Pulmonary embolism: Predicting disease severity

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Volumn 369, Issue 1954, 2011, Pages 4255-4277

  Burrowes, K S ^a   Clark, A R ^b   Marcinkowski, A ^b   Wilsher, M L ^d   Milne, D G ^c   Tawhai, M H ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d AUCKLAND DISTRICT HEALTH BOARD   (New Zealand)

Author keywords

Computational modelling; Pulmonary embolism; Redistribution of blood flow

Indexed keywords

BLOOD; HEMODYNAMICS; TISSUE;

BLOOD FLOW; COMPUTATIONAL MODEL; COMPUTATIONAL MODELLING; DISEASE SEVERITY; EXACT CONTROLS; HAEMODYNAMICS; HYPOXEMIA; LUNG TISSUE; PATHOPHYSIOLOGICAL; PILOT STUDIES; PULMONARY ARTERIAL HYPERTENSION; PULMONARY BLOOD FLOW; PULMONARY EMBOLISM; PULMONARY HYPERTENSION; REDISTRIBUTION OF BLOOD FLOW;

PULMONARY DISEASES;

ALGORITHM; ARTICLE; AUDIOVISUAL EQUIPMENT; BIOLOGY; BLOOD FLOW; BLOOD FLOW VELOCITY; COMORBIDITY; COMPUTER SIMULATION; HUMAN; LUNG; LUNG CIRCULATION; LUNG EMBOLISM; METHODOLOGY; PATHOPHYSIOLOGY; PILOT STUDY; RISK; VASCULARIZATION;

ALGORITHMS; BLOOD FLOW VELOCITY; COMORBIDITY; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; HUMANS; LUNG; MODELS, ANATOMIC; PILOT PROJECTS; PULMONARY CIRCULATION; PULMONARY EMBOLISM; REGIONAL BLOOD FLOW; RISK;

EID: 80955172245     PISSN: 1364503X     EISSN: None     Source Type: Journal    
DOI: 10.1098/rsta.2011.0129     Document Type: Review

References (90)

