The lung physiome: Merging imaging-based measures with predictive computational models

Wiley Interdisciplinary Reviews: Systems Biology and Medicine

Volumn 1, Issue 1, 2009, Pages 61-72

  Tawhai, Merryn H ^a   Hoffman, Eric A ^b   Lin, Ching Long ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; AUDIOVISUAL EQUIPMENT; BIOLOGICAL MODEL; BIOLOGY; DIAGNOSTIC IMAGING; FEMALE; HISTOLOGY; HUMAN; LUNG; MALE; PHYSIOLOGY; REVIEW; SHEEP;

ANIMALS; COMPUTATIONAL BIOLOGY; DIAGNOSTIC IMAGING; FEMALE; HUMANS; LUNG; MALE; MODELS, ANATOMIC; MODELS, BIOLOGICAL; SHEEP;

EID: 78249239610     PISSN: 19395094     EISSN: 1939005X     Source Type: Journal    
DOI: 10.1002/wsbm.17     Document Type: Review

References (91)

1. Hoffman EA, Reinhardt JM, Sonka M, Simon BA, Guo J, et al. Characterization of the interstitial lung diseases via density-based and texture-based analysis of computed tomography images of lung structure and function. Acad Radiol 2003, 10:1104-1118.
2. Burrowes K, Tawhai M. Computational predictions of pulmonary blood flow gradients: gravity versus structure. Respir Physiol Neurobiol 2006, 154:515-523.
3. Burrowes KS, Hunter PJ, Tawhai MH. Anatomicallybased finite element models of the human pulmonary arterial and venous trees including supernumerary vessels. J Appl Physiol 2005, 99:731-738.
4. Tawhai MH, Hunter PJ, Tschirren J, Reinhardt JM, McLennan G, et al. CT-based geometry analysis and finite element models of the human and ovine bronchial tree. J Appl Physiol 2004, 97:2310-2321.
5. Tawhai MH, Nash MP, Hoffman EA. An imagingbased computational approach to model ventilation distribution and soft tissue deformation in the ovine lung. Acad Radiol 2006, 13:113-120.
6. Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, et al. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med 2004, 351:1057-1067.
7. Hoffman EA, Clough AV, Christensen GE, Lin CL, McLennan G, et al. The comprehensive imaging-based analysis of the lung: a forum for team science (1). Acad Radiol 2004, 11:1370-1380.
8. Li B, Christensen GE, McLennan G, Hoffman EA, Reinhardt JM. Establishing a normative atlas of the human lung: Inter-subject warping and registration of volumetric CT. Acad Radiol 2003, 10:255-265.
9. Zhang L, Hoffman EA, Reinhardt JM. Atlas-driven lung lobe segmentation in volumetric X-ray CT images. IEEE Trans Med Imaging 2006, 25:1-16.
10. Ukil S, Reinhardt JM. Smoothing lung segmentation surfaces in three-dimensional X-ray CT images using anatomic guidance. Acad Radiol 2005, 12:1502-1511.
11. Weibel ER. Morphometry of the Human Lung. Berlin: Springer-Verlag; 1963.
12. Horsfield K, Dart G, Olson DE, Filley GF, Cumming G. Models of the human bronchial tree. J Appl Physiol 1971, 31:207-217.
13. Tawhai MH, Hunter PJ.Multibreath washout analysis: modelling the influence of conducting airway asymmetry. Respir Physiol 2001, 127:249-258.
14. Tawhai MH, Pullan AJ, Hunter PJ. Generation of an anatomically based three-dimensionalmodel of the conducting airways. Ann Biomed Eng 2000, 28:793-802.
15. Tawhai MH, Hunter PJ. Modeling water vapor and heat transfer in the normal and the intubated airway. Ann Biomed Eng 2004, 32:609-622.
16. Nowak N, Kakade PP, Annapragada AV. Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs. Ann Biomed Eng 2003, 31:374-390.
17. van Ertbruggen C, Hirsch C, Paiva M. Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics. J Appl Physiol 2005, 98:970-980.
18. Horsfield K, Cumming G. Morphology of the bronchial tree in man. J Appl Physiol 1968, 24:373-383.
19. Sauret V, Halson PM, Brown IW, Fleming JS, Bailey AG. Study of the three-dimensional geometry of the central conducting airways in man using computed tomographic (CT) images. J Anat 2000, 200:123-134.
20. Schmidt A, Zidowitz S, Kriete A, Denhard T, Krass S, et al. A digital reference model of the human bronchial tree. Comput Med Imaging Graph 2004, 28:203-211.
