The α-amino group of the threonine substrate as the general base during tRNA aminoacylation: A new version of substrate-assisted catalysis predicted by hybrid DFT

Journal of Physical Chemistry A

Volumn 115, Issue 45, 2011, Pages 13050-13060

  Huang, Wenjuan ^a   Bushnell, Eric A C ^a   Francklyn, Christopher S ^b   Gauld, James W ^a  

^a UNIVERSITY OF WINDSOR   (Canada)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMINO GROUP; AMINOACYL TRANSFER; AMINOACYLATION; CATALYTIC MECHANISMS; CHEMICAL MODEL; DENSITY FUNCTIONALS; GENERAL BASE; HYBRID DFT; O-H BOND; PROTON ACCEPTORS; PROTONATED; RATE LIMITING; RATE-LIMITING STEPS; SUBSTRATE-ASSISTED CATALYSIS; SYNTHETASES; TETRAHEDRAL INTERMEDIATES;

AMINO ACIDS; CATALYSIS; DENSITY FUNCTIONAL THEORY; PROTONATION; PROTONS; QUANTUM CHEMISTRY;

SUBSTRATES;

THREONINE; TRANSFER RNA;

AMINOACYLATION; ARTICLE; CATALYSIS; CHEMISTRY; ENZYME ACTIVE SITE; QUANTUM THEORY;

AMINOACYLATION; CATALYSIS; CATALYTIC DOMAIN; QUANTUM THEORY; RNA, TRANSFER; THREONINE;

EID: 80855128989     PISSN: 10895639     EISSN: 15205215     Source Type: Journal    
DOI: 10.1021/jp205037a     Document Type: Article

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