메뉴 건너뛰기




Volumn 25, Issue 5, 2011, Pages 967-980

The Biology of Chronic Myelogenous Leukemia Progression: Who, What, Where, and Why?

Author keywords

Blast crisis; Chronic myeloid leukemia; Genetic instability; Progression

Indexed keywords

DASATINIB; FINGOLIMOD; FORSKOLIN; HISTONE DEACETYLASE INHIBITOR; HYDROXYCHLOROQUINE; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NILOTINIB; PROTEIN FARNESYLTRANSFERASE INHIBITOR;

EID: 80755189382     PISSN: 08898588     EISSN: 15581977     Source Type: Journal    
DOI: 10.1016/j.hoc.2011.09.002     Document Type: Review
Times cited : (6)

References (80)
  • 1
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • Branford S., Rudzki Z., Walsh S., et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003, 102(1):276-283.
    • (2003) Blood , vol.102 , Issue.1 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 2
    • 23044458596 scopus 로고    scopus 로고
    • ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia
    • Soverini S., Martinelli G., Rosti G., et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 2005, 23(18):4100-4109.
    • (2005) J Clin Oncol , vol.23 , Issue.18 , pp. 4100-4109
    • Soverini, S.1    Martinelli, G.2    Rosti, G.3
  • 3
    • 34249676964 scopus 로고    scopus 로고
    • Chronic myeloid leukaemia as a model of disease evolution in human cancer
    • Melo J.V., Barnes D.J. Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer 2007, 7(6):441-453.
    • (2007) Nat Rev Cancer , vol.7 , Issue.6 , pp. 441-453
    • Melo, J.V.1    Barnes, D.J.2
  • 4
    • 77954977940 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: mechanisms of blastic transformation
    • Perrotti D., Jamieson C., Goldman J., et al. Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest 2010, 120(7):2254-2264.
    • (2010) J Clin Invest , vol.120 , Issue.7 , pp. 2254-2264
    • Perrotti, D.1    Jamieson, C.2    Goldman, J.3
  • 6
    • 33644525274 scopus 로고    scopus 로고
    • Gene expression changes associated with progression and response in chronic myeloid leukemia
    • Radich J.P., Dai H., Mao M., et al. Gene expression changes associated with progression and response in chronic myeloid leukemia. Proc Natl Acad Sci U S A 2006, 103(8):2794-2799.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.8 , pp. 2794-2799
    • Radich, J.P.1    Dai, H.2    Mao, M.3
  • 7
    • 67349123327 scopus 로고    scopus 로고
    • Chronic myeloid leukemia in Asia
    • Au W.Y., Caguioa P.B., Chuah C., et al. Chronic myeloid leukemia in Asia. Int J Hematol 2009, 89(1):14-23.
    • (2009) Int J Hematol , vol.89 , Issue.1 , pp. 14-23
    • Au, W.Y.1    Caguioa, P.B.2    Chuah, C.3
  • 8
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • Branford S., Rudzki Z., Walsh S., et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 2002, 99(9):3472-3475.
    • (2002) Blood , vol.99 , Issue.9 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 9
    • 9144264829 scopus 로고    scopus 로고
    • Imatinib produces significantly superior molecular responses compared to interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase
    • Branford S., Rudzki Z., Harper A., et al. Imatinib produces significantly superior molecular responses compared to interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Leukemia 2003, 17(12):2401-2409.
    • (2003) Leukemia , vol.17 , Issue.12 , pp. 2401-2409
    • Branford, S.1    Rudzki, Z.2    Harper, A.3
  • 10
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah N.P., Nicoll J.M., Nagar B., et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2002, 2(2):117-125.
    • (2002) Cancer Cell , vol.2 , Issue.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3
  • 11
    • 33745608455 scopus 로고    scopus 로고
    • BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance
    • Koptyra M., Falinski R., Nowicki M.O., et al. BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Blood 2006, 108(1):319-327.
    • (2006) Blood , vol.108 , Issue.1 , pp. 319-327
    • Koptyra, M.1    Falinski, R.2    Nowicki, M.O.3
  • 12
    • 14944367962 scopus 로고    scopus 로고
    • Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib mesylate treatment
    • Chu S., Xu H., Shah N.P., et al. Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib mesylate treatment. Blood 2005, 105(5):2093-2098.
