Development of fetal hippocampal grafts in intact and lesioned hippocampus

Progress in Neurobiology

Volumn 50, Issue 5-6, 1996, Pages 597-653

  Shetty, Ashok K ^a   Turner, Dennis A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN ISCHEMIA; GRAFT PATENCY; HEAD INJURY; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; STROKE; SUBSTANTIA NIGRA; TEMPORAL LOBE EPILEPSY; TRANSPLANTATION;

EID: 0030476817     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(96)00048-2     Document Type: Article

References (345)

1. Abercrombie, M. (1946) Estimation of nuclear population from microtome sections. Anat. Rec. 94, 239-246.
2. Altman, J. and Bayer, S. A. (1990) Mosaic organization of the hippocampal neuroepithelium and the multiple germinal sources of dentate granule cells. J. Comp. Neurol. 301, 325-342.
3. Amaral, D. G: (1978) A Golgi study of cell types in the hilar region of the hippocampus in the rat. J. Comp. Neurol. 182, 851-914.
4. Arbuthnott, G. W. and Dunnett, S. B. (1990) Identification of grafted neurons with fluorescent-labelled microbeads. Prog. Brain Res. 82, 385-390.
5. Ardizzoni, S. C., Michaels, A. and Arendash, G. W. (1988) Labeling of neural cells by gold-filled Sendai virus envelopes before intracerebral transplantation. Science 239, 635-637.
6. Auer, R. N., Jensen, M. L. and Whishaw, I. Q. (1989) Neurobehavioral deficit due to ischemic brain damage limited to half the CA1 sector of the hippocampus. J. Neurosci. 9, 1641-1647.
7. Backes, M. G., Lund, R. D., Lagenaur, C. F., Kunz, H. W. and Gill, T. J. (1990) Cellular events associated with peripherally induced rejection of mature neural xenografts placed into neonatal rat brains. J. Comp. Neurol. 295, 428-437.
8. Baetge, E. E. (1993) Neural stem cells for CNS transplantation. Ann. NY Acad. Sci. 695, 285-291.
9. Baimbridge, K. G., Celio, M. R. and Rogers, J. H. (1992) Calcium-binding proteins in the nervous system. Trends Neurosci. 15, 303-308.
10. 28K. Synapse 7, 269-277.
11. Balaban, C. D., O'Callaghan, J. P. and Billingsey, M. L. (1988) Trimethyltin-induced neuronal damage in the rat brain: Comparative studies using silver degeneration stains, immunocytochemistry and immunoassay for neuronotypic and gliotypic proteins. Neuroscience 26, 337-361.
12. Banker, G. A. (1980) Trophic interactions between astroglial cells and hippocampal neurons in culture. Science 209, 809-810.
13. Bayer, S. A. (1980) Development of the hippocampal region in the rat. I. Neurogenesis examined with [3H]thymidine autoradiographic study. J. Comp. Neurol. 190, 87-114.
14. Bayer, S. A., Brunner, R. L., Hine, R. and Altman, J. (1973) Behavioral effects of interference with the postnatal acquisition of hippocampal granule cells. Nature New Biol. 242, 222-224.
15. Bayer, S. A. and Peters, P. J. (1977) A method for X-irradiating selected brain regions in infant rats. Brain Res. Bull. 2, 153-156.
16. Ben-Ari, Y. (1984) The role of seizures in kainic acid induced brain damage. In: Excitotoxins, pp. 184-198. Eds. K. Fuxe, P. Roberts, P. and R. Schwarcz. Plenum press: New York.
17. Ben-Ari, Y. (1985) Limbic seizures and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14, 375-403.
18. Ben-Ari, Y. and Represa, A. (1990) Brief seizure episodes induce long term potentiation and mossy fiber sprouting in the hippocampus. Trends Neurosci. 13, 312-318.
19. Ben-Ari, Y., Tremblay, E. and Ottersen, O. P. (1980a) Injections of kainic acid into the amygdaloid complex of the rat: an electrographic, clinical and histological study in relation to the pathology of epilepsy. Neuroscience 5, 515-528.
20. Ben-Ari, Y., Tremblay, E., Ottersen, O. P. and Meldrum, B. S. (1980b) The role of epileptic activity in hippocampal and "remote" cerebral lesions induced by kainic acid. Brain Res. 191, 79-97.
21. Berger, M. L., Bass, K., Lassmann, H. and Hornykiewicz, O. (1990) The kainic acid model of human temporal lobe epilepsy: the superiority of intra-amygdaloid injection versus other application routes. In: Amino acids: Chemistry, Biology and Medicine. Eds G. Lubec and G. A. Rosenthal. ESCOM Sci. Publ.: Vienna.
22. Best, N., Mitchell, J., Baimbridge, K. G. and Wheal, H. V. (1993) Changes in parvalbumin immunoreactive neurons in the rat hippocampus following a kainic acid lesion. Neurosci. Lett. 155, 1-6.
23. Bjorklund, A. (1991) Neural transplantation - An experimental tool with clinical possibilities. Trends Neurosci. 8, 319-322.
24. Bjorklund, A. (1992) Dopaminergic transplants in experimental parkinsonism: cellular mechanisms of graft-induced functional recovery. Curr. Opin. Neurobiol. 2, 683-689.
25. Bjorklund, A., Dunnett, S. B. and Nikkhah, G. (1994) Nigral transplants in the rat Parkinson model. In: Functional neural transplantation, pp. 47-69. Eds. S. B. Dunnett and A. Bjorklund. Raven: New York.
26. Bjorklund, A., Lindvall, O., Isacson, O., Brundin, P., Wictorin, K., Strecker, R. E., Clarke, D. J. and Dunnett, S. B. (1987) Mechanisms of action of intracerebral neural implants: Studies on nigral and striatal grafts to the lesioned striatum. Trends Neurosci. 10, 509-516.
27. Bjorklund, A. and Stenevi, U. (1979) Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res. 177, 555-560.
28. Bjorklund, A. and Stenevi, U. (1984) Intracerebral neural implants: neural replacement and reconstruction of damaged circuitries. Annu. Rev. Neurosci. 7, 279-308.
29. Bjorklund, A., Stenevi, U., Scmidt, R. H., Dunnett, S. B. and Gage, F. H. (1983) Intracerebral grafting of neuronal cell suspensions. II. Survival and growth of nigral cell suspensions implanted in different brain sites. Acta Physiol. Scand. 522, 9-18.
30. Bjorklund, A., Stenevi, U. and Svendgaard, N. A. (1976) Growth of transplanted monoaminergic neurons into the adult hippocampus along the perforant path. Nature 262, 787-790.
31. Blackstad, T. W. (1963) Uttrastructural studies on the hippocampal region. Prog. Brain Res. 3, 122-148.
32. Blackstad, T. W. (1967) Cortical grey matter. Correlation of light and electron microscopic data. In: The neuron, pp. 49-118. Ed H. Hyden. Elsevier: Amsterdam.
33. Blackstad, T. W., Brink, K., Hem, J. and Jeune, B. (1970) Distribution of hippocampal mossy fibers in the rat: An experimental study with silver impregnation methods. J. Comp. Neurol. 138, 433-449.
34. Bregman, B. S. and Reier, P. J. (1986) Neural tissue transplants rescue axotomized rubrospinal cells from retrograde death. J. Comp. Neurol. 244, 86-95.
35. Brenneman, D. E., Schultzberg, M., Bartfai, T. and Gozes, I. (1992) Cytokine regulation of neuronal survival. J. Neurochem. 58, 454-460.
36. Brierley, J. B. (1977) Experimental hypoxic brain damage. J. Clin. Pathol. 30, 181-187.
37. Brierley, J. B. and Graham, D. I. (1984) Hypoxia and vascular disorders of the central nervous system. In: Greenfield's Neuropathology, 4th edn., pp. 125-207. Eds J. Hulme Adams, J. A. N. Corsellis and L. W. Duchen. Arnold:London.
38. Brown, A. W. (1977) Structural abnormalities in neurons. J. Clin. Pathol. 30, 155-169.
39. Brown, A. W., Aldridge, W. N., Street, B. W. and Verschoyle, R. D. (1979) The behavioral and neuropathologic sequelae of intoxication by trimethyltin compounds in the rat. Am. J. Pathol. 97, 59-82.
40. Brundin, P. and Bjorklund, A. (1987) Survival, growth and function of dopaminergic neurons grafted to the brain. Prog. Brain Res. 71, 293-308.
41. Buzsaki, G., Bayardo, F., Miles, R., Wong, R. K. S. and Gage, F. H. (1989a) The grafted hippocampus: an epileptic focus. Expl. Neurol. 105, 10-22.
42. Buzsaki, G., Czopf, J., Kondakor, I., Bjorklund, A. and Gage, F. H. (1987a) Cellular activity of intracerebrally transplanted fetal hippocampus during behavior. Neuroscience 22, 871-883.
43. Buzsaki, G. and Gage, F. H. (1988) Mechanisms of action of neural grafts in the limbic system. Can. J. Neurol. Sci. 15, 99-105.
44. Buzsaki, G., Gage, F. H., Kellenyi, L. and Bjorklund, A. (1987b) Behavioral dependence of the electrical activity of intracerebrally transplanted fetal hippocampus. Brain Res. 400, 321-333.
45. Buzsaki, G., Masliah, E., Chen, L. S., Horvath, Z., Terry, R. and Gage, F. H. (1991) Hippocampal grafts into the intact brain induce epileptic patterns. Brain Res. 554, 30-37.