1. Hoffman, E. A. et al. 2004 The comprehensive imaging-based analysis of the lung: a forum for team science (1). Acad. Radiol. 11, 1370-1380. (doi:10.1016/j.acra.2004.09.005 (Pubitemid 39642824)
2. Tawhai, M. H., Hunter, P. J., Tschirren, J., Reinhardt, J. M., McLennan, G. & Hoffman, E. A. 2004 CT-based geometry analysis and finite element models of the human and ovine bronchial tree. J. Appl. Physiol. 97, 2310-2321. (doi:10.1152/japplphysiol.00520.2004 (Pubitemid 39552472)
3. Burrowes, K. S., Hunter, P. J. & Tawhai, M. H. 2005 Anatomically-based finite element models of the human pulmonary arterial and venous trees including supernumerary vessels. J. Appl. Physiol. 99, 731-738. (doi:10.1152/japplphysiol.01033.2004 (Pubitemid 41061172)
4. Lin, C.-L., Tawhai, M. H., McLennan, G. & Hoffman, E. A. 2008 Computational fluid dynamics. IEEE Eng. Med. Biol. Mag. 28, 25-33.
5. Yin, Y., Choi, J., Hoffman, E. A., Tawhai, M. H. & Lin, C.-L. 2010 Simulation of pulmonary air flow with a subject-specific boundary condition. J. Biomech. 43, 2159-2163. (doi:10.1016/ j.jbiomech.2010.03.048
6. Burrowes, K. S. & Tawhai, M. H. 2006 Computational predictions of pulmonary blood flow gradients: gravity versus structure. Respir. Physiol. Neurobiol. 154, 515-523. (doi:10.1016/ j.resp.2005.11.007 (Pubitemid 44751700)
7. Tawhai, M. H., Nash, M. P. & Hoffman, E. A. 2006 An imaging-based computational approach to model ventilation distribution and soft-tissue deformation in the ovine lung. Acad. Radiol. 13, 113-120. (doi:10.1016/j.acra. 2005.09.088 (Pubitemid 43041900)
8. Lin, C.-L., Tawhai, M. H., McLennan, G. & Hoffman, E. A. 2007 Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways. Respir. Physiol. Neurobiol. 157, 295-309. (doi:10.1016/j.resp.2007.02.006 (Pubitemid 46777492)
9. Tawhai, M. H. & Lin, C.-L. 2010 Image-based modeling of lung structure and function. J. Magn. Reson. Imag. 32, 1421-1431. (doi:10.1002/jmri.22382
10. Tawhai, M. H., Hoffman, E. A. & Lin, C.-L. 2009 The lung physiome: merging imaging-based measures with predictive computational models. Wiley Interdiscip. Rev. Syst. Biol. Med. 1, 61-72. (doi:10.1002/wsbm.17
11. Burrowes, K. S., Swan, A. J.,Warren, N. J. & Tawhai, M. H. 2008 Towards a virtual lung: multiscale, multi-physics modelling of the pulmonary system. Phil. Trans. R. Soc. A 366, 3247-3263. (doi:10.1098/rsta.2008.0073
12. World Health Organization. 2008 World health statistics. World Health Organization Press: Geneva, Switzerland.
13. Clark, A. R., Burrowes, K. S. & Tawhai, M. H. 2010 Contribution of serial and parallel microperfusion to spatial variability in pulmonary inter- and intra-acinar blood flow. J. Appl. Physiol. 108, 1116-1126. (doi:10.1152/japplphysiol.01177.2009
14. Ghaye, B., Ghuysen, A., Bruyere, P. J., D'Orio, V. & Dondelinger, R. F. 2006 Can CT pulmonary angiography allow assessment of severity and prognosis in patients presenting with pulmonary embolism? What the radiologist needs to know. Radiographics 26, 23-39. (doi:10.1148/rg.261055062 (Pubitemid 43234998)
15. Clark, A. R., Tawhai, M. H., Hoffman, E. A. & Burrowes, K. S. 2011 The interdependent contributions of gravitational and structural features to distribution in a multi-scale model of the pulmonary circulation. J. Appl. Physiol. 110, 943-955. (doi:10.1152/ japplphysiol.00775.2010
16. Galie, N. et al. 2009 Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur. Heart J. 30, 2493-2573. (doi:10.1093/eurheartj/ ehp297
17. Kovacs, G., Berghold, A., Scheidl, S. & Olschewski, H. 2009 Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review. Eur. Respir. J. 34, 888-894. (doi:10.1183/09031936.00145608
