메뉴 건너뛰기




Volumn 8, Issue 4, 2011, Pages 721-735

Progress in Cell Grafting Therapy for Temporal Lobe Epilepsy

Author keywords

Cell therapy for epilepsy; Chronic epilepsy; Complex partial seizures; GABA ergic transplants; Hippocampal neurogenesis; Neural stem cell grafts; Spontaneous recurrent seizures; Temporal lobe epilepsy

Indexed keywords

ADENOSINE; ANTICONVULSIVE AGENT;

EID: 80955125660     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-011-0064-y     Document Type: Review
Times cited : (35)

References (96)
  • 1
    • 0027430322 scopus 로고
    • Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination
    • French JA, Williamson PD, Thadani VM, et al. Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Ann Neurol 1993; 34: 774-780.
    • (1993) Ann Neurol , vol.34 , pp. 774-780
    • French, J.A.1    Williamson, P.D.2    Thadani, V.M.3
  • 2
    • 0033600245 scopus 로고    scopus 로고
    • Emerging insights into the genesis of epilepsy
    • McNamara JO. Emerging insights into the genesis of epilepsy. Nature 1999; 399: A15-A22.
    • (1999) Nature , vol.399
    • McNamara, J.O.1
  • 3
    • 27244441153 scopus 로고    scopus 로고
    • Losing neurons: selective vulnerability and mesial temporal sclerosis
    • Lewis DV. Losing neurons: selective vulnerability and mesial temporal sclerosis. Epilepsia 2005; 46(suppl 7): 39-44.
    • (2005) Epilepsia , vol.46 , Issue.SUPPL. 7 , pp. 39-44
    • Lewis, D.V.1
  • 4
    • 0026793558 scopus 로고
    • National General Practice Study of Epilepsy: partial seizure patterns in a general population
    • Manford M, Hart YM, Sander JW, Shorvon SD. National General Practice Study of Epilepsy: partial seizure patterns in a general population. Neurology 1992; 42: 1911-1917.
    • (1992) Neurology , vol.42 , pp. 1911-1917
    • Manford, M.1    Hart, Y.M.2    Sander, J.W.3    Shorvon, S.D.4
  • 5
    • 21844467976 scopus 로고    scopus 로고
    • Psychological distress, comorbidities, and health behaviors among U.S. adults with seizures: results from the 2002 National Health Interview Survey
    • Strine TW, Kobau R, Chapman DP, Thurman DJ, Price P, Balluz LS. Psychological distress, comorbidities, and health behaviors among U. S. adults with seizures: results from the 2002 National Health Interview Survey. Epilepsia 2005; 46: 1133-1139.
    • (2005) Epilepsia , vol.46 , pp. 1133-1139
    • Strine, T.W.1    Kobau, R.2    Chapman, D.P.3    Thurman, D.J.4    Price, P.5    Balluz, L.S.6
  • 6
    • 0024412565 scopus 로고
    • Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy
    • de Lanerolle NC, Kim JH, Robbins RJ, Spencer DD. Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy. Brain Res 1989; 495: 387-395.
    • (1989) Brain Res , vol.495 , pp. 387-395
    • de Lanerolle, N.C.1    Kim, J.H.2    Robbins, R.J.3    Spencer, D.D.4
  • 7
    • 0034911829 scopus 로고    scopus 로고
    • Mesial temporal lobe epilepsy: what have we learned?
    • Engel J Jr. Mesial temporal lobe epilepsy: what have we learned? Neuroscientist 2001; 7: 340-352.
    • (2001) Neuroscientist , vol.7 , pp. 340-352
    • Engel Jr., J.1
  • 8
    • 0034555122 scopus 로고    scopus 로고
    • Fetal hippocampal CA3 cell transplants restore host hippocampal GAD-positive interneuron numbers in a rat model of TLE
    • Shetty AK, Turner DA. Fetal hippocampal CA3 cell transplants restore host hippocampal GAD-positive interneuron numbers in a rat model of TLE. J Neurosci 2000; 20: 8788-8801.
    • (2000) J Neurosci , vol.20 , pp. 8788-8801
    • Shetty, A.K.1    Turner, D.A.2
  • 9
    • 0034986966 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase positive hippocampal interneurons undergo a permanent reduction in number following kainic acid induced destruction of CA3 pyramidal neurons
    • Shetty AK, Turner DA. Glutamic acid decarboxylase positive hippocampal interneurons undergo a permanent reduction in number following kainic acid induced destruction of CA3 pyramidal neurons. Exp Neurol 2001; 176: 276-297.
    • (2001) Exp Neurol , vol.176 , pp. 276-297
    • Shetty, A.K.1    Turner, D.A.2
  • 10
    • 0001490738 scopus 로고    scopus 로고
    • Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy
    • Pitkanen A, Sutula TP. Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. Lancet Neurol 2002; 1: 173-81.
    • (2002) Lancet Neurol , vol.1 , pp. 173-181
    • Pitkanen, A.1    Sutula, T.P.2
  • 11
    • 0037444634 scopus 로고    scopus 로고
    • Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy
    • Kobayashi M, Buckmaster PS. Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy. J Neurosci 2003; 23: 2440-2452.
    • (2003) J Neurosci , vol.23 , pp. 2440-2452
    • Kobayashi, M.1    Buckmaster, P.S.2
  • 12
    • 16344371983 scopus 로고    scopus 로고
    • A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats
    • Detour J, Schroeder H, Desor D, Nehlig A. A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats. Epilepsia 2005; 46: 499-508.