46. Buzsaki, G., Ponomareff, G., Bayardo, F., Shaw, T. and Gage, F. H. (1988) Suppression and induction of epileptic activity by neuronal grafts. Proc. Natl. Acad. Sci. U.S.A. 85, 9327-9330.
47. Buzsaki, G., Wiesner, J., Henriksen, S. J. and Gage, F. H. (1989b) Long term potentiation of evoked and spontaneous neuronal activity in the grafted hippocampus. Expl. Brain Res. 76, 401-408.
48. Cadusseau, J. and Peschanski, M. (1989) Direct neuronal and macroglial versus indirect macrophagic labeling in transplants of fetal neural tissue incubated with gold particles. Expl. Neurol. 106, 265-274.
49. Cadusseau, J. and Peschanski, M. (1992) Identifying grafted cells. In: Neural transplantation: a practical approach, pp. 177-201. Eds. S.B. Dunnett and A. Bjorklund. IRL press: Oxford.
50. Carder, R. K., Snyder-Keller, A. M. and Lund, R. D. (1988) Behavioral and anatomical correlates of immunologically induced rejection of nigral xenografts. J. Comp. Neurol. 277, 291-402.
51. Carman-Krzan, M., Vige, X. and Wise, B. C. (1991) Regulation by interleukin-1 of nerve growth factor secretion and nerve growth factor mRNA expression in rat primary astroglial cultures. J. Neurochem. 56, 636-643.
52. Cassel, J. C., Ballough, G. P., Kelche, C., Hofferer, E., Cassel, S. and Will, B. (1993) Injections of fluid or septal cell suspension grafts into the dentate gyrus of rats induce granule cell degeneration. Neurosci. Lett. 150, 89-94.
53. Cassel, J. C., Kelche, C., Majchrzak, M. and Will, B. E. (1992) Factors influencing structure and function of intracerebral grafts in the mammalian brain: a review. Restor. Neurol. Neurosci. 4, 65-96.
54. Castro, A. J., Zimmer, J., Sunde, N. A. and Bold, E. L. (1985) Transplantation of fetal cortex to the brain of newborn rats: a retrograde fluorescent analysis of callosal and thalamic projections from transplant to host. Neurosci Lett. 60, 283-288.
55. Cavalheiro, E., Riche, D. and Le Gal La Salle, G. (1982) Long-term effects of intrahippocampal kainic acid in rats: a method for introducing spontaneous recurrent seizures. Electroencep. Clin. Neurophysiol. 53, 581-582.
56. Cepko, C. L. (1988) Immortalization of neuronal cells via oncogene transduction. Trends Neurosci. 11, 6-8.
57. Cepko, C. L. (1989) Immortalization of neural cells via retrovirus-mediated oncogene transduction. Annu. Rev. Neurosci. 12, 47-65.
58. Cheng, B. and Mattson, M. P. (1991) NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycaemic damage by stabilizing calcium homeostasis. Neuron 7, 1031-1041.
59. Claiborne, B. J., Amaral, D. G. and Cowan, W. M. (1990) Quantitative three dimensional analysis of granule cell dendrites in the rat dentate gyrus. J. Comp. Neurol. 302, 206-219.
60. Clowry, G. J. and Vrbova, G. (1992) Observations on the development of transplanted embryonic ventral horn neurons grafted into adult rat spinal cord and connected to skeletal muscle implants via a peripheral nerve. Expl. Brain Res. 91, 249-258.
61. Cornish, S. M. and Wheal, H. V. (1989) Long-term loss of paired-pulse inhibition in the kainic acid-lesioned hippocampus of the rat. Neuroscience 28, 563-571.
62. Crossin, K. L., Prieto, A. L., Hoffman, S., Jones, F. S. and Friedlander, D. R. (1990) Expression of adhesion molecules and the establishment of boundaries during embryonic and neural development. Expl. Neurol. 109, 6-18.
63. Danscher, G. (1981) Histochemical demonstration of heavy metals: a revised version of the silver sulphide method suitable for both light and electron microscopy. Histochem. 71, 1-16.
64. Das, G. D. (1983) Neural transplantation in mammalian brain: Some conceptual and technical considerations. In: Neural tissue transplantation research. Eds R. B. Wallace and G. D. Das. Springer Verlag: New York.
65. Das, G. D. and Altman, J. (1971) Transplanted precursors of nerve cells: Their fate in the cerebellum of young rats. Science 173, 637-638.
66. Das, G. D. and Altman, J. (1972) Studies on transplantation of developing neural tissue in the mammalian brain. I. Transplantation of cerebellar slabs into the cerebellum of neonate rats. Brain Res. 38, 233-249.
67. Davenport, C. J., Brown, W. J. and Babb, T. L. (1990) Sprouting of GABAergic and mossy fiber axons in dentate gyrus following intrahippocampal kainate in the rat. Expl. Neurol. 109, 180-190.
68. David, S., Bouchard, C., Tsatas, O. and Giftochristos, N. (1990) Macrophages can modify the non-permissive nature of the adult mammalian central nervous system. Neuron 5, 463-469.
69. Davies, S. J. A., Field, P. M. and Raisman, G. (1993) Long fiber growth by axons of embryonic mouse hippocampal neurons microtransplanted into the adult rat fimbria. Eur. J. Neurosci. 5, 95-106.
70. Davies, S. J. A., Field, P. M. and Raisman, G. (1994) Long interfascicular axon growth from embryonic neurons transplanted into adult myelinated tracts. J. Neurosci. 14, 1596-1612.
71. Deacon, T. W., Pakzaban, P., Burns, L. H., Dinsmore, J. and Isacson, O. (1994) Cytoarchitectonic development and axon-glia relationships in homotopic porcine striatal xenografts in rats. Expl. Neurol. 130, 151-167.
72. Deckel, A. W., Moran, T. H., Coyle, J. T., Sanberg, P. R. and Robinson, R. G. (1986) Anatomical predictors of behavioral recovery following fetal striatal transplants. Brain Res. 365, 249-258.
73. Del Rio, J. A. and Soriano, E. (1989) Immunocytochemical detection of 5′-bromodeoxyuridine incorporation in the central nervous system of the mouse. Devl. Brain Res. 49, 311-317.
74. Desmond, N. L. and Levy, W. B. (1982) A quantitative anatomical study of the granule cell dendritic fields of the rat dentate gyrus using a novel probabilistic method. J. Comp. Neurol. 212, 131-145.
75. Diemer, N. H. and Seimkowicz, E. (1981) Regional neuron damage after cerebral ischemia in normo-and hypoglycemic rats. Neuropathol. Appl. Neurobiol. 7, 217-227.
76. Doering, L. C. (1992) Appropriate target interactions prevent abnormal cytoskeletal changes in neurons: a study with intra-sciatic grafts of the septum and the hippocampus. J. Neurosci. 12, 3399-3413.
77. Doering, L. C. (1993) Probing modifications of the neuronal cytoskeleton. Mol. Neurobiol. 7, 265-291.
78. Dolleman-Van Der Weel, M. J., Nijssen, A. and Steinbusch, H. W. M. (1993) Morphological and behavioral drawbacks of fetal dopaminergic grafts, prelabeted with phaseolus vulgaris leucoagglutinin. Expl. Neurol. 122, 260-272.
79. Duan, W. M., Widner, H., Frodl, E. M. and Brundin, P. (1995) Immune reactions following systemic immunization prior or subsequent to intrastriatal transplantation of allogenic mesencephalic tissue in adult rats. Neuroscience 64, 629-641.
80. Dudek, F. E., Obenaus, A., Schweitzer, J. S. and Wuarin, J.-P. (1994) Functional significance of hippocampal plasticity in epileptic brain: Electrophysiological changes of the dentate granule cells associated with mossy fiber sprouting. Hippocampus 4, 259-265.
81. Dunnett, S. B. (1990) Functional analysis of neural grafts in the neostriatum. In: Brain Repair, pp. 355-373. Eds A. Bjorklund, A. J. Aguayo and D. Ottosson. McMillan Press: London.
82. Dunnett, S. B. (1995) Functional repair of striatal systems by neural transplants: evidence of circuit reconstruction. Behav. Brain Res. 66, 133-142.
83. Dunnett, S. B., Toniolo, G., Fine, A., Ryan, C. N., Bjorklund, A. and Iversen, S. D. (1985) Transplantation of embryonic ventral forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis II. Sensorimotor and learning impairments. Neuroscience 16, 787-797.
84. Dunnett, S. B. and Svendsen, C. N. (1993) Huntington's disease: animal models and transplantation repair. Curr. Opin. Neurobiol. 3, 790-796.
85. Dyer, R. S., Walsh, T. J. and Bercegeay, M. (1982) The trimethyltin syndrome in rats. Neurobehav. Toxocol. Teratol. 4, 127-133.
86. Emmett, C. J., Lawrence, J. M., Raisman, G. and Seeley, P. J. (1991) Cultured epithelioid astrocytes migrate after transplantation into the adult rat brain. J. Comp. Neurol. 311, 330-341.
87. Farber, S. D., Onifer, S. M., Kaseda, Y., Murphy, S. H., Wells, D. G., Vietje, B. P., Wells, J. and Low, W. C. (1988) Neural transplantation of horseradish peroxidase-labeled hippocampal cell suspensions in an experimental model of cerebral ischemia. Prog. Brain Res. 78, 103-107.
88. Ferrara, N., Ousley, F. and Gospodarowicz, D. (1988) Bovine brain astrocytes express basic fibroblast growth factor, a neurotropic and angiogenic mitogen. Brain Res. 462, 223-232.