    • (2005) Blood , vol.105 , Issue.5 , pp. 2093-2098
    • Chu, S.1    Xu, H.2    Shah, N.P.3
  • 13
    • 34249693090 scopus 로고    scopus 로고
    • Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells
    • Jiang X., Saw K.M., Eaves A., et al. Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells. J Natl Cancer Inst 2007, 99(9):680-693.
    • (2007) J Natl Cancer Inst , vol.99 , Issue.9 , pp. 680-693
    • Jiang, X.1    Saw, K.M.2    Eaves, A.3
  • 14
    • 0023155043 scopus 로고
    • Chronic myelogenous leukemia: amplification of a rearranged c-abl oncogene in both chronic phase and blast crisis
    • Collins S.J., Groudine M.T. Chronic myelogenous leukemia: amplification of a rearranged c-abl oncogene in both chronic phase and blast crisis. Blood 1987, 69(3):893-898.
    • (1987) Blood , vol.69 , Issue.3 , pp. 893-898
    • Collins, S.J.1    Groudine, M.T.2
  • 15
    • 0037097732 scopus 로고    scopus 로고
    • Derivative chromosome 9 deletions in chronic myeloid leukemia: poor prognosis is not associated with loss of ABL-BCR expression, elevated BCR-ABL levels, or karyotypic instability
    • Huntly B.J., Bench A.J., Delabesse E., et al. Derivative chromosome 9 deletions in chronic myeloid leukemia: poor prognosis is not associated with loss of ABL-BCR expression, elevated BCR-ABL levels, or karyotypic instability. Blood 2002, 99(12):4547-4553.
    • (2002) Blood , vol.99 , Issue.12 , pp. 4547-4553
    • Huntly, B.J.1    Bench, A.J.2    Delabesse, E.3
  • 16
    • 0042638382 scopus 로고    scopus 로고
    • Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions
    • Huntly B.J., Guilhot F., Reid A.G., et al. Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions. Blood 2003, 102(6):2205-2212.
    • (2003) Blood , vol.102 , Issue.6 , pp. 2205-2212
    • Huntly, B.J.1    Guilhot, F.2    Reid, A.G.3
  • 17
    • 0028950123 scopus 로고
    • Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene
    • Sawyers C.L., McLaughlin J., Witte O.N. Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene. J Exp Med 1995, 181(1):307-313.
    • (1995) J Exp Med , vol.181 , Issue.1 , pp. 307-313
    • Sawyers, C.L.1    McLaughlin, J.2    Witte, O.N.3
  • 18
    • 0000506439 scopus 로고    scopus 로고
    • P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members
    • Ilaria R.L., Van Etten R.A. P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem 1996, 271(49):31704-31710.
    • (1996) J Biol Chem , vol.271 , Issue.49 , pp. 31704-31710
    • Ilaria, R.L.1    Van Etten, R.A.2
  • 19
    • 0029810923 scopus 로고    scopus 로고
    • Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
    • Shuai K., Halpern J., ten Hoeve J., et al. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 1996, 13(2):247-254.
    • (1996) Oncogene , vol.13 , Issue.2 , pp. 247-254
    • Shuai, K.1    Halpern, J.2    ten Hoeve, J.3
  • 20
    • 0029063970 scopus 로고
    • Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells
    • Skorski T., Kanakaraj P., Nieborowska-Skorska M., et al. Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells. Blood 1995, 86(2):726-736.
    • (1995) Blood , vol.86 , Issue.2 , pp. 726-736
    • Skorski, T.1    Kanakaraj, P.2    Nieborowska-Skorska, M.3
  • 21
    • 0028971466 scopus 로고
    • CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells
    • Salgia R., Uemura N., Okuda K., et al. CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells. J Biol Chem 1995, 270(49):29145-29150.
    • (1995) J Biol Chem , vol.270 , Issue.49 , pp. 29145-29150
    • Salgia, R.1    Uemura, N.2    Okuda, K.3
  • 22
    • 25444488489 scopus 로고    scopus 로고
    • Bcr-Abl expression levels determine the rate of development of resistance to imatinib mesylate in chronic myeloid leukemia
    • Barnes D.J., Palaiologou D., Panousopoulou E., et al. Bcr-Abl expression levels determine the rate of development of resistance to imatinib mesylate in chronic myeloid leukemia. Cancer Res 2005, 65(19):8912-8919.