    • (2005) Epilepsia , vol.46 , pp. 499-508
    • Detour, J.1    Schroeder, H.2    Desor, D.3    Nehlig, A.4
  • 13
    • 3042724976 scopus 로고    scopus 로고
    • Therapy for neurobehavioral disorders in epilepsy
    • Devinsky O. Therapy for neurobehavioral disorders in epilepsy. Epilepsia 2004; 45(S2): 34-40.
    • (2004) Epilepsia , vol.45 , Issue.S2 , pp. 34-40
    • Devinsky, O.1
  • 14
    • 24944581582 scopus 로고    scopus 로고
    • Repair of the injured adult hippocampus through graft-mediated modulation of the plasticity of the dentate gyrus in a rat model of temporal lobe epilepsy
    • Shetty AK, Zaman V, Hattiangady B. Repair of the injured adult hippocampus through graft-mediated modulation of the plasticity of the dentate gyrus in a rat model of temporal lobe epilepsy. J Neurosci 2005; 25: 8391-8401.
    • (2005) J Neurosci , vol.25 , pp. 8391-8401
    • Shetty, A.K.1    Zaman, V.2    Hattiangady, B.3
  • 15
    • 72949102234 scopus 로고    scopus 로고
    • Vulnerability of hippocampal GABA-ergic interneurons to kainate induced excitotoxic injury during old age
    • Shetty AK, Hattiangady B, Rao MS. Vulnerability of hippocampal GABA-ergic interneurons to kainate induced excitotoxic injury during old age. J Cell Mol Med 2009; 13(8B): 2408-2423.
    • (2009) J Cell Mol Med , vol.13 , Issue.8 B , pp. 2408-2423
    • Shetty, A.K.1    Hattiangady, B.2    Rao, M.S.3
  • 16
    • 34548208178 scopus 로고    scopus 로고
    • Epileptogenesis in the dentate gyrus: a critical perspective
    • Dudek FE, Sutula TP. Epileptogenesis in the dentate gyrus: a critical perspective. Prog Brain Res 2007; 163: 755-773.
    • (2007) Prog Brain Res , vol.163 , pp. 755-773
    • Dudek, F.E.1    Sutula, T.P.2
  • 17
    • 17744399912 scopus 로고    scopus 로고
    • Epileptic seizures may begin hours in advance of clinical onset: A report of five patients
    • Litt B, Esteller R, Echauz J, et al. Epileptic seizures may begin hours in advance of clinical onset: A report of five patients. Neuron 2001; 30: 51-64.
    • (2001) Neuron , vol.30 , pp. 51-64
    • Litt, B.1    Esteller, R.2    Echauz, J.3
  • 18
    • 0037089803 scopus 로고    scopus 로고
    • Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task
    • Astur RS, Taylor LB, Mamelak AN, et al. Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task. Behav Brain Res 2002; 132: 77-84.
    • (2002) Behav Brain Res , vol.132 , pp. 77-84
    • Astur, R.S.1    Taylor, L.B.2    Mamelak, A.N.3
  • 19
    • 40649100989 scopus 로고    scopus 로고
    • Medial temporal fMRI activation reflects memory lateralization and memory performance in patients with epilepsy
    • Vannest J, Szaflarski JP, Privitera MD, Schefft BK, Holland SK. Medial temporal fMRI activation reflects memory lateralization and memory performance in patients with epilepsy. Epilepsy Behav 2008; 12: 410-418.
    • (2008) Epilepsy Behav , vol.12 , pp. 410-418
    • Vannest, J.1    Szaflarski, J.P.2    Privitera, M.D.3    Schefft, B.K.4    Holland, S.K.5
  • 20
    • 77953188859 scopus 로고    scopus 로고
    • The ketogenic diet: an appropriate first-line therapy?
    • Kossoff EH. The ketogenic diet: an appropriate first-line therapy? Expert Rev Neurother 2010; 10: 843-845.
    • (2010) Expert Rev Neurother , vol.10 , pp. 843-845
    • Kossoff, E.H.1
  • 21
    • 62949137030 scopus 로고    scopus 로고
    • Ketogenic diets: evidence for short- and long-term efficacy
    • Kossoff EH, Rho JM. Ketogenic diets: evidence for short- and long-term efficacy. Neurotherapeutics 2008; 6: 406-414.
    • (2008) Neurotherapeutics , vol.6 , pp. 406-414
    • Kossoff, E.H.1    Rho, J.M.2
  • 22
    • 39049142635 scopus 로고    scopus 로고
    • Temporal lobe resection-does the prospect of seizure freedom outweigh the cognitive risks?
    • Helmstaedter C. Temporal lobe resection--does the prospect of seizure freedom outweigh the cognitive risks? Nat Clin Pract Neurol 2008; 4: 66-67.
    • (2008) Nat Clin Pract Neurol , vol.4 , pp. 66-67
    • Helmstaedter, C.1
  • 23
    • 65449138017 scopus 로고    scopus 로고
    • Vagal nerve stimulation-a 15-year survey of an established treatment modality in epilepsy surgery
    • Vonck K, De Herdt V, Boon P. Vagal nerve stimulation--a 15-year survey of an established treatment modality in epilepsy surgery. Adv Tech Stand Neurosurg 2009; 34: 111-146.
