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Volumn 10, Issue , 2011, Pages

Microbial production of hyaluronic acid: current state, challenges, and perspectives

Author keywords

Hyaluronic acid; Metabolic engineering; Molecular weight; Streptococcus zooepidemicus

Indexed keywords

HYALURONIC ACID;

EID: 81055131734     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/1475-2859-10-99     Document Type: Review
Times cited : (323)

References (49)
  • 1
    • 33845661145 scopus 로고    scopus 로고
    • Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications
    • Kogan G, Šoltés L, Stern R, Gemeiner R. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett 2007, 29:17-25.
    • (2007) Biotechnol Lett , vol.29 , pp. 17-25
    • Kogan, G.1    Šoltés, L.2    Stern, R.3    Gemeiner, R.4
  • 3
    • 35348881459 scopus 로고    scopus 로고
    • Enhanced hyaluronic acid production in Bacillus subtilis by coexpressing bacterial hemoglobin
    • Chien LJ, Lee CK. Enhanced hyaluronic acid production in Bacillus subtilis by coexpressing bacterial hemoglobin. Biotechnol Prog 2007, 23:1017-1022.
    • (2007) Biotechnol Prog , vol.23 , pp. 1017-1022
    • Chien, L.J.1    Lee, C.K.2
  • 4
    • 35648979026 scopus 로고    scopus 로고
    • Hyaluronic acid production by recombinant Lactococcus lactis
    • 10.1007/s00253-007-1153-z, 17805528
    • Chien LJ, Lee CK. Hyaluronic acid production by recombinant Lactococcus lactis. Appl Microbiol Biotechnol 2007, 77:339-346. 10.1007/s00253-007-1153-z, 17805528.
    • (2007) Appl Microbiol Biotechnol , vol.77 , pp. 339-346
    • Chien, L.J.1    Lee, C.K.2
  • 5
    • 0142075681 scopus 로고    scopus 로고
    • Aerobic cultivation of Streptococcus zooepidemicus and the role of NADH oxidase
    • Fong Chong B, Nielsen LK. Aerobic cultivation of Streptococcus zooepidemicus and the role of NADH oxidase. Biochem Eng J 2003, 16:153-162.
    • (2003) Biochem Eng J , vol.16 , pp. 153-162
    • Fong Chong, B.1    Nielsen, L.K.2
  • 6
    • 0037426672 scopus 로고    scopus 로고
    • Amplifying the cellular reduction potential of Streptococcus zooepidemicus
    • 10.1016/S0168-1656(02)00239-0, 12413784
    • Chong FB, Nielsen LK. Amplifying the cellular reduction potential of Streptococcus zooepidemicus. J Biotechnol 2003, 100:33-41. 10.1016/S0168-1656(02)00239-0, 12413784.
    • (2003) J Biotechnol , vol.100 , pp. 33-41
    • Chong, F.B.1    Nielsen, L.K.2
  • 7
    • 39149089680 scopus 로고    scopus 로고
    • Enhanced hyaluronic acid production of Streptococcus zooepidemicus by an intermittent alkaline stress strategy
    • 10.1111/j.1472-765X.2008.02325.x, 18221275
    • Liu L, Wang M, Du GC, Chen J. Enhanced hyaluronic acid production of Streptococcus zooepidemicus by an intermittent alkaline stress strategy. Lett Appl Microbiol 2008, 46:383-388. 10.1111/j.1472-765X.2008.02325.x, 18221275.
    • (2008) Lett Appl Microbiol , vol.46 , pp. 383-388
    • Liu, L.1    Wang, M.2    Du, G.C.3    Chen, J.4
  • 8
    • 22144435605 scopus 로고    scopus 로고
    • Hyaluronic acid production in Bacillus subtilis
    • 10.1128/AEM.71.7.3747-3752.2005, 1168996, 16000785
    • Widner B, Behr R, Von Dollen S. Hyaluronic acid production in Bacillus subtilis. Appl Environ Microbiol 2005, 71:3747-3752. 10.1128/AEM.71.7.3747-3752.2005, 1168996, 16000785.
