메뉴 건너뛰기




Volumn 37, Issue 3, 2011, Pages 228-241

Distinct pathological patterns in relapsing-remitting and chronic models of experimental autoimmune enchephalomyelitis and the neuroprotective effect of glatiramer acetate

Author keywords

Axonal damage; Experimental autoimmune encephalomyelitis (EAE); Glatiramer acetate (GA); Motor neuron loss; Multiple sclerosis (MS); Remyelination

Indexed keywords

GLATIRAMER; MYELIN;

EID: 80755139618     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2011.06.003     Document Type: Article
Times cited : (77)

References (50)
  • 2
    • 53049085062 scopus 로고    scopus 로고
    • Mechanisms of Inflammation induced tissue injury in multiple sclerosis
    • Lassmann H. Mechanisms of Inflammation induced tissue injury in multiple sclerosis. J Neurol Sci 2008, 274:45-47.
    • (2008) J Neurol Sci , vol.274 , pp. 45-47
    • Lassmann, H.1
  • 3
    • 46749151850 scopus 로고    scopus 로고
    • The immunology of multiple sclerosis: disease mechanisms and therapeutic targets
    • Holmoy T. The immunology of multiple sclerosis: disease mechanisms and therapeutic targets. Minerva Med 2008, 99:119-140.
    • (2008) Minerva Med , vol.99 , pp. 119-140
    • Holmoy, T.1
  • 5
  • 6
    • 48249139449 scopus 로고    scopus 로고
    • Multiple Sclerosis an immune or neurodegenerative disease
    • Trapp B.D., Nave K.A. Multiple Sclerosis an immune or neurodegenerative disease. Annu Rev Neurosci 2008, 31:247-269.
    • (2008) Annu Rev Neurosci , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 7
    • 80755138257 scopus 로고    scopus 로고
    • Evidence for primary neurodegeneration in MS
    • Bruck W. Evidence for primary neurodegeneration in MS. Mult Scler 2008, 9-13. Supp1.
    • (2008) Mult Scler , Issue.SUPP. 1 , pp. 9-13
    • Bruck, W.1
  • 8
    • 77955659717 scopus 로고    scopus 로고
    • Neurodegeneration in autoimmune CNS inflammation
    • Herz J., Zipp F., Siffrin V. Neurodegeneration in autoimmune CNS inflammation. Exp Neurol 2009, 225:9-17.
    • (2009) Exp Neurol , vol.225 , pp. 9-17
    • Herz, J.1    Zipp, F.2    Siffrin, V.3
  • 9
    • 48849116689 scopus 로고    scopus 로고
    • Grey matter pathology in multiple sclerosis
    • Geurts J.J., Barkhof F. Grey matter pathology in multiple sclerosis. Lancet Neurol 2008, 7:841-851.
    • (2008) Lancet Neurol , vol.7 , pp. 841-851
    • Geurts, J.J.1    Barkhof, F.2
  • 10
  • 11
    • 79952250522 scopus 로고    scopus 로고
    • Models of autoimmune demyelination in the central nervous system: on the way to translational medicine
    • Linker R.A., De-Hyung L. Models of autoimmune demyelination in the central nervous system: on the way to translational medicine. Exp Transl Stroke Med 2009, 1:1-10.
    • (2009) Exp Transl Stroke Med , vol.1 , pp. 1-10
    • Linker, R.A.1    De-Hyung, L.2
  • 12
    • 42649135852 scopus 로고    scopus 로고
    • Pattern of axonal injury in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis: implications for multiple sclerosis
    • Herrero-Herranz E., Pardo L.A., Gold R., Linker R.A. Pattern of axonal injury in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis: implications for multiple sclerosis. Neurobiol Dis 2008, 30:162-173.
    • (2008) Neurobiol Dis , vol.30 , pp. 162-173
    • Herrero-Herranz, E.1    Pardo, L.A.2    Gold, R.3    Linker, R.A.4
  • 13
    • 23444441299 scopus 로고    scopus 로고
    • Motor neuron pathology in experimental autoimmune encephalomyelitis: studies in THY-YFP transgenic mice
    • Bannerman P.G., Hahn A., Morley M., Bonnemann C., Yu S., Zhang G.X., et al. Motor neuron pathology in experimental autoimmune encephalomyelitis: studies in THY-YFP transgenic mice. Brain 2005, 128:1877-1886.
    • (2005) Brain , vol.128 , pp. 1877-1886
    • Bannerman, P.G.1    Hahn, A.2    Morley, M.3    Bonnemann, C.4    Yu, S.5    Zhang, G.X.6
  • 14
    • 56349101474 scopus 로고    scopus 로고
    • Axonal loss and gray matter pathology as a direct result of autoimmunity to neurofilaments
    • Huizinga R., Gerritsen W., Heijmans N., Amor S. Axonal loss and gray matter pathology as a direct result of autoimmunity to neurofilaments. Neurobiol Dis 2008, 32:461-470.
    • (2008) Neurobiol Dis , vol.32 , pp. 461-470
