The combination of metallothionein and superoxide dismutase protects pancreatic β cells from oxidative damage

Diabetes/Metabolism Research and Reviews

Volumn 27, Issue 8, 2011, Pages 802-808

  Park, Leejin ^a   Min, Dongsoo ^a   Kim, Hyunok ^a   Park, Jinseu ^b   Choi, Sooyoung ^b   Park, Yongsoo ^a  

^a Hanyang University College of Medicine   (South Korea)

^b Hallym University   (South Korea)

Author keywords

Antioxidant; Diabetes; Oxidative stress; Rejection; Tat fusion protein

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; HYBRID PROTEIN; LIPOCORTIN 5; METALLOTHIONEIN; NITRIC OXIDE; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; DNA FRAGMENTATION; GENETIC TRANSDUCTION; GRAFT FAILURE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ANIMALS; DIABETES MELLITUS, TYPE 1; GENE PRODUCTS, TAT; HEP G2 CELLS; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; METALLOTHIONEIN; MICE; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS; SUPEROXIDE DISMUTASE; TRANSDUCTION, GENETIC;

EID: 80855138454     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.1254     Document Type: Article

References (13)

1. Poitout V, Robertson RP. Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev 2008; 29: 351-366.
2. Kahn SE, Zraika S, Utzschneider KM, Hull RL. The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia 2009; 52(6): 1003-1012.
3. Barshes NR, Wyllie S, Goss JA. Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts. J Leukoc Biol 2005; 77(5): 587-597.
4. Cai L, Klein JB, Kang YJ. Metallothionein inhibits peroxynitrite-induced DNA and lipoprotein damage. J Biol Chem 2000; 275(50): 38957-38960.
5. Eum WS, Chung IS, Li MZ, et al. HIV-1 Tat-mediated protein transduction of Cu, Zn-superoxide dismutase into pancreatic β cells in vitro and in vivo. Free Radic Biol Med 2004; 37: 339-349.
6. Becker-Hepak M, McAllister SS, Dowdy SF. Tat-mediated protein transduction. Methods 2001; 24: 247-256.
7. Embury J, Klein D, Pileggi A, et al. Proteins linked to a protein transduction domain efficiently transduce pancreatic islets. Diabetes 2001; 50: 1706-1713.
8. Gotoh M, Maki T, Kiyoizumi T, Satomi S, Monaco AP. An improved method for isolation of mouse pancreatic islets. Transplantation 1985; 40(4): 437-438.
9. O'Driscoll L, Gammell P, Clynes M. Mechanisms associated with loss of glucose responsiveness in beta cells. Transplant Proc 2004; 36: 1159-1162.
10. Rolo AP, Palmeira CM. Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol 2006; 212(2): 167-178.
11. Li N, Frigerio F, Maechler P. The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress. Biochem Soc Trans 2008; 36(Pt 5): 930-934.
12. Kessler L, Jesser C, Lombard Y, et al. Cytotoxicity of peritoneal murine macrophages against encapsulated pancreatic rat islets: in vivo and in vitro studies. J Leukoc Biol 1996; 60: 729-36.
13. Chen H, Li X, Epstein PN. MnSOD and catalase transgenes demonstrate that protection of islets from oxidative stress does not alter cytokine toxicity. Diabetes 2005; 54: 1437-1446.