    • (2005) Cancer Res , vol.65 , Issue.19 , pp. 8912-8919
    • Barnes, D.J.1    Palaiologou, D.2    Panousopoulou, E.3
  • 23
    • 25444457705 scopus 로고    scopus 로고
    • Dose-dependent effects of Bcr-Abl in cell line models of different stages of chronic myeloid leukemia
    • Barnes D.J., Schultheis B., Adedeji S., et al. Dose-dependent effects of Bcr-Abl in cell line models of different stages of chronic myeloid leukemia. Oncogene 2005, 24(42):6432-6440.
    • (2005) Oncogene , vol.24 , Issue.42 , pp. 6432-6440
    • Barnes, D.J.1    Schultheis, B.2    Adedeji, S.3
  • 24
    • 34249988828 scopus 로고    scopus 로고
    • Role of BCR/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells
    • Modi H., McDonald T., Chu S., et al. Role of BCR/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells. Blood 2007, 109(12):5411-5421.
    • (2007) Blood , vol.109 , Issue.12 , pp. 5411-5421
    • Modi, H.1    McDonald, T.2    Chu, S.3
  • 25
    • 34250178439 scopus 로고    scopus 로고
    • From mRNA metabolism to cancer therapy: chronic myelogenous leukemia shows the way
    • Perrotti D., Neviani P. From mRNA metabolism to cancer therapy: chronic myelogenous leukemia shows the way. Clin Cancer Res 2007, 13(6):1638-1642.
    • (2007) Clin Cancer Res , vol.13 , Issue.6 , pp. 1638-1642
    • Perrotti, D.1    Neviani, P.2
  • 26
    • 62649139996 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation
    • Abrahamsson A.E., Geron I., Gotlib J., et al. Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci U S A 2009, 106(10):3925-3929.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.10 , pp. 3925-3929
    • Abrahamsson, A.E.1    Geron, I.2    Gotlib, J.3
  • 27
    • 33244477005 scopus 로고    scopus 로고
    • BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells
    • Klein F., Feldhahn N., Herzog S., et al. BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells. Oncogene 2006, 25(7):1118-1124.
    • (2006) Oncogene , vol.25 , Issue.7 , pp. 1118-1124
    • Klein, F.1    Feldhahn, N.2    Herzog, S.3
  • 28
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J., Vodyanik M.A., Smuga-Otto K., et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318(5858):1917-1920.
    • (2007) Science , vol.318 , Issue.5858 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 29
    • 67649881121 scopus 로고    scopus 로고
    • Lin28 promotes transformation and is associated with advanced human malignancies
    • Viswanathan S.R., Powers J.T., Einhorn W., et al. Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet 2009, 41(7):843-848.
    • (2009) Nat Genet , vol.41 , Issue.7 , pp. 843-848
    • Viswanathan, S.R.1    Powers, J.T.2    Einhorn, W.3
  • 30
    • 2542500611 scopus 로고    scopus 로고
    • The biology of CML blast crisis
    • Calabretta B., Perrotti D. The biology of CML blast crisis. Blood 2004, 103(11):4010-4022.
    • (2004) Blood , vol.103 , Issue.11 , pp. 4010-4022
    • Calabretta, B.1    Perrotti, D.2
  • 31
    • 0036050013 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia: mechanisms underlying disease progression
    • Shet A.S., Jahagirdar B.N., Verfaillie C.M. Chronic myelogenous leukemia: mechanisms underlying disease progression. Leukemia 2002, 16(8):1402-1411.
    • (2002) Leukemia , vol.16 , Issue.8 , pp. 1402-1411
    • Shet, A.S.1    Jahagirdar, B.N.2    Verfaillie, C.M.3
  • 32
    • 0036560577 scopus 로고    scopus 로고
    • Oncogenic tyrosine kinases and the DNA-damage response
    • Skorski T. Oncogenic tyrosine kinases and the DNA-damage response. Nat Rev Cancer 2002, 2(5):351-360.
    • (2002) Nat Rev Cancer , vol.2 , Issue.5 , pp. 351-360
    • Skorski, T.1
  • 33
    • 0036343687 scopus 로고    scopus 로고
    • Does the BCR/ABL-mediated increase in the efficacy of DNA repair play a role in the drug resistance of cancer cells?
    • Majsterek I., Blasiak J., Mlynarski W., et al. Does the BCR/ABL-mediated increase in the efficacy of DNA repair play a role in the drug resistance of cancer cells?. Cell Biol Int 2002, 26(4):363-370.
