Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway

FEBS Letters

Volumn 585, Issue 22, 2011, Pages 3569-3576

  Kim, Hee Jin ^a   Cho, Jung Hee ^a   Quan, Hexiu ^a   Kim, Jae Ryong ^a  

^a Yeungnam University College of Medicine   (South Korea)

Author keywords

Aurora B kinase; Cellular senescence; Human primary cells; p53

Indexed keywords

AURORA B KINASE; CYCLIN A; DOXORUBICIN; PROTEIN P16; PROTEIN P53;

ARTICLE; CHROMOSOME CONDENSATION; CHROMOSOME SEGREGATION; CONTROLLED STUDY; CYTOKINESIS; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; SIGNAL TRANSDUCTION; UPREGULATION;

CELL AGING; DOWN-REGULATION; ENDOTHELIAL CELLS; FIBROBLASTS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NEOPLASM PROTEINS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 80855131512     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.10.022     Document Type: Article

References (27)

1. L. Hayflick, and P.S. Moorhead The serial cultivation of human diploid cell strains Exp. Cell Res. 25 1961 585 621
2. F. Rodier, and J. Campisi Four faces of cellular senescence J. Cell Biol. 192 2011 547 556
3. M. Collado, M.A. Blasco, and M. Serrano Cellular senescence in cancer and aging Cell 130 2007 223 233 (Pubitemid 47081143)
4. J. Campisi Cellular senescence. putting the paradoxes in perspective Curr. Opin. Genet. Dev. 21 2011 107 112
5. I. Ben-Porath, and R.A. Weinberg The signals and pathways activating cellular senescence Int. J. Biochem. Cell Biol. 37 2005 961 976 (Pubitemid 40311739)
6. S. Schmidt The centrosome and mitotic spindle apparatus in cancer and senescence Cell Cycle 9 2010 4469 4473
7. D.H. Ly, D.J. Lockhart, R.A. Lerner, and P.G. Schultz Mitotic misregulation and human aging Science 287 2000 2486 2492 (Pubitemid 30185444)
8. K. Maehara, K. Takahashi, and S. Saitoh CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses Mol. Cell. Biol. 30 2010 2090 2104
9. D. Yang, D.J. McCrann, H. Nguyen, C. St Hilaire, R.A. DePinho, M.R. Jones, and K. Ravid Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence Aging Cell 6 2007 257 260 (Pubitemid 46455069)
10. K.H. Walen Human diploid fibroblast cells in senescence; cycling through polyploidy to mitotic cells In Vitro Cell. Dev. Biol. Anim. 42 2006 216 224 (Pubitemid 44744157)
11. M. Wagner, B. Hampel, D. Bernhard, M. Hala, W. Zwerschke, and P. Jansen-Durr Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis Exp. Gerontol. 36 2001 1327 1347 (Pubitemid 32707871)
12. A.B. Mukherjee, and S. Thomas A longitudinal study of human age-related chromosomal analysis in skin fibroblasts Exp. Cell Res. 235 1997 161 169 (Pubitemid 27381694)
13. A.R. Barr, and F. Gergely Aurora-A: the maker and breaker of spindle poles J. Cell Sci. 120 2007 2987 2996 (Pubitemid 47517082)
14. H. Katayama, and S. Sen Aurora kinase inhibitors as anticancer molecules Biochim. Biophys. Acta 1799 2010 829 839
15. R.R. Adams, M. Carmena, and W.C. Earnshaw Chromosomal passengers and the (aurora) ABCs of mitosis Trends Cell Biol. 11 2001 49 54 (Pubitemid 32144751)
16. M. Carmena, S. Ruchaud, and W.C. Earnshaw Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins Curr. Opin. Cell Biol. 21 2009 796 805
17. A.A. Dar, L.W. Goff, S. Majid, J. Berlin, and W. El-Rifai Aurora kinase inhibitors-rising stars in cancer therapeutics? Mol. Cancer Ther. 9 2010 268 278
18. D. Zhang Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice Oncogene 27 2008 4305 4314 (Pubitemid 352010006)
19. J.J. Huck MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo Mol. Cancer Res. 8 2010 373 384
20. X.F. Huang Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia Blood 111 2008 2854 2865
21. J.E. Jung Survivin inhibits anti-growth effect of p53 activated by aurora B Biochem. Biophys. Res. Commun. 336 2005 1164 1171
22. K.S. Kim, Y.B. Seu, S.H. Baek, M.J. Kim, K.J. Kim, J.H. Kim, and J.R. Kim Induction of cellular senescence by insulin-like growth factor binding protein-5 through a p53-dependent mechanism Mol. Biol. Cell 18 2007 4543 4552
23. G.P. Dimri A biomarker that identifies senescent human cells in culture and in aging skin in vivo Proc. Natl. Acad. Sci. USA 92 1995 9363 9367
24. D.A. Alcorta, Y. Xiong, D. Phelps, G. Hannon, D. Beach, and J.C. Barrett Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts Proc. Natl. Acad. Sci. USA 93 1996 13742 13747 (Pubitemid 26424190)
25. S. Hauf The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint J. Cell Biol. 161 2003 281 294 (Pubitemid 36529847)
26. H. Vaziri, and S. Benchimol From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence. the telomere loss/DNA damage model of cell aging Exp. Gerontol. 31 1996 295 301 (Pubitemid 26079680)
27. S.W. Lowe Activation of p53 by oncogenes Endocr. Relat. Cancer 6 1999 45 48 (Pubitemid 29197227)