메뉴 건너뛰기




Volumn 45, Issue 3, 2011, Pages 467-472

Neuronal life span versus health span: Principles of natural selection at work in the degenerating brain

Author keywords

Alzheimer's; Neurodegeneration; Neuroprotection; Solubility; Tau

Indexed keywords

ALPHA TOCOPHEROL; INDOLEPROPIONIC ACID; RESVERATROL; TAU PROTEIN;

EID: 80855131568     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9540-4     Document Type: Conference Paper
Times cited : (2)

References (44)
  • 1
    • 78449254717 scopus 로고    scopus 로고
    • Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice
    • 21084594 10.1523/JNEUROSCI.3155-10.2010 1:CAS:528:DC%2BC3cXhsFWitbzI
    • JF Abisambra LJ Blair SE Hill, et al. 2010 Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice J Neurosci 30 15374 15382 21084594 10.1523/JNEUROSCI.3155-10.2010 1:CAS:528:DC%2BC3cXhsFWitbzI
    • (2010) J Neurosci , vol.30 , pp. 15374-15382
    • Abisambra, J.F.1    Blair, L.J.2    Hill, S.E.3
  • 2
    • 78650902065 scopus 로고    scopus 로고
    • Neuroprotective properties of resveratrol in different neurodegenerative disorders
    • 20848560 10.1002/biof.118 1:CAS:528:DC%2BC3cXhtl2msLjO
    • D Albani L Polito A Signorini G Forloni 2010 Neuroprotective properties of resveratrol in different neurodegenerative disorders Biofactors 36 370 376 20848560 10.1002/biof.118 1:CAS:528:DC%2BC3cXhtl2msLjO
    • (2010) Biofactors , vol.36 , pp. 370-376
    • Albani, D.1    Polito, L.2    Signorini, A.3    Forloni, G.4
  • 3
    • 0041803006 scopus 로고    scopus 로고
    • Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
    • 12859672 10.1046/j.1471-4159.2003.01879.x 1:CAS:528:DC%2BD3sXlvF2ntbs%3D
    • C Andorfer Y Kress M Espinoza, et al. 2003 Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms J Neurochem 86 582 590 12859672 10.1046/j.1471-4159.2003.01879.x 1:CAS:528:DC%2BD3sXlvF2ntbs%3D
    • (2003) J Neurochem , vol.86 , pp. 582-590
    • Andorfer, C.1    Kress, Y.2    Espinoza, M.3
  • 4
    • 59649110562 scopus 로고    scopus 로고
    • SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells
    • 19098903 10.1038/ncb1819 1:CAS:528:DC%2BD1MXht1Oqt7g%3D
    • RD Bell R Deane N Chow, et al. 2009 SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells Nat Cell Biol 11 143 153 19098903 10.1038/ncb1819 1:CAS:528:DC%2BD1MXht1Oqt7g%3D
    • (2009) Nat Cell Biol , vol.11 , pp. 143-153
    • Bell, R.D.1    Deane, R.2    Chow, N.3
  • 5
    • 75149148788 scopus 로고    scopus 로고
    • Why vitamin e therapy fails for treatment of Alzheimer's disease
    • 20061623
    • GJ Brewer 2010 Why vitamin E therapy fails for treatment of Alzheimer's disease J Alzheimers Dis 19 27 30 20061623
    • (2010) J Alzheimers Dis , vol.19 , pp. 27-30
    • Brewer, G.J.1
  • 6
    • 33846471269 scopus 로고    scopus 로고
    • Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype
    • 17215356 10.1073/pnas.0608251104 1:CAS:528:DC%2BD2sXhtVegtr0%3D
    • N Chow RD Bell R Deane, et al. 2007 Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype Proc Natl Acad Sci USA 104 823 828 17215356 10.1073/pnas.0608251104 1:CAS:528:DC%2BD2sXhtVegtr0%3D
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 823-828
    • Chow, N.1    Bell, R.D.2    Deane, R.3
  • 7
    • 0033042978 scopus 로고    scopus 로고
    • Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation
    • 10100846 10.1016/S0014-5793(99)00222-7 1:CAS:528:DyaK1MXhvVCmtLw%3D
    • R Dayanandan M Van Slegtenhorst TG Mack, et al. 1999 Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation FEBS Lett 446 228 232 10100846 10.1016/S0014-5793(99)00222-7 1:CAS:528:DyaK1MXhvVCmtLw%3D