89. Field, P. M., Seeley, P. J., Frotscher, M. and Raisman, G. (1991) Selective innervation of embryonic hippocampal transplants by adult host dentate granule cell axons. Neuroscience 41, 713-727.
90. Fisher, L. J., Jinnah, H. A., Kale, L. C., Higgins, G. A. and Gage, F. H. (1991) Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-DOPA. Neuron 6, 371-380.
91. Floeter, M. K. and Jones, E. G. (1984) Connections made by transplants to the cerebral cortex of rat brains damaged in utero. J. Neurosci. 4, 141-150.
92. Floeter, M. K. and Jones, E. G. (1985) Transplantation of fetal postmitotic neurons to rat cortex: survival, early pathway choices and long-term projections of outgrowing axons. Devl. Brain Res. 22, 19-38.
93. Franck, J. E. (1984) Dynamic alterations in hippocampal morphology following intra-ventricular kainic acid. Acta Neuropathol. 62, 242-253.
94. Franck, J. and Schwartzkroin, P. A. (1985) Do kainate-lesioned hippocampi become epileptogenic?. Brain Res. 329, 309-313.
95. Freeman, J. N., Baisden, R. H. and Woodruff, M. L. (1995) Fetal ammon's horn transplants improve acquisition of radial arm maze and a low-rate operant schedule in Trimethyltin-treated rats. Cell Transplant. 4, 113-122.
96. Freed, W. J. (1985) Transplantation of tissues to the cerebral ventricles: Methodological details and rate of graft survival. In: Neural grafting in the mammalian CNS, pp. 32-40. Eds. A. Bjorklund and U. Stenevi. Elsevier: Amsterdam.
97. Freed, W. J., Morihisa, J. M., Spoor, E., Hoffer, B. J., Olson, L., Seiger, A. and Wyatt, R. J. (1981) Transplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behavior. Nature 292, 351-352.
98. Frei, K., Fredrickson, S., Fontana, A. and Link, H. (1991) Interleukin-6 is elevated in plasma in multiple sclerosis. J. Neuroimmunol. 31, 147-153.
99. Frotscher, M. and Zimmer, J. (1983) Lesion-induced mossy fibers to the molecular layer of the rat fascia dentata: Identification of postsynaptic granule cells by the Golgi-EM technique. J. Comp. Neurol. 215, 299-311.
100. Frotscher, M. and Zimmer, J. (1987) GABA-ergic nonpyramidal neurons in intracerebral transplants of the rat hippocampus and fascia dentata: a combined light and electron microscopic immunocytochemical study. J. Comp. Neurol. 259, 266-276.
101. Gaarskjaer, F. B. (1981) The hippocampal mossy fiber system of the rat studied with retrograde tracing techniques. Correlation between topographic organization and neurogenetic gradients. J. Comp. Neurol. 203, 717-735.
102. Gage, F. H., Bjorklund, A. and Stenevi, U. (1984) Denervation releases a neuronal survival factor in adult rat hippocampus. Nature 308, 637-639.
103. Gage, F. H., Coates, P. W., Palmer, T. D., Kuhn, H. G., Fisher, L. J., Suhonen, J. O., Peterson, D. A., Suhr, S. T. and Ray, J. (1995a) Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. Proc. Nalt. Acad. Sci. U.S.A. 92, 1879-1883.
104. Gage, F. H. and Fisher, L. J. (1991) Intracerebral grafting: A tool for the neurobiologist. Neuron 6, 1-12.
105. Gage, F. H., Kawaja, M. D. and Fisher, L. J. (1991) Genetically modified cells: applications for intracerebral grafting. Trends Neurosci. 14, 328-333.
106. Gage, F. H., Ray, J. and Fisher, L. J. (1995b) Isolation, characterization, and use of stem cells from the CNS. Annu. Rev. Neurosci. 18, 159-192.
107. Gage, F. H., Wolff, J. A., Rosenberg, M. B., Xu, L., Yee, J. K., Shults, C. and Friedmann, T. (1987) Grafting genetically modified cells to the brain: possibilities for the future. Neuroscience 23, 795-807.
108. Gall, C., Murray, K. and Isaakson, P. (1991) Kainic acid-induced seizures stimulate increased expression of nerve growth factor MRNA in rat hippocampus. Molec. Brain Res. 9, 113-123.
109. Gao, W.-Q. and Hatten, M. E. (1994) Immortalizing oncogenes subvert the establishment of granule cell identity in developing cerebellum. Development 120, 1059-1070.
110. Garcia, A. R., Deacon, T. W., Dinsmore, J. and Isacson, O. (1995) Extensive axonal and glial fiber growth from fetal porcine cortical xenografts in the adult rat cortex. Cell Transplant. 4, 515-527.
111. Gibson, M. J., Krieger, D. T., Charlton, H. M., Zimmerman, E. A., Silverman, A. J. and Perlow, M. J. (1984) Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts. Science 225, 949-951.
112. Gibson, M. J., Silverman, R. C. and Silverman, A. J. (1990) Current progress in studies of GnRH cell-containing brain grafts in hypogonadat mice. Prog. Brain Res. 82, 169-178.
113. Giulian, D., Allen, R. L., Baker, T. J. and Tomozawa, Y. (1986) Brain peptides and glial growth. I. Glia-promoting factors as regulators of gliogenesis in the developing and injured central nervous system. J. Cell Biol. 101, 803-811.
114. Giulian, D. and Lachman, L. B. (1985) Interleukin-1 stimulation of astroglial proliferation after brain injury. Science 228, 497-499.
115. Giulian, D., Vaca, K. and Johnson, B. (1988) Secreted peptides as regulators of neuron-glia and glia-glia interactions in the developing nervous system. J. Neurosci. Res. 21, 487-500.
116. Goldberg, W. J. and Bernstein, J. J. (1988) Fetal cortical astrocytes migrate from cortical homografts throughout the host brain and over the glia limitans. J. Neurosci. Res. 20, 38-45.
117. Goldschmidt, R. B. and Steward, O. (1982) Neurotoxic effects of colchicine: differential susceptibility of CNS neuronal populations. Neuroscience 7, 695-699.
118. Gopinath, G., Shetty, A. K. and Tandon, P. N. (1991) Ageing changes in the transplants of fetal substantia nigra grafted to striatum of adult rat. Neuroscience 40, 429-443.
119. Granholm, A.-C., Bergman, H., Dudek, E. and Browning, M. (1995) Synapsin I in intraocular hippocampal transplants during maturation and aging: effects of brainstem co-grafts. Cell Transplant. 4, 3-12.
120. Granholm, A.-C., Eriksdottor-Nilsson, M., Stromberg, I., Stieg, P., Seiger, A., Bygdeman, M., Geffard, M., Oertel, W., Dahl, D. and Olson, L. (1989) Morphological and electrophysiological studies of human hippocampal transplants in the anterior eye chamber of athymic nude rats. Expl. Neurol. 104, 162-171.
121. Graham, D. I. (1977) Pathology of hypoxic brain damage in man. J. Clin. Pathol. 30, 170-180.
122. Graham, D. I. (1985) The pathology of brain ischemia and possibilities for therapeutic intervention. Br. J. Anaesth. 57, 3-17.
123. Hachinski, V. (1979) Relevance of cerebrovascular changes to mental function. Mech. Aging Develop. 9, 173-183.
124. Hagan, J. J. and Beauguard, M. (1990) The effects of forebrain ischaemia on spatial learning. Behav. Brain Res. 41, 29-35.
125. Han, Z.-S., Buhl, E. H., Lorinczi, Z. and Somogyi, P. (1993) A high degree of spatial selectivity in the axonal and dendritic domains of physiologically identified local-circuit neurons in the dentate gyrus of the rat hippocampus. Eur. J. Neurosci. 5, 395-410.
126. Hankin, M. H. and Lund, R. D. (1987) Role of the target in directing the outgrowth of retinal axons:transplants reveal surface-related and surface-independent cues. J. Comp. Neurol. 263, 455-466.
127. Hankin, M. H. and Lund, R. D. (1990) Induction of target-directed optic axon outgrowth: effect of retinae transplanted to anophthalmic mice. Dev. Biol. 138, 136-146.
128. Haug, F.-M. S. (1974) Sulfide silver stainable (Timm's stainable) fiber systems in the brain. In: Neurobiology of zinc, pp. 213-228. Eds C. J. Frederickson and G. A. Howell. Alan R. Liss: New York.
129. Heacock, A., Schonfeld, A. and Katzman, R. (1986) Hippocampal neurotrophic factor: characterization and response to denervation. Brain Res. 363, 299-306.
130. Hefner, C. D., Lumsden, A. and O'Leary, D. (1990) Target control of collateral extension and directional axon growth in the mammalian brain. Science 247, 217-220.
131. Hjorth-Simonsen, A. (1972) Projection of the lateral part of the entorhinal area to the hippocampus and fascia dentata. J. Comp. Neurol. 146, 219-232.
132. Hjorth-Simonsen, A. and Jeune, B. (1972) Origin and termination of the hippocampal perforant path in the rat studied by silver impregnation. J. Comp. Neurol. 144, 215-232.
133. Holmes, G. L., Thompson, J. L., Huh, K., Holmes, C. and Carl, G. F. (1991) Effect of neural transplants on seizure frequency and kindling in immature rats following kainic acid. Devl. Brain Res. 64, 47-56.