18. Anderson, F. A., Wheeler, H. B., Goldberg, R. J., Hosmer, D. W., Patwardhan, N. A., Jovanovic, B., Forcier, A., & Dalen, J. E. 1991 A populations-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism: the Worcester DVT study. Arch. Intern. Med. 151, 933-938. (doi:10.1001/archinte.151.5.933
19. Heit, J. A. 2003 Risk factors for venous thromboembolism. Clin. Chest Med. 24, 1-12. (doi:10.1016/S0272-5231(02)00077-1 (Pubitemid 36363134)
20. Sox, H. S. 2006 Better care for patients with suspected pulmonary embolism (editorial). Ann. Intern. Med. 144, 210-212.
21. Ryu, J. H., Olson, E. J. & Pellikka, P. A. 1998 Clinical recognition of pulmonary embolism: problem of unrecognized and asymptomatic cases. Mayo Clin. Proc. 73, 873-879. (doi:10.4065/ 73.9.873 (Pubitemid 28411331)
22. Haunch, O., Jorgensen, L. N., Khattar, S. C., Teglbjaerg, C. S., Wahlin, A. B., Rathenborg, P. & Wille-Jørgensen, P. 1990 Fatal pulmonary embolism associated with surgery. Acta Chir. Scand. 156, 747-749.
23. Karwinski, B. & Svendsen, E. 1989 Comparison of clinical and postmortem diagnosis of pulmonary embolism. J. Clin. Pathol. 42, 135-139. (doi:10.1136/jcp.42.2.135 (Pubitemid 19048467)
24. Silfvast, T. 1991 Cause of death in unsuccessful prehospital resuscitation. J. Intern. Med. 229, 331-335. (doi:10.1111/j.1365-2796.1991. tb00355.x
25. Iles, S., Beckert, L., Than, M. & Town, I. 2003 Making a diagnosis of pulmonary embolism-new methods and clinical issues. N. Z. Med. J. 116, U499.
26. Hull, R. D. 2006 Diagnosing pulmonary embolism with improved certainty and simplicity. J. Am. Med. Assoc. 295, 213-235. (doi:10.1001/jama.295.2.213 (Pubitemid 43076442)
27. D'Alonzo, G. E. & Dantzker, D. R. 1984 Gas exchange alterations following pulmonary thromboembolism. Clin. Chest Med. 5, 411-419. (Pubitemid 14014395)
28. Smulders, Y. M. 2000 Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction. Cardiovasc. Res. 48, 23-33. (doi:10.1016/S0008-6363(00)00168-1
29. Delcroix, M., Mélot, C., Lejeune, P., Leeman, M. & Naeije, R. 1990 Effects of vasodilators on gas exchange in acute canine embolic pulmonary hypertension. Anesthesiology 72, 77-84. (doi:10. 1097/00000542-199001000-00015 (Pubitemid 20031316)
30. Smulders, Y. M. 2001 Contribution of pulmonary vasoconstriction to haemodynamic instability after acute pulmonary embolism: implications for treatment? The Netherlands J. Med. 58, 241-247. (doi:10.1016/S0300-2977(01) 00117-6 (Pubitemid 32611649)
31. McIntyre, K. & Sasahara, A. 1971 Hemodynamic alterations related to extent of lung scan perfusion defect in pulmonary embolism. J. Nucl. Med. 4, 166-170.
32. McIntyre, K. & Sasahara, A. 1971 The hemodynamic response to pulmonary embolism in patients without prior cardiopulmonary disease. Am. J. Cardiol. 28, 288-294. (doi:10.1016/ 0002-9149(71)90116-0
33. Pengo, V. et al. 2004 Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N. Engl. J. Med. 350, 2257-2264. (doi:10.1056/NEJMoa032274 (Pubitemid 38669208)
34. Tapson, V. F. & Humbert, M. 2006 Incidence and prevalence of chronic thromboembolic pulmonary hypertension: from acute to chronic pulmonary embolism. Proc. Am. Thorac. Soc. 3, 564-567. (doi:10.1513/pats.200605-112LR (Pubitemid 44411620)
35. Becattini, C., Agnelli, G., Pesavento, R., Silingardi, M., Poggio, R., Taliani, M. & Ageno, W. 2006 Incidence of chronic thromboembolic pulmonary hypertension after a first episode of pulmonary embolism. Chest 130, 172-175. (doi:10.1378/chest.130.1.172 (Pubitemid 44116856)