    • Huizinga, R.1    Gerritsen, W.2    Heijmans, N.3    Amor, S.4
  • 15
    • 70350044493 scopus 로고    scopus 로고
    • Lower motor neuron loss in multiple sclerosis and experimental autoimmue encephalomyelitis
    • Voget J., Paul F., Aktas O., Muller-Wielsch K., Dorr J., Dorr S., et al. Lower motor neuron loss in multiple sclerosis and experimental autoimmue encephalomyelitis. Ann Neurol 2009, 66:310-322.
    • (2009) Ann Neurol , vol.66 , pp. 310-322
    • Voget, J.1    Paul, F.2    Aktas, O.3    Muller-Wielsch, K.4    Dorr, J.5    Dorr, S.6
  • 16
    • 51649118004 scopus 로고    scopus 로고
    • An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination axonal and neuronal loss
    • Hampton D.W., Anderson J., Pryce G., Irvine K.-A., Giovannoni G., Fawcett J.W., et al. An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination axonal and neuronal loss. J Neuroimmunol 2008, 201:200-211.
    • (2008) J Neuroimmunol , vol.201 , pp. 200-211
    • Hampton, D.W.1    Anderson, J.2    Pryce, G.3    Irvine, K.-A.4    Giovannoni, G.5    Fawcett, J.W.6
  • 17
  • 18
    • 70350551949 scopus 로고    scopus 로고
    • Linkage between immunomodulation neuroprotection and neurogeneisis
    • Aharoni R., Arnon R. Linkage between immunomodulation neuroprotection and neurogeneisis. Drug News Prospect 2009, 22:301-313.
    • (2009) Drug News Prospect , vol.22 , pp. 301-313
    • Aharoni, R.1    Arnon, R.2
  • 20
    • 0242659411 scopus 로고    scopus 로고
    • The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS
    • Reynolds R., Dawson M., Papadopoulos D., Polito A., Di Bello I.C., Pham-Dinh D., et al. The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS. J Neurocytol 2002, 31:523-536.
    • (2002) J Neurocytol , vol.31 , pp. 523-536
    • Reynolds, R.1    Dawson, M.2    Papadopoulos, D.3    Polito, A.4    Di Bello, I.C.5    Pham-Dinh, D.6
  • 21
    • 0036789957 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice
    • Picard-Riera N., Decker L., Delarasse C., Goude K., Nait-Oumesmar B., Liblau R., et al. Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice. Proc Natl Acad Sci USA 2002, 99:13211-13216.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13211-13216
    • Picard-Riera, N.1    Decker, L.2    Delarasse, C.3    Goude, K.4    Nait-Oumesmar, B.5    Liblau, R.6
  • 22
    • 77956493706 scopus 로고    scopus 로고
    • Immunomodulatory drug treatment in multiple sclerosis
    • Aharoni R. Immunomodulatory drug treatment in multiple sclerosis. Expert Rev Neurother 2010, 10:1423-1436.
    • (2010) Expert Rev Neurother , vol.10 , pp. 1423-1436
    • Aharoni, R.1
  • 23
    • 0015103005 scopus 로고
    • Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide
    • Teitelbaum D., Meshorer M., Hirshfeld T., Sela M., Arnon R. Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide. Eur J Immunol 1971, 1:242-248.
    • (1971) Eur J Immunol , vol.1 , pp. 242-248
    • Teitelbaum, D.1    Meshorer, M.2    Hirshfeld, T.3    Sela, M.4    Arnon, R.5
  • 24
    • 0028340163 scopus 로고
    • Direct binding of myelin basic protein and synthetic copolymer 1 class II major histocompatibility complex molecules on living antigen presenting cells-specificity and promiscuity
    • Fridkis-Hareli M., Teitelbaum D., Gurevich E., Pecht I., Brautbar C., Kwon O.J., et al. Direct binding of myelin basic protein and synthetic copolymer 1 class II major histocompatibility complex molecules on living antigen presenting cells-specificity and promiscuity. Proc Natl Acad Sci USA 1994, 91:4872-4876.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4872-4876
    • Fridkis-Hareli, M.1    Teitelbaum, D.2    Gurevich, E.3    Pecht, I.4    Brautbar, C.5    Kwon, O.J.6
  • 25
    • 0033582242 scopus 로고    scopus 로고
    • Copolymer 1 acts against the immunodominant epitope 82-100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking
    • Aharoni R., Teitelbaum D., Arnon R., Sela M. Copolymer 1 acts against the immunodominant epitope 82-100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking. Proc Natl Acad Sci USA 1999, 96:634-639.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 634-639
    • Aharoni, R.1    Teitelbaum, D.2    Arnon, R.3    Sela, M.4
  • 26
    • 23744480760 scopus 로고    scopus 로고
    • Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action
    • Farina C., Weber M.S., Meinl E., Wekerle H., Hohlfeld R. Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action. Lancet Neurol 2005, 4:567-575.
    • (2005) Lancet Neurol , vol.4 , pp. 567-575
    • Farina, C.1    Weber, M.S.2    Meinl, E.3    Wekerle, H.4    Hohlfeld, R.5
  • 27
    • 34547699396 scopus 로고    scopus 로고
    • Type II monocytes modulate T cell-mediated central nervous system autoimmune disease
    • Weber M.S., Prod'homme T., Youssef S., Dunn S.E., Rundle C.D., Lee L., et al. Type II monocytes modulate T cell-mediated central nervous system autoimmune disease. Nat Med 2007, 13:935-943.
    • (2007) Nat Med , vol.13 , pp. 935-943
    • Weber, M.S.1    Prod'homme, T.2    Youssef, S.3    Dunn, S.E.4    Rundle, C.D.5    Lee, L.6
  • 28
    • 0030987548 scopus 로고    scopus 로고
    • Copolymer 1 induces T cells of the T helper type 2 that cross react with myelin basic protein and suppress experimental autoimmune encephalomyelitis
    • Aharoni R., Teitelbaum D., Sela M., Arnon R. Copolymer 1 induces T cells of the T helper type 2 that cross react with myelin basic protein and suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 1997, 94:10821-10826.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10821-10826
    • Aharoni, R.1    Teitelbaum, D.2    Sela, M.3    Arnon, R.4
  • 29
    • 0034691165 scopus 로고    scopus 로고
    • Multiple sclerosis comparison of copolymer-1 reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells
    • Neuhaus O., Farina C., Yassouridis A. Multiple sclerosis comparison of copolymer-1 reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells. Proc Natl Acad Sci USA 2000, 97:7452-7457.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7452-7457
    • Neuhaus, O.1    Farina, C.2    Yassouridis, A.3
  • 30
    • 0034633663 scopus 로고    scopus 로고
    • Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1
    • Aharoni R., Teitelbaum D., Leitner O., Meshorer A., Sela M., Arnon R. Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1. Proc Natl Acad Sci USA 2000, 97:11472-11477.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11472-11477
    • Aharoni, R.1    Teitelbaum, D.2    Leitner, O.3    Meshorer, A.4    Sela, M.5    Arnon, R.6
  • 31
    • 0344198593 scopus 로고    scopus 로고
    • Glatiramer acetate-specific T cells in the brain express T helper 2/3 cytokines and brain-derived neurotrophic factor in situ
    • Aharoni R., Kayhan B., Eilam R., Sela M., Arnon R. Glatiramer acetate-specific T cells in the brain express T helper 2/3 cytokines and brain-derived neurotrophic factor in situ. Proc Nat Acad Sci USA 2003, 100:14157-14162.
    • (2003) Proc Nat Acad Sci USA , vol.100 , pp. 14157-14162
    • Aharoni, R.1    Kayhan, B.2    Eilam, R.3    Sela, M.4    Arnon, R.5
  • 32
    • 54449085895 scopus 로고    scopus 로고
    • Downregulation of IL-17 and IL-6 in the central nervous system by glatiramer acetate in experimental autoimmune encephalomyelitis
    • Begum-Haque S., Sharma A., Kasper I., Foureau D.M., Mielcarz D.W., Haque A., et al. Downregulation of IL-17 and IL-6 in the central nervous system by glatiramer acetate in experimental autoimmune encephalomyelitis. J Neuroimmunol 2008, 204:58-65.
    • (2008) J Neuroimmunol , vol.204 , pp. 58-65
    • Begum-Haque, S.1    Sharma, A.2    Kasper, I.3    Foureau, D.M.4    Mielcarz, D.W.5    Haque, A.6
  • 33
    • 77955658134 scopus 로고    scopus 로고
    • Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing-remitting or chronic EAE
    • Aharoni R., Eilam R., Stock A., Vainshtein A., Shezen E., Gal H., et al. Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing-remitting or chronic EAE. J Neuroimmunol 2010, 225:100-111.
    • (2010) J Neuroimmunol , vol.225 , pp. 100-111
    • Aharoni, R.1    Eilam, R.2    Stock, A.3    Vainshtein, A.4    Shezen, E.5    Gal, H.6
  • 34
    • 30044451754 scopus 로고    scopus 로고
    • The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice
    • Aharoni R., Eylam R., Domev H., Labunsky G., Sela M., Arnon R. The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice. Proc Natl Acad Sci USA 2005, 102:19045-19050.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 19045-19050