    • (2005) Appl Environ Microbiol , vol.71 , pp. 3747-3752
    • Widner, B.1    Behr, R.2    Von Dollen, S.3
  • 9
    • 0001413280 scopus 로고
    • The polysaccharide of the vitreous humor
    • Meyer K, Palmer JW. The polysaccharide of the vitreous humor. J Biol Chem 1934, 107:629-634.
    • (1934) J Biol Chem , vol.107 , pp. 629-634
    • Meyer, K.1    Palmer, J.W.2
  • 10
    • 0002435546 scopus 로고
    • A serologically inactive polysaccharide elaborated by mucoid strains of group A hemolytic streptococcus
    • Kendall FE, Heidelberger M, Dawson MH. A serologically inactive polysaccharide elaborated by mucoid strains of group A hemolytic streptococcus. J Biol Chem 1937, 118:61-69.
    • (1937) J Biol Chem , vol.118 , pp. 61-69
    • Kendall, F.E.1    Heidelberger, M.2    Dawson, M.H.3
  • 12
    • 83355166013 scopus 로고
    • New and controversial aspects of retinal detachment
    • New York: Harper and Row, McPherson A
    • Balazs EA, Sweeney DB. New and controversial aspects of retinal detachment. 1968, 371-376. New York: Harper and Row, McPherson A.
    • (1968) , pp. 371-376
    • Balazs, E.A.1    Sweeney, D.B.2
  • 13
    • 33745954554 scopus 로고    scopus 로고
    • Increase in hyaluronic acid production by Streptococcus equi subsp zooepidemicus strain deficient in beta-glucuronidase in laboratory conditions
    • 10.1007/s00253-005-0173-9, 16292534
    • Krahulec J, Krahulcova J. Increase in hyaluronic acid production by Streptococcus equi subsp zooepidemicus strain deficient in beta-glucuronidase in laboratory conditions. Appl Microbiol Biotechnol 2006, 71:415-422. 10.1007/s00253-005-0173-9, 16292534.
    • (2006) Appl Microbiol Biotechnol , vol.71 , pp. 415-422
    • Krahulec, J.1    Krahulcova, J.2
  • 14
    • 35348901938 scopus 로고    scopus 로고
    • Recombinant synthesis of hyaluronan by Agrobacterium sp
    • Mao Z, Chen RR. Recombinant synthesis of hyaluronan by Agrobacterium sp. Biotechnol Prog 2007, 23:1038-1042.
    • (2007) Biotechnol Prog , vol.23 , pp. 1038-1042
    • Mao, Z.1    Chen, R.R.2
  • 15
    • 37349103842 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for biosynthesis of hyaluronic acid
    • Yu HM, Stephanopoulos G. Metabolic engineering of Escherichia coli for biosynthesis of hyaluronic acid. Metabolic Eng 2008, 10:24-32.
    • (2008) Metabolic Eng , vol.10 , pp. 24-32
    • Yu, H.M.1    Stephanopoulos, G.2
  • 16
    • 67650566399 scopus 로고    scopus 로고
    • Hyaluronan molecular weight is controlled by UDP-N-acetylglucosamine concentration in Streptococcus zooepidemicus
    • 10.1074/jbc.M109.011999, 2709399, 19451654
    • Chen WY, Marcellin E, Hung J, Nielsen LK. Hyaluronan molecular weight is controlled by UDP-N-acetylglucosamine concentration in Streptococcus zooepidemicus. J Biol Chem 2009, 284:18007-18014. 10.1074/jbc.M109.011999, 2709399, 19451654.
    • (2009) J Biol Chem , vol.284 , pp. 18007-18014
    • Chen, W.Y.1    Marcellin, E.2    Hung, J.3    Nielsen, L.K.4
  • 17
    • 72149097857 scopus 로고    scopus 로고
    • Influence of competing metabolic processes on the molecular weight of hyaluronic acid synthesized by Streptococcus zooepidemicus
    • Jagannath S, Ramachandran KB. Influence of competing metabolic processes on the molecular weight of hyaluronic acid synthesized by Streptococcus zooepidemicus. Biochem Eng J 2010, 48:148-158.