21. Lin C-L, Tawhai MH, McLennan G, Hoffman EA. Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways. Respir Physiol Neurobiol 2007, 157:295-309.
22. Vial L, Perchet D, Fodil R, Caillibotte G, Fetita C, et al. Airflow modeling of steady inspiration in two realistic proximal airway trees reconstructed from human thoracic tomodensitometric images. Comput Methods Biomech Biomed Engin 2005, 8:267-277.
23. de Rochefort L, Vial L, Fodil R, Mâ i{dotless}tre X, Louis B, et al. In vitro validation of computational fluid dynamic simulation in human proximal airways with hyperpolarized 3He magnetic resonance phase-contrast velocimetry. J Appl Physiol 2007, 102:2012-2023.
24. Hoffman EA, Simon BA, McLennan G. State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary disease. Proc Am Thorac Soc 2006, 3:519-532.
25. Chon D, Beck KC, Simon BA, Shikata H, Saba OI, et al. Effect of low-xenon and krypton supplementation on signal/noise of regional CT-based ventilation measurements. J Appl Physiol 2007, 102:1535-1544.
26. Chon D, Simon BA, Beck KC, Shikata H, SabaOI, et al. Differences in regional wash-in and wash-out time constants for xenon-CT ventilation studies. Respir Physiol Neurobiol 2005, 148:65-83.
27. Marcucci C, Nyhan D, Simon BA. Distribution of pulmonary ventilation using Xe-enhanced computed tomography in prone and supine dogs. J Appl Physiol 2001, 90:421-430.
28. Chon D, Beck KC, Larsen RL, Shikata H, Hoffman EA. Regional pulmonary blood flow in dogs by 4D-x-ray CT. J Appl Physiol 2006, 101:1451-1465.
29. Sanders C, Nath PH, Bailey WC. Detection of emphysema with computed tomography correlation with pulmonary function tests and chest radiography. Invest Radiol 1988, 23:262-266.
30. Wollmer P, Albrechtsson U, Brauer K, Eriksson L, Jonson B, et al. Measurement of pulmonary density by means of x-ray computerized tomography. Chest 1986, 90:387-391.
31. Vock P, Salzmann C. Comparison of computed tomographic lung density with haemodynamic data of the pulmonary circulation. Clin Radiol 1986, 37:459-464.
32. Hopkins SR, Harms CA. Gender and pulmonary gas exchange during exercise. Exerc Sport Sci Rev 2004, 32:50-56.
33. Harms CA, Rosenkranz S. Sex differences in pulmonary function during exercise. Med Sci Sports Exerc 2008, 40:664-668.
34. Harms CA. Does gender affect pulmonary function and exercise capacity? Respir Physiol Neurobiol 2006, 151:124-131.
35. Keller JM, Edwards FM, Rundle R. Automatic outlining of regions on CT scans. J Comput Assist Tomogr 1981, 5:240-245.
36. Hu S, Hoffman EA, Reinhardt JM. Automatic lung segmentation for accurate quantitation of volumetric X-ray CT images. IEEE Trans Med Imaging 2001, 20:490-498.
37. Zhang L, Hoffman EA, Reinhardt JM. Lung lobar segmentation by graph search with 3D shape constraints. Proc SPIE Medical Imaging 2001, 4321:204-215.
38. Hoffman EA, Gnanaprakasam D, Gupta KB, Hoford JD, Kugelmass SD, et al. VIDA: An environment for multidimensional image display and analysis. Proc SPIE Medical Imaging 1992, 1660:694-711.
39. Aykac D, Hoffman EA, McLennan G, Reinhardt JM. Segmentation and analysis of human airway tree from 3D X-ray images. IEEE Trans Med Imaging 2003, 22:940-950.
40. Tschirren J, Hoffman EA, McLennan G, Sonka M. Intrathoracic airway trees: segmentation and airway morphology analysis from low-dose CT scans. IEEE Trans Med Imaging 2005, 24:1529-1539.
41. Wood SA, Zerhouni EA, Hoford JD, Hoffman EA, Mitzner W. Measurement of three-dimensional lung tree structures by using computed tomography. J Appl Physiol 1995, 79:1687-1697.
42. Pisupati C, Wolff L, Mitzner W, Zerhouni E. Geometric tree matching with applications to 3D lung structures. Proc. ACM Symposium on Computational Geometry. 1996.
43. Palagyi K, Tschirren J, Hoffman EA, Beck K, Sonka M. Quantitative assessment of segmental volume and radii of intrathoracic airway trees imaged by multi-row detector spiral CT. Am J Respir Crit Care Med 2003, 167:A846.