36. Macdougall, D. A., Feliu, A. L., Boccuzzi, S. J. & Lin, J. 2006 Economic burden of deep-vein thrombosis, pulmonary embolism, and post-thrombotic syndrome. Am. J. Health Syst. Pharm. 63(Suppl. 6), S5-S15. (doi:10.2146/ ajhp060388 (Pubitemid 44672124)
37. Davidson, B. L. & Karmy-Jones, R. 2006 When pulmonary embolism treatment isn't working. Chest 129, 839-840. (doi:10.1378/chest.129.4.839
38. Rich, S., Levitsky, S. & Brundage, B. H. 1988 Pulmonary hypertension from chronic pulmonary thromboembolism. Anna. Intern. Med. 108, 425-434.
39. Fedullo, P. F., Rubin, L. J., Kerr, K. M., Auger, W. R. & Channick, R. N. 2000 The natural history of acute and chronic thromboembolic disease: the search for the missing link. Eur. Respir. J. 15, 435-437. (doi:10.1034/j.1399- 3003.2000.15.01.x (Pubitemid 30158176)
40. Huang, W., Tian, Y., Gao, J. & Yen, R. T. 1998 Comparison of theory and experiment in pulsatile flow in cat lung. Ann. Biomed. Eng. 26, 812-820. (doi:10.1114/1.107 (Pubitemid 128608599)
41. Burrowes, K. S. & Tawhai, M. H. 2010 Coupling of lung tissue tethering force to fluid dynamics in the pulmonary circulation. Int. J. Num. Method Biomed. Eng. 26, 862-875 (doi:10.1002/cnm.1386).
42. Burrowes, K. S., Hoffman, E. A. & Tawhai, M. H. 2009 Species-specific pulmonary arterial asymmetry determines species differences in regional pulmonary perfusion. Ann. Biomed. Eng. 37, 2497-2509. (doi:10.1007/s10439-009- 9802-2
43. Li, C. W. & Cheng, H. D. 1993 A nonlinear fluid model for pulmonary blood circulation. J. Biomech. 26, 653-664. (doi:10.1016/0021-9290(93)90029-E (Pubitemid 23162354)
44. Tang, B. T., Fonte, T. A., Chan, F. P., Tsao, P. S., Feinstein, J. A. & Taylor, C. A. 2010 Three-dimensional hemodynamics in the human pulmonary arteries under resting and exercise conditions. Ann. Biomed. Eng. 1, 347-358. (doi:10.1007/s10439-010-0124-1
45. Parker, J. C., Cave, C. B., Ardell, J. L., Hamm, C. R. & Williams, S. G. 1997 Vascular tree structure affects lung blood flow heterogeneity simulated in three dimensions. J. Appl. Physiol. 83, 1370-1382. (Pubitemid 27433107)
46. Glenny, R. W. & Robertson, H. T. 1991 Fractal modeling of pulmonary blood flow heterogeneity. J. Appl. Physiol. 70, 1024-1030.
47. Spilker, R. L., Feinstein, J. A., Parker, D. W., Reddy, V. M. & Taylor, C. A. 2007 Morphometrybased impedance boundary conditions for patient-specific modeling of blood flow in pulmonary arteries. Ann. Biomed. Eng. 35, 546-559. (doi:10.1007/s10439-006-9240-3 (Pubitemid 46448161)
48. Fung, Y. & Sobin, S. 1969 Theory of sheet flow in lung alveoli. J. Appl. Physiol. 26, 472-488.
49. Dhadwal, A., Wiggs, B., Doerschuk, C. & Kamm, R. 1997 Effects of anatomic variability on blood flow and pressure gradients in the pulmonary circulation. J. Appl. Physiol. 83, 1711-1720. (Pubitemid 27495354)
50. Huang, Y., Doerschuk, C. M. & Kamm, R. D. 2001 Computational modeling of RBC and neutrophil transit through the pulmonary capillaries. J. Appl. Physiol. 90, 545-564. (doi:10.1063/1.1379354
51. Burrowes, K. S., Tawhai, M. H. & Hunter, P. J. 2004 Modeling RBC and neutrophil distribution through an anatomically based pulmonary capillary network. Ann. Biomed. Eng. 32, 585-595. (doi:10.1023/B:ABME.0000019178.95185.ad
52. Popel, A. S. & Johnson, P. C. 2005 Microcirculation and hemorheology. Annu. Rev. Fluid Mech. 37, 43-69. (doi:10.1146/annurev.fluid.37.042604.133933 (Pubitemid 40301251)
53. Pries, A. R., Secomb, T. W., Gaehtgens, P. & Gross, J. F. 1990 Blood flow in microvascular networks. Experiments and simulation. Circ. Res. 67, 826-834. (Pubitemid 20315014)