    • (2010) Biochem Eng J , vol.48 , pp. 148-158
    • Jagannath, S.1    Ramachandran, K.B.2
  • 18
    • 66849138278 scopus 로고    scopus 로고
    • Use of induction promoters to regulate hyaluronan synthase and UDP-glucose-6-dehydrogenase of Streptococcus zooepidemicus expression in Lactococcus lactis: a case study of the regulation mechanism of hyaluronic acid polymer
    • 10.1111/j.1365-2672.2009.04185.x, 19302304
    • Sheng JZ, Ling PX, Zhu XQ, Guo XP, Zhang TM, He YL, Wang FS. Use of induction promoters to regulate hyaluronan synthase and UDP-glucose-6-dehydrogenase of Streptococcus zooepidemicus expression in Lactococcus lactis: a case study of the regulation mechanism of hyaluronic acid polymer. J Appl Microbiol 2009, 107:136-144. 10.1111/j.1365-2672.2009.04185.x, 19302304.
    • (2009) J Appl Microbiol , vol.107 , pp. 136-144
    • Sheng, J.Z.1    Ling, P.X.2    Zhu, X.Q.3    Guo, X.P.4    Zhang, T.M.5    He, Y.L.6    Wang, F.S.7
  • 19
    • 84855296044 scopus 로고    scopus 로고
    • Genzyme Corporation Annual Report 2009
    • Genzyme Corporation Annual Report 2009. , http://www.genzyme.com/corp/investors/fin_fact.asp
  • 20
    • 84855255286 scopus 로고    scopus 로고
    • Research Markets Global Markets Hyaluronic Acid Viscosupplementation
    • Research Markets Global Markets Hyaluronic Acid Viscosupplementation. , http://mrg.net/Products-and-Services/Syndicated-Report.aspx?r=RPGL20HA10
  • 21
    • 0030957567 scopus 로고    scopus 로고
    • Growth and amino acids requirements of hyaluronic-acid-producing Streptococcus zooepidemicus
    • Armstrong DC, Cooney MJ, Johns MR. Growth and amino acids requirements of hyaluronic-acid-producing Streptococcus zooepidemicus. Appl Microbiol Biotechnol 1997, 47:309-312.
    • (1997) Appl Microbiol Biotechnol , vol.47 , pp. 309-312
    • Armstrong, D.C.1    Cooney, M.J.2    Johns, M.R.3
  • 22
    • 73249143550 scopus 로고    scopus 로고
    • Modeling and optimization of microbial hyaluronic acid production by Streptococcus zooepidemicus using radial basis function neural network coupling quantum-behaved particle swarm optimization algorithm
    • Liu L, Sun J, Xu WB, Wang M, Du GC, Chen J. Modeling and optimization of microbial hyaluronic acid production by Streptococcus zooepidemicus using radial basis function neural network coupling quantum-behaved particle swarm optimization algorithm. Biotechnol Prog 2009, 25:1819-1825.
    • (2009) Biotechnol Prog , vol.25 , pp. 1819-1825
    • Liu, L.1    Sun, J.2    Xu, W.B.3    Wang, M.4    Du, G.C.5    Chen, J.6
  • 23
    • 33747121393 scopus 로고    scopus 로고
    • A serum-free medium for colony growth and hyaluronic acid production by Streptococcus zooepidemicus NJUST01
    • Zhang JF, Ding X, Yang LY, Kong ZM. A serum-free medium for colony growth and hyaluronic acid production by Streptococcus zooepidemicus NJUST01. Appl Microbiol Biotechnol 2007, 72:168-172.
    • (2007) Appl Microbiol Biotechnol , vol.72 , pp. 168-172
    • Zhang, J.F.1    Ding, X.2    Yang, L.Y.3    Kong, Z.M.4
  • 24
    • 78149465867 scopus 로고    scopus 로고
    • The influence of mineral ions on the microbial production and molecular weight of hyaluronic acid
    • 10.1007/s12010-010-8987-z, 20495890
    • Pires AMB, Eguchi SY, Santana MHA. The influence of mineral ions on the microbial production and molecular weight of hyaluronic acid. Appl Biochem Biotechnol 2010, 162:2125-2135. 10.1007/s12010-010-8987-z, 20495890.