44. Palagyi K, Tschirren J, Hoffman EA, Sonka M. Quantitative analysis of pulmonary airway tree structures. Comput Biol Med 2006, 36:974-996.
45. Tschirren J, McLennan G, Palagyi K, Hoffman EA, Sonka M. Matching and anatomical labeling of human airway tree. IEEE Trans Med Imaging 2005, 24:1540-1547.
46. Tschirren J. Segmentation, Anatomical Labeling, Branch-Point Matching, and Quantitative Analysis of Human Airway Tree in Volumetric CT Iimages. Iowa City, IA: The University of Iowa; 2003.
47. Tschirren J. Segmentation, Anatomical Labeling, Branch-point Matching, and Quantitative Analysis of Human Airway Tree in Volumetric CT Images. Iowa City, IA: The University of Iowa; 2003.
48. Phalen RF, Yeh HC, Schum GM, Raabe OG. Application of an idealized model to morphometry of the mammalian tracheobronchial tree. Anat Rec 1978, 190:167-176.
49. Tgavalekos N, Tawhai MH, Harris RS, Venegas J, Lutchen KR. Identifying airways responsible for heterogeneous ventilation and mechanical dysfunction in asthma: an image-functional modeling approach. J Appl Physiol 2005, 99:2388-2397.
50. Comer JK, Kleinstreuer C, Zhang Z. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 1. Airflow fields. J Fluid Mech 2001, 435:25-54.
51. Comer JK, Kleinstreuer C, Zhang Z. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition. J Fluid Mech 2001, 435:55-80.
52. Zhang Z, Kleinstreuer C. Transient airflow structures and particle transport in a sequentially branching lung airway model. Phys Fluids 2002, 14:862-880.
53. Zhang Z, Kleinstreuer C, Kim CS, Hickey AJ. Aerosol transport and deposition in a triple bifurcation bronchial airway model with local tumors. Inhal Toxicol 2002, 14:1111-1133.
54. Hollander PA, Blonde L, Rowe R, Mehta AE, Milburn JL, et al. Efficacy and safety of inhaled insulin (exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, comparative trial. Diabetes Care 2004, 27:2356-2362.
55. Lippmann M, Esch JL. Effect of lung airway branching pattern and gas composition on particle deposition. I. Background and literature review. Exp Lung Res 1988, 14:311-320.
56. Tajik JK, Tran BQ, Hoffman EA. Xenon enhanced CT imaging of local pulmonary ventilation. Proc SPIE Medical Imaging 1996, 2709:40-54.
57. Albert MS, Cates GD, Driehuys B, Happer WB, Springer CSJ, et al. Biological magnetic resonance imaging using laser-polarized 129Xe. Nature 1994, 370:199-201.
58. Black RD, Middleton HL, Cates GD, Cofer GP, Driehuys B, et al. In vivo He-3 MR images of guinea pig lungs. Radiology 1996, 199:867-870.
59. Middleton H, Black RD, Saam B, Cates GD, Cofer GP, et al. MR imaging with hyperpolarized 3He gas. Magn Reson Med 1995, 33:271-275.
60. Wild J, Schreiber W, Kauczor H, Mugler JP, de Lange EE, et al. Functional MRI of the lungs using hyperpolarized 3-helium gas. J Magn Reson Imaging 2004, 20:540-554.
61. Balásházy I, Hofmann W, Heistracher T. Local particle deposition patterns may play a key role in the development of lung cancer. J Appl Physiol 2003, 94:1719-1725.
62. Zhang Z, Kleinstreuer C. Airflow structures and nanoparticle deposition in a human upper airway model. J Comput Phys 2004, 198:178-210.
63. Luo HY, Liu Y, Yang XL. Particle deposition in obstructed airways. J Biomech 2007, 40:3096-3104.
64. Yang XL, Liu Y, Luo HY. Respiratory flow in obstructed airways. J Biomech 2006, 39:2743-2751.
65. Yang XL, Liu Y, So RMC, Yang JM. The effect of inlet velocity profile on the bifurcation COPD airway flow. Comput Biol Med 2006, 36:181-194.
66. Choi LT, Tu JY, Li HF, Thien F. Flow and particle deposition patterns in a realistic human double bifurcation airway model. Inhal Toxicol 2007, 19:117-131.
67. Lin C-L, Hoffman EA. A numerical study of gas transport in human lung models. Proc SPIE Medical Imaging 2005, 5746:92-100.
