ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1

Neuro-Oncology

Volumn 13, Issue 11, 2011, Pages 1202-1212

  Day, Bryan W ^a,b   Stringer, Brett W ^a   Spanevello, Mark D ^a,b   Charmsaz, Sara ^a   Jamieson, Paul R ^a   Ensbey, Kathleen S ^a   Carter, Jacinta C ^a   Cox, Joanne M ^a   Ellis, Vicky J ^c   Brown, Christopher L ^c   Walker, David G ^d   Inglis, Po L ^e   Allan, Suzanne ^a,e   Reynolds, Brent A ^f   Lickliter, Jason D ^a   Boyd, Andrew W ^a,b  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c GRIFFITH UNIVERSITY   (Australia)

^d BrizBrain and Spine Research Foundation   (Australia)

^e ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^f UNIVERSITY OF FLORIDA   (United States)

Author keywords

Apoptosis; ELK4; Glioblastoma; Glioma; Mcl 1

Indexed keywords

PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; TRANSCRIPTION FACTOR ELK 4;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BINDING SITE; CANCER CHEMOTHERAPY; CELL SURVIVAL; DOWN REGULATION; GLIOBLASTOMA; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ANIMALS; APOPTOSIS; BASE SEQUENCE; BCL-X PROTEIN; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ETS-DOMAIN PROTEIN ELK-4; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; LUCIFERASES; MICE; MICE, INBRED NOD; MICE, SCID; MOLECULAR SEQUENCE DATA; NEOPLASM GRADING; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-BCL-2; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 80755159034     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nor119     Document Type: Article

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