    • (2010) Appl Biochem Biotechnol , vol.162 , pp. 2125-2135
    • Pires, A.M.B.1    Eguchi, S.Y.2    Santana, M.H.A.3
  • 25
    • 78649658943 scopus 로고    scopus 로고
    • Metabolic effects of the initial glucose concentration on microbial production of hyaluronic acid
    • 10.1007/s12010-010-8956-6, 20411440
    • Pires AMB, Santana MH. Metabolic effects of the initial glucose concentration on microbial production of hyaluronic acid. Appl Biochem Biotechnol 2010, 162:1751-1761. 10.1007/s12010-010-8956-6, 20411440.
    • (2010) Appl Biochem Biotechnol , vol.162 , pp. 1751-1761
    • Pires, A.M.B.1    Santana, M.H.2
  • 26
    • 0028278496 scopus 로고
    • Effect of pH, agitation and aeration on hyaluronic acid production by Streptococcus zooepidemicus
    • Johns MR, Goh LT, Oeggerli A. Effect of pH, agitation and aeration on hyaluronic acid production by Streptococcus zooepidemicus. Biotechnol Lett 1994, 16:507-512.
    • (1994) Biotechnol Lett , vol.16 , pp. 507-512
    • Johns, M.R.1    Goh, L.T.2    Oeggerli, A.3
  • 27
    • 0030298350 scopus 로고    scopus 로고
    • Selection of a Streptococcus equi mutant and optimization of culture conditions for the production of high molecular weight hyaluronic acid
    • Kim JH, Yoo SJ, Oh DK, Kweon YG, Park DW, Lee CH, Gil GH. Selection of a Streptococcus equi mutant and optimization of culture conditions for the production of high molecular weight hyaluronic acid. Enzyme Microbial Technol 2007, 19:440-445.
    • (2007) Enzyme Microbial Technol , vol.19 , pp. 440-445
    • Kim, J.H.1    Yoo, S.J.2    Oh, D.K.3    Kweon, Y.G.4    Park, D.W.5    Lee, C.H.6    Gil, G.H.7
  • 28
    • 48649100560 scopus 로고    scopus 로고
    • Effect of oxygen and shear stress on molecular weight of hyaluronic acid produced by Streptococcus zooepidemicus
    • Duan XJ, Yang L, Zhang X, Tan WS. Effect of oxygen and shear stress on molecular weight of hyaluronic acid produced by Streptococcus zooepidemicus. J Microbiol Biotechnol 2008, 18:718-724.
    • (2008) J Microbiol Biotechnol , vol.18 , pp. 718-724
    • Duan, X.J.1    Yang, L.2    Zhang, X.3    Tan, W.S.4
  • 29
    • 64549126962 scopus 로고    scopus 로고
    • Mechanism analysis of effect of oxygen on molecular weight of hyaluronic acid produced by Streptococcus zooepidemicus
    • Duan XJ, Niu HX, Tan WS, Zhang X. Mechanism analysis of effect of oxygen on molecular weight of hyaluronic acid produced by Streptococcus zooepidemicus. J Microbiol Biotechnol 2009, 19:299-306.
    • (2009) J Microbiol Biotechnol , vol.19 , pp. 299-306
    • Duan, X.J.1    Niu, H.X.2    Tan, W.S.3    Zhang, X.4
  • 30
    • 33750986535 scopus 로고    scopus 로고
    • The role of dissolved oxygen and function of agitation in hyaluronic acid fermentation
    • Huang WC, Chen SJ, Chen TL. The role of dissolved oxygen and function of agitation in hyaluronic acid fermentation. Biochem Eng J 2006, 32:239-243.