    • (2009) Adv Tech Stand Neurosurg , vol.34 , pp. 111-146
    • Vonck, K.1    de Herdt, V.2    Boon, P.3
  • 24
    • 0030476817 scopus 로고    scopus 로고
    • Development of fetal hippocampal grafts in intact and lesioned hippocampus
    • Shetty AK, Turner DA. Development of fetal hippocampal grafts in intact and lesioned hippocampus. Prog Neurobiol 1996; 50: 597-653.
    • (1996) Prog Neurobiol , vol.50 , pp. 597-653
    • Shetty, A.K.1    Turner, D.A.2
  • 25
    • 0037371266 scopus 로고    scopus 로고
    • Clinical prospects for neural grafting therapy for hippocampal lesions and epilepsy
    • Turner DA, Shetty AK. Clinical prospects for neural grafting therapy for hippocampal lesions and epilepsy. Neurosurgery 2003; 52: 632-644.
    • (2003) Neurosurgery , vol.52 , pp. 632-644
    • Turner, D.A.1    Shetty, A.K.2
  • 26
    • 34447637444 scopus 로고    scopus 로고
    • Strategies for promoting anti-seizure effects of hippocampal fetal cells grafted into the hippocampus of rats exhibiting chronic temporal lobe epilepsy
    • Rao MS, Hattiangady B, Rai KS, Shetty AK. Strategies for promoting anti-seizure effects of hippocampal fetal cells grafted into the hippocampus of rats exhibiting chronic temporal lobe epilepsy. Neurobiol Dis 2007; 27: 117-132.
    • (2007) Neurobiol Dis , vol.27 , pp. 117-132
    • Rao, M.S.1    Hattiangady, B.2    Rai, K.S.3    Shetty, A.K.4
  • 27
    • 35348903757 scopus 로고    scopus 로고
    • Concise review: prospects of stem cell therapy for temporal lobe epilepsy
    • Shetty AK, Hattiangady B. Concise review: prospects of stem cell therapy for temporal lobe epilepsy. Stem Cells 2007; 25: 2396-2407.
    • (2007) Stem Cells , vol.25 , pp. 2396-2407
    • Shetty, A.K.1    Hattiangady, B.2
  • 28
    • 39149095942 scopus 로고    scopus 로고
    • Cell and gene therapies in epilepsy - promising avenues or blind alleys?
    • Löscher W, Gernert M, Heinemann U. Cell and gene therapies in epilepsy - promising avenues or blind alleys? Trends Neurosci 2008; 31: 62-73.
    • (2008) Trends Neurosci , vol.31 , pp. 62-73
    • Löscher, W.1    Gernert, M.2    Heinemann, U.3
  • 29
    • 62949134598 scopus 로고    scopus 로고
    • Transplantation of GABA-producing cells for seizure control in models of temporal lobe epilepsy
    • Thompson K. Transplantation of GABA-producing cells for seizure control in models of temporal lobe epilepsy. Neurotherapeutics 2009; 6: 284-294.
    • (2009) Neurotherapeutics , vol.6 , pp. 284-294
    • Thompson, K.1
  • 30
    • 77649336367 scopus 로고    scopus 로고
    • Recent advancements in stem cell and gene therapies for neurological disorders and intractable epilepsy
    • Naegele JR, Maisano X, Yang J, Royston S, Ribeiro E. Recent advancements in stem cell and gene therapies for neurological disorders and intractable epilepsy. Neuropharmacol 2010; 58: 855-864.
    • (2010) Neuropharmacol , vol.58 , pp. 855-864
    • Naegele, J.R.1    Maisano, X.2    Yang, J.3    Royston, S.4    Ribeiro, E.5
  • 32
    • 15544370150 scopus 로고    scopus 로고
    • Adult neurogenesis: from precursors to network and physiology
    • Abrous DN, Koehl M, Le Moal M. Adult neurogenesis: from precursors to network and physiology. Physiol Rev 2005; 85: 523-569.
    • (2005) Physiol Rev , vol.85 , pp. 523-569
    • Abrous, D.N.1    Koehl, M.2    Le Moal, M.3
  • 33
    • 0030907041 scopus 로고    scopus 로고
    • Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
    • Parent JM, Yu TW, Leibowitz RT, Geschwind DH, Sloviter RS, Lowenstein DH. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci 1997; 17: 3727-3738.
    • (1997) J Neurosci , vol.17 , pp. 3727-3738
    • Parent, J.M.1    Yu, T.W.2    Leibowitz, R.T.3    Geschwind, D.H.4    Sloviter, R.S.5    Lowenstein, D.H.6
  • 34
    • 0034663012 scopus 로고    scopus 로고
    • Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis
    • Scharfman HE, Goodman JH, Sollas AL. Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis. J Neurosci 2000; 20: 6144-6158.
    • (2000) J Neurosci , vol.20 , pp. 6144-6158
    • Scharfman, H.E.1    Goodman, J.H.2    Sollas, A.L.3
  • 35
    • 0034638255 scopus 로고    scopus 로고
    • Pattern of long-distance projections from fetal hippocampal field CA3 and CA1 cell grafts in lesioned CA3 of adult hippocampus follows intrinsic character of respective donor cells
    • Shetty AK, Zaman V, Turner DA. Pattern of long-distance projections from fetal hippocampal field CA3 and CA1 cell grafts in lesioned CA3 of adult hippocampus follows intrinsic character of respective donor cells. Neuroscience 2000; 99: 243-255.