    • (1999) FEBS Lett , vol.446 , pp. 228-232
    • Dayanandan, R.1    Van Slegtenhorst, M.2    MacK, T.G.3
  • 8
    • 78650238276 scopus 로고    scopus 로고
    • Caspase activation precedes and leads to tangles
    • A de Calignon LM Fox R Pitstick, et al. 2010 Caspase activation precedes and leads to tangles Nature 26 787 789
    • (2010) Nature , vol.26 , pp. 787-789
    • De Calignon, A.1    Fox, L.M.2    Pitstick, R.3
  • 9
    • 0027186334 scopus 로고
    • The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex
    • 8328966 1:CAS:528:DyaK3sXks12lsb8%3D
    • J Ghiso E Matsubara A Koudinov, et al. 1993 The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex Biochem J 293 Pt 1 27 30 8328966 1:CAS:528:DyaK3sXks12lsb8%3D
    • (1993) Biochem J , vol.293 , Issue.PART 1 , pp. 27-30
    • Ghiso, J.1    Matsubara, E.2    Koudinov, A.3
  • 10
    • 0033958696 scopus 로고    scopus 로고
    • Vitamin e and Alzheimer disease: The basis for additional clinical trials
    • 10681271 1:STN:280:DC%2BD3c7kt1Onsg%3D%3D
    • M Grundman 2000 Vitamin E and Alzheimer disease: the basis for additional clinical trials Am J Clin Nutr 71 630S 636S 10681271 1:STN:280: DC%2BD3c7kt1Onsg%3D%3D
    • (2000) Am J Clin Nutr , vol.71
    • Grundman, M.1
  • 11
    • 0028301455 scopus 로고
    • Altered microtubule organization in small-calibre axons of mice lacking tau protein
    • 8202139 10.1038/369488a0 1:CAS:528:DyaK2cXksl2nsLY%3D
    • A Harada K Oguchi S Okabe, et al. 1994 Altered microtubule organization in small-calibre axons of mice lacking tau protein Nature 369 488 491 8202139 10.1038/369488a0 1:CAS:528:DyaK2cXksl2nsLY%3D
    • (1994) Nature , vol.369 , pp. 488-491
    • Harada, A.1    Oguchi, K.2    Okabe, S.3
  • 12
    • 65849450639 scopus 로고    scopus 로고
    • Indole-3-propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus
    • 19235887 10.1002/jnr.22030 1:CAS:528:DC%2BD1MXlvV2rt70%3D
    • IK Hwang KY Yoo H Li, et al. 2009 Indole-3-propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus J Neurosci Res 87 2126 2137 19235887 10.1002/jnr.22030 1:CAS:528:DC%2BD1MXlvV2rt70%3D
    • (2009) J Neurosci Res , vol.87 , pp. 2126-2137
    • Hwang, I.K.1    Yoo, K.Y.2    Li, H.3
  • 13
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • 15100718 10.1038/nrn1387 1:CAS:528:DC%2BD2cXjt1ClsLY%3D
    • C Iadecola 2004 Neurovascular regulation in the normal brain and in Alzheimer's disease Nat Rev Neurosci 5 347 360 15100718 10.1038/nrn1387 1:CAS:528:DC%2BD2cXjt1ClsLY%3D
    • (2004) Nat Rev Neurosci , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 14
    • 77955322042 scopus 로고    scopus 로고
    • Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
    • 20655099 10.1016/j.cell.2010.06.036 1:CAS:528:DC%2BC3cXpvFKrtr4%3D
    • LM Ittner YD Ke F Delerue, et al. 2010 Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models Cell 142 387 397 20655099 10.1016/j.cell.2010.06.036 1:CAS:528:DC%2BC3cXpvFKrtr4%3D
    • (2010) Cell , vol.142 , pp. 387-397
    • Ittner, L.M.1    Ke, Y.D.2    Delerue, F.3
  • 15
    • 70349617699 scopus 로고    scopus 로고
    • Chemical manipulation of hsp70 ATPase activity regulates tau stability
    • 19793966 10.1523/JNEUROSCI.3345-09.2009 1:CAS:528:DC%2BD1MXht12qu7zN
    • UK Jinwal Y Miyata J Koren 3rd, et al. 2009 Chemical manipulation of hsp70 ATPase activity regulates tau stability J Neurosci 29 12079 12088 19793966 10.1523/JNEUROSCI.3345-09.2009 1:CAS:528:DC%2BD1MXht12qu7zN