    • (2006) Biochem Eng J , vol.32 , pp. 239-243
    • Huang, W.C.1    Chen, S.J.2    Chen, T.L.3
  • 31
    • 69249219377 scopus 로고    scopus 로고
    • Comparative study on the influence of dissolved oxygen control approaches on the microbial hyaluronic acid production of Streptococcus zooepidemicus
    • Liu L, Du GC, Chen J, Wang M, Sun J. Comparative study on the influence of dissolved oxygen control approaches on the microbial hyaluronic acid production of Streptococcus zooepidemicus. Bioproc Biosyst Eng 2009, 32:755-763.
    • (2009) Bioproc Biosyst Eng , vol.32 , pp. 755-763
    • Liu, L.1    Du, G.C.2    Chen, J.3    Wang, M.4    Sun, J.5
  • 32
    • 70350235052 scopus 로고    scopus 로고
    • Proteomic investigation of the impact of oxygen on the protein profiles of hyaluronic acid-producing Streptococcus zooepidemicus
    • 10.1002/pmic.200800868, 19688725
    • Wu TF, Huang WC, Chen YH, Tsay YG, Chang CS. Proteomic investigation of the impact of oxygen on the protein profiles of hyaluronic acid-producing Streptococcus zooepidemicus. Proteomics 2009, 9:4507-4518. 10.1002/pmic.200800868, 19688725.
    • (2009) Proteomics , vol.9 , pp. 4507-4518
    • Wu, T.F.1    Huang, W.C.2    Chen, Y.H.3    Tsay, Y.G.4    Chang, C.S.5
  • 33
    • 0032818670 scopus 로고    scopus 로고
    • Productivity of concentrated hyaluronic acid using maxblend fermentor
    • 10.1016/S1389-1723(99)80178-9, 16232576
    • Hasegawa S, Nagatsuru M, Shibutani M. Productivity of concentrated hyaluronic acid using maxblend fermentor. J Biosci Bioeng 1999, 88:68-71. 10.1016/S1389-1723(99)80178-9, 16232576.
    • (1999) J Biosci Bioeng , vol.88 , pp. 68-71
    • Hasegawa, S.1    Nagatsuru, M.2    Shibutani, M.3
  • 34
    • 19644363813 scopus 로고    scopus 로고
    • Stable production of hyaluronic acid in Streptococcus zooppidemicus chemostats operated at high dilution rate
    • 10.1002/bit.20466, 15803469
    • Blank LM, McLaughlin RL, Nielsen LK. Stable production of hyaluronic acid in Streptococcus zooppidemicus chemostats operated at high dilution rate. Biotechnol Bioeng 2005, 90:685-693. 10.1002/bit.20466, 15803469.
    • (2005) Biotechnol Bioeng , vol.90 , pp. 685-693
    • Blank, L.M.1    McLaughlin, R.L.2    Nielsen, L.K.3
  • 35
    • 62349136971 scopus 로고    scopus 로고
    • Fermentation process development for hyaluronic acid production by Streptococcus zooepidemicus ATCC 39920
    • Chen SJ, Chen JL, Huang WC, Chen HL. Fermentation process development for hyaluronic acid production by Streptococcus zooepidemicus ATCC 39920. Korean J Chem Eng 2009, 26:428-432.
    • (2009) Korean J Chem Eng , vol.26 , pp. 428-432
    • Chen, S.J.1    Chen, J.L.2    Huang, W.C.3    Chen, H.L.4
  • 36
    • 44449140369 scopus 로고    scopus 로고
    • Production of hyaluronic acid by repeated batch fermentation
    • Huang WC, Chen SJ, Chen TL. Production of hyaluronic acid by repeated batch fermentation. Biochem Eng J 2008, 40:460-464.
    • (2008) Biochem Eng J , vol.40 , pp. 460-464
    • Huang, W.C.1    Chen, S.J.2    Chen, T.L.3
  • 37
    • 70350248049 scopus 로고    scopus 로고
    • Optimization of medium components for high molecular weight hyaluronic acid production by Streptococcus sp. ID9102 via a statistical approach
    • 10.1007/s10295-009-0618-8, 19626354
    • Im JH, Song JM, Kang JH, Kang DJ. Optimization of medium components for high molecular weight hyaluronic acid production by Streptococcus sp. ID9102 via a statistical approach. J Ind Microbiol Biotechnol 2009, 36:1337-1344. 10.1007/s10295-009-0618-8, 19626354.