    • (2000) Neuroscience , vol.99 , pp. 243-255
    • Shetty, A.K.1    Zaman, V.2    Turner, D.A.3
  • 36
    • 33646139642 scopus 로고    scopus 로고
    • Incorporation of embryonic CA3 cell grafts into the adult hippocampus at 4-months after injury: effects of combined neurotrophic supplementation and caspase inhibition
    • Hattiangady B, Rao MS, Zaman V, Shetty AK. Incorporation of embryonic CA3 cell grafts into the adult hippocampus at 4-months after injury: effects of combined neurotrophic supplementation and caspase inhibition. Neuroscience 2006; 139: 1369-1383.
    • (2006) Neuroscience , vol.139 , pp. 1369-1383
    • Hattiangady, B.1    Rao, M.S.2    Zaman, V.3    Shetty, A.K.4
  • 37
    • 77954824190 scopus 로고    scopus 로고
    • Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy
    • Waldau B, Hattiangady B, Kuruba R, Shetty AK. Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy. Stem Cells 2010; 28: 1153-1164.
    • (2010) Stem Cells , vol.28 , pp. 1153-1164
    • Waldau, B.1    Hattiangady, B.2    Kuruba, R.3    Shetty, A.K.4
  • 38
    • 0034093828 scopus 로고    scopus 로고
    • Survival of grafted fetal neural cells in kainic acid lesioned CA3 region of adult hippocampus depends upon cell specificity
    • Zaman V, Turner DA, Shetty AK. Survival of grafted fetal neural cells in kainic acid lesioned CA3 region of adult hippocampus depends upon cell specificity. Exp Neurol 2000; 161: 535-561.
    • (2000) Exp Neurol , vol.161 , pp. 535-561
    • Zaman, V.1    Turner, D.A.2    Shetty, A.K.3
  • 39
    • 0035079326 scopus 로고    scopus 로고
    • Prolonged post-lesion transplantation delay adversely influences survival of both homotopic and heterotopic fetal hippocampal cell grafts in Kainate-lesioned CA3 region of adult hippocampus
    • Zaman V, Turner DA, Shetty AK. Prolonged post-lesion transplantation delay adversely influences survival of both homotopic and heterotopic fetal hippocampal cell grafts in Kainate-lesioned CA3 region of adult hippocampus. Cell Transplant 2001; 10: 41-52.
    • (2001) Cell Transplant , vol.10 , pp. 41-52
    • Zaman, V.1    Turner, D.A.2    Shetty, A.K.3
  • 40
    • 0035664278 scopus 로고    scopus 로고
    • Fetal hippocampal CA3 cell grafts transplanted to lesioned CA3 region of the adult hippocampus exhibit long-term survival in a rat model of temporal lobe epilepsy
    • Zaman V, Shetty AK. Fetal hippocampal CA3 cell grafts transplanted to lesioned CA3 region of the adult hippocampus exhibit long-term survival in a rat model of temporal lobe epilepsy. Neurobiol Dis 2001; 8: 942-52.
    • (2001) Neurobiol Dis , vol.8 , pp. 942-952
    • Zaman, V.1    Shetty, A.K.2
  • 41
    • 79951531485 scopus 로고    scopus 로고
    • Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
    • Buckmaster PS, Lew FH. Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. J Neurosci 2011; 31: 2337-2347.
    • (2011) J Neurosci , vol.31 , pp. 2337-2347
    • Buckmaster, P.S.1    Lew, F.H.2
  • 42
    • 16644368127 scopus 로고    scopus 로고
    • Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography
    • Santhakumar V, Aradi I, Soltesz I. Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography. J Neurophysiol 2005; 93: 437-453.
    • (2005) J Neurophysiol , vol.93 , pp. 437-453
    • Santhakumar, V.1    Aradi, I.2    Soltesz, I.3
  • 43
    • 0043065674 scopus 로고    scopus 로고
    • Surviving granule cells of the sclerotic human hippocampus have reduced Ca(2+) influx because of a loss of calbindin-D(28 k) in temporal lobe epilepsy
    • Nägerl UV, Mody I, Jeub M, Lie AA, Elger CE, Beck H. Surviving granule cells of the sclerotic human hippocampus have reduced Ca(2+) influx because of a loss of calbindin-D(28 k) in temporal lobe epilepsy. J Neurosci 2000; 20: 1831-1836.
    • (2000) J Neurosci , vol.20 , pp. 1831-1836
    • Nägerl, U.V.1    Mody, I.2    Jeub, M.3    Lie, A.A.4    Elger, C.E.5    Beck, H.6
  • 44
    • 33645865872 scopus 로고    scopus 로고
    • Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy
    • Rao MS, Hattiangady B, Reddy DS, Shetty AK. Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy. J Neurosci Res 2006; 83: 1088-1105.
    • (2006) J Neurosci Res , vol.83 , pp. 1088-1105
    • Rao, M.S.1    Hattiangady, B.2    Reddy, D.S.3    Shetty, A.K.4
  • 45
    • 84873081826 scopus 로고    scopus 로고
    • Efficacy of hippocampal precursor cell grafting early after status epilepticus for restraining epileptogenesis and chronic spontaneous seizures in a rat model of temporal lobe epilepsy
    • Hattiangady B, Rao MS, Kuruba R, et al. Efficacy of hippocampal precursor cell grafting early after status epilepticus for restraining epileptogenesis and chronic spontaneous seizures in a rat model of temporal lobe epilepsy. Soc Neurosci Abstr 2008; 527: 4.