134. Horellou, P., Lundberg, C., Le Bourdelles, B., Wictorin, K., Brundin, P., Kalen, P., Bjorklund, A. and Mallet, J. (1991) Behavioral effects of genetically engineered cells releasing dopa and dopamine after intracerebral grafting in a rat model of Parkinson's disease. J. de Physiologie 85, 158-170.
135. Hounsgaard, J. and Yarom, Y. (1985) Intrinsic control of electro-responsive properties of transplanted mammalian brain neurons. Brain Res. 335, 372-376.
136. Houser, C. R., Miyashiro, J. E., Swartz, B. E., Walsh, G. O., Rich, J. R. and Delgado-Escueta, A. V. (1990) Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy. J. Neurosci. 10, 267-282.
137. Isacson, O., Deacon, T. W., Pakzaban, P., Galpern, W. R., Dinsmore, J. and Burns, L. H. (1995) Transplanted xenogenic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibers. Nature Med. 1, 1189-1194.
138. Jorgensen, M. B. and Diemer, N. H. (1982) Selective neuron loss after cerebral ischemia in the rat: Possible role of transmitter glutamate. Acta Neurol. Scand. 66, 536-546.
139. Kamo, H. S., Kim, U., McGeer, P. L., Araki, M., Tomimoto, H. and Kimura, H. (1987) Transplantation of cultured human spinal cord cells into the rat motor cortex: use of phaseolus vulgaris leucoagglutinin as a cell marker. Neurosci. Lett. 76, 163-167.
140. Katayama, Y., Tsubokawa, T., Koshinaga, M. and Miyazaki, S. (1991) Temporal pattern of survival and dendritic growth of fetal hippocampal cells transplanted into ischemic lesions of the adult rat hippocampus. Brain Res. 562, 352-355.
141. Kesslak, J. P., Nieto-Sampedro, M., Globus, J. and Cotman, C. (1986) Transplants of purified astrocytes promote behavioral recovery after frontal cortex ablation. Expl. Neurol. 92, 377-390.
142. Kesslak, J. P., Walencewicz, A., Calin, L., Nieto-Sampedro, M. and Cotman, C. (1988) Hippocampal but not astrocyte transplants enhance recovery on a forced choice alteration task after kainate lesions. Brain Res. 454, 347-354.
143. Kimble, D. P., Bremiller, R. and Stickrod, G. (1986) Fetal brain implants improve maze performance in hippocampal lesioned rats. Brain Res. 363, 358-363.
144. Kitagawa, K., Matsumoto, M., Niinobe, N., Hata, R., Tagaya, S., Nakabayashi, H., Handa, N., Fukunaga, R., Kimura, K., Mikoshiba, K., Sobue, K. and Kamata, T. (1989) Deafferentation and reactive synaptogenesis following cerebral ischemia:immunohistochemical investigation of synapsin I as a marker of presynaptic terminals. Proc. Jpn. Soc. Neural Growth, Regen. Transplant. 1, 67-68.
145. Köhler, C. (1984) Neuronal degeneration after intracerebral injections of excitotoxins. A histological analysis of kainic acid, ibotenic acid and quinolinic acid lesions in the rat brain. In Excitotoxins, pp. 99-111. Eds. K. Fuxe, P. Roberts, and R. Schwarcz. Plenum Press: New York.
146. Köhler, C. and Schwarcz, R. (1983) Comparison of ibotenate and kainate neurotoxicity in rat brain: a histological study. Neuroscience 8, 819-835.
147. Köhler, C., Schwarcz, R. and Fuxe, K. (1979) Intrahippocampal injections of ibotenic acid provide histological evidence for a neurotoxic mechanism different from kainic acid. Neurosci. Lett. 15, 223-228.
148. Kordower, J. H., Freeman, T. B., Snow, B. J., Vingerhoets, F. J. G., Mufson, E. J., Sanberg, P. R., Hauser, R. A., Smith, D. A., Nauert, G. M., Perl, D. P. and Olanow, C. W. (1995) Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. New Eng. J. Med. 332, 1118-1124.
149. Kott, J. N., Westrum, L. E. and Bhatia, A. M. (1991) Is phaseolus vulgaris leucoagglutinin (PHA-L) a useful marker for labeling neural grafts?. J. Neur. Transplant. 2, 249-253.
150. Kromer, L. F., Bjorklund, A. and Stenevi, U. (1981a) Innervation of embryonic hippocampal implants by regenerating axons of cholinergic septal neurons in the adult rat. Brain Res. 210, 153-171.
151. Kromer, L. F., Bjorklund, A. and Stenevi, U. (1981b) Regeneration of the septo-hippocampal pathways in adult rats is promoted by utilizing embryonic hippocampal implants as bridges. Brain Res. 210, 173-200.
152. Kromer, L. F., Bjorklund, A. and Stenevi, U. (1983) Intracephalic embryonic neural implants in the adult rat brain. I. Growth and mature organization of brainstem, cerebellar and hippocampal implants. J. Comp. Neurol. 218, 433-459.
153. Kromer, L. F. and Cornbrooks, C. J. (1987) Identification of trophic factors and transplanted cellular environments that promote CNS axonal regeneration. Ann. NY Acad. Sci. 495, 207-223.
154. Lancaster, B. and Wheat, H. V. (1982) A comparative histological and electrophysiological study of some neurotoxins in the rat hippocampus. J. Comp. Neurol. 211, 105-114.
155. Laurberg, S. (1979) Commissural and intrinsic connections of the rat hippocampus. J. Comp. Neurol. 184, 685-708.
156. Laurberg, S., Sunde, N. and Zimmer, J. (1982) Transplants from the hippocampal dentate area can form normal afferent and efferent connections when donated to newborn X-irradiated littermates. Neurosci. Lett. (Suppl.) 10, S282.
157. Laurberg, S. and Zimmer, J. (1981) Lesion-induced sprouting of hippocampal mossy fiber collateral to the fascia dentata in developing and adult rats. J. Comp. Neurol. 200, 433-459.
158. Legendre, D. L., Vietje, P. and Wells, J. (1994) The differentiation of dentate granule cells following transplantation. Expl. Neurol. 125, 247-257.
159. Lendhal, U. and McKay, R. D. G. (1990) The use of cell lines in neurobiology. Trends Neurosci. 13, 132-137.
160. Lindsay, R. M. and Raisman, G. (1984) An autoradiographic study of neuronal development, vascularization and glial cell migration from hippocampal transplants labeled in intermediate explant culture. Neuroscience 112, 513-530.
161. Lindvall, O. (1991) Prospects of transplantation in human neurodegenerative diseases. Trends Neurosci. 14, 376-384.
162. Lindvall, O. (1995) Neural transplantation. Cell Transplant. 4, 393-400.
163. Lindvall, O., Widner, H., Rehncrona, S., Brundin, P., Odin, P., Gustavii, B., Leenders, K. L., Sawle, G., Rothwell, J. C., Bjorklund, A. and Marsden, C. D. (1992) Transplantation of fetal dopamine neurons in Parkinson's disease: One year clinical and neurophysiological observations in two patients with putaminal implants. Ann. Neurol. 31, 155-165.
164. Low, W. C., Lewis, P. R., Bunch, S. T., Dunnett, S. B., Thomas, S. R., Iversen, S. D., Bjorklund, A. and Stenevi, U. (1982) Functional recovery following neural transplantation of embryonic septal nuclei in adult rats with septo-hippocampal lesion. Nature 300, 260-262.
165. Lowenstein, D. H., Seren, M. S. and Longo, F. M. (1993) Prolonged increases in neurotrophic activity associated with kainate-induced hippocampal synaptic reorganization. Neuroscience 56, 597-604.
166. Lund, R. D. and Hauschka, S. D. (1976) Transplanted neural tissue develops connections with host rat brain. Science 193, 582-584.
167. Lundberg, C., Winkler, C., Whittemore, S. R. and Bjorklund, A. (1996) Conditionally immortalized neural progenitor cells grafted to the striatum exhibit site-specific neuronal differentiation and establish connections with the host globus pallidus. Neurobiol. Dis. 3, 33-50.
168. Macklis, J. D. (1993) Transplanted neocortical neurons migrate selectively into regions of neuronal degeneration produced by chromophore-targeted laser photolysis. J. Neurosci. 13, 3848-3863.
169. Macklis, J. D. and Madison, R. D. (1985) Unfocused laser illumination kills dye targeted mouse neurons by selective photothermolysis. Brain Res. 359, 158-165.
170. Macklis, J. D. and Madison, R. D. (1991) Neuroblastoma grafts are noninvasively removed within mouse neocortex by selective laser activation of intracellular photolytic chromophore. J. Neurosci. 11, 2055-2062.
171. Madison, R. D., Macklis, J. D. and Frosch, M. P. (1988) Noninvasive laser microsurgery selectively damages labeled mouse neurons: dependence on incidence laser dose and absorption. Brain Res. 445, 101-110.
172. Madison, R. D. and Macklis, J. D. (1989) Noninvasive laser lesioning of neuronal subpopulations. In: Short course 2: Selective lesioning in the nervous system, pp. 42-52. Eds C. W. Cotman. Society for Neuroscience: Washington, D. C.
173. Madison, R. D. and Macklis, J. D. (1993) Noninvasively induced degeneration of neocortical pyramidal neurons in vivo: Selective targeting by laser activation of retrogradely transported photolytic chromophore. Expl. Neurol. 121, 153-159.
