RNA-assisted catalysis in a protein enzyme: The 2′-hydroxyl of tRNAThr A76 promotes aminoacylation by threonyl-tRNA synthetase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 46, 2008, Pages 17748-17753

  Minajigi, Anand ^a   Francklyn, Christopher S ^a,b  

^a UNIVERSITY OF VERMONT   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Aminoacyl tRNA synthetase; Proton relay; Threonine; Transient kinetics; Translation

Indexed keywords

RNA; THREONINE TRANSFER RNA; TRANSFER RNA;

AMINOACYLATION; ARTICLE; CATALYSIS; CONTROLLED STUDY; ESCHERICHIA COLI; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

AMINOACYLATION; CATALYSIS; CATALYTIC DOMAIN; DNA MUTATIONAL ANALYSIS; ESCHERICHIA COLI; HISTIDINE; HYDROXYL RADICAL; KINETICS; MODELS, MOLECULAR; MUTANT PROTEINS; RNA, TRANSFER, THR; THREONINE-TRNA LIGASE;

ESCHERICHIA COLI;

EID: 56649088287     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804247105     Document Type: Article

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