Caffeic acid phenethyl ester (CAPE) prevents methotrexate-induced hepatorenal oxidative injury in rats

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 12, 2011, Pages 1566-1571

  Çakir, Tuǧrul ^a   Özkan, Erkan ^a   Dulundu, Ender ^a   Topaloǧlu, Ümit ^a   Şehirli, Ahmet Özer ^b   Ercan, Feriha ^b   Şener, Emre ^b   Şener, Göksel ^b  

^a GATA HAYDARPASA TRAINING HOSPITAL   (Turkey)

^b MARMARA UNIVERSITY   (Turkey)

Author keywords

caffeic acid phenethyl ester; kidney; liver; methotrexate; oxidative damage

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CAFFEIC ACID PHENETHYL ESTER; GLUTATHIONE; INTERLEUKIN 1BETA; MALONALDEHYDE; METHOTREXATE; MYELOPEROXIDASE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DECAPITATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HISTOPATHOLOGY; KIDNEY PARENCHYMA; LIVER PARENCHYMA; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT; RENAL PROTECTION; SINGLE DRUG DOSE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CAFFEIC ACIDS; DRUG-INDUCED LIVER INJURY; FEMALE; GLUTATHIONE; INTERLEUKIN-1BETA; KIDNEY DISEASES; MALE; MALONDIALDEHYDE; METHOTREXATE; OXIDATIVE STRESS; PEROXIDASE; PHENYLETHYL ALCOHOL; RATS; RATS, WISTAR; SODIUM-POTASSIUM-EXCHANGING ATPASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80955125184     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01359.x     Document Type: Article

References (45)