174. Margerison, J. H. and Corsellis, J. A. N. (1966) Epilepsy and the temporal lobe. Brain 89, 499-530.
175. Mattson, M. P., Murrain, M., Guthrie, P. B. and Kater, S. B. (1989) Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture. J. Neurosci. 9, 3728-3740.
176. McConnell, S. K. (1985) Migration and differentiation of cerebral cortical neurons after transplantation into the brains of ferrets. Science 229, 1268-1271.
177. McKeon, R. J., Schreiber, R. C., Rudge, J. S. and Silver, J. (1991) Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes. J. Neurosci. 11, 3398-3411.
178. Mickley, G. A., Ferguson, J. L., Mulvihill, M. A. and Nemith, T. J. (1989b) Progressive behavioral changes during the maturation of rats with early radiation-induced hypoplasia of fascia dentata granule cells. Neurotoxicol. Teratol. 11, 385-393.
179. Mickley, G. A., Ferguson, J. L., Mulvihill, M. A. and Nemith, T. J. (1991) Early neural grafts transiently reduce the behavioral effects of radiation-induced fascia dentata granule cell hypoplasia. Brain Res. 550, 24-34.
180. Mickley, G. A., Ferguson, J. L., Nemeth, T. J. and Mulvihill, M. A. (1990) Neural grafts attenuate behavioral deficits produced by early radiation-induced hypoplasia of fascia dentata granule cells. Brain Res. 509, 280-292.
181. Mickley, G. A., Ferguson, J. L., Nemith, T. J., Mulvihill, M. A. and Alderks, C. E. (1989a) Spontaneous perseverative turning in rats with radiation-induced hippocampal damage. Behav. Neurosci. 103, 722-730.
182. McMillan, D. E. and Wenger, G. R. (1985) Neurobehavioral toxicology of trakytins. Pharmacol. Rev. 37, 365-379.
183. Miller, M. W. and Nowakowski, R. S. (1988) Use of bromodeoxyuridine-immunohistochemistry to examine the proliferation, migration and time of origin of cells in the central nervous system. Brain Res. 457, 44-52.
184. Miller, M. W. and Nowakowski, R. S. (1991) Effect of prenatal exposure to ethanol on the cell cycle kinetics and growth fraction in the proliferative zones of fetal rat cerebral cortex. Alcohol. Clin. Exp. Res. 15, 229-232.
185. Mitchell, J., Sundstrom, L. E. and Wheal, H. V. (1993) Microglial and astrocytic cell responses in the rat hippocampus after an intracerebroventricular kainic acid injection. Expl. Neurol. 121, 224-230.
186. Morgan, T. E., Nichols, N. R., Pasinetti, G. M. and Finch, C. E. (1993) TGF-BI MRNA increases in macrophage/microglial cells of the hippocampus in response to deafferentation and kainic acid induced neurodegeneration. Expl. Neurol. 120, 291-301.
187. Mudrick, L. A. and Baimbridge, K. G. (1989) Long-term structural changes in the rat hippocampal formation following cerebral ischemia. Brain Res. 493, 179-184.
188. Mudrick, L. A. and Baimbridge, K. G. (1991) Hippocampal neurons transplanted into ischemically lesioned hippocampus: anatomical assessment of survival, maturation and integration. Expl. Brain Res. 86, 233-247.
189. Mudrick, L. A., Leung, P. P.-H., Baimbridge, K. G. and Miller, J. J. (1988) Neuronal transplants used in the repair of acute ischemic injury in the CNS. Prog. Brain Res. 78, 87-93.
190. Mudrick, L. A., Baimbridge, K. G. and Peet, M. J. (1989) Hippocampal neurons transplanted into ischemically lesioned hippocampus: electro-responsiveness and re-establishment of circuitries. Expl. Brain Res. 76, 333-342.
191. Nadler, J. V. (1981) Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci. 29, 2031-2042.
192. Nadler, J. V., Perry, B. W. and Cotman, C. W. (1978) Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells. Nature 271, 676-677.
193. Nadler, J. V., Perry, B., Gentry, C. and Cotman, C. W. (1980a) Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid. J. Comp. Neurol. 192, 333-359.
194. Nadler, J. V., Perry, W. P. and Cotman, C. W. (1980b) Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid. Brain Res. 182, 1-9.
195. Nakajima, S., Franck, J. E., Bilkey, D. and Schwartzkroin, P. A. (1991) Local circuit synaptic interactions between CA1 pyramidal cells and interneurons in the kainate-lesioned hyperexcitable hippocampus. Hippocampus. 1, 67-78.
196. Netto, C. A., Hodges, H., Sinden, J. D., Le Peillet, E., Kershaw, T., Sowinski, P., Meldrurn, B. S. and Gray, J. A. (1993) Effects of fetal hippocampal field grafts on ischemic-induced deficits in spatial navigation in the water maze. Neuroscience 54, 69-92.
197. Nieto-Sampedro, M., Manthrope, M., Barbin, G., Varon, S. and Cotman, C. W. (1983) Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity. J. Neurosci. 3, 2219-2229.
198. Nieto-Sampedro, M., Whittemore, S. R., Needels, D. L., Larson, J. and Cotman, C. W. (1984) The survival of brain transplants is enhanced by extracts from injured brain. Proc. Natl. Acad. Sci. U.S.A. 81, 6250-6254.
199. Nikkhah, G., Bentlage, C., Cunningham, M. G. and Bjorklund, A. (1994) Intranigral fetal dopamine grafts induce behavioral compensation in the rat Parkinson model. J. Neurosci. 14, 3449-3461.
200. Nikkhah, G., Cunningham, M. G., Cenci, M. A., McKay, R. D. and Bjorklund, A. (1995) Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. I. Evidence for anatomical reconstruction of the nigrostriatal pathway. J. Neurosci. 15, 3548-3561.
201. Nitsch, C., Goping, G. and Klatzo, I. (1989) Preservation of GABAergic perikarya and butons after transient ischemia in the gerbil hippocampal CA1 field. Brain Res. 495, 243-252.
202. Nobel, M., Fok-Seang, J. and Cohen, J. (1984) Glia are a unique substrate for the in vitro growth of central nervous system neurons. J. Neurosci. 4, 1892-1903.
203. Nunn, J. A., Le Peillet, E., Netto, C. A., Sowinski, P., Hodges, H., Gray, J. A. and Meldrum, B. S. (1991) CA1 cell loss produces deficits in learning and memory in the water maze regardless of additional intra-and extra-hippocampal damage. J. Cerebr. Blood Flow Metab 11 Suppl. 2, S338.
204. Okazaki, M. M., Evenson, D. A. and Nadler, J. V. (1995) Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: Visualization after retrograde transport of biocytin. J. Comp. Neurol. 352, 515-534.
205. O'Keefe, J. and Nadel, L. (1978) The Hippocampus as a Cognitive Map, pp. 102-140. Oxford University Press: Oxford.
206. Olanow, C. W., Kordower, J. H. and Freeman, T. B. (1996) Fetal nigral transplantation as a therapy for Parkinson's disease. Trends Neurosci. 19, 102-109.
207. Olson, L., Seiger, A. and Stromberg, I. (1983) Intraocular transplantation in rodents. A detailed account of the procedure and examples of its use in neurobiology with special reference to brain tissue grafting. In: Advances in cellular neurobiology, vol. 4., pp. 407-442. Ed S. Fedoroff. Academic Press: New York.
208. Olten, D. S. (1983) Memory functions and the hippocampus. In: Neurobiology of the Hippocampus, pp. 335-373. Academic Press: London.
209. Onifer, S. M. and Low, W. C. (1990) Spatial memory deficit resulting from ischemia-induced damage to the hippocampus is ameliorated by intra-hippocampal transplants of fetal hippocampal neurons. Prog. Brain Res. 82, 359-366.
210. Onifer, S. M., White, L. A., Whittemore, S. R. and Holets, V. R. (1993a) In vitro strategies for identifying transplanted primary CNS tissue and neuronal cell lines. Cell transplant. 2, 131-149.
211. Onifer, S. M., Whittemore, S. R. and Holets, V. R. (1993b) Variable morphological differentiation of a raphe-derived neuronal cell line following transplantation into the adult rat CNS. Expl. Neurol. 122, 130-142.
212. Paramore, C. G., Turner, D. A. and Madison, R. D. (1992) Fluorescent labeling of dissociated fetal cells for tissue culture. J. Neurosci. Methods 44, 7-17.
213. Perlow, M. J., Freed, W. J., Hoffer, B. J., Seiger, A., Olson, L. and Wyatt, R. J. (1979) Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science 204, 643-647.
214. Peschanski, M., Defer, G., N'Guyen, J. P., Ricolfi, F., Monfort, J. C., Remy, P., Geny, C., Samson, Y., Hantraye, P., Jeny, R., Gaston, A., Keravel, Y., Degos, J. D. and Cesaro, P. (1994) Bilateral motor improvement and alteration of L-DOPA effect on two patients with Parkinson's disease following intrastriatal transplantation of fetal ventral mesencephalon. Brain 117, 487-499.
215. Pisa, M., Sanberg, P. R., Corcoran, M. E. and Fibiger, H. C. (1980) Spontaneously recurrent seizures after intracerebral injections of kainic acid in rat: a possible model of human temporal lobe epilepsy. Brain Res. 200, 481-487.
216. Pokorny, J., Langmeier, M. and Trojan, S. (1991) Survival and maturation of hippocampal suspension grafts. J. Hirnforsch. 32, 611-615.
217. Pritzel, M., Isacson, O., Brundin, P., Wiklund, L. and Bjorklund, A. (1986) Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats. Expl. Brain Res. 65, 112-126.