    • (2009) J Ind Microbiol Biotechnol , vol.36 , pp. 1337-1344
    • Im, J.H.1    Song, J.M.2    Kang, J.H.3    Kang, D.J.4
  • 38
    • 47749124974 scopus 로고    scopus 로고
    • Enhanced hyaluronic acid production by a two-stage culture strategy based on the modeling of batch and fed-batch cultivation of Streptococcus zooepidemicus
    • 10.1016/j.biortech.2008.02.035, 18397825
    • Liu L, Wang M, Sun J, Du GC, Chen J. Enhanced hyaluronic acid production by a two-stage culture strategy based on the modeling of batch and fed-batch cultivation of Streptococcus zooepidemicus. Bioresour Technol 2008, 99:8532-8536. 10.1016/j.biortech.2008.02.035, 18397825.
    • (2008) Bioresour Technol , vol.99 , pp. 8532-8536
    • Liu, L.1    Wang, M.2    Sun, J.3    Du, G.C.4    Chen, J.5
  • 39
    • 77953355161 scopus 로고    scopus 로고
    • Hyaluronic acid production by Streptococcus zooepidemicus in marine by-products media from mussel processing wastewaters and tuna peptone viscera
    • Vázquez JA, Montemayor MI, Fraguas J, Murado MA. Hyaluronic acid production by Streptococcus zooepidemicus in marine by-products media from mussel processing wastewaters and tuna peptone viscera. Microbial Cell Fact 2010, 9:46.
    • (2010) Microbial Cell Fact , vol.9 , pp. 46
    • Vázquez, J.A.1    Montemayor, M.I.2    Fraguas, J.3    Murado, M.A.4
  • 40
    • 0033199210 scopus 로고    scopus 로고
    • Structured model-based analysis and control of the hyaluronic acid fermentation by Streptococcus zooepidemicus: Physiological implications of glucose and complex-nitrogen limited growth
    • 10.1021/bp990078n, 10514260
    • Cooney MJ, Goh LT, Lee PL, Johns MR. Structured model-based analysis and control of the hyaluronic acid fermentation by Streptococcus zooepidemicus: Physiological implications of glucose and complex-nitrogen limited growth. Biotechnol Prog 1999, 15:898-910. 10.1021/bp990078n, 10514260.
    • (1999) Biotechnol Prog , vol.15 , pp. 898-910
    • Cooney, M.J.1    Goh, L.T.2    Lee, P.L.3    Johns, M.R.4
  • 41
    • 75749157289 scopus 로고    scopus 로고
    • Kinetics of hyaluronic acid production by Streptococcus zooepidemicus considering the effect of glucose
    • Don MM, Shoparwe NF. Kinetics of hyaluronic acid production by Streptococcus zooepidemicus considering the effect of glucose. Biochem Eng J 2010, 49:95-103.
    • (2010) Biochem Eng J , vol.49 , pp. 95-103
    • Don, M.M.1    Shoparwe, N.F.2
  • 42
    • 0030818188 scopus 로고    scopus 로고
    • Culture conditions affect the molecular weight properties of hyaluronic acid produced by Streptococcus zooepidemicus
    • 1389204, 16535649
    • Armstrong DC, Johns MR. Culture conditions affect the molecular weight properties of hyaluronic acid produced by Streptococcus zooepidemicus. Appl Environ Microbiol 1997, 63:2759-2764. 1389204, 16535649.
    • (1997) Appl Environ Microbiol , vol.63 , pp. 2759-2764
    • Armstrong, D.C.1    Johns, M.R.2
  • 43
    • 48449097259 scopus 로고    scopus 로고
    • Evolution of the hyaluronic acid synthesis (has) operon in Streptococcus zooepidemicus and other pathogenic streptococci
    • 10.1007/s00239-008-9117-1, 18551332
    • Blank LM, Hugenholtz P, Nielsen LK. Evolution of the hyaluronic acid synthesis (has) operon in Streptococcus zooepidemicus and other pathogenic streptococci. J Mol Evol 2008, 67:13-22. 10.1007/s00239-008-9117-1, 18551332.
