, Spolidorio DMP, Spolidorio LC (2002) Effect of selective cyclooxygenase-2 inhibition on the development of ligature-induced periodontitis in rats. J Periodontol 73: 1030-1036.
25. Bradley PP, Priebat DA, Christensen RD, Rothstein G (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Derm 78: 206-209.
26. Harvima IT, Nilsson G, Suttle MM, Naukkarinen A (2008) Is there a role for mast cells in psoriasis? Arch Dermatol Res 300: 461-478.
27. Walsh L (2003) Mast cells and oral inflammation. Crit Rev Oral Biol Med 14: 188-198.
28. Caughey GH (1994) Serine proteinases of mast cell and leukocyte granules. A league of their own. Am J Respir Crit Care Med 150: S138-S142.
29. Welle M (1997) Development, significance and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase. J Leukocyte Biol 61: 233-245.
30. Corteling R, Bonneau O, Ferretti S, Ferretti M, Trifilieff A (2003) Differential DNA synthesis in response to activation of protease-activated receptors on cultured guinea-pig tracheal smooth muscle cells. Arch Pharmacol 368: 10-16.
31. Qiu J, Beckman MJ, Qian J, Jiranek W (2005) Simultaneous labeling of mast cell proteases and protease mRNAs at the bone-implant interface of aseptically loosened hip implants. J Orthop Res 23: 942-948.
32. Teronen O, Hietanen J, Lindqvist C, Salo T, Sorsa T, Eklund KK (1996) Mast cell-derived tryptase in odontogenic cysts. J Oral Pathol Med 25: 376-381.
33. Nystedt S, Emilsson K, Wahlestredt C, Sundelin J (1994) Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci 91: 9208-9212.
34. Böhm SK, Kong W, Bromme D (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J 314: 1009-1016.
35. Holzhausen M, Spolidorio LC, Vergnolle N (2005) Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis. Men Inst Oswaldo Cruz 100: 177-180.
36. Cocks TM, Moffatt JD (2000) Protease-activated receptors: sentries for inflammation? TIPS 21: 103-108.
37. Vergnolle N, Bunnet NW, Sharkey KA, Brussee V, Compton S, Grady E et al (2001) Proteinase-activated receptor-2 and hyperalgesia: novel pain pathway. Nat Med 7: 821-826.
38. Coughlin SR, Camerer E (2003) PARticipation in inflammation. J Clin Invest 111: 25-27.
39. Lourbakos A, Chinni C, Thompson P, Potemba J, Travis J, Mackie EJ et al (1998) Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Phophyromonas gingivalis. FEBS Lett 435: 45-48.
40. Abraham LA, Chinni C, Jenkins AL (2000) Expression of protease-activated receptor-2 by osteoblast. Bone 26: 7-14.
41. Lourbakos A, Potemba J, Travis J (2001) Arginine-specific protease from Phophyromonas gingivalis activates protease-activated receptors on human oral ephitelial cells and induces interlukin-6 secretion. Infect Immun 69: 5121-5130.
42. Uehara A, Muramoto K, Takada H, Sugawara S (2003) Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through proteinase-activated receptor-2. J Immunol 170: 5690-5696.
43. Holzhausen M, Spolidorio LC, Vergnolle N (2005) Proteinase-activated receptor-2 (PAR2) agonist causes periodontitis in rats. J Dent Res 84: 154-159.
44. Holzhausen M, Spolidorio LC, Ellen RP, Jobin MC, Steinhoff M, Andrade-Gordon P, Vergnolle N (2006) Protease-Activated receptor-2 activation: a major role in the pathogenesis of Phophyromonas gingivalis infection. Am J Pathol 168: 1189-1199.