High temperature liquid chromatography hyphenated with ESI-MS and ICP-MS detection for the structural characterization and quantification of halogen containing drug metabolites

Analytica Chimica Acta

Volumn 698, Issue 1-2, 2011, Pages 69-76

  de Vlieger, Jon S B ^a   Giezen, Mark J N ^b   Falck, David ^a   Tump, Cornelis ^b   van Heuveln, Fred ^b   Giera, Martin ^a   Kool, Jeroen ^a   Lingeman, Henk ^a   Wieling, Jaap ^b   Honing, Maarten ^c   Irth, Hubertus ^a   Niessen, Wilfried M A ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b QPS Netherlands BV   (Netherlands)

^c DSM RESOLVE   (Netherlands)

Author keywords

Drug metabolism; ESI MS; High temperature liquid chromatography; Hyphenation; ICP MS; Kinase inhibitors

Indexed keywords

BIOMOLECULES; ENZYME INHIBITION; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; LIQUIDS; MASS SPECTROMETERS; METABOLITES;

DRUG METABOLISMS; ESI-MS; HIGH-TEMPERATURE LIQUID CHROMATOGRAPHIES; HYPHENATION; ICP-MS; KINASE INHIBITORS;

LIQUID CHROMATOGRAPHY;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CLOTIAPINE; CLOZAPINE DERIVATIVE; CYTOCHROME P450; DRUG METABOLITE; HALOGEN; ISOCLOZAPINE; LOXAPINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; OXYGEN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH TEMPERATURE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIATION DETECTION; ULTRAVIOLET RADIATION;

BACTERIA (MICROORGANISMS);

EID: 80955177169     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2011.04.053     Document Type: Article

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