Sex differences in sleep after a single oral morning dose of olanzapine in healthy volunteers

Human Psychopharmacology

Volumn 26, Issue 7, 2011, Pages 498-507

  Giménez, Sandra ^a,b,c   Romero, Sergio ^d,e   Gich, Ignasi ^a,b,c,f   Clos, Susana ^a,b,c   Grasa, Eva ^a,b,c   Rosa Mariáa, Antonijoan ^a,b,c,f   Barbanoj, Manuel José ^a,b,c,f  

^a Institut de Recerca de l'Hscsp   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^d UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

^e BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^f HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

healthy volunteers; olanzapine; schizophrenia; sex differences; sleep; spectral analysis

Indexed keywords

OLANZAPINE; PLACEBO;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; ELECTROENCEPHALOGRAPHY; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPNOSIS; MALE; MAXIMUM PLASMA CONCENTRATION; MORNING DOSAGE; NORMAL HUMAN; PHARMACODYNAMICS; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REM SLEEP; SEX DIFFERENCE; SINGLE DRUG DOSE; SLEEP; SLOW WAVE SLEEP; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ADULT; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; MALE; POLYSOMNOGRAPHY; SEX FACTORS; SLEEP; YOUNG ADULT;

EID: 80755153163     PISSN: 08856222     EISSN: 10991077     Source Type: Journal    
DOI: 10.1002/hup.1232     Document Type: Article

References (40)