    • (2008) Soc Neurosci Abstr , vol.527 , pp. 4
    • Hattiangady, B.1    Rao, M.S.2    Kuruba, R.3
  • 46
    • 80955131940 scopus 로고    scopus 로고
    • Hippocampal precursor cell grafting early after status epilepticus considerably attenuates learning and memory Dysfunction
    • Kuruba, R, Hattiangady B, Rao MS, Shetty AK. Hippocampal precursor cell grafting early after status epilepticus considerably attenuates learning and memory Dysfunction. Soc Neurosci Abstr 2008; 527: 2.
    • (2008) Soc Neurosci Abstr , vol.527 , pp. 2
    • Kuruba, R.1    Hattiangady, B.2    Rao, M.S.3    Shetty, A.K.4
  • 48
    • 0024560520 scopus 로고
    • Long-term loss of paired pulse inhibition in the kainic acid-lesioned hippocampus of the rat
    • Cornish SM, Wheal HV. Long-term loss of paired pulse inhibition in the kainic acid-lesioned hippocampus of the rat. Neurosci 1989; 28: 563-571.
    • (1989) Neurosci , vol.28 , pp. 563-571
    • Cornish, S.M.1    Wheal, H.V.2
  • 49
    • 0029011707 scopus 로고
    • Hippocampal GABA transporter function in temporal-lobe epilepsy
    • During MJ, Ryder KM, Spencer DD. Hippocampal GABA transporter function in temporal-lobe epilepsy. Nature 1995; 376: 174-177.
    • (1995) Nature , vol.376 , pp. 174-177
    • During, M.J.1    Ryder, K.M.2    Spencer, D.D.3
  • 50
    • 0022625004 scopus 로고
    • A decrease in the number of GABAergic somata is associated with the preferential loss of GABAergic terminals at epileptic foci
    • Ribak CE, Hunt CA, Bakay RA, Oertel WH. A decrease in the number of GABAergic somata is associated with the preferential loss of GABAergic terminals at epileptic foci. Brain Res 1986; 363: 78-90.
    • (1986) Brain Res , vol.363 , pp. 78-90
    • Ribak, C.E.1    Hunt, C.A.2    Bakay, R.A.3    Oertel, W.H.4
  • 51
    • 0024411770 scopus 로고
    • Changes in GABA-immunoreactive cell density during motor focal epilepsy induced by cobalt in the rat
    • Esclapez M, Trottier S. Changes in GABA-immunoreactive cell density during motor focal epilepsy induced by cobalt in the rat. Exp Brain Res 1989; 76: 369-385.
    • (1989) Exp Brain Res , vol.76 , pp. 369-385
    • Esclapez, M.1    Trottier, S.2
  • 52
    • 0346688806 scopus 로고    scopus 로고
    • Transplants of cells engineered to produce GABA suppress spontaneous seizures
    • Thompson KW, Suchomelova LM. Transplants of cells engineered to produce GABA suppress spontaneous seizures. Epilepsia 2004; 45: 4-12.
    • (2004) Epilepsia , vol.45 , pp. 4-12
    • Thompson, K.W.1    Suchomelova, L.M.2
  • 53
    • 20444502536 scopus 로고    scopus 로고
    • Genetically engineered cells with regulatable GABA production can affect after discharges and behavioral seizures after transplantation into the dentate gyrus
    • Thompson KW. Genetically engineered cells with regulatable GABA production can affect after discharges and behavioral seizures after transplantation into the dentate gyrus. Neurosci 2005; 133: 1029-1037.
    • (2005) Neurosci , vol.133 , pp. 1029-1037
    • Thompson, K.W.1
  • 54
    • 2642702860 scopus 로고    scopus 로고
    • Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra
    • Löscher W, Ebert U, Lehmann H, Rosenthal C, Nikkhah G. Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra. J Neurosci Res 1998; 51: 196-209.
    • (1998) J Neurosci Res , vol.51 , pp. 196-209
    • Löscher, W.1    Ebert, U.2    Lehmann, H.3    Rosenthal, C.4    Nikkhah, G.5
  • 55
    • 33646541363 scopus 로고    scopus 로고
    • Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat
    • Castillo CG, Mendoza S, Freed WJ, Giordano M. Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat. Behav Brain Res 2006; 171: 109-115.
    • (2006) Behav Brain Res , vol.171 , pp. 109-115
    • Castillo, C.G.1    Mendoza, S.2    Freed, W.J.3    Giordano, M.4
  • 56
    • 47849095176 scopus 로고    scopus 로고
    • Intranigral transplants of a GABAergic cell line produce long-term alleviation of established motor seizures
    • Castillo CG, Mendoza-Trejo S, Aguilar MB, Freed WJ, Giordano M. Intranigral transplants of a GABAergic cell line produce long-term alleviation of established motor seizures. Behav Brain Res 2008; 193: 17-27.
    • (2008) Behav Brain Res , vol.193 , pp. 17-27
    • Castillo, C.G.1    Mendoza-Trejo, S.2    Aguilar, M.B.3    Freed, W.J.4    Giordano, M.5
  • 57
    • 49549091329 scopus 로고    scopus 로고
    • Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures
    • Nolte MW, Löscher W, Herden C, Freed WJ, Gernert M. Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures. Neurobiol Dis 2008; 31: 342-354.