218. Pulsinelli, W. A. (1985) Selective neuronal vulnerability: morphological and molecular characteristics. Prog. Brain Res. 63, 29-37.
219. Pulsinelli, W. A. and Brierley, J. B. (1979) A new model of bilateral hemispheric ischemia in the unaesthetized rat. Stroke 10, 267-272.
220. Pyapali, G. K., Turner, D. A. and Madison, R. D. (1992) Anatomical and physiological localization of prelabeled grafts in rat hippocampus. Expl. Neurol. 116, 133-144.
221. Pyapali, G. K., Dong, W.-Q., Deupree, D. L., Bradley, J. and Turner, D. A. (1994a) Influence of fetal hippocampal grafts on lesions induced by intraventricular infusion of N-methyt-D-aspartate (NMDA). Restor. Neurol. Neurosci. 6, 251-256.
222. Pyapali, G. K., Turner, D. A. and Madison, R. D. (1994b) Fetal transplants in rat hippocampus following kainic acid lesions: influence of post-lesion delay on graft survival and integration. Restor. Neurol. Neurosci. 6, 113-126.
223. Raisman, G., Cowan, W. M. and Powell, T. P. S. (1965) The extrinsic afferent, commissural and association fibers of the hippocampus. Brain 88, 963-996.
224. Raisman, G. and Ebner, F. F. (1983) Mossy fiber projections into and out of hippocampal transplants. Neuroscience 9, 783-801.
225. Raisman, G., Lawrence, J. M., Zhou, C.-F. and Lindsay, R. M. (1985) Some neuronal, glial and vascular interactions which occur when developing hippocampal primordia are incorporated into adult host hippocampi. In: Neural grafting in the mammalian CNS, pp. 125-150. Eds. A. Bjorklund and U. Stenevi. Elsevier: Amsterdam.
226. Raisman, G., Morris, R. J. and Zhou, C. F. (1987) Specificity in the reinnervation of adult hippocampal transplants. Prog. Brain Res. 71, 325-333.
227. Ray, J., Peterson, D. A., Schinstine, M. and Gage, F. H. (1993) Proliferation, differentiation, and long-term culture of primary hippocampal neurons. Proc. Natl.. Acad. Sci. USA. 90, 3602-3606.
228. Reier, P. J. (1985) Neural tissue grafts and repair of the injured spinal cord. Neuropath. Appl. Neurobiol. 11, 81-104.
229. Renfranz, P. J., Cunningham, M. G. and McKay, R. D. G. (1991) Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain. Cell 66, 713-729.
230. Reynolds, B. A., Tetzlaff, W. and Weiss, S. (1992) A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J. Neurosci. 12, 4565-4574.
231. Reynolds, B. A. and Weiss, S. (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255, 1707-1710.
232. Reynolds, B. A. and Weiss, S. (1996) Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell Devl. Biol. 175, 1-13.
233. Ribak, C. E., Seress, L. and Amaral, D. G. (1985) The development, ultrastructure and synaptic connections of the mossy cells of the dentate gyrus. J. Neurocytol. 14, 835-857.
234. Rihn, L. L. and Claiborne, B. J. (1990) Dendritic growth and regression in rat dentate granule cells during late postnatal development. Devl. Brain Res. 54, 115-124.
235. Riva, M. A., Donati, E., Tascedda, F., Zolli, M. and Racagni, G. (1994) Short and long term induction of basic fibroblast growth factor gene expression in rat central nervous system following kainate injection. Neuroscience 59, 55-65.
236. Rosenstein, J. M. and Brightman, M. W. (1978) Intact cerebral ventricle as a site for tissue transplantation. Nature 276, 83-85.
237. 18F)-6-L-fluorodopa studies in two patients with putaminal implants. Ann. Neurol. 31, 166-173.
238. Schlessinger, A. R., Cowan, W. M. and Swanson, L. W. (1978) The time of origin in Ammon's horn and the associated retrohippocampal fields. Anat. Embryol. 154, 153-173.
239. Schwarcz, R., Hokfelt, T., Fuxe, K., Jonsson, G., Goldstein, M. and Trenius, L. (1979) Ibotenic acid-induced neuronal degeneration: a morphological and neurochemical study. Expl. Brain Res. 37, 199-216.
240. Segal, M., Stenevi, U. and Bjorklund, A. (1981) Reformation in adult rats of functional septo-hippocampal connections across an embryonic hippocampal tissue bridge. Neurosci. Lett. 27, 7-12.
241. Seiger, A. (1985) Preparation of immature central nervous system regions for transplantation. In: Neural grafting in the mammalian CNS, pp. 71-77. Eds A. Bjorklund and U. Stenevi. Elsevier: Amsterdam.
242. Shetty, A. K., Gopinath, G. and Tandon, P. N. (1991a) Fetal nigral transplants in the lateral ventricle of adult rats: A long-term morphological study. Devl. Neurosci. 13, 1-10.
243. Shetty, A. K., Gopinath, G. and Tandon, P. N. (1991b) Fetal nigral grafts in the anterior eye chamber of adult rats: a long-term morphological study. Expl. Neurol. 111, 106-114.
244. Shetty, A. K., Madison, R. D., Bradley, J. and Turner, D. A. (1994) Quantitative graft integration of fetal hippocampal transplants labeled with 5′-bromodeoxyuridine into normal adult hippocampus. Expl. Neurol. 126, 205-224.
245. Shetty, A. K., Rapoza, D., Madison, R. D. and Turner, D. A. (1995) Selective laser-activated lesioning of prelabeled fetal hippocampal grafts by intracellular photolytic chromophore. Neuroscience 69, 407-416.
246. Shetty, A. K. and Turner, D. A. (1995a) Enhanced cell survival in fetal hippocampal suspension transplants grafted to adult rat hippocampus following kainate lesions: A three-dimensional graft reconstruction study. Neuroscience 67, 561-582.
247. Shetty, A. K. and Turner, D. A. (1995b) Fetal hippocampal grafts in kainate lesioned hippocampus establish specific connections and reduce aberrant mossy fiber sprouting. Soc. Neurosci. Abstr. 21, 2028.
248. Shetty, A. K. and Turner, D. A. (1995c) Non-phosphorylated neurofilament protein immunoreactivity in adult and developing rat hippocampus: specificity and application in grafting studies. Brain Res. 676, 293-306.
249. Shetty, A. K. and Turner, D. A. (1995d) Intracerebroventricular kainic acid administration in adult rat alters hippocampal calbindin and non-phosphorylated neurofilament expression. J. Comp. Neurol. 363, 581-599.
250. Shetty, A. K. and Turner, D. A. Fetal hippocampal cells grafted to kainate-lesioned CA3 of adult hippocampus suppress aberrant supragranular sprouting of host mossy fibers. Submitted for publication.
251. Shetty, A. K. and Turner, D. A. (1997) Development of long-distance efferent projections from fetal hippocampal grafts depends upon pathway specificity and graft location in kainate-lesioned adult hippocampus. Neuroscience, in press.
252. Shihabuddin, L. S., Brunschwig, J.-P., Holets, V. R., Bunge, M. B. and Whittemore, S. R. (1996a) Induction of mature neuronal properties in immortalized neuronal precursor cells following grafting into the neonatal CNS. J. Neurocytol. 25, 101-111.
253. Shihabuddin, L. S., Hertz, J. A., Holets, V. R. and Whittemore, S. R. (1995) The adult CNS retains the potential to direct region-specific differentiation of a transplanted neuronal precursor cell line. J. Neurosci. 15, 6666-6678.
254. Shihabuddin, L. S., Holets, V. R. and Whittemore, S. R. (1996b) Selective hippocampal lesions differentially affect the phenotypic fate of transplanted neuronal precursor cells. Expl. Neurol. 139, 61-72.
255. Smith, M. L., Auer, R. N. and Siesjo, B. K. (1984) The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropathol. 64, 319-332.
256. Snyder, E. Y., Deitcher, D. L., Walsh, C., Arnold-Aldea, S., Hartwieg, E. A. and Cepko, C. L. (1992) Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell 66, 33-51.
257. Sofroniew, M. V., Isacson, O. and Bjorklund, A. (1986) Cortical grafts prevent atrophy of cholinergic basal nucleus neurons induced by excitotoxic cortical damage. Brain Res. 378, 409-415.
258. Sorensen, T. and Zimmer, J. (1988) Ultrastructural organization of normal and transplanted fascia dentata: II. A quantitative analysis of the synaptic organization of intracerebral and intraocular grafts. J. Comp. Neuraol. 267, 43-54.
259. Sorensen, T., Jensen, S., Moller, A. and Zimmer, J. (1986) Intracephalic transplants of freeze-stored rat hippocampal tissue. J. Comp. Neurol. 252, 468-482.
260. Sorensen, J. C., Castro, A. J., Neafsey, E. J. and Zimmer, J. (1989) Reduction of post-lesional atrophy by transplants of fetal cerebral cortical tissue. Host-transplant connections and trophic factors. In: Brain Repair, pp. 133-143. Eds A. Bjorklund, A. J. Aguayo and D. Ottoson. Stockton Press.
261. Soriano, E. and Del Rio, J. A. (1991) Simultaneous immunocyto-chemical visualization of bromodeoxyuridine and neural tissue antigens. J. Histochem. Cytochem. 39, 255-263.