68. Lin C-L, Tawhai MH, McLennan G, Hoffman EA. Multiscale simulation of gas flow in subject-specific models of the human lung. IEEE Eng Med Biol Mag 2008, In press.
69. Longest PW, Vinchurkar S. Effects of mesh style and grid convergence on particle deposition in bifurcating airway models with comparisons to experimental data. Med Eng Phys 2007, 29:350-366.
70. Robinson RJ, Snyder P, Oldham MJ. Comparison of particle tracking algorithms in commercial CFD packages: sedimentation and diffusion. Inhal Toxicol 2007, 19:517-531.
71. Comer JK, Kleinstreuer C, Hyun S, Kim CS. Aerosol transport and deposition in sequentially bifurcating airways. J Biomech Eng-T Asme 2000, 122:152-158.
72. Stapleton K, Guentsch E, Hoskinson MK, Finlay WH. On the suitability of k-e ?turbulence modeling for aerosol deposition in the mouth and throat. J Aerosol Sci 2000, 31:739-749.
73. Lö hner R, Cebral J, Soto O, Yim P, Burgess JE. Applications of patient-specific CFD in medicine and life science. Int J Numer Methods Fluids 2003, 43:637-650.
74. Heenan AF, Finlay WH, Grgic B, Pollard A, Burnell PKP. An investigation of the relationship between the flow field and regional deposition in realistic extrathoracic airways. J Aerosol Sci 2004, 35:1013-1023.
75. Caro C. Swirling steady inspiratory flow in models of human bronchial airways (abstract of presentation at BMES annual meeting, RTP 2001). Ann Biomed Eng 2001, 29:S138.
76. Heged-s CJ, Balashazy I, Farkas A. Detailed mathematical description of the geometry of airway bifurcations. Respir Physiol Neurobiol 2004, 141:99-114.
77. Farkas A, Balashazy I, Szocs K. Characterization of regional and local deposition of inhaled eerosol drugs in the respiratory system by computational fluid and particle dynamics methods. J Aerosol Med 2006, 19:329-343.
78. Baer GA, Terho M, Tiensuu T. Morphologic study of the adult trachea at the 7th and 12th ring: a study on specimens from 205 autopsies. Surg Radiol Anat 1987, 9:169-172.
79. Gamsu G, Webb WR. Computed tomography of the trachea: normal and abnormal. Am J Roentgenol 1982, 139:321-326.
80. Finlay WH. The Mechanics of Inhaled Pharmaceutical Aerosols (An Introduction). London, UK: Academic Press; 2001.
81. Wilcox DC. Turbulence Modeling for CFD. La Canada, CA: DCW Industries, Inc.; 1994.
82. Heenan AF, Matida E, Pollard A, Finlay WH. Experimental measurements and computational modeling of the flow field in an idealized human oropharynx. Exp Fluids 2003, 35:70-84.
83. Pope SB. Turbulent Flows. Cambridge, UK: Cambridge University Press; 2003.
84. Holmes P, Lumley JL, Berkooz G. Turbulence, Coherent Structures, Dynamical Systems and Symmetry. Cambidge, UK: Cambridge University Press; 1996.
85. Warren NJ, Nielsen P, Tawhai MH. Computational model of airway surface liquid regulation. Respirology 2007, 12(Supplement 1):A7.
86. Warren NJ, Nielsen PM, Tawhai MH. Description of airway periciliary height liquid regulation via a multiscale computational model of coupled cellular kinetics and geometrical airway conditions. Am J Respir Crit Care Med 2007, 175(Supplement):A263.
87. Burrowes KS, Tawhai MHH, Hunter PJ. Evaluation of arterial blood flow heterogeneity via an image-based computational model. Proc SPIE Medical Imaging 2005, 5746:257-266.
88. Burrowes KS, Tawhai MH, Hunter PJ. Modeling RBC neutrophil distribution through an anatomically based pulmonary capillary network. Ann Biomed Eng 2004, 32:585-595.
89. Burrowes KS, Tawhai MH. The effect of lung orientation on functional imaging of blood flow. Proc. SPIE Medical Imaging: Physiology, Structure, and Function from Medical Images. Sandiego, CA, 2007, 6511.
90. Swan A, Hunter PJ, Tawhai MH. Pulmonary gas exchange in anatomically-based models of the lung. Adv Exp Med Biol 2008, 605:184-189.
91. Tawhai MH, Ben-Tal A. Multiscale modeling for the Lung Physiome. Cardiovasc Eng 2004, 3:19-26.