    • (2008) Neurobiol Dis , vol.31 , pp. 342-354
    • Nolte, M.W.1    Löscher, W.2    Herden, C.3    Freed, W.J.4    Gernert, M.5
  • 58
    • 47349084354 scopus 로고    scopus 로고
    • Grafting of striatal precursor cells into hippocampus shortly after status epilepticus restrains chronic temporal lobe epilepsy
    • Hattiangady B, Rao MS, Shetty AK. Grafting of striatal precursor cells into hippocampus shortly after status epilepticus restrains chronic temporal lobe epilepsy. Exp Neurol 2008; 212: 468-481.
    • (2008) Exp Neurol , vol.212 , pp. 468-481
    • Hattiangady, B.1    Rao, M.S.2    Shetty, A.K.3
  • 59
    • 70349349163 scopus 로고    scopus 로고
    • Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice
    • Baraban SC, Southwell DG, Estrada RC, et al. Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1. 1 mutant mice. Proc Natl Acad Sci USA 2009; 106: 15472-15477.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 15472-15477
    • Baraban, S.C.1    Southwell, D.G.2    Estrada, R.C.3
  • 60
    • 77954921964 scopus 로고    scopus 로고
    • Transplant of GABAergic precursors restores hippocampal inhibitory function in a mouse model of seizure susceptibility
    • Zipancic I, Calcagnotto ME, Piquer-Gil M, Mello LE, Alvarez-Dolado M. Transplant of GABAergic precursors restores hippocampal inhibitory function in a mouse model of seizure susceptibility. Cell Transplant 2010; 19: 549-564.
    • (2010) Cell Transplant , vol.19 , pp. 549-564
    • Zipancic, I.1    Calcagnotto, M.E.2    Piquer-Gil, M.3    Mello, L.E.4    Alvarez-Dolado, M.5
  • 61
    • 13544274000 scopus 로고    scopus 로고
    • Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies
    • Boison D. Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies. Neuroscientist 2005; 11: 25-36.
    • (2005) Neuroscientist , vol.11 , pp. 25-36
    • Boison, D.1
  • 62
    • 0036337632 scopus 로고    scopus 로고
    • Seizure suppression by adenosine-releasing cells is independent of seizure frequency
    • Boison D, Huber A, Padrun V, Deglon N, Aebischer P, Mohler H. Seizure suppression by adenosine-releasing cells is independent of seizure frequency. Epilepsia 2002; 43: 788-796.
    • (2002) Epilepsia , vol.43 , pp. 788-796
    • Boison, D.1    Huber, A.2    Padrun, V.3    Deglon, N.4    Aebischer, P.5    Mohler, H.6
  • 63
    • 0032728754 scopus 로고    scopus 로고
    • Seizure suppression in kindled rats by intraventricular grafting of an adenosine releasing synthetic polymer
    • Boison D, Scheurer L, Tseng JL, Aebischer P, Mohler H. Seizure suppression in kindled rats by intraventricular grafting of an adenosine releasing synthetic polymer. Exp Neurol 1999; 160: 164-174.
    • (1999) Exp Neurol , vol.160 , pp. 164-174
    • Boison, D.1    Scheurer, L.2    Tseng, J.L.3    Aebischer, P.4    Mohler, H.5
  • 65
    • 16244364339 scopus 로고    scopus 로고
    • Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts
    • Guttinger M, Padrun V, Pralong WF, Boison D. Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts. Exp Neurol 2005; 193: 53-64.
    • (2005) Exp Neurol , vol.193 , pp. 53-64
    • Guttinger, M.1    Padrun, V.2    Pralong, W.F.3    Boison, D.4
  • 66
    • 34249694599 scopus 로고    scopus 로고
    • Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants
    • Li T, Steinbeck JA, Lusardi T, et al. Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants. Brain 2007; 130: 1276-1288.
    • (2007) Brain , vol.130 , pp. 1276-1288
    • Li, T.1    Steinbeck, J.A.2    Lusardi, T.3
  • 67
    • 38849100495 scopus 로고    scopus 로고
    • Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice
    • Li T, Ren G, Lusardi T, et al. Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest 2008; 118: 571-582.
    • (2008) J Clin Invest , vol.118 , pp. 571-582
    • Li, T.1    Ren, G.2    Lusardi, T.3
  • 68
    • 0026535505 scopus 로고
    • Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
    • Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992; 255: 1707-1710.
    • (1992) Science , vol.255 , pp. 1707-1710
    • Reynolds, B.A.1    Weiss, S.2
  • 69
    • 0033216122 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS
    • Palmer TD, Markakis EA, Willhoite AR, Safar F, Gage FH. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci 1999; 19: 8487-8497.
    • (1999) J Neurosci , vol.19 , pp. 8487-8497
    • Palmer, T.D.1    Markakis, E.A.2    Willhoite, A.R.3    Safar, F.4    Gage, F.H.5
  • 71
    • 67650106862 scopus 로고    scopus 로고
    • Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease
    • Leonard BW, Mastroeni D, Grover A, et al. Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease. J Comp Neurol 2009; 515: 269-294.
    • (2009) J Comp Neurol , vol.515 , pp. 269-294
    • Leonard, B.W.1    Mastroeni, D.2    Grover, A.3
  • 72
    • 70450285340 scopus 로고    scopus 로고
    • Technical challenges in using human induced pluripotent stem cells to model disease
    • Saha K, Jaenisch R. Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell 2009; 5: 584-595.
    • (2009) Cell Stem Cell , vol.5 , pp. 584-595
    • Saha, K.1    Jaenisch, R.2
  • 73
    • 78049404183 scopus 로고    scopus 로고
    • Patient-specific pluripotent stem cells become even more accessible
    • Yamanaka S. Patient-specific pluripotent stem cells become even more accessible. Cell Stem Cell 2010; 7: 1-2.