54. Pries, A. R. & Secomb, T. W. 2000 Microcirculatory network structures and models. Ann. Biomed. Eng. 28, 916-921. (doi:10.1114/1.1308495 (Pubitemid 32085376)
55. Zhou, Q., Gao, J., Huang, W. & Yen, M. 2006 Vascular impedance analysis in human pulmonary circulation. Biomed. Sci. Instrum. 42, 470-475.
56. Mélot, C., Delcroix, M., Closset, J., Vanderhoeft, P., Lejeune, P., Leeman, M. & Naeije R. 1995 Starling resistor versus distensible vessel models for embolic pulmonary hypertension. Am. J. Physiol. Heart Circ. Physiol. 268, H817-H27.
57. Mitzner, W. & Sylvester, J. T. 1981 Hypoxic vasoconstriction and fluid filtration in pig lungs. J. Appl. Physiol. 51, 1056-1071.
58. Haworth, S. T., Linehan, J. H., Bronikowski, T. A. & Dawson, C. A. 1991 A hemodynamic model representation of the dog lung. J. Appl. Physiol. 70, 15-26.
59. Zhuang, F. Y., Fung, Y. C. & Yen, R. T. 1983 Analysis of blood flow in cat's lung with detailed anatomical and elasticity data. J. Appl. Physiol. 55, 1341-1348. (Pubitemid 13021828)
60. Roselli, R. J. & Parker, R. E. 1987 Venous occlusion measurement of pulmonary capillary pressure: effects of embolization. J. Appl. Physiol. 63, 2340-2342. (Pubitemid 18024855)
61. Qanadli, S. D. et al. 2001 New CT index to quantify arterial obstruction in pulmonary embolism: comparison with angiographic index and echocardiography. Am. J. Roentgenol. 176, 1415-1420. (Pubitemid 32510254)
62. Ng, C. S., Wells, A. U. & Padley, S. P. 1999 A CT sign of chronic pulmonary arterial hypertension: the ratio of main pulmonary artery to aortic diameter. J. Thorac. Imag. 14, 270-278. (doi:10.1097/00005382-199910000-00007 (Pubitemid 29470994)
63. Stein, P. D. & Henry, J. W. 1997 Prevalence of acute pulmonary embolism in central and subsegmental pulmonary arteries and relation to probability interpretation of ventilation/perfusion lung scans. Chest 111, 1246-1248. (doi:10.1378/chest.111.5.1246 (Pubitemid 27200079)
64. Oser, R. F., Zuckerman, D. A., Gutierrez, F. R. & Brink, J. A. 1996 Anatomic distribution of pulmonary emboli at pulmonary angiography: implications for cross-sectional imaging. Cardiovasc. Radiol. 199, 31-35. (Pubitemid 26095810)
65. Pryce, D. M. & Heard, B. E. 1954 The distribution of experimental pulmonary emboli in the rabbit. J. Pathol. Bacteriol. 71, 15-25. (doi:10.1002/path.1700710104
66. Fung, Y. C. & Sobin, S. S. 1972 Pulmonary alveolar blood flow. Circ. Res. 30, 470-490.
67. Tawhai, M., Nash, N., Lin, C.-L. & Hoffman, E. 2009 Supine and prone differences in regional lung density and pleural pressure gradients in the human lung with constant shape. J. Appl. Physiol. 107, 912-920. (doi:10.1152/ japplphysiol.00324.2009
68. Hopkins, S. R., Henderson, A. C., Levin, D. L., Yamada, K., Arai, T., Buxton, R. B. & Prisk, G. K. 2007 Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect. J. Appl. Physiol. 103, 240-248. (doi:10.1152/japplphysiol.01289.2006 (Pubitemid 47092298)
69. West, J. B., Dollery, C. T. & Naimark, A. 1964 Distribution of blood flow in isolated lung; relation to vascular and alveolar pressures. J. Appl. Physiol. 19, 713-724.
70. Glenny, R. W., Bernard, S., Robertson, H. T. & Hlastala, M. P. 1999 Gravity is an important but secondary determinant of regional pulmonary blood flow in upright primates. J. Appl. Physiol. 86, 623-632. (Pubitemid 29075817)
71. Glenny, R. W., Lamm, W. J. E., Albert, R. K. & Robertson, H. T. 1991 Gravity is a minor determinant of pulmonary blood flow distribution. J. Appl. Physiol. 71, 620-629.