1. Abel KM, Drake R, Goldstein JM,. 2010. Sex differences in schizophrenia. Int Rev Psychiatr 22 (5): 417-28.
2. Aeschbach D, Borbély AA,. 1993. All night dynamics of the human sleep EEG. J Sleep Res 2: 70-81. (Pubitemid 23203432)
3. Benson KL, Faull KF, Zarcone VP,. 1991. Evidence for the role of serotonin in the regulation of slow wave sleep in schizophrenia. Sleep 14: 133-139.
4. Cohrs S,. 2008. Sleep disturbances in patients with schizophrenia: impact and effect of antipsychotics. CNS Drugs 22: 939-962.
5. Cosgrove KP, Mazure CM, Staley JK,. 2007. Evolving knowledge of sex differences in brain structure, function and. Biol Psychiat 62 (8): 847-855. (Pubitemid 47488220)
6. Davies W, Wilkinson LS,. 2006. It is not all hormones: alternative explanations for sexual differentiation of the brain. Brain Res 1126: 36-45. (Pubitemid 44895536)
7. Dijk DJ,. 2010. Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep. J Psychopharmacol 24: 1613-1618.
8. Feinberg I, Floyd TC,. 1979. Systematic trends across the night in human sleep cycles. Psychophysiology 16: 282-291.
9. Gex-Fabry M, Balant-Gorgia AE, Balant LP,. 2003. Therapeutic drug monitoring of olanzapine: the combined effect of age, gender, smoking and comedication. Ther Drug Monit 25: 46-53. (Pubitemid 36139825)
10. Goldstein JM, Cohen LS, Horton NJ, et al,. 2002. Sex differences in clinical response to olanzapine compared with haloperidol. Psychiatr Res 111: 27-37. (Pubitemid 34451094)
11. Görder R, Aldenhoff JB, Boigs M, et al,. 2006. Delta power in sleep in relation to neuropsychological performance in healthy subjects and schizophrenia patients. J Neuropsychiatr Clin Neurosci 18 (4): 529-535. (Pubitemid 44713892)
12. Howard CH, Fiedosewicz H, Patel C, et al,. 2001. Treatment response and gender in patients with schizophrenia and schizoaffective disorder. Schizophr Res 49: 232.
13. Kassahun K, Mattiuz E, Nyhart EJ, et al,. 1997. Disposition and biotransformation of the antipsychotic agent olanzapine in humans. Drug Metab Dispos 25: 81-93. (Pubitemid 27045138)
14. Kelly DL, Conley RR, Tamminga CA,. 1999. Differential olanzapine plasma concentrations by sex in a fixed-dose study. Schizophr Res 40: 101-104. (Pubitemid 29494233)
15. Labelle A, Light M, Dunbar F,. 2001. Risperidone treatment of outpatients with schizophrenia: no evidence of sex differences in treatment response. Can J Psychiatr 46: 534-541. (Pubitemid 32861420)
16. Lankford DA, Corser BC, Zheng YP, et al,. 2008. Effect of gaboxadol on sleep in adult and elderly patients with primary insomnia: results from two randomized, placebo-controlled, 30-night polysomnography studies. Sleep 31: 1359-1370.
17. 2C receptor gene (HTR2C). Genomics 27: 274-279.
18. 2C Cys23 Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses. Biol Psychiatr 46: 821-826. (Pubitemid 29460909)
19. Latta F, Leproult R, Tasali E, et al,. 2005. Sex differences in delta and alpha EEG activities in healthy older adults. Sleep 28: 1525-1534. (Pubitemid 41747080)
20. Lavalaye J, Booij J, Reneman L, et al,. 2000. Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers. Eur J Nucl Med 27: 867-869. (Pubitemid 30456771)
21. Li H, Huguenard JR, Fisher RS,. 2007. Gender and age differences in expression of GABAA receptor subunits in rat somatosensory thalamus and cortex in an absence epilepsy model. Neurobiol Dis 25: 623-630.
22. Lindberg N, Virkkunen M, Tani P, et al,. 2002. Effect of a single-dose of olanzapine on sleep in healthy females and males. Int Clin Psychopharmacol 17: 177-184. (Pubitemid 34686788)
23. Lipkovich I, Deberdt W, Csernansky JG, et al,. 2007. Predictors of risk for relapse in patients with schizophrenia or schizoaffective disorder during olanzapine drug therapy. J Psychiatric Res 41: 305-310. (Pubitemid 44854999)
24. Müller MJ, Regenbogen B, Sachse J, et al,. 2006. Gender aspects in the clinical treatment of schizophrenic inpatients with amisulpride: a therapeutic drug monitoring study. Pharmacopsychiatr 39: 41-46.
25. Murck H, Nickel T, Künzel H, et al,. 2003. State markers of depression in sleep EEG: dependency on drug and gender in patients treated with tianeptine or paroxetine. Neuropsychopharmacology 28: 348-358.
26. 1A receptor binding potential measured by PET using [C-11]WAY-100635. Brain Res 954: 173-182. (Pubitemid 35284657)
27. Paterson LM, Nutt DJ, Wilson SJ,. 2011. Sleep and its disorders in translational medicine. J Psychopharmacol. DOI: 10.1177/0269881111400643
28. Pinals DA, Malhotra AK, Missar CD, et al,. 1996. Lack of gender differences in neuroleptic response in patients with schizophrenia. Schizophr Res 22: 215-222. (Pubitemid 27019288)
29. Rechtschaffen A, Kales A,. 1968. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. U.S. Government Printing Office: Washington, DC.
30. Roehrs T, Kapke A, Roth T, et al,. 2006. Sex differences in polysomnographic sleep of young adults: a community-based study. Sleep Med 7: 49-53. (Pubitemid 43033545)
31. Schwartz JB,. 2003. The influence of sex on pharmacokinetics. Clin Pharmacokinet 43: 107-121. (Pubitemid 36188552)
32. Seeman MV,. 2004. Gender differences in the prescribing of antipsychotic drugs. Am J Psychiatr 161: 1324-1333. (Pubitemid 38989084)
33. Sharpley AL, Solomon RA, Fernando AI, et al,. 1990. Dose-related effects of selective 5-HT2 receptor antagonists on slow wave sleep in humans. Psychopharmacology 101: 568-569. (Pubitemid 20220053)
34. Sharpley AL, Elliott JM, Attenburrow MJ, et al,. 1994. Slow wave sleep in humans: role of 5-HTA and 5HT2C receptors. Neuropharmacology 33: 467-471.
35. 2C receptor (HT2RC) and the increase in slow wave sleep produced by olanzapine. Psychopharmacology 153: 271-272. (Pubitemid 32127899)
36. Smith S,. 2010a. Gender differences in antipsychotic prescribing. Int Rev Psychiatr 22 (5): 472-84.
37. Smith M,. 2010b. Gender differences in antipsychotic prescribing. Int Rev Psychiatr 22 (5): 472-84.
38. Staner L, Haba J, Granier LA, et al,. 2002. Comparison of the effects on sleep EEG of morning versus evening administration of olanzapine: a placebo- controlled study in healthy volunteers (abstract). Eur Neuropsychopharmacol 12: S326.
39. Szymanski S, Lieberman J, Pollack S, et al,. 1996. Gender differences in neuroleptic -nonresponsive clozapine-treatment schizophrenics. Biol Psychiatr 39: 249-254. (Pubitemid 26083148)
40. Usall J, Suarez D, Haro JM, SOHO Study Group. 2007. Gender differences in response to antipsychotic treatment in outpatients with schizophrenia. Psychiatr Res 153: 225-231. (Pubitemid 47632800)