    • (2002) Cell Biol Int , vol.26 , Issue.4 , pp. 363-370
    • Majsterek, I.1    Blasiak, J.2    Mlynarski, W.3
  • 34
    • 0036261727 scopus 로고    scopus 로고
    • Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis
    • Slupianek A., Hoser G., Majsterek I., et al. Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis. Mol Cell Biol 2002, 22(12):4189-4201.
    • (2002) Mol Cell Biol , vol.22 , Issue.12 , pp. 4189-4201
    • Slupianek, A.1    Hoser, G.2    Majsterek, I.3
  • 35
    • 0034637599 scopus 로고    scopus 로고
    • The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells
    • Sattler M., Verma S., Shrikhande G., et al. The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. J Biol Chem 2000, 275(32):24273-24278.
    • (2000) J Biol Chem , vol.275 , Issue.32 , pp. 24273-24278
    • Sattler, M.1    Verma, S.2    Shrikhande, G.3
  • 36
    • 0345299213 scopus 로고    scopus 로고
    • Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations
    • Fioretos T., Strombeck B., Sandberg T., et al. Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations. Blood 1999, 94(1):225-232.
    • (1999) Blood , vol.94 , Issue.1 , pp. 225-232
    • Fioretos, T.1    Strombeck, B.2    Sandberg, T.3
  • 37
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine A.J. p53, the cellular gatekeeper for growth and division. Cell 1997, 88(3):323-331.
    • (1997) Cell , vol.88 , Issue.3 , pp. 323-331
    • Levine, A.J.1
  • 38
    • 0026788001 scopus 로고
    • Dominant negative MYC blocks transformation by ABL oncogenes
    • Sawyers C.L., Callahan W., Witte O.N. Dominant negative MYC blocks transformation by ABL oncogenes. Cell 1992, 70(6):901-910.
    • (1992) Cell , vol.70 , Issue.6 , pp. 901-910
    • Sawyers, C.L.1    Callahan, W.2    Witte, O.N.3
  • 39
    • 0020028066 scopus 로고
    • Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line
    • Collins S., Groudine M. Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line. Nature 1982, 298(5875):679-681.
    • (1982) Nature , vol.298 , Issue.5875 , pp. 679-681
    • Collins, S.1    Groudine, M.2
  • 40
    • 0035970039 scopus 로고    scopus 로고
    • Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics
    • Virtaneva K., Wright F.A., Tanner S.M., et al. Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics. Proc Natl Acad Sci U S A 2001, 98(3):1124-1129.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.3 , pp. 1124-1129
    • Virtaneva, K.1    Wright, F.A.2    Tanner, S.M.3
  • 41
    • 0142243204 scopus 로고    scopus 로고
    • Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase
    • Medina J., Kantarjian H., Talpaz M., et al. Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Cancer 2003, 98(9):1905-1911.
    • (2003) Cancer , vol.98 , Issue.9 , pp. 1905-1911
    • Medina, J.1    Kantarjian, H.2    Talpaz, M.3
  • 42
    • 0028069226 scopus 로고
    • Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia
    • Mitani K., Ogawa S., Tanaka T., et al. Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J 1994, 13(3):504-510.
    • (1994) EMBO J , vol.13 , Issue.3 , pp. 504-510
    • Mitani, K.1    Ogawa, S.2    Tanaka, T.3
  • 43
    • 9044241254 scopus 로고    scopus 로고
    • Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
    • Nakamura T., Largaespada D.A., Lee M.P., et al. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nat Genet 1996, 12(2):154-158.
    • (1996) Nat Genet , vol.12 , Issue.2 , pp. 154-158
    • Nakamura, T.1    Largaespada, D.A.2    Lee, M.P.3
  • 44
    • 0035857078 scopus 로고    scopus 로고
    • Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia
    • Cuenco G.M., Ren R. Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia. Oncogene 2001, 20(57):8236-8248.
    • (2001) Oncogene , vol.20 , Issue.57 , pp. 8236-8248
    • Cuenco, G.M.1    Ren, R.2
  • 45
    • 0037188538 scopus 로고    scopus 로고
    • A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9
    • Dash A.B., Williams I.R., Kutok J.L., et al. A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Proc Natl Acad Sci U S A 2002, 99(11):7622-7627.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.11 , pp. 7622-7627
    • Dash, A.B.1    Williams, I.R.2    Kutok, J.L.3
  • 46
    • 77955512823 scopus 로고    scopus 로고
    • Regulation of myeloid leukaemia by the cell-fate determinant Musashi
    • Ito T., Kwon H.Y., Zimdahl B., et al. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature 2010, 466(7307):765-768.