    • (2009) J Neurosci , vol.29 , pp. 12079-12088
    • Jinwal, U.K.1    Miyata, Y.2    Koren III, J.3
  • 16
    • 60249098801 scopus 로고    scopus 로고
    • Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease
    • 19041676 10.1016/j.neuint.2008.10.008 1:CAS:528:DC%2BD1MXit1Krt7Y%3D
    • SS Karuppagounder JT Pinto H Xu HL Chen MF Beal GE Gibson 2009 Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease Neurochem Int 54 111 118 19041676 10.1016/j.neuint.2008. 10.008 1:CAS:528:DC%2BD1MXit1Krt7Y%3D
    • (2009) Neurochem Int , vol.54 , pp. 111-118
    • Karuppagounder, S.S.1    Pinto, J.T.2    Xu, H.3    Chen, H.L.4    Beal, M.F.5    Gibson, G.E.6
  • 17
    • 34447308268 scopus 로고    scopus 로고
    • SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
    • 17581637 10.1038/sj.emboj.7601758 1:CAS:528:DC%2BD2sXnsFejt7k%3D
    • D Kim MD Nguyen MM Dobbin, et al. 2007 SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis EMBO J 26 3169 3179 17581637 10.1038/sj.emboj.7601758 1:CAS:528:DC%2BD2sXnsFejt7k%3D
    • (2007) EMBO J , vol.26 , pp. 3169-3179
    • Kim, D.1    Nguyen, M.D.2    Dobbin, M.M.3
  • 18
    • 78649660787 scopus 로고    scopus 로고
    • Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss
    • 20921222 10.1074/jbc.M110.136630 1:CAS:528:DC%2BC3cXhsVOku7nP
    • T Kimura T Fukuda N Sahara, et al. 2010 Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss J Biol Chem 285 38692 38699 20921222 10.1074/jbc.M110.136630 1:CAS:528: DC%2BC3cXhsVOku7nP
    • (2010) J Biol Chem , vol.285 , pp. 38692-38699
    • Kimura, T.1    Fukuda, T.2    Sahara, N.3
  • 19
    • 33751218015 scopus 로고    scopus 로고
    • Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid
    • 17101697 10.1083/jcb.200605187 1:CAS:528:DC%2BD28Xht1GksbvK
    • ME King HM Kan PW Baas A Erisir CG Glabe GS Bloom 2006 Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid J Cell Biol 175 541 546 17101697 10.1083/jcb.200605187 1:CAS:528:DC%2BD28Xht1GksbvK
    • (2006) J Cell Biol , vol.175 , pp. 541-546
    • King, M.E.1    Kan, H.M.2    Baas, P.W.3    Erisir, A.4    Glabe, C.G.5    Bloom, G.S.6
  • 20
    • 0032946019 scopus 로고    scopus 로고
    • Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome
    • 10211483 10.1002/1531-8249(199904)45:4<537::AID-ANA20>3.0.CO;2-2 1:STN:280:DyaK1M3is1Cltw%3D%3D
    • E Matsubara J Ghiso B Frangione, et al. 1999 Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome Ann Neurol 45 537 541 10211483 10.1002/1531-8249(199904)45:4<537::AID-ANA20>3.0.CO;2-2 1:STN:280:DyaK1M3is1Cltw%3D%3D
    • (1999) Ann Neurol , vol.45 , pp. 537-541
    • Matsubara, E.1    Ghiso, J.2    Frangione, B.3
  • 21
    • 79251555689 scopus 로고    scopus 로고
    • Methylene blue reduces abeta levels and rescues early cognitive deficit by increasing proteasome activity
    • 20731659 10.1111/j.1750-3639.2010.00430.x 1:CAS:528:DC%2BC3MXls1Cis74%3D
    • DX Medina A Caccamo S Oddo 2011 Methylene blue reduces abeta levels and rescues early cognitive deficit by increasing proteasome activity Brain Pathol 21 2 140 149 20731659 10.1111/j.1750-3639.2010.00430.x 1:CAS:528: DC%2BC3MXls1Cis74%3D
    • (2011) Brain Pathol , vol.21 , Issue.2 , pp. 140-149
    • Medina, D.X.1    Caccamo, A.2    Oddo, S.3
  • 22
    • 36749011905 scopus 로고    scopus 로고
    • Inhibition of amyloid fibrillation of lysozyme by indole derivatives-possible mechanism of action
    • 18028426 1:CAS:528:DC%2BD2sXhsVOnsrbF
