HTR2C Cys23Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses

Biological Psychiatry

Volumn 46, Issue 6, 1999, Pages 821-826

  Lappalainen, Jaakko ^a   Long, Jeffrey C ^a   Virkkunen, Matti ^b   Ozaki, Norio ^a   Goldman, David ^a   Linnoila, Markku ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

5 HT2C receptors; Alcoholism; MHPG; Polymorphism; Serotonin

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 5 HYDROXYINDOLEACETIC ACID; BRAIN MONOAMINE; DOPAMINE; HOMOVANILLIC ACID; NORADRENALIN; SEROTONIN; SEROTONIN 2C RECEPTOR;

5 HYDROXYINDOLEACETIC ACID BRAIN LEVEL; ADULT; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOAMINE METABOLISM; NORADRENALIN BRAIN LEVEL; PRIORITY JOURNAL; SEROTONIN BRAIN LEVEL;

ALCOHOLISM; BIOGENIC MONOAMINES; BRAIN; DOPAMINE; GENES; GENOTYPE; HOMOVANILLIC ACID; HUMANS; HYDROXYINDOLEACETIC ACID; MALE; MENTAL DISORDERS; METHOXYHYDROXYPHENYLGLYCOL; NOREPINEPHRINE; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; RECEPTORS, SEROTONIN;

EID: 0032871036     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00361-8     Document Type: Article

References (27)

1. Aulakh C.S., Hill J.L., Murphy D. Effects of various serotonin receptor subtype selective agonists alone and on m-chlorophenylpiperazine induced neuroendocrine changes in rats. J Pharm Exp Ther. 263:1992;588-595.
2. rd edition rev. 1987;American Psychiatric Press, Washington, DC.
3. Bagdy G., Kalogeras K.T., Szemeredi T. Effect of 5-HT1C and 5-HT2 receptor stimulation on excessive grooming, penile erection and plasma oxytocin concentrations. Eur J Pharmacol. 229:1992;9-14.
4. Ballenger J.C., Goodwin F.L., Major L.F., Brown G.L. Alcohol and central serotonin in man. Arch Gen Psychiatry. 36:1979;224-227.
5. Blandina B., Goldfarb J., Walcott J., Green J.P. Serotonergic modulation of the release of endogenous norepinephrine from rat hypothalamic slices. J Pharm Exp Ther. 256:1991;341-347.
6. Charney D.S., Woods S., Nagy L., Southwick S.M., Krystal J.H., Heninger G.R. Noradrenergic function in panic disorder. J Clin Psychiatry. 51:1990;5-11.
7. Chiang G., Aston-Jones G. A 5-hydroxytryptamine2 agonist augments gamma-aminobutyric acid and amino acid inputs to noradrenergic locus coeruleus neurons. Neuroscience. 54:1993;409-420.
8. Cloninger R.C. Neurogenetic adaptive mechanisms in alcoholism. Science. 236:1987;410-416.
9. Done C.J.G., Sharp T. Biochemical evidence for the regulation of central noradrenergic activity by 5-HT1A and 5-HT2 receptors Microdialysis studies in the awake and anesthetized rat . Neuropharmacology. 33:1994;411-421.
10. George T.D., Benkelfat C., Rawlings R.R., Eckart M.J., Nutt D.J., Wynne D., et al. Behavioral and neuroendocrine responses to m-chlorophenylpiperazine in subtypes of alcoholics and healthy comparison subjects. Am J Psychiatry. 154:1997;81-87.
11. Higley J.D., Suomi S.J., Linnoila M. A nonhuman primate model of type II alcoholism? Part I. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations correlate with excessive alcohol consumption. Alcohol Clin Exp Res. 20:1996;629-642.
12. Jonsson E.G., Nothen M.M., Gustavsson P., Neidt H., Bunzel R., Propping P., et al. Polymorphism in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to monoamine metabolite concentrations in CSF of healthy volunteers. Psychiatry Research. 79:1998;1-9.
13. Kahn R.S., Wetzler S. m-Chlorophenylpiperazine as a probe of serotonin function. Biol Psychiatry. 30:1991;1139-1166.
14. King B.H., Brazell C., Dourish C.T., Middlemiss D.N. MK-212 increases rat plasma ACTH concentrations by activation of the 5-HT1C receptor subtype. Neurosci Lett. 105:1989;174-176.
15. Kopin I.J. Cathecholamine metabolism Basic aspects and clinical significance . Pharm Rev. 37:1985;333-364.
16. Krystal J.H., Webb E., Cooney N., Kranzler H.R., Charney D.S. Specificity of ethanol like effects elicted by serotonergic and noradrenergic mechanisms. Arch Gen Psychiatry. 51:1994;898-911.
17. Lappalainen J., Zhang L., Dean M., Oz M., Ozaki N., Yu D., et al. Identification, expression and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2C receptor gene (HTR2C). Genomics. 27:1995;274-279.
18. Linnoila M., Virkkunen M., Scheinin M., Nuutila A., Rimon R., Goodwin F.K. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci. 33:1983;2609-2614.
19. Moss H.B., Yao J.K., Panzak G.L. Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse. Biol Psychiatry. 28:1990;325-338.
20. Oxenstierna G., Edman G., Iselius L., Oreland L., Ross S.B., Sedvall G. Concentrations of monoamine metabolites in the cerebrospinal fluid in twins and unrelated individuals - a genetic study. J Psychiatr Res. 20:1986;19-29.
21. Pompeiano M., Palacios J.M., Mengod G. Distribution of the serotonin 5-HT2 receptor family Comparison between 5-HT2A and 5-HT2C receptors . Molecular Brain Res. 23:1994;163-178.
22. Redmond D.E. Jr, Katz M.M., Maas J.W., Swann A., Casper R., Davis J.M. Cerebrospinal fluid amine metabolites. Relationship with behavioral measurements in depressed, manic, and healthy control subjects. Arch Gen Psychiatry. 43:1986;938-947.
23. Scheinin M., Chang W.H., Kirk K.L., Linnoila M. Simultaneous determination of 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detection. Anal Biochem. 131:1983;246-253.
24. Snedecor G.W., Cochran W.G. Statistical Methods. 8th edition. 1989;Iowa State University Press, Ames, Iowa.
25. Strombom U., Krotkiewski M., Blennow K., Mansson J-E., Ekman R., Bjorntorp P. The concentrations of monoamine metabolites and neuropeptides in the cerebrospinal fluid of obese women with different body fat distribution. Int J Obesity and Rel Metabolic Disorders. 20:1996;361-368.
26. Svensson T. Peripheral, autonomic regulation of locus coeruleus noradrenergic neurons in brain Putative implications for psychiatry and psychopharmacology . Psychopharmacology. 92:1987;1-7.
27. Virkkunen M., Nuutila A., Goodwin F.K., Linnoila M. Cerebrospinal fluid monoamine metabolites in male arsonists. Arch Gen Psychiatry. 44:1987;241-247.