    • (2010) Nature , vol.466 , Issue.7307 , pp. 765-768
    • Ito, T.1    Kwon, H.Y.2    Zimdahl, B.3
  • 47
    • 0024538767 scopus 로고
    • Rare occurrence of N-ras point mutations in Philadelphia chromosome positive chronic myeloid leukemia
    • Collins S.J., Howard M., Andrews D.F., et al. Rare occurrence of N-ras point mutations in Philadelphia chromosome positive chronic myeloid leukemia. Blood 1989, 73(4):1028-1032.
    • (1989) Blood , vol.73 , Issue.4 , pp. 1028-1032
    • Collins, S.J.1    Howard, M.2    Andrews, D.F.3
  • 48
    • 0345560273 scopus 로고
    • Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia
    • Ahuja H., Bar-Eli M., Advani S.H., et al. Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia. Proc Natl Acad Sci U S A 1989, 86(17):6783-6787.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.17 , pp. 6783-6787
    • Ahuja, H.1    Bar-Eli, M.2    Advani, S.H.3
  • 49
    • 0028900889 scopus 로고
    • Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia
    • Sill H., Goldman J.M., Cross N.C. Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood 1995, 85(8):2013-2016.
    • (1995) Blood , vol.85 , Issue.8 , pp. 2013-2016
    • Sill, H.1    Goldman, J.M.2    Cross, N.C.3
  • 50
    • 27644569730 scopus 로고    scopus 로고
    • The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
    • Neviani P., Santhanam R., Trotta R., et al. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell 2005, 8(5):355-368.
    • (2005) Cancer Cell , vol.8 , Issue.5 , pp. 355-368
    • Neviani, P.1    Santhanam, R.2    Trotta, R.3
  • 51
    • 34547958804 scopus 로고    scopus 로고
    • High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBPalpha-driven myeloid differentiation
    • Chang J.S., Santhanam R., Trotta R., et al. High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBPalpha-driven myeloid differentiation. Blood 2007, 110(3):994-1003.
    • (2007) Blood , vol.110 , Issue.3 , pp. 994-1003
    • Chang, J.S.1    Santhanam, R.2    Trotta, R.3
  • 52
    • 0036340784 scopus 로고    scopus 로고
    • BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2
    • Perrotti D., Cesi V., Trotta R., et al. BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2. Nat Genet 2002, 30(1):48-58.
    • (2002) Nat Genet , vol.30 , Issue.1 , pp. 48-58
    • Perrotti, D.1    Cesi, V.2    Trotta, R.3
  • 53
    • 33646589342 scopus 로고    scopus 로고
    • Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy
    • Wagner K., Zhang P., Rosenbauer F., et al. Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy. Proc Natl Acad Sci U S A 2006, 103(16):6338-6343.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.16 , pp. 6338-6343
    • Wagner, K.1    Zhang, P.2    Rosenbauer, F.3
  • 54
    • 0030975671 scopus 로고    scopus 로고
    • Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    • Korinek V., Barker N., Morin P.J., et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 1997, 275(5307):1784-1787.
    • (1997) Science , vol.275 , Issue.5307 , pp. 1784-1787
    • Korinek, V.1    Barker, N.2    Morin, P.J.3
  • 55
    • 0242361176 scopus 로고    scopus 로고
    • Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta
    • Rask K., Nilsson A., Brannstrom M., et al. Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta. Br J Cancer 2003, 89(7):1298-1304.
    • (2003) Br J Cancer , vol.89 , Issue.7 , pp. 1298-1304
    • Rask, K.1    Nilsson, A.2    Brannstrom, M.3
  • 56
    • 0242551656 scopus 로고    scopus 로고
    • Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression
    • Uematsu K., He B., You L., et al. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene 2003, 22(46):7218-7221.
    • (2003) Oncogene , vol.22 , Issue.46 , pp. 7218-7221
    • Uematsu, K.1    He, B.2    You, L.3
  • 57
    • 34250004905 scopus 로고    scopus 로고
    • {beta}-Catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation
    • Guo Z., Dose M., Kovalovsky D., et al. {beta}-Catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood 2007, 109(12):5463-5472.