    • D Morshedi N Rezaei-Ghaleh A Ebrahim-Habibi S Ahmadian M Nemat-Gorgani 2007 Inhibition of amyloid fibrillation of lysozyme by indole derivatives-possible mechanism of action FEBS J 274 6415 6425 18028426 1:CAS:528:DC%2BD2sXhsVOnsrbF
    • (2007) FEBS J , vol.274 , pp. 6415-6425
    • Morshedi, D.1    Rezaei-Ghaleh, N.2    Ebrahim-Habibi, A.3    Ahmadian, S.4    Nemat-Gorgani, M.5
  • 23
    • 0034662501 scopus 로고    scopus 로고
    • Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation
    • 10944232 10.1073/pnas.97.17.9735 1:CAS:528:DC%2BD3cXmtVentLs%3D
    • K Niwa L Younkin C Ebeling, et al. 2000 Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation Proc Natl Acad Sci USA 97 9735 9740 10944232 10.1073/pnas.97.17.9735 1:CAS:528:DC%2BD3cXmtVentLs%3D
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9735-9740
    • Niwa, K.1    Younkin, L.2    Ebeling, C.3
  • 25
    • 57649245230 scopus 로고    scopus 로고
    • Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis
    • 19109907 10.1016/j.neuron.2008.10.047
    • T O'Connor KR Sadleir E Maus, et al. 2008 Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis Neuron 60 988 1009 19109907 10.1016/j.neuron.2008.10.047
    • (2008) Neuron , vol.60 , pp. 988-1009
    • O'Connor, T.1    Sadleir, K.R.2    Maus, E.3
  • 26
    • 77958566761 scopus 로고    scopus 로고
    • Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
    • 21040568 10.1186/1750-1326-5-45
    • JC O'Leary 3rd Q Li P Marinec, et al. 2010 Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden Mol Neurodegener 5 45 21040568 10.1186/1750-1326-5-45
    • (2010) Mol Neurodegener , vol.5 , pp. 45
    • O'Leary III, J.C.1    Li, Q.2    Marinec, P.3
  • 27
    • 0036121232 scopus 로고    scopus 로고
    • Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae
    • 11888511 10.1016/S0021-9150(01)00660-8 1:CAS:528:DC%2BD38XhvVWksLY%3D
    • D Paris KP Townsend J Humphrey DF Obregon K Yokota M Mullan 2002 Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae Atherosclerosis 161 293 299 11888511 10.1016/S0021-9150(01)00660-8 1:CAS:528:DC%2BD38XhvVWksLY%3D
    • (2002) Atherosclerosis , vol.161 , pp. 293-299
    • Paris, D.1    Townsend, K.P.2    Humphrey, J.3    Obregon, D.F.4    Yokota, K.5    Mullan, M.6
  • 28
    • 20344381835 scopus 로고    scopus 로고
    • Vitamin e and donepezil for the treatment of mild cognitive impairment
    • 15829527 10.1056/NEJMoa050151 1:CAS:528:DC%2BD2MXltVCjsbg%3D
    • RC Petersen RG Thomas M Grundman, et al. 2005 Vitamin E and donepezil for the treatment of mild cognitive impairment N Engl J Med 352 2379 2388 15829527 10.1056/NEJMoa050151 1:CAS:528:DC%2BD2MXltVCjsbg%3D
    • (2005) N Engl J Med , vol.352 , pp. 2379-2388
    • Petersen, R.C.1    Thomas, R.G.2    Grundman, M.3
  • 29
    • 0037197836 scopus 로고    scopus 로고
    • Tau is essential to beta-amyloid-induced neurotoxicity
    • 11959919 10.1073/pnas.092136199 1:CAS:528:DC%2BD38XjslWnt74%3D
    • M Rapoport HN Dawson LI Binder MP Vitek A Ferreira 2002 Tau is essential to beta-amyloid-induced neurotoxicity Proc Natl Acad Sci USA 99 6364 6369 11959919 10.1073/pnas.092136199 1:CAS:528:DC%2BD38XjslWnt74%3D
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6364-6369
    • Rapoport, M.1    Dawson, H.N.2    Binder, L.I.3    Vitek, M.P.4    Ferreira, A.5
  • 30
    • 0037417899 scopus 로고    scopus 로고
    • Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis
    • 12552120 10.1073/pnas.242746599 1:CAS:528:DC%2BD3sXhtF2gu7k%3D
    • JM Redwine B Kosofsky RE Jacobs, et al. 2003 Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis Proc Natl Acad Sci USA 100 1381 1386 12552120 10.1073/pnas.242746599 1:CAS:528:DC%2BD3sXhtF2gu7k%3D