262. Sperk, G. (1994) Kainic acid seizures in the rat. Prog. Neurobiol. 42, 1-32.
263. Spranger, M., Lindholm, D., Bandtlow, C., Heumann, R., Gnahn, M., Naher-Noe, M. and Thoenen, H. (1990) Regulation of nerve growth factor (NGF) synthesis in the central nervous system: Comparison between the effects of interleukin-1 and various growth factors in astrocyte cultures and in vivo. Eur. J. Neurosci. 2, 69-76.
264. Sprick, U. (1991a) Morphology of embryonic hippocampus transplants and generation of long-distance extrinsic graft fiber connections to the lateral septum and the entorhinal cortex in the mature rat brain. Restor. Neurol. Neurosci. 3, 23-34.
265. Sprick, U. (1991b) Transient and long-lasting beneficial behavioral effects of grafts in the damaged hippocampus of rat. Behav. Brain Res. 42, 229-249.
266. Sprick, U. (1993) Energy metabolism and structural factors of long-term grafts in the CNS of rat correlate with graft induced recovery of function. J. Hirnforsch. 34, 165-177.
267. Squire, L. R. (1986) Mechanisms of memory. Science 232, 1612-1619.
268. Stanfield, B. B. and O'Leary, D. (1985) Fetal occipital cortical neurons transplanted to the rostral cortex can extend and maintain a pyramidal tract axon. Nature 313, 135-137.
269. Steinbusch, H. W. M., Vermeulen, R. J. and Tonnaer, J. A. D. M. (1990) Basic fibroblast growth factor enhances survival and sprouting of fetal dopaminergic cells implanted in the denervated rat caudate-putamen: preliminary observations. Prog. Brain Res. 82, 81-86.
270. Steindler, D. A., O'Brien, T. F., Laywell, E., Harrington, K., Faissner, A. and Schachner, M. (1990) Boundaries during normal and abnormal brain development: in vivo and in vitro studies of glia and glycoconjgates. Expl. Neurol. 109, 35-56.
271. Steindler, D. A. (1993) Glial boundaries in the developing nervous system. Annu. Rev. Neurosci. 16, 445-470.
272. Stenevi, U., Bjorklund, A. and Svendgaard, N. A. (1976) Transplantation of central and peripheral monoaminergic neurons to the adult rat brain: techniques and conditions for survival. Brain Res. 114, 1-20.
273. Steward, O. (1976) Topographical organization of the projections from the entorhinal area to the hippocampal formation of the rat. J. Comp. Neurol. 167, 285-314.
274. Stoppinni, L., Helm, G. A., Stringer, J. L., Lothman, E. W. and Bennett Jr, J. P. (1989) In vitro and in vivo transplantation of fetal rat brain cells following incubation with various anatomic tracing substances. J. Neurosci. Methods 27, 121-132.
275. Stromberg, I., Herrera-Marschitz, M., Ungerstedt, U., Ebendal, T. and Olson, L. (1985) Chronic implants of chromaffin tissue into the dopamine-denervated striatum. Effects of NGF on graft survival, fiber growth and rotational behavior. Expl. Brain Res. 60, 335-349.
276. Sunde, N. A., Laurberg, S. and Zimmer, J. (1984) Brain grafts can restore irradiation damaged neuronal connections in the newborn rat. Nature 310, 51-53.
277. Sunde, N. A., Zimmer, J. and Laurberg, S. (1985) Repair of neonatal irradiation-induced damage to the rat fascia dentata. Effects of delayed intracerebral transplantation. In: Neural grafting in the mammalian CNS, pp. 301-308. Eds A. Bjorklund and U. Stenevi. Elsevier:Amsterdam.
278. Sunde, N. A. and Zimmer, J. (1981a) Transplantation of central nervous tissue. An introduction with results and comments. Acta Neurol. Scand. 63, 323-335.
279. Sunde, N. A. and Zimmer, J. (1981b) Dentate granule cells transplanted to hippocampal field CA1 form aberrant mossy fiber projection in rats. Neurosci. Lett. (Suppl.) 7, S33.
280. Sunde, N. A. and Zimmer, J. (1983a) Cellular, histochemical and connective organization of the hippocampus and fascia dentata transplanted to different regions of immature and adult rat brains. Dev. Brain Res. 8, 165-191.
281. Sunde, N. A. and Zimmer, J. (1983b) Cholinergic and non-cholinergic afferents to hippocampal transplants. Neurosci. Lett. (Suppl.) 14, S361.
282. Svendsen, C. N., Fawcett, J., Bentlage, C. and Dunnett, S. B. (1995) Increased survival of rat EGF-generated CNS progenitor cells using B27 supplemented medium. Expl. Brain Res. 102, 407-414.
283. Svendsen, C. N., Clarke, D. J., Rosser, A. E. and Dunnett, S. B. (1996) Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system. Expl. Neurol. 137, 376-388.
284. Svendsen, C. N. and Rosser, A. E. (1995) Neurons from stem cells?. Trends Neurosci. 18, 465-467.
285. Swanson, L. W. and Cowan, W. M. (1977) An autoradiographic study of the organization of the efferent connections of the hippocampal formation in the rat. J. Comp. Neurol. 172, 49-84.
286. Tanaka, S., Kondo, S., Tanaka, T. and Yonemasu, Y. (1988) Long-term observation of rats after unilateral intra-amygdaloid injection of kainic acid. Brain Res. 463, 163-167.
287. Tandon, P., McLamb, R. L., Novicki, D., Shuey, D. L. and Tilson, H. A. (1988) Fetal hippocampal cell suspensions ameliorate behavioral effects of intradentate colchicine in the rat. Brain Res. 473, 241-248.
288. Tandon, P. N. and Gopinath, G. (1994) Clinical use of neural transplant: The unresolved problems. In Neural transplantation, CNS neuronal injury, and regeneration-recent advances, pp. 1-15. Eds J. Marwah, H. Teitelbaum and K. N. Prasad. CRC Press.
289. Tauck, D. L. and Nadler, J. V. (1985) Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J. Neurosci. 4, 1016-1022.
290. Thomas, W. E. (1992) Brain macrophages: evaluation of microglia and their functions. Brain Res. Rev. 17, 61-74.
291. Tilson, H. A. and Peterson, N. J. (1987) Colchicine as an investigative tool in neurobiology. Toxicology 46, 159-173.
292. Tønder N. (1995) Neural transplantation to the normal and lesioned brain: An experimental study of the rat hippocampus. Acta Neurol. Scand. 91, 6-30.
293. Tønder N., Sorenson, J. C., Bakkum, E., Danielsen, E. and Zimmer, J. (1988) Hippocampal neurons grafted to newborn rats establish efferent commissural connections. Expl. Brain Res. 72, 577-583.
294. Tønder N., Sorensen, T. and Zimmer, J. (1990) Grafting of fetal CA3 neurons to excitotoxic, axon-sparing lesions of the hippocampal CA3 area in adult rats. Prog. Brain Res. 83, 391-409.
295. Tønder N., Sorensen, T., Zimmer, J., Jorgensen, M. B., Johansen, F. F. and Diemer, N. H. (1989a) Neural grafting to ischemic lesions of the adult rat hippocampus. Expl. Brain Res. 74, 512-526.
296. Tønder N., Sorensen, T. and Zimmer, J. (1989b) Enhanced host perforant path innervation of neonatal dentate tissue after grafting to axon sparing, ibotenic acid lesions in adult rats. Expl. Brain Res. 75, 483-496.
297. Torres-Aleman, I., Naftolin, F. and Robbins, R. J. (1990) Trophic effects of basic fibroblast growth factor on fetal rat hypothalamic cells: interactions with insulin-like growth factor I. Devl. Brain Res. 52, 253-257.
298. Toth, K. and Freund, T. F. (1992) Calbindin D28k-containing non-pyramidal cells in the rat hippocampus: their immunoreactivity for GABA and projection to the medial septum. Neuroscience 49, 793-805.
299. Turner, D. A. and Kearney, W. (1993) Scientific and ethical concerns in neural fetal tissue transplantation. Neurosurg. 33, 1031-1037.
300. Turner, D. A., Li, X.-G., Pyapali, G. K., Ylinen, L. and Buzsaki, G. (1995) Morphometric and electrical properties of reconstructed CA3 hippocampal neurons recorded in vivo. J. Comp. Neurol. 356, 580-594.
301. Turner, D. A. and Wheal, H. V. (1991a) Excitatory synaptic potentials in kainic-acid denervated rat CA1 pyramidal neurons. J. Neurosci. 11, 2786-2794.
302. Turner, D. A. and Wheal, H. V. (1991b) An overview of basic mechanisms of epilepsy and their relationship to treatment. In Neurosurgical Aspects of Epilepsy, pp. 27-42. Ed. Apuzzo M. Williams and Wilkins: New York.
303. Unsicker, K., Reichert-Preibsch, H., Schmidt, R., Pettmann, B., Labourdette, G. and Sensenbrenner, M. (1987) Astroglial and fibroblast growth factor have neurotrophic functions for cultured peripheral and central nervous system neurons. Proc. Natl. Acad. Sci. U.S.A. 84, 5459-5463.
304. Valdes, J. J., Mactutus, C. F., Santos-Anderson, R. M., Dawson, R. Jr. and Annau, Z. et al.. (1983) Selective neurochemical and histological lesions in rat hippocampus following chronic trimethyltin exposure. Neurobehav. Toxicol. Teratol. 5, 357-361.
305. Vescovi, A. L., Gritti, A., Cova, L. and Parati, E. A. (1994) LIF supports the differentiation of pluripotential stem cells of the human embryonic CNS in vitro. Soc. Neuroci Abstr. 20, 215.