    • (2007) Blood , vol.109 , Issue.12 , pp. 5463-5472
    • Guo, Z.1    Dose, M.2    Kovalovsky, D.3
  • 58
    • 3943088431 scopus 로고    scopus 로고
    • Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    • Jamieson C.H., Ailles L.E., Dylla S.J., et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 2004, 351(7):657-667.
    • (2004) N Engl J Med , vol.351 , Issue.7 , pp. 657-667
    • Jamieson, C.H.1    Ailles, L.E.2    Dylla, S.J.3
  • 59
    • 7044269527 scopus 로고    scopus 로고
    • JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells
    • Passegue E., Wagner E.F., Weissman I.L. JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell 2004, 119(3):431-443.
    • (2004) Cell , vol.119 , Issue.3 , pp. 431-443
    • Passegue, E.1    Wagner, E.F.2    Weissman, I.L.3
  • 60
    • 67649383125 scopus 로고    scopus 로고
    • Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia
    • Hoshino K., Quintas-Cardama A., Radich J., et al. Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia. Leuk Res 2009, 33(10):1361-1366.
    • (2009) Leuk Res , vol.33 , Issue.10 , pp. 1361-1366
    • Hoshino, K.1    Quintas-Cardama, A.2    Radich, J.3
  • 61
    • 0026316545 scopus 로고
    • A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells
    • Hromas R., Collins S.J., Hickstein D., et al. A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. J Biol Chem 1991, 266(22):14183-14187.
    • (1991) J Biol Chem , vol.266 , Issue.22 , pp. 14183-14187
    • Hromas, R.1    Collins, S.J.2    Hickstein, D.3
  • 62
    • 0035395824 scopus 로고    scopus 로고
    • Mzf1 controls cell proliferation and tumorigenesis
    • Gaboli M., Kotsi P.A., Gurrieri C., et al. Mzf1 controls cell proliferation and tumorigenesis. Genes Dev 2001, 15(13):1625-1630.
    • (2001) Genes Dev , vol.15 , Issue.13 , pp. 1625-1630
    • Gaboli, M.1    Kotsi, P.A.2    Gurrieri, C.3
  • 63
    • 0028801328 scopus 로고
    • Overexpression of the zinc finger protein MZF1 inhibits hematopoietic development from embryonic stem cells: correlation with negative regulation of CD34 and c-myb promoter activity
    • Perrotti D., Melotti P., Skorski T., et al. Overexpression of the zinc finger protein MZF1 inhibits hematopoietic development from embryonic stem cells: correlation with negative regulation of CD34 and c-myb promoter activity. Mol Cell Biol 1995, 15(11):6075-6087.
    • (1995) Mol Cell Biol , vol.15 , Issue.11 , pp. 6075-6087
    • Perrotti, D.1    Melotti, P.2    Skorski, T.3
  • 64
    • 0037131409 scopus 로고    scopus 로고
    • Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression
    • Guaita S., Puig I., Franci C., et al. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem 2002, 277(42):39209-39216.
    • (2002) J Biol Chem , vol.277 , Issue.42 , pp. 39209-39216
    • Guaita, S.1    Puig, I.2    Franci, C.3
  • 65
    • 8344280283 scopus 로고    scopus 로고
    • Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts
    • Le Mee S., Fromigue O., Marie P.J. Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts. Exp Cell Res 2005, 302(1):129-142.
    • (2005) Exp Cell Res , vol.302 , Issue.1 , pp. 129-142
    • Le Mee, S.1    Fromigue, O.2    Marie, P.J.3
  • 66
    • 1942469421 scopus 로고    scopus 로고
    • Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells
    • Miyoshi A., Kitajima Y., Sumi K., et al. Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer 2004, 90(6):1265-1273.
    • (2004) Br J Cancer , vol.90 , Issue.6 , pp. 1265-1273
    • Miyoshi, A.1    Kitajima, Y.2    Sumi, K.3
  • 67
    • 0036723652 scopus 로고    scopus 로고
    • I-Mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways
    • Kusano S., Raab-Traub N. I-Mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. Mol Cell Biol 2002, 22(18):6393-6405.
    • (2002) Mol Cell Biol , vol.22 , Issue.18 , pp. 6393-6405
    • Kusano, S.1    Raab-Traub, N.2
  • 68
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-catenin, and cadherin pathways
    • Nelson W.J., Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004, 303(5663):1483-1487.