    • (2010) Cell Stem Cell , vol.7 , pp. 1-2
    • Yamanaka, S.1
  • 74
    • 77951735163 scopus 로고    scopus 로고
    • Effects of grafting of hippocampal stem/progenitor cells shortly after status epilepticus on the development of chronic epilepsy
    • Kuruba R, Hattiangady B, Shuai B, Shetty AK. Effects of grafting of hippocampal stem/progenitor cells shortly after status epilepticus on the development of chronic epilepsy. Cell Transplant 2009; 18: 221-221.
    • (2009) Cell Transplant , vol.18 , pp. 221
    • Kuruba, R.1    Hattiangady, B.2    Shuai, B.3    Shetty, A.K.4
  • 75
    • 77249088635 scopus 로고    scopus 로고
    • Seizure suppression in amygdala-kindled mice by transplantation of neural stem/progenitor cells derived from mouse embryonic stem cells
    • Shindo A, Nakamura T, Matsumoto Y, et al. Seizure suppression in amygdala-kindled mice by transplantation of neural stem/progenitor cells derived from mouse embryonic stem cells. Neurol Med Chir 2010; 50: 98-105.
    • (2010) Neurol Med Chir , vol.50 , pp. 98-105
    • Shindo, A.1    Nakamura, T.2    Matsumoto, Y.3
  • 76
    • 34547881910 scopus 로고    scopus 로고
    • Increased dentate neurogenesis after grafting of glial restricted progenitors or neural stem cells in the aging hippocampus
    • Hattiangady B, Shuai B, Cai J, Coksaygan T, Rao MS, Shetty AK. Increased dentate neurogenesis after grafting of glial restricted progenitors or neural stem cells in the aging hippocampus. Stem Cells 2007; 25: 2104-2117.
    • (2007) Stem Cells , vol.25 , pp. 2104-2117
    • Hattiangady, B.1    Shuai, B.2    Cai, J.3    Coksaygan, T.4    Rao, M.S.5    Shetty, A.K.6
  • 77
    • 34548348778 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis in depression
    • Sahay A, Hen R. Adult hippocampal neurogenesis in depression. Nat Neurosci 2007; 10: 1110-1115.
    • (2007) Nat Neurosci , vol.10 , pp. 1110-1115
    • Sahay, A.1    Hen, R.2
  • 78
    • 45849151100 scopus 로고    scopus 로고
    • Spatial relational memory requires hippocampal adult neurogenesis
    • Dupret D, Revest JM, Koehl M, et al. Spatial relational memory requires hippocampal adult neurogenesis. PLoS ONE 2008; 3: e1959.
    • (2008) PLoS ONE , vol.3
    • Dupret, D.1    Revest, J.M.2    Koehl, M.3
  • 79
    • 52949147794 scopus 로고    scopus 로고
    • Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    • Imayoshi I, Sakamoto M, Ohtsuka T, et al. Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci 2008; 11: 1153-1161.
    • (2008) Nat Neurosci , vol.11 , pp. 1153-1161
    • Imayoshi, I.1    Sakamoto, M.2    Ohtsuka, T.3
  • 80
    • 67650450542 scopus 로고    scopus 로고
    • A functional role for adult hippocampal neurogenesis in spatial pattern separation
    • Clelland CD, Choi M, Romberg C, et al. A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 2009; 325: 210-213.
    • (2009) Science , vol.325 , pp. 210-213
    • Clelland, C.D.1    Choi, M.2    Romberg, C.3
  • 81
    • 59649095732 scopus 로고    scopus 로고
    • Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
    • Jessberger S, Clark RE, Broadbent NJ, et al. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem 2009; 16: 147-154.
    • (2009) Learn Mem , vol.16 , pp. 147-154
    • Jessberger, S.1    Clark, R.E.2    Broadbent, N.J.3
  • 82
    • 4544290431 scopus 로고    scopus 로고
    • Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats
    • Chu K, Kim M, Jung KH, et al. Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. Brain Res 2004; 1023: 213-21.
    • (2004) Brain Res , vol.1023 , pp. 213-221
    • Chu, K.1    Kim, M.2    Jung, K.H.3
  • 83
    • 70349241505 scopus 로고    scopus 로고
    • The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting
    • Jing M, Shingo T, Yasuhara T, et al. The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting. Brain Res 2009; 295: 203-217.
    • (2009) Brain Res , vol.295 , pp. 203-217
    • Jing, M.1    Shingo, T.2    Yasuhara, T.3
  • 84
    • 80955150910 scopus 로고    scopus 로고
    • Intrahippocampal grafting of NSCs after status epilepticus eases both spontaneous seizures & cognitive dysfunction in a rat model of temporal lobe epilepsy
    • Hattiangady B, Kuruba R, Parihar VK, Shetty AK. Intrahippocampal grafting of NSCs after status epilepticus eases both spontaneous seizures & cognitive dysfunction in a rat model of temporal lobe epilepsy. Soc Neurosci Abstr 2010; 29: 30.
    • (2010) Soc Neurosci Abstr , vol.29 , pp. 30
    • Hattiangady, B.1    Kuruba, R.2    Parihar, V.K.3    Shetty, A.K.4
  • 85
    • 80955149278 scopus 로고    scopus 로고
    • Lasting inhibition of spontaneous recurrent motor seizures after hippocampal precursor cell grafting in rats exhibiting chronic temporal lobe epilepsy
    • Hattiangady B, Rao MS, Rai KS, Zeng YC, Reddy DS, Shetty AK. Lasting inhibition of spontaneous recurrent motor seizures after hippocampal precursor cell grafting in rats exhibiting chronic temporal lobe epilepsy. Soc Neurosci Abstr 2006; 280: 4.
