Citrus grandis peel increases the bioavailability of cyclosporine and tacrolimus, two important immunosuppressants, in rats

Journal of Medicinal Food

Volumn 14, Issue 11, 2011, Pages 1463-1468

  Lin, Shiuan Pey ^a   Chao, Pei Dawn Lee ^a   Tsai, Shang Yuan ^a   Wang, Meng Ju ^a   Hou, Yu Chi ^a,b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Citrus grandis; cyclosporine; cytochrome P 450 3A4; drug interaction; P glycoprotein; tacrolimus

Indexed keywords

CITRUS GRANDIS EXTRACT; CYCLOSPORIN; CYTOCHROME P450 3A4; GLYCOPROTEIN P; PLANT EXTRACT; TACROLIMUS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; ENZYME INHIBITION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PUMMELO; RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CITRUS; CYCLOSPORINE; CYTOCHROME P-450 ENZYME SYSTEM; FLUORESCENCE POLARIZATION IMMUNOASSAY; IMMUNOSUPPRESSIVE AGENTS; MALE; P-GLYCOPROTEIN; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TACROLIMUS;

CITRUS MAXIMA; RATTUS;

EID: 80755182297     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2011.1596     Document Type: Article

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