72. Mélot, C. & Naeije, R. 2000 Pulmonary vascular diseases. In Pulmonary and peripheral gas exchange in health and disease (eds J. Roca, R. Rodriguez-Roisin & P. D. Wagner). New York, NY: Marcel Dekker.
73. Dantzker, D. R. & Bower, J. S. 1982 Alterations in gas exchange following pulmonary thromboembolism. Chest 81, 495-501. (doi:10.1378/chest.81.4. 495 (Pubitemid 12150256)
74. Mure, M., Domino, K., Lindahl, S., Hlastala, M., Altemeier, W. & Glenny, R. 2000 Regional ventilation-perfusion distribution is more uniform in the prone position. J. Appl. Physiol. 88, 1076-1083. (Pubitemid 30154914)
75. Petersson, J. et al. 2009 Regional lung blood flow and ventilation in upright humans studied with quantitative SPECT. Respir. Physiol. Neurobiol. 166, 54-60. (doi:10.1016/j.resp.2009.01.008
76. Altemeier, W., Robertson, H., McKinney, S. & Glenny, R. 1998 Pulmonary embolization causes hypoxemia by redistributing regional blood flow without changing ventilation. J. Appl. Physiol. 85, 2337-2343. (Pubitemid 28558094)
77. Tsang, J., Frazer, D. & Hlastala, M. P. 2000 Ventilation heterogeneity does not change following pulmonary microembolism. J. Appl. Physiol. 88, 705-712. (doi:10.1063/1.373725 (Pubitemid 30097117)
78. Tsoukias, N. M. 2008 Nitric oxide bioavailability in the microcirculation: insights from mathematical models. Microcirculation 15, 813-834. (doi:10.1080/10739680802010070
79. Perrier, A., Bounameaux, H. 2006 Accuracy or outcome in suspected pulmonary embolism. N. Engl. J. Med. 354, 2383-2385. (doi:10.1056/NEJMe068076 (Pubitemid 43801285)
80. Stein, P. D. et al. 2006 Multidetector computed tomography for acute pulmonary embolism. N. Engl. J. Med. 354, 2317-2327. (doi:10.1056/NEJMoa052367 (Pubitemid 43801277)
81. Egermayer, P. & Town, G. I. 1997 The clinical significance of pulmonary embolism: uncertainties and implications for treatment-a debate. J. Intern. Med. 241, 5-10. (doi:10.1046/j.1365-2796.1997.74880000.x (Pubitemid 27051197)
82. Le Gal, G., Righini, M., Parent, F., van Strijen, M. & Couturaud, F. 2006 Diagnosis and management of subsegmental pulmonary embolism. J. Thromb. Haemostatis 4, 724-731. (doi: 10.1111/j.1538-7836.2006.01819.x
83. Egermayer, P., Inder, A. & Town, G. I. 2001 The use of warfarin in Christchurch for the treatment of venous thromboembolism. N. Z. Med. J. 114, 336-338. (Pubitemid 32701427)
84. Elliot, F. M. & Reid, L. 1965 Some new facts about the pulmonary artery and its branching pattern. Clin. Radiol. 16, 193-198. (doi:10.1016/S0009-9260(65)80042-3
85. Filenz, M. 1970 Innervation of pulmonary and bronchial blood vessels of the dog. J. Anat. 106, 449-461.
86. Bunton, D. C., Fisher, A., Shaw, A. M., MacDonald, A., Montgomory, I. & McGrath, J. C. 1996 Musculo-elastic structure at origin of pulmonary supernumerary artery resembles a baffle valve 119. Br. J. Pharmacol. 119, 323P.
87. Bunton, D., MacDonald, A., Brown, T., Tracey, A., McGrath, J. & Shaw, A. 2000 5- Hydroxytryptamine- and U46619-mediated vasoconstriction in bovine pulmonary conventional and supernumerary arteries: effect of endogenous nitric oxide. Clin. Sci. 98, 81-89. (doi:10.1042/ CS19990115 (Pubitemid 30076882)
88. Dalen, J. E. 2002 Pulmonary embolism: what have we learned since Virchow? Chest 122, 1440-1456. (doi:10.1378/chest.122.4.1440 (Pubitemid 35339565)
89. Huang, W., Yen, R. T., McLaurine, M. & Bledsoe, G. 1996 Morphometry of the human pulmonary vasculature. J. Appl. Physiol. 81, 2123-2133. (Pubitemid 26384541)
90. Godbey, P. S., Graham, J. A., Presson Jr, R. G., Wagner Jr, W. W. & Lloyd, Jr, T. C. 1995 Effect of capillary pressure and lung distension on capillary recruitment. J. Appl. Physiol. 79, 1142-1147.