    • (2006) Soc Neurosci Abstr , vol.280 , pp. 4
    • Hattiangady, B.1    Rao, M.S.2    Rai, K.S.3    Zeng, Y.C.4    Reddy, D.S.5    Shetty, A.K.6
  • 86
    • 80955128647 scopus 로고    scopus 로고
    • Medial ganglionic eminence precursor cell grafting diminishes spontaneous seizures and improves memory function in a rat model of temporal lobe epilepsy
    • Hattiangady B, Shuai B, Parihar VK, Shetty AK. Medial ganglionic eminence precursor cell grafting diminishes spontaneous seizures and improves memory function in a rat model of temporal lobe epilepsy. Cell Transplant 2011; 20: 562-563.
    • (2011) Cell Transplant , vol.20 , pp. 562-563
    • Hattiangady, B.1    Shuai, B.2    Parihar, V.K.3    Shetty, A.K.4
  • 87
    • 0036315219 scopus 로고    scopus 로고
    • Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats
    • Gernert M, Thompson KW, Löscher W, Tobin AJ. Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats. Exp Neurol 2002; 176: 183-192.
    • (2002) Exp Neurol , vol.176 , pp. 183-192
    • Gernert, M.1    Thompson, K.W.2    Löscher, W.3    Tobin, A.J.4
  • 88
    • 33746103337 scopus 로고    scopus 로고
    • Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain
    • Alvarez-Dolado M, Calcagnotto ME, Karkar KM, et al. Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. J Neurosci 2006; 26: 7380-7389.
    • (2006) J Neurosci , vol.26 , pp. 7380-7389
    • Alvarez-Dolado, M.1    Calcagnotto, M.E.2    Karkar, K.M.3
  • 89
    • 34249285188 scopus 로고    scopus 로고
    • Seizure suppression by GDNF gene therapy in animal models of epilepsy
    • Kanter-Schlifke I, Georgievska B, Kirik D, Kokaia M. Seizure suppression by GDNF gene therapy in animal models of epilepsy. Mol Ther 2007; 15: 1106-1113.
    • (2007) Mol Ther , vol.15 , pp. 1106-1113
    • Kanter-Schlifke, I.1    Georgievska, B.2    Kirik, D.3    Kokaia, M.4
  • 91
    • 9644289380 scopus 로고    scopus 로고
    • Chronic temporal lobe epilepsy is associated with severely diminished dentate neurogenesis in the adult hippocampus
    • Hattiangady B, Rao MS, Shetty AK. Chronic temporal lobe epilepsy is associated with severely diminished dentate neurogenesis in the adult hippocampus. Neurobiol Dis 2004; 17: 473-490.
    • (2004) Neurobiol Dis , vol.17 , pp. 473-490
    • Hattiangady, B.1    Rao, M.S.2    Shetty, A.K.3
  • 92
    • 75149160465 scopus 로고    scopus 로고
    • Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy
    • Hattiangady B, Shetty AK. Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy. Hippocampus 2010; 20: 97-112.
    • (2010) Hippocampus , vol.20 , pp. 97-112
    • Hattiangady, B.1    Shetty, A.K.2
  • 93
    • 62949147663 scopus 로고    scopus 로고
    • Embryonic stem cell-derived neural precursor grafts for treatment of temporal lobe epilepsy
    • Maisano X, Carpentino J, Becker S, et al. Embryonic stem cell-derived neural precursor grafts for treatment of temporal lobe epilepsy. Neurotherapeutics 2009; 6: 263-277.
    • (2009) Neurotherapeutics , vol.6 , pp. 263-277
    • Maisano, X.1    Carpentino, J.2    Becker, S.3
  • 94
    • 77950688386 scopus 로고    scopus 로고
    • Prospective isolation of cortical interneuron precursors from mouse embryonic stem cells
    • Maroof AM, Brown K, Shi SH, et al. Prospective isolation of cortical interneuron precursors from mouse embryonic stem cells. J Neurosci 2010; 30: 4667-4675.
    • (2010) J Neurosci , vol.30 , pp. 4667-4675
    • Maroof, A.M.1    Brown, K.2    Shi, S.H.3
  • 95
    • 0002059790 scopus 로고    scopus 로고
    • Porcine fetal GABA-producting neural cell grafts for human partial-onset seizures: safety and feasibility
    • Schachter SC, Schomer DL, Blume H, Ives JR, Joseph J. Porcine fetal GABA-producting neural cell grafts for human partial-onset seizures: safety and feasibility. Epilepsia 1998; 39(supp 6); 67.
    • (1998) Epilepsia , vol.39 , Issue.supp 6 , pp. 67
    • Schachter, S.C.1    Schomer, D.L.2    Blume, H.3    Ives, J.R.4    Joseph, J.5
  • 96
    • 78650038409 scopus 로고    scopus 로고
    • The promise of an interneuron-based cell therapy for epilepsy
    • Sebe JY, Baraban SC. The promise of an interneuron-based cell therapy for epilepsy. Dev Neurobiol 2011; 71: 107-117.
    • (2011) Dev Neurobiol , vol.71 , pp. 107-117
    • Sebe, J.Y.1    Baraban, S.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.