Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep

Journal of Psychopharmacology

Volumn 24, Issue 11, 2010, Pages 1613-1618

  Dijk, D J ^a   James, L M ^a   Peters, S ^a   Walsh, J K ^b,c   Deacon, S ^d  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b St Lukes Hospital   (United States)

^c SAINT LOUIS UNIVERSITY   (United States)

^d H LUNDBECK A S   (Denmark)

Author keywords

EEG power spectra; GABA; GABAA receptor; gaboxadol; gender differences; hypnotics; neurosteroids; zolpidem

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; GABOXADOL; NEUROSTEROID; ZOLPIDEM;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DELTA RHYTHM; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG RECEPTOR BINDING; ELECTROENCEPHALOGRAM; FEMALE; HUMAN; HUMAN EXPERIMENT; INSOMNIA; MALE; NEUROMODULATION; NONREM SLEEP; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR AFFINITY; REM SLEEP; SEX DIFFERENCE; SLEEP SPINDLE; THETA RHYTHM;

ADOLESCENT; ADULT; CROSS-OVER STUDIES; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; ISOXAZOLES; MALE; MIDDLE AGED; PYRIDINES; RECEPTORS, GABA-A; SEX FACTORS; SLEEP; SLEEP STAGES; SLEEP, REM; YOUNG ADULT;

EID: 78650080287     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881109105788     Document Type: Article

References (24)

1. Brown, N., Kerby, J., Bonnert, TP, Whiting, PJ, Wafford, KA (2002) Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. Br J Pharmacol 136: 965-974.
2. Carrier, J., Land, S., Buysse, DJ, Kupfer, DJ, Monk, TH (2001) The effects of age and gender on sleep EEG power spectral density in the middle years of life (ages 20-60 years old). Psychophysiology 38: 232-242.
3. Cosgrove, KP, Mazure, CM, Staley, JK (2007) Evolving knowledge of sex differences in brain structure, function, and chemistry. Biol Psychiatry 62: 847-855.
4. Dijk, DJ (2006) Sleep of aging women and men: back to basics. Sleep 29: 12-13.
5. Dijk, DJ, Beersma, DG, Bloem, GM (1989) Sex differences in the sleep EEG of young adults: visual scoring and spectral analysis. Sleep 12: 500-507.
6. Driver, HS, Dijk, DJ, Werth, E., Biedermann, K., Borbely, AA (1996) Sleep and the sleep electroencephalogram across the menstrual cycle in young healthy women. J Clin Endocrinol Metab 81: 728-735.
7. Ebert, B., Wafford, KA, Deacon, S. (2006) Treating insomnia: current and investigational pharmacological approaches. Pharmacol Ther 112: 612-629.
8. Gonzalez-Flores, O., Sanchez, N., Garcia-Juarez, M., Lima-Hernandez, FJ, Gonzalez-Mariscal, G., Beyer, C. (2004) Estradiol and testosterone modulate the anesthetic action of the GABA-A agonist THIP, but not of the neurosteroid 3alpha,5beta-pregnanolone in the rat. Psychopharmacology (Berl) 172: 283-290.
9. Groeger, JA, Zijlstra, FR, Dijk, DJ (2004) Sleep quantity, sleep difficulties and their perceived consequences in a representative sample of some 2000 British adults. J Sleep Res 13: 359-371.
10. Gulinello, M., Gong, QH, Li, X., Smith, SS (2001) Short-term exposure to a neuroactive steroid increases alpha4 GABA(A) receptor subunit levels in association with increased anxiety in the female rat. Brain Res 910: 55-66.
11. Gulinello, M., Gong, QH, Smith, SS (2003) Progesterone withdrawal increases the anxiolytic actions of gaboxadol: role of alpha4beta-delta GABA(A) receptors. Neuroreport 14: 43-46.
12. Gulinello, M., Smith, SS (2003) Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats. J Pharmacol Exp Ther 305: 541-548.
13. Herd, MB, Belelli, D., Lambert, JJ (2007) Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors. Pharmacol Ther 116: 20-34.
14. Lancel, M. (1999) Role of GABAA receptors in the regulation of sleep: initial sleep responses to peripherally administered modulators and agonists. Sleep 22: 33-42.
15. Lankford, DA, Corser, BC, Zheng, YP, Li, Z., Snavely, DB, Lines, CR, et al. (2008) Effect of gaboxadol on sleep in adult and elderly patients with primary insomnia: results from two randomized, placebo-controlled, 30-night polysomnography studies. Sleep 31: 1359-1370.
16. Latta, F., Leproult, R., Tasali, E., Hofmann, E., Van, CE (2005) Sex differences in delta and alpha EEG activities in healthy older adults. Sleep 28: 1525-1534.
17. Li, H., Huguenard, JR, Fisher, RS (2007) Gender and age differences in expression of GABAA receptor subunits in rat somatosensory thalamus and cortex in an absence epilepsy model. Neurobiol Dis 25: 623-630.
18. Mongrain, V., Carrier, J., Dumont, M. (2005) Chronotype and sex effects on sleep architecture and quantitative sleep EEG in healthy young adults. Sleep 28: 819-827.
19. Morlock, RJ, Tan, M., Mitchell, DY (2006) Patient characteristics and patterns of drug use for sleep complaints in the United States: analysis of National Ambulatory Medical Survey data, 1997-2002. Clin Ther 28: 1044-1053.
20. Rudolph, U., Mohler, H. (2006) GABA-based therapeutic approaches: GABAA receptor subtype functions. Curr Opin Pharmacol 6: 18-23.
21. Salva, P., Costa, J. (1995) Clinical pharmacokinetics and pharmacodynamics of zolpidem. Therapeutic implications. Clin Pharmacokinet 29: 142-153.
22. Smith, SS, Shen, H., Gong, QH, Zhou, X. (2007) Neurosteroid regulation of GABA(A) receptors: focus on the alpha4 and delta subunits. Pharmacol Ther 116: 58-76.
23. Walsh, JK, Deacon, S., Dijk, DJ, Lundahl, J. (2007) The selective extrasynaptic GABAA agonist, gaboxadol, improves traditional hypnotic efficacy measures and enhances slow wave activity in a model of transient insomnia. Sleep 30: 593-602.
24. Winsky-Sommerer, R., Vyazovskiy, VV, Homanics, GE, Tobler, I. (2007) The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A)delta-subunit-containing receptors. Eur J Neurosci 25: 1893-1899.