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1381-1386
    • Redwine, J.M.1    Kosofsky, B.2    Jacobs, R.E.3
  • 31
    • 34248181511 scopus 로고    scopus 로고
    • Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
    • 17478722 10.1126/science.1141736 1:CAS:528:DC%2BD2sXkvVWrtrw%3D
    • ED Roberson K Scearce-Levie JJ Palop, et al. 2007 Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model Science 316 750 754 17478722 10.1126/science.1141736 1:CAS:528: DC%2BD2sXkvVWrtrw%3D
    • (2007) Science , vol.316 , pp. 750-754
    • Roberson, E.D.1    Scearce-Levie, K.2    Palop, J.J.3
  • 32
    • 22344438508 scopus 로고    scopus 로고
    • Tau suppression in a neurodegenerative mouse model improves memory function
    • 16020737 10.1126/science.1113694 1:CAS:528:DC%2BD2MXmtVersLc%3D
    • K Santacruz J Lewis T Spires, et al. 2005 Tau suppression in a neurodegenerative mouse model improves memory function Science 309 476 481 16020737 10.1126/science.1113694 1:CAS:528:DC%2BD2MXmtVersLc%3D
    • (2005) Science , vol.309 , pp. 476-481
    • Santacruz, K.1    Lewis, J.2    Spires, T.3
  • 33
    • 0027999030 scopus 로고
    • Transthyretin sequesters amyloid beta protein and prevents amyloid formation
    • 8078889 10.1073/pnas.91.18.8368 1:CAS:528:DyaK2cXlslKktLk%3D
    • AL Schwarzman L Gregori MP Vitek, et al. 1994 Transthyretin sequesters amyloid beta protein and prevents amyloid formation Proc Natl Acad Sci USA 91 8368 8372 8078889 10.1073/pnas.91.18.8368 1:CAS:528:DyaK2cXlslKktLk%3D
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8368-8372
    • Schwarzman, A.L.1    Gregori, L.2    Vitek, M.P.3
  • 34
    • 0034521392 scopus 로고    scopus 로고
    • Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
    • 11120756 10.1172/JCI10498 1:CAS:528:DC%2BD3cXovFagtbs%3D
    • M Shibata S Yamada SR Kumar, et al. 2000 Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier J Clin Invest 106 1489 1499 11120756 10.1172/JCI10498 1:CAS:528:DC%2BD3cXovFagtbs%3D
    • (2000) J Clin Invest , vol.106 , pp. 1489-1499
    • Shibata, M.1    Yamada, S.2    Kumar, S.R.3
  • 35
    • 70549088602 scopus 로고    scopus 로고
    • Genome-wide association study reveals genetic risk underlying Parkinson's disease
    • 19915575 10.1038/ng.487 1:CAS:528:DC%2BD1MXhsVWlsbrP
    • J Simon-Sanchez C Schulte JM Bras, et al. 2009 Genome-wide association study reveals genetic risk underlying Parkinson's disease Nat Genet 41 1308 1312 19915575 10.1038/ng.487 1:CAS:528:DC%2BD1MXhsVWlsbrP
    • (2009) Nat Genet , vol.41 , pp. 1308-1312
    • Simon-Sanchez, J.1    Schulte, C.2    Bras, J.M.3
  • 36
    • 0035152814 scopus 로고    scopus 로고
    • Neurotrophins are required for nerve growth during development
    • 11135642 10.1038/82868 1:CAS:528:DC%2BD3MXitVegsQ%3D%3D
    • KL Tucker M Meyer YA Barde 2001 Neurotrophins are required for nerve growth during development Nat Neurosci 4 29 37 11135642 10.1038/82868 1:CAS:528:DC%2BD3MXitVegsQ%3D%3D
    • (2001) Nat Neurosci , vol.4 , pp. 29-37
    • Tucker, K.L.1    Meyer, M.2    Barde, Y.A.3
  • 37
    • 0030833577 scopus 로고    scopus 로고
    • Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: Implications for cerebral amyloid angiopathy
    • 9274858 1:CAS:528:DyaK2sXlvFeisL4%3D
    • B Urmoneit I Prikulis G Wihl, et al. 1997 Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy Lab Invest 77 157 166 9274858 1:CAS:528:DyaK2sXlvFeisL4%3D
    • (1997) Lab Invest , vol.77 , pp. 157-166
