Langerhans cells are precommitted to immune tolerance induction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 44, 2011, Pages 18049-18054

  Shklovskaya, Elena ^a   O'Sullivan, Brendan J ^b   Ng, Lai Guan ^a,c,d   Roediger, Ben ^a   Thomas, Ranjeny ^b   Weninger, Wolfgang ^a,c   Fazekas De St Groth, Barbara ^a,c  

^a CENTENARY INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d AGENCY FOR SCIENCE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR RELB;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; EFFECTOR CELL; EPIDERMIS CELL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; LANGERHANS CELL; MEMORY CELL; MOUSE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; SKIN EPITHELIUM; UPREGULATION;

ANIMALS; ANTIGENS, CD; HUMANS; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; LANGERHANS CELLS; MICE;

EID: 81055141487     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110076108     Document Type: Article

References (36)

1. Steinman RM, Banchereau J (2007) Taking dendritic cells into medicine. Nature 449: 419-426. (Pubitemid 47509552)
2. Romani N, Clausen BE, Stoitzner P (2010) Langerhans cells and more: Langerinexpressing dendritic cell subsets in the skin. Immunol Rev 234:120-141.
3. + dendritic cells but not by Langerhans cells. Science 301:1925-1928.
4. Bennett CL, et al. (2005) Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol 169:569-576. (Pubitemid 41002850)
5. Bennett CL, Noordegraaf M, Martina CA, Clausen BE (2007) Langerhans cells are required for efficient presentation of topically applied hapten to T cells. J Immunol 179: 6830-6835.
6. Grabbe S, Steinbrink K, Steinert M, Luger TA, Schwarz T (1995) Removal of the majority of epidermal Langerhans cells by topical or systemic steroid application enhances the effector phase of murine contact hypersensitivity. J Immunol 155: 4207-4217.
7. Kaplan DH, Jenison MC, Saeland S, Shlomchik WD, Shlomchik MJ (2005) Epidermal Langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23:611-620. (Pubitemid 41779483)
8. Igyarto BZ, et al. (2009) Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and Langerhans cell-derived IL-10. J Immunol 183: 5085-5093.
9. Kissenpfennig A, et al. (2005) Dynamics and function of Langerhans cells in vivo: Dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22:643-654. (Pubitemid 40719199)
10. + T cell proliferation in vivo. J Immunol 181:418-430.
11. + T cells from T cell receptor transgenic mice. J Exp Med 176:1091-1098.
12. Smith AL, Wikstrom ME, Fazekas de St Groth B (2000) Visualizing T cell competition for peptide/MHC complexes: A specific mechanism to minimize the effect of precursor frequency. Immunity 13:783-794. (Pubitemid 32041801)
13. Martin E, O'Sullivan B, Low P, Thomas R (2003) Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. Immunity 18:155-167. (Pubitemid 36120696)
14. Widera G, et al. (1987) Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: An in vivo approach to investigate Ia gene function. Cell 51: 175-187.
15. Merad M, et al. (2002) Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol 3:1135-1141. (Pubitemid 35469697)
16. +T cells in low-dose irradiated mice: Role of T cell antigen receptor and IL-7 receptor signals. J Immunol 177:8320-8330.
17. Sallusto F, Geginat J, Lanzavecchia A (2004) Central memory and effector memory T cell subsets: Function, generation, and maintenance. Annu Rev Immunol 22: 745-763. (Pubitemid 38680440)
18. Hawiger D, et al. (2001) Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 194:769-779. (Pubitemid 32983013)
19. Stoitzner P, Tripp CH, Douillard P, Saeland S, Romani N (2005) Migratory Langerhans cells in mouse lymph nodes in steady state and inflammation. J Invest Dermatol 125: 116-125. (Pubitemid 40981432)
20. Holzmann S, et al. (2004) A model system using tape stripping for characterization of Langerhans cell-precursors in vivo. J Invest Dermatol 122:1165-1174. (Pubitemid 38651091)
21. O'Sullivan BJ, Thomas R (2002) CD40 ligation conditions dendritic cell antigenpresenting function through sustained activation of NF-κB. J Immunol 168:5491-5498. (Pubitemid 34556127)
22. Ng LG, et al. (2008) Migratory dermal dendritic cells act as rapid sensors of protozoan parasites. PLoS Pathog 4:e1000222.
23. + dendritic cells. Nat Immunol 10:488-495.
24. + conventional dendritic cells. J Exp Med 207:823-836.
25. + T cell survival is not directly linked to self-MHC-induced TCR signaling. Nat Immunol 1:329-335.
26. Allenspach EJ, Lemos MP, Porrett PM, Turka LA, Laufer TM (2008) Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells. Immunity 29:795-806.
27. Watts TH (2010) Staying alive: T cell costimulation, CD28, and Bcl-xL. J Immunol 185: 3785-3787.
28. Martin E, et al. (2007) Antigen-specific suppression of established arthritis in mice by dendritic cells deficient in NF-κB. Arthritis Rheum 56:2255-2266. (Pubitemid 47173574)
29. Hochweller K, et al. (2010) Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen. Proc Natl Acad Sci USA 107:5931-5936.
30. + T cells, but affect their long-term life span. Immunity 5:217-228.
31. + T cells in the absence of MHC class I is Fas-dependent and not blocked by Bcl-xL. Eur J Immunol 33: 2917-2926.
32. Lee JW, et al. (2007) Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol 8:181-190.
33. Stoecklinger A, et al. (2007) Epidermal Langerhans cells are dispensable for humoral and cell-mediated immunity elicited by gene gun immunization. J Immunol 179: 886-893.
34. Bursch LS, Rich BE, Hogquist KA (2009) Langerhans cells are not required for the CD8 T cell response to epidermal self-antigens. J Immunol 182:4657-4664.
35. Bobr A, et al. (2010) Acute ablation of Langerhans cells enhances skin immune responses. J Immunol 185:4724-4728.
36. Lindquist RL, et al. (2004) Visualizing dendritic cell networks in vivo. Nat Immunol 5: 1243-1250. (Pubitemid 41057739)