Differential olanzapine plasma concentrations by sex in a fixed-dose study

Schizophrenia Research

Volumn 40, Issue 2, 1999, Pages 101-104

  Kelly, Deanna L ^a   Conley, Robert R ^a   Tamminga, Carol A ^a  

^a MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

Atypical antipsychotic; Olanzapine; Plasma concentration; Sex

Indexed keywords

CYTOCHROME P450 ISOENZYME; LORAZEPAM; OLANZAPINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG METABOLISM; FEMALE; HUMAN; INTRAARTICULAR DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHIZOPHRENIA; SEX DIFFERENCE; STEADY STATE;

ADULT; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; PIRENZEPINE; RANDOMIZED CONTROLLED TRIALS; SCHIZOPHRENIA; SEROTONIN UPTAKE INHIBITORS; SEX FACTORS;

EID: 0032742782     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(99)00053-5     Document Type: Article

References (9)

1. Conley R.R., Tamminga C.A., Bartko J.J., et al. Olanzapine compared with chlorpromazine in treatment-resistant schizophrenia. Am. J. Psychiatry. 155:1998;914-920.
2. Ereshefsky L., Saklad S.R., Watanabe M.D., et al. Thiothixene pharmacokinetic interactions: a study of hepatic enzyme inducers clearance inhibitors, and demographic variables. J. Clin. Psychopharmacol. 11:1991;296-301.
3. Miller D.D., Fleming F., Holman T.L., et al. Plasma clozapine concentrations as a predictor of clinical response: a follow-up study. J. Clin. Psychiatry. 55:1994;117-121.
4. Perry J.P., Sanger T., Beasley C. Olanzapine plasma concentrations and clinical response in acutely ill schizophrenic patients. J. Clin. Psychopharmacol. 17:1997;472-477.
5. Pollock B. Gender differences in psychotropic drug metabolism. Psychopharmacol. Bull. 33:(2):1997;235-241.
6. Seeman M.V. Interaction of sex, age and neuroleptic dose. Compr. Psychiatry. 24:1983;125-128.
7. Simpson G.M., Yadalam K.G., Levinson D.F., et al. Single dose pharmacokinetics of fluphenazine after fluphenazine decanoate administration. J. Clin. Psychopharmacol. 10:1990;417-421.
8. Szymanski S., Lieberman J., Pollack S., et al. Gender differences in neuroleptic-nonresponsive clozapine-treatment schizophrenics. Biol. Psychiatry. 39:1996;249-254.
9. Yonkers K.A., Kando J.C., Cole J.O., et al. Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication. Am. J. Psychiatry. 14:(5):1992;587-595.