    • Urmoneit, B.1    Prikulis, I.2    Wihl, G.3
  • 38
    • 0029998294 scopus 로고    scopus 로고
    • Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation
    • 8799840 1:CAS:528:DyaK28XktValsrk%3D
    • U Wagner M Utton JM Gallo CC Miller 1996 Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation J Cell Sci 109 Pt 6 1537 1543 8799840 1:CAS:528:DyaK28XktValsrk%3D
    • (1996) J Cell Sci , vol.109 , Issue.PART 6 , pp. 1537-1543
    • Wagner, U.1    Utton, M.2    Gallo, J.M.3    Miller, C.C.4
  • 39
    • 33845620279 scopus 로고    scopus 로고
    • Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease
    • 17077308 10.1096/fj.06-6281com 1:CAS:528:DC%2BD28XhtFylsrnL
    • J Wang L Ho Z Zhao, et al. 2006 Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease FASEB J 20 2313 2320 17077308 10.1096/fj.06-6281com 1:CAS:528: DC%2BD28XhtFylsrnL
    • (2006) FASEB J , vol.20 , pp. 2313-2320
    • Wang, J.1    Ho, L.2    Zhao, Z.3
  • 40
    • 65249128503 scopus 로고    scopus 로고
    • Challenges in the conduct of disease-modifying trials in AD: Practical experience from a phase 2 trial of Tau-aggregation inhibitor therapy
    • 19300883 10.1007/s12603-009-0046-5 1:STN:280:DC%2BD1M3it1WgtQ%3D%3D
    • C Wischik R Staff 2009 Challenges in the conduct of disease-modifying trials in AD: practical experience from a phase 2 trial of Tau-aggregation inhibitor therapy J Nutr Health Aging 13 367 369 19300883 10.1007/s12603-009- 0046-5 1:STN:280:DC%2BD1M3it1WgtQ%3D%3D
    • (2009) J Nutr Health Aging , vol.13 , pp. 367-369
    • Wischik, C.1    Staff, R.2
  • 41
    • 0029742937 scopus 로고    scopus 로고
    • Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines
    • 8855335 10.1073/pnas.93.20.11213 1:CAS:528:DyaK28XmtVOqsLg%3D
    • CM Wischik PC Edwards RY Lai M Roth CR Harrington 1996 Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines Proc Natl Acad Sci USA 93 11213 11218 8855335 10.1073/pnas.93.20.11213 1:CAS:528:DyaK28XmtVOqsLg%3D
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11213-11218
    • Wischik, C.M.1    Edwards, P.C.2    Lai, R.Y.3    Roth, M.4    Harrington, C.R.5
  • 42
    • 0031013110 scopus 로고    scopus 로고
    • Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma
    • 9003062 10.1046/j.1471-4159.1997.68020721.x 1:CAS:528: DyaK2sXot1yktA%3D%3D
    • DS Yang JD Smith Z Zhou SE Gandy RN Martins 1997 Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma J Neurochem 68 721 725 9003062 10.1046/j.1471-4159.1997.68020721.x 1:CAS:528:DyaK2sXot1yktA%3D%3D
    • (1997) J Neurochem , vol.68 , pp. 721-725
    • Yang, D.S.1    Smith, J.D.2    Zhou, Z.3    Gandy, S.E.4    Martins, R.N.5
  • 43
    • 39549117998 scopus 로고    scopus 로고
    • Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice
    • 18272688 10.1523/JNEUROSCI.5242-07.2008 1:CAS:528:DC%2BD1cXnvVSrt7s%3D
    • A Yuan A Kumar C Peterhoff K Duff RA Nixon 2008 Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice J Neurosci 28 1682 1687 18272688 10.1523/JNEUROSCI.5242-07.2008 1:CAS:528:DC%2BD1cXnvVSrt7s%3D
    • (2008) J Neurosci , vol.28 , pp. 1682-1687
    • Yuan, A.1    Kumar, A.2    Peterhoff, C.3    Duff, K.4    Nixon, R.A.5
  • 44
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • 18215617 10.1016/j.neuron.2008.01.003 1:CAS:528:DC%2BD1cXhvVSrtrc%3D
    • BV Zlokovic 2008 The blood-brain barrier in health and chronic neurodegenerative disorders Neuron 57 178 201 18215617 10.1016/j.neuron.2008.01. 003 1:CAS:528:DC%2BD1cXhvVSrtrc%3D
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.