1. Bleyer WA,. Methotrexate: clinical pharmacology, current status and therapeutic guidelines. Cancer Treat Rev 1977; 4: 87-101. (Pubitemid 8146048)
2. Widemann BC, et al,. High-dose methotrexate-induced nephrotoxocity in patients with osteosarcoma, incidence, treatment and outcome. Cancer 2004; 100: 2222-2232. (Pubitemid 38580344)
3. Braun J, Rau R,. An update on methotrexate. Curr Opin Rheumatol 2009; 21: 216-223.
4. Jolivet J, et al,. The pharmacology and clinical use of methotrexate. N Engl J Med 1983; 309: 1094-1104. (Pubitemid 13023161)
5. Widemann BC, Adamson PC,. Understanding and managing methotrexate nephrotoxicity. Oncologist 2006; 11: 694-703. (Pubitemid 43967624)
6. Aithal GP, Medscape. Hepatotoxicity related to antirheumatic drugs. Nat Rev Rheumatol 2011; 7: 139-150.
7. Miyazono Y, et al,. Oxidative stress contributes to methotrexate induced small intestinal toxicity in rats. Scand J Gastroenterol 2004; 39: 1119-1127. (Pubitemid 39536402)
8. Babiak RM, et al,. Methotrexate: pentose cycle and oxidative stress. Cell Biochem Funct 1998; 16: 283-293. (Pubitemid 28523763)
9. Chladek J, et al,. An in vitro study on methotrexate hydroxylation in rat human liver. Physiol Res 1997; 46: 371-379. (Pubitemid 27471204)
10. Kintzel PE,. Anticancer drug-induced kidney disorders. Drug Saf 2001; 24: 19-38.
11. Tseng TH, Lee YJ,. Evaluation of natural and synthetic compounds from East Asiatic folk medicinal plants on the mediation of cancer. Anticancer Agents Med Chem 2006; 6: 347-365.
12. Özen S, et al,. Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin induced nephrotoxicity in rats. J Appl Toxicol 2004; 24: 27-35. (Pubitemid 38185778)
13. Koksel O, et al,. Effects of CAPE on lipopolisaccharide-induced lung injury in rats. Pulm Pharmacol Ther 2006; 19: 90-95. (Pubitemid 43052995)
14. Lin WL, et al,. Antitumor progression potential of caffeic acid phenethyl ester involving p75 (NTR) in C6 glioma cells. Chem Biol Interact 2010; 188: 607-615.
15. Wang T, et al,. Potential cytoprotection: antioxidant defence by caffeic acid phenethyl ester against free radical-induced damage of lipids, DNA, and proteins. Can J Physiol Pharmacol 2008; 86: 279-287. (Pubitemid 351705489)
16. Albukhari AA, et al,. Caffeic acid phenethyl ester protects against tamoxifen-induced hepatotoxicity in rats. Food Chem Toxicol 2009; 47: 1689-1695.
17. Oktar S, et al,. Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats. J Physiol Biochem 2009; 65: 339-344.
18. Gökçe A, et al,. Protective effect of caffeic acid phenethyl ester on cyclosporine A-induced nephrotoxicity in rats. Ren Fail 2009; 31: 843-847.
19. Yilmaz HR, et al,. Protective effect of CAPE on lipid peroxidation and antioxidant enzymes in diabetic rat liver. J Biochem Mol Toxicol 2004; 18: 234-238.
20. Banskota AH, et al,. Recent progress in pharmacological research of propolis. Phytother Res 2001; 15: 561-571. (Pubitemid 33021859)
21. Uz E, et al,. The activities of purine-catabolizing enzymes and the level of nitric oxide in rat kidneys subjected to methotrexate: protective effect of caffeic acid phenethyl ester. Mol Cell Biochem 2005; 277: 165-170. (Pubitemid 41236199)
22. Oktem F, et al,. Methotrexate-induced renal oxidative stress in rats: the role of a novel antioxidant caffeic acid phenethyl ester. Toxicol Ind Health 2006; 22: 241-247. (Pubitemid 44186622)
23. Armagan A, et al,. Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat. Hum Exp Toxicol 2008; 27: 547-552.
24. Beuge JA, Aust SD,. Microsomal lipid peroxidation. Methods Enzymol 1978; 52: 302-310.
25. Beutler E,. Glutathione in Red Blood Cell Metabolism. A Manual of Biochemical Methods. New York: Grune &Stratton, 1975: 112-114.
26. Hillegas LM, et al,. Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Methods 1990; 24: 285-295.
27. Reading HW, Isbir T,. The role of cation-activated ATPases in transmitter release from the rat iris. Q J Exp Physiol Cogn Med Sci 1980; 65: 105-116.
28. Fiske CH, Subbarow Y,. The colorimetric determination of phosphorus. J Biol Chem 1925; 66: 375-400.
29. Lowry OH, et al,. Protein measurements with the folin phenol reagent. J Biol Chem 1951; 193: 265-275.
30. Chládek J, et al,. An in vitro study on methotrexate hydroxilation in rat and human liver. Physiol Res 1997; 46: 371-379. (Pubitemid 27471204)
31. Kamen BA, et al,. Methotrexate accumulation and folate depletion in cell as a possible mechanism of chronic toxicity to the drug. Br J Haematol 1981; 49: 355-360. (Pubitemid 11027829)
32. Sener G, et al,. Beta-glucan ameliorates methotrexate induced oxidative organ injury via its antioxidant and immunomodulatory effects. Eur J Pharmacol 2006; 542: 170-178. (Pubitemid 44066363)
33. Van Den Bongard HJ, et al,. Successful rescue with leucovorin and thymidine in a patient with high-dose methotrexate induced acute renal failure. Cancer Chemother Pharmacol 2001; 47: 537-540. (Pubitemid 32477302)
34. Dobrota D, et al,. Na/K-ATPase under oxidative stress: molecular mechanisms of injury. Cell Mol Neurobiol 1999; 19: 141-149. (Pubitemid 29102102)
35. Thomas CE, Reed DJ,. Radical-induced inactivation of kidney Na+,K(+)-ATPase: sensitivity to membrane lipid peroxidation and the protective effect of vitamin E. Arch Biochem Biophys 1990; 281: 96-105. (Pubitemid 20232878)
36. Ballatori N, et al,. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem 2009; 390: 191-214.
37. Jahovic N, et al,. Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. J Pineal Res 2003; 34: 282-287. (Pubitemid 36469775)
38. Jahovic N, et al,. Amelioration of methotrexate-induced enteritis by melatonin in rats. Cell Biochem Funct 2004; 22: 169-784.
39. Ozyurt H, et al,. Oxidative stress in testicular tissues of rats exposed to cigarette smoke and protective effects of caffeic acid phenethyl ester. Asian J Androl 2006; 8: 189-193. (Pubitemid 43349189)
40. Ilhan A, et al,. Protective effects of caffeic acid phenethyl ester against experimental allergic encephalomyelitis-induced oxidative stress in rats. Free Radic Biol Med 2004; 37: 386-394. (Pubitemid 38834004)
41. Motawi TK, et al,. Effects of caffeic acid phenethyl ester on endotoxin-induced cardiac stress in rats: a possible mechanism of protection. J Biochem Mol Toxicol 2011; 25: 84-94.
42. Khayyal MT, et al,. Mechanism involved in the antiinflammatory effect of propolis extract. Drugs Exp Clin Res 1993; 19: 197-203. (Pubitemid 24029191)
43. Michaluart P, et al,. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res 1999; 59: 2347-2352. (Pubitemid 29242281)
44. Donnahoo KK, et al,. Early kidney TNF-a expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion. Am J Physiol 1999; 277 (3 Pt 2): R922-R929. (Pubitemid 29458168)
45. Winterbourn CC, et al,. Myeloperoxidase. Curr Opin Hematol 2000; 7: 53-58. (Pubitemid 30007688)