306. Vietje, B. P. and Wells, J. (1989) Selective lesions of granule cells by fluid injections into the dentate gyrus. Expl. Neurol. 106, 275-282.
307. Vige, X., Costa, E. and Wise, B. C. (1991) Mechanism of nerve growth factor mRNA regulation by interleukin-1 and basic fibroblast growth factor in primary cultures of rat astrocytes. Molec. Pharmac. 40, 186-192.
308. Voll, C. L., Whishaw, I. Q. and Auer, R. N. (1989) Post-ischemic insulin reduces spatial learning deficit following transient forebrain ischemia in rats. Stroke 20, 646-651.
309. Volpe, B. T. and Petito, C. K. (1985) Dementia with bilateral medial temporal lobe ischemia. Neurology 35, 1793-1797.
310. Volpe, B. T., Pulsinelli, W. A. and Davis, H. P. (1985) Amnesia in humans and animals after ischemic cerebral injury. Ann. N. Y. Acad. Sci. 444, 492-493.
311. Volpe, T. E., Davies, H. P., Towle, A. and Dunlap, W. P. (1992) Loss of hippocampal CA1 pyramidal neurons correlates with memory impairment in rats with ischemic or neurotoxin lesions. Behav. Neurosci. 101, 603-616.
312. Walicke, P. A., Cowan, W. M., Ueno, N., Baird, A. and Guillemin, R. (1986) Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension. Proc. Natl. Acad. Sci. U.S.A. 83, 3012-3016.
313. Wallace, R. B., Kaplan, R. F. and Werboff, J. (1976) Behavioral correlates of focal hippocampal X-irradiation in rats. Expl. Brain Res. 24, 343-349.
314. Wallace, R. B., Graziadel, R. and Werboff, J. (1981) Behavioral correlates of focal hippocampal X-irradiation in rats II. Expl. Brain Res. 43, 207-212.
315. Walsh, T. J., Schulz, D. W., Tilson, H. A. and Schmechel, D. E. (1986) Colchicine-induced granule cell loss in rat hippocampus: selective behavioral and histological alterations. Brain Res. 398, 23-36.
316. Wheal, H. V. (1989) Function of synapses in the CA1 region of the hippocampus: their contribution to the generation or control of epileptiform activity. Comp. Biochem. Physiol. 93, 211-220.
317. Whittemore, S. R. and White, L. A. (1993) Target regulation of neuronal differentiation in a temperature-sensitive cell line derived from medullary raphe. Brain Res. 615, 27-40.
318. Whittemore, S. R., White, L.A. Shihabuddin, L. S. and Eaton, M. J. (1995) Phenotypic diversity in neuronal cell lines derived from raphe nucleus by retroviral transduction. In: Methods, a companion to Methods in enzymology, vol. 7, pp. 285-296. Eds A. Russo and S. Green. Academic Press: San Diego.
319. Whittington, D. L., Woodruff, M. L. and Baisden, R. H. (1989) The time-course of trimethyltin-induced fiber and terminal degeneration in hippocampus. Neurotoxicol. Teratol. 11, 21-33.
320. Wictorin, K. (1992) Anatomy and connectivity of intrastriatal striatal transplants. Prog. Neurobiol. 38, 611-639.
321. Wictorin, K., Simerly, R. B., Isacson, O., Swanson, L. W. and Bjorklund, A. (1989) Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum. III. Efferent projecting graft neurons and their relation to host afferents within the grafts. Neuroscience 30, 313-330.
322. Wictorin, K., Brundin, P., Gustavii, B., Lindvall, O. and Bjorklund, A. (1990) Reformation of long axon pathways in adult rat central nervous system by human forebrain neuroblasts. Nature 347, 556-558.
323. Wictorin, K., Lagenaur, C. F., Lund, R. D. and Bjorklund, A. (1991) Efferent projections to the host brain from intrastriatal striatal mouse-to-rat grafts: Time course and tissue-type specificity as revealed by a mouse specific neuronal marker. Eur. J. Neurosci. 3, 86-101.
324. Wolff, J. A., Fisher, L. J., Xu, L., Jinnah, H. A., Langlais, P. J., Iuvone, P. M., O'Malley, K. L., Rosenberg, M. B., Shimohama, S. and Friedmann, T. (1989) Grafting fibroblasts genetically modified to produce L-DOPA in a rat model of Parkinson disease. Proc. Natl. Acad. Sci. U.S.A. 86, 9011-9014.
325. Woodhams, P. L., Webb, M., Atkinson, D. J. and Seeley, P. J. (1989) A monoclonal antibody, Py, distinguishes different classes of hippocampal neurons. J. Neurosci. 9, 2170-2181.
326. Woodruff, M. L., Baisden, R. H., Whittington, D. L. and Bensen, A. E. (1987) Embryonic hippocampal grafts ameliorate the deficit in DRL acquisition produced by hippocampectomy. Brain Res. 408, 97-117.
327. Woodruff, M. L., Baisden, R. H., Whittington, D. L., Shelton, N. L. and Wray, S. (1988) Grafts containing fetal hippocampal tissue reduce activity and improve passive avoidance in hippocampectomized or trimethyltin-exposed rats. Expl. Neurol. 102, 130-143.
328. Woodruff, M. L., Baisden, R. H. and Nonneman, A. J. (1991) Anatomical and behavioral sequelae of fetal brain transplants in rats with trimethyltin-induced neurodegeneration. Neurotoxicol. 12, 427-444.
329. Woodruff, M. L., Baisden, R. H. and Nonneman, A. J. (1992) Effects of transplantation of fetal hippocampal or hindbrain tissue into the brains of adult rats with hippocampal lesions on water maze acquisition. Behav. Neurosci. 106, 39-50.
330. Woodruff, M. L., Baisden, R. H. and Cannon, R. L. (1993) Transplant-induced working memory deficits in hippocampectomized rats. Physiol. Behav. 54, 579-587.
331. Woodward, W. R., Nishin, R., Meshul, C. K., Williams, T. E., Coulombe, M. and Eckenstein, F. P. (1992) Nuclear and cytoplasmic localization of basic fibroblast growth factor in astrocytes and CA2 hippocampal neurons. J. Neurosci. 12, 142-152.
332. Yamada, M. and Hatanaka, H. (1994) Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death. Brain Res. 643, 173-180.
333. Yoshida, K. and Gage, F. H. (1992) Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines. Brain Res. 569, 14-25.
334. Yurek, D. and Sladek, J. R. Jr. (1990) Dopamine cell replacement: Parkinson's disease. Annu. Rev. Neurosci. 13, 415-440.
335. Zhou, C. F., Raisman, G. and Morris, R. J. (1985) Specific patterns of fiber outgrowth from transplants to host mice hippocampi, shown immunohistochemically by the use of allelic forms of Thy-1. Neuroscience 16, 819-833.
336. Zimmer, J. (1971) Ipsilateral afferent to the commissural zone of the fascia dentata, demonstrated in decommissurated rats by silver impregnation. J. Comp. Neurol. 142, 393-416.
337. Zimmer, J., Laurberg, S. and Sunde, N. (1983) Neuroanatomical aspects of normal and transplanted hippocampal tissue. In: Neurobiology of the Hippocampus, pp. 39-64. Ed W. Seifert, Academic Press: London.
338. Zimmer, J., Sunde, N. and Sorensen, T. (1985) Reorganization and restoration of central nervous connections after injury: a lesion and transplant study of the rat hippocampus. In: Brain Plasticity, Learning and Memory, pp. 505-518. Eds B. E. Will, P. Schmitt and J. C. Dalrymple-Alford. Plenum: London.
339. Zimmer, J., Laurberg, S. and Sunde, N. (1986) Non-cholinergic afferents determine the distribution of the cholinergic septohippocampal projection: a study of the AChE staining pattern in the rat fascia dentata and hippocampus after lesions X-irradiation and intracerebral grafting. Expl. Brain Res. 64, 158-168.
340. Zimmer, J., Finsen, B., Sorenson, T. and Sunde, N. (1987) Hippocampal transplants: synaptic organization, their use in repair of neural circuits and mouse to rat xenografting. In: Glial-neuronal communication in development and regeneration, pp. 545-563. Eds H. Althaus and W. Seifert. Springer: Heidelberg.
341. Zimmer, J., Finsen, B., Sorenson, T. and Poulsen, P. H. (1988a) Xenografts of mouse hippocampal tissue: Exchange of laminar and neuropeptide specific nerve connections with the host brain. Brain Res. Bull. 20, 369-379.
342. Zimmer, J., Finsen, B., Sorenson, T. and Poulsen, P. H. (1988b) Xenografts of mouse hippocampal tissue. Formation of nerve connections between the graft fascia dentata and the host rat brain. Prog. Brain Res. 78, 271-280.
343. Zimmer, J., Finsen, B., Sorenson, T., Sunde, N. A. and Poulsen, P. H. (1988c) Brain grafts: a survey with examples of repair and xenografting of hippocampal tissue. In: Recovery of Function in the Nervous system, pp. 161-184. Eds F. Cohadon and J. Lobo Antunes. Fidia Research Series.
344. Zimmer, J. and Sunde, N. A. (1984) Neuropeptides and astroglia in intracerebral hippocampal transplants: An immunohistochemical study in the rat. J. Comp. Neurol. 227, 331-347.
345. Zola-Morgan, S., Squire, L. R. and Amaral, D. G. (1986) Human amnesia and the medial temporal region:enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J. Neurosci.