    • (2008) J Mol Evol , vol.67 , pp. 13-22
    • Blank, L.M.1    Hugenholtz, P.2    Nielsen, L.K.3
  • 44
    • 38049110137 scopus 로고    scopus 로고
    • Cloning of hyaluronan synthase (sz-has) gene from Streptococcus zooepidemicus in Escherichia coli
    • Jongsareejit B, Bhumiratana A, Morikawa M, Kanaya S. Cloning of hyaluronan synthase (sz-has) gene from Streptococcus zooepidemicus in Escherichia coli. Sci Asia 2007, 33:389-395.
    • (2007) Sci Asia , vol.33 , pp. 389-395
    • Jongsareejit, B.1    Bhumiratana, A.2    Morikawa, M.3    Kanaya, S.4
  • 45
    • 68349108043 scopus 로고    scopus 로고
    • A recombinant E. coli bioprocess for hyaluronan synthesis
    • 10.1007/s00253-009-1963-2, 19308402
    • Mao Z, Shin HD, Chen RR. A recombinant E. coli bioprocess for hyaluronan synthesis. Appl Microbiol Biotechnol 2009, 84:63-69. 10.1007/s00253-009-1963-2, 19308402.
    • (2009) Appl Microbiol Biotechnol , vol.84 , pp. 63-69
    • Mao, Z.1    Shin, H.D.2    Chen, R.R.3
  • 46
    • 77149178416 scopus 로고    scopus 로고
    • Hyaluronic acid production is enhanced by the additional co-expression of UDP-glucose pyrophosphorylase in Lactococcus lactis
    • 10.1007/s00253-009-2293-0, 19862515
    • Prasad SB, Jayaraman G, Ramachandran KB. Hyaluronic acid production is enhanced by the additional co-expression of UDP-glucose pyrophosphorylase in Lactococcus lactis. Appl Microbiol Biotechnol 2010, 86:273-283. 10.1007/s00253-009-2293-0, 19862515.
    • (2010) Appl Microbiol Biotechnol , vol.86 , pp. 273-283
    • Prasad, S.B.1    Jayaraman, G.2    Ramachandran, K.B.3
  • 47
    • 77955503048 scopus 로고    scopus 로고
    • Microbial production of hyaluronic acid from agricultural resource derivatives
    • 10.1016/j.biortech.2010.03.074, 20363616
    • Pires AMB, Macedo AC, Eguchi SY, Santana MHA. Microbial production of hyaluronic acid from agricultural resource derivatives. Bioresour Technol 2010, 101:6506-6509. 10.1016/j.biortech.2010.03.074, 20363616.
    • (2010) Bioresour Technol , vol.101 , pp. 6506-6509
    • Pires, A.M.B.1    Macedo, A.C.2    Eguchi, S.Y.3    Santana, M.H.A.4
  • 48
    • 33644820781 scopus 로고    scopus 로고
    • Metabolic engineering under uncertainty. I: Framework development
    • 10.1016/j.ymben.2005.11.003, 16414298
    • Wang LQ, Hatzimanikatis V. Metabolic engineering under uncertainty. I: Framework development. Metab Eng 2006, 8:133-141. 10.1016/j.ymben.2005.11.003, 16414298.
    • (2006) Metab Eng , vol.8 , pp. 133-141
    • Wang, L.Q.1    Hatzimanikatis, V.2
  • 49
    • 28844474829 scopus 로고    scopus 로고
    • Metabolic control analysis of Aspergillus niger L-Arabinose catabolism
    • 10.1021/bp050189o, 16321042
    • Groot MJL, Prathumpai W, Visser J, Ruijter GJG. Metabolic control analysis of Aspergillus niger L-Arabinose catabolism. Biotechnol Prog 2005, 21:1610-1616. 10.1021/bp050189o, 16321042.
    • (2005) Biotechnol Prog , vol.21 , pp. 1610-1616
    • Groot, M.J.L.1    Prathumpai, W.2    Visser, J.3    Ruijter, G.J.G.4


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