    • (2004) Science , vol.303 , Issue.5663 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 69
    • 43049139905 scopus 로고    scopus 로고
    • BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
    • Mullighan C.G., Miller C.B., Radtke I., et al. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 2008, 453(7191):110-114.
    • (2008) Nature , vol.453 , Issue.7191 , pp. 110-114
    • Mullighan, C.G.1    Miller, C.B.2    Radtke, I.3
  • 70
    • 70350090181 scopus 로고    scopus 로고
    • Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a retrospective analysis
    • Gratwohl A., Stern M., Brand R., et al. Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a retrospective analysis. Cancer 2009, 115(20):4715-4726.
    • (2009) Cancer , vol.115 , Issue.20 , pp. 4715-4726
    • Gratwohl, A.1    Stern, M.2    Brand, R.3
  • 71
    • 64749091867 scopus 로고    scopus 로고
    • Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    • Zhao C., Chen A., Jamieson C.H., et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009, 458(7239):776-779.
    • (2009) Nature , vol.458 , Issue.7239 , pp. 776-779
    • Zhao, C.1    Chen, A.2    Jamieson, C.H.3
  • 72
    • 43049112747 scopus 로고    scopus 로고
    • Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias
    • Perrotti D., Neviani P. Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias. Cancer Metastasis Rev 2008, 27(2):159-168.
    • (2008) Cancer Metastasis Rev , vol.27 , Issue.2 , pp. 159-168
    • Perrotti, D.1    Neviani, P.2
  • 73
    • 41949088658 scopus 로고    scopus 로고
    • BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors
    • Copland M., Pellicano F., Richmond L., et al. BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors. Blood 2008, 111(5):2843-2853.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2843-2853
    • Copland, M.1    Pellicano, F.2    Richmond, L.3
  • 74
    • 42049086836 scopus 로고    scopus 로고
    • BCR/ABL, DNA damage and DNA repair: implications for new treatment concepts
    • Skorski T. BCR/ABL, DNA damage and DNA repair: implications for new treatment concepts. Leuk Lymphoma 2008, 49(4):610-614.
    • (2008) Leuk Lymphoma , vol.49 , Issue.4 , pp. 610-614
    • Skorski, T.1
  • 75
    • 0038092769 scopus 로고    scopus 로고
    • Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority
    • Bumm T., Muller C., Al-Ali H.K., et al. Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority. Blood 2003, 101(5):1941-1949.
    • (2003) Blood , vol.101 , Issue.5 , pp. 1941-1949
    • Bumm, T.1    Muller, C.2    Al-Ali, H.K.3
  • 76
    • 0345382731 scopus 로고    scopus 로고
    • Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate
    • O'Dwyer M.E., Gatter K.M., Loriaux M., et al. Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate. Leukemia 2003, 17(3):481-487.
    • (2003) Leukemia , vol.17 , Issue.3 , pp. 481-487
    • O'Dwyer, M.E.1    Gatter, K.M.2    Loriaux, M.3
  • 77
    • 0028786297 scopus 로고
    • Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals
    • Biernaux C., Loos M., Sels A., et al. Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals. Blood 1995, 86(8):3118-3122.
    • (1995) Blood , vol.86 , Issue.8 , pp. 3118-3122
    • Biernaux, C.1    Loos, M.2    Sels, A.3
  • 78
    • 0032211172 scopus 로고    scopus 로고
    • The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease
    • Bose S., Deininger M., Gora-Tybor J., et al. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood 1998, 92(9):3362-3367.
    • (1998) Blood , vol.92 , Issue.9 , pp. 3362-3367
    • Bose, S.1    Deininger, M.2    Gora-Tybor, J.3
  • 79
    • 70350451078 scopus 로고    scopus 로고
    • The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data
    • Oehler V.G., Yeung K.Y., Choi Y.E., et al. The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data. Blood 2009, 114(15):3292-3298.
    • (2009) Blood , vol.114 , Issue.15 , pp. 3292-3298
    • Oehler, V.G.1    Yeung, K.Y.2    Choi, Y.E.3
  • 80
    • 60149093892 scopus 로고    scopus 로고
    • Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia using a novel nanofluidic platform and mutation-specific PCR
    • Oehler V.G., Qin J., Ramakrishnan R., et al. Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia using a novel nanofluidic platform and mutation-specific PCR. Leukemia 2009, 23(2):396-399.
    • (2009) Leukemia , vol.23 , Issue.2 , pp. 396-399
    • Oehler, V.G.1    Qin, J.2    Ramakrishnan, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.