    • Aharoni, R.1    Eylam, R.2    Domev, H.3    Labunsky, G.4    Sela, M.5    Arnon, R.6
  • 35
    • 24144469398 scopus 로고    scopus 로고
    • Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: reversal by glatiramer acetate
    • Azoulay D., Vachapova V., Shihman B., Miler A., Karni A. Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: reversal by glatiramer acetate. J Neuroimmunol 2005, 167:215-218.
    • (2005) J Neuroimmunol , vol.167 , pp. 215-218
    • Azoulay, D.1    Vachapova, V.2    Shihman, B.3    Miler, A.4    Karni, A.5
  • 36
    • 24744435759 scopus 로고    scopus 로고
    • Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis
    • Aharoni R., Arnon R., Eilam R. Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis. J Neuroscience 2005, 25:8217-8228.
    • (2005) J Neuroscience , vol.25 , pp. 8217-8228
    • Aharoni, R.1    Arnon, R.2    Eilam, R.3
  • 37
    • 49649090657 scopus 로고    scopus 로고
    • Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis
    • Aharoni R., Herschkovitz A., Eilam R., Blumberg-Hazan M., Sela M., Bruck W., et al. Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2008, 105:11358-11363.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11358-11363
    • Aharoni, R.1    Herschkovitz, A.2    Eilam, R.3    Blumberg-Hazan, M.4    Sela, M.5    Bruck, W.6
  • 38
    • 0033634813 scopus 로고    scopus 로고
    • Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
    • Feng G., Mellor R.H., Bernstein M., Keller-Peak C., Nguyen Q.T., Wallace M., et al. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 2000, 28:41-51.
    • (2000) Neuron , vol.28 , pp. 41-51
    • Feng, G.1    Mellor, R.H.2    Bernstein, M.3    Keller-Peak, C.4    Nguyen, Q.T.5    Wallace, M.6
  • 39
    • 8644241770 scopus 로고    scopus 로고
    • Differential expression of calcitonin gene-related peptide (CGRP) and choline acetyltransferase (ChAT) in the axotomized motoneurons of normoxic and hypoxic rats
    • Chang H.M., Wei I.H., Tseng C.Y., Lue J.H., Wen C.Y., Shieh J.Y. Differential expression of calcitonin gene-related peptide (CGRP) and choline acetyltransferase (ChAT) in the axotomized motoneurons of normoxic and hypoxic rats. J Chem Neuroanat 2004, 28:239-251.
    • (2004) J Chem Neuroanat , vol.28 , pp. 239-251
    • Chang, H.M.1    Wei, I.H.2    Tseng, C.Y.3    Lue, J.H.4    Wen, C.Y.5    Shieh, J.Y.6
  • 40
    • 79951786397 scopus 로고    scopus 로고
    • GFAP in health and disease
    • Middeldorp J., Hol E.M. GFAP in health and disease. Prog Neurobiol 2011, 93:421-443.
    • (2011) Prog Neurobiol , vol.93 , pp. 421-443
    • Middeldorp, J.1    Hol, E.M.2
  • 41
    • 0032953691 scopus 로고    scopus 로고
    • Markers for neuronal degeneration in organotypic slice cultures
    • Noraberg J., Kristensen B.W., Zimmer J. Markers for neuronal degeneration in organotypic slice cultures. Brain Res Prot 1999, 3:278-290.
    • (1999) Brain Res Prot , vol.3 , pp. 278-290
    • Noraberg, J.1    Kristensen, B.W.2    Zimmer, J.3
  • 42
    • 63849213783 scopus 로고    scopus 로고
    • Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis
    • Centonze D., Muzio L., Rossi S., Cavasinni F., De Chiara V., Bergami A., et al. Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis. J Neurosci 2009, 18:3442-3452.
    • (2009) J Neurosci , vol.18 , pp. 3442-3452
    • Centonze, D.1    Muzio, L.2    Rossi, S.3    Cavasinni, F.4    De Chiara, V.5    Bergami, A.6
  • 43
    • 77951792412 scopus 로고    scopus 로고
    • Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE
    • Ziehn M.O., Avedisian A.A., Tiwari-Woodruff S., Voskuhl R.R. Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE. Lab Invest 2010, 90:774-786.
    • (2010) Lab Invest , vol.90 , pp. 774-786
    • Ziehn, M.O.1    Avedisian, A.A.2    Tiwari-Woodruff, S.3    Voskuhl, R.R.4
  • 46
    • 0036136532 scopus 로고    scopus 로고
    • Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis
    • Wujek J.R., Bjartmar C., Richer E., Ransohoff R.M., Yu M., Tuohy V.K., et al. Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis. J Neuropathol Exp Neurol 2002, 61:23-32.
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 23-32
    • Wujek, J.R.1    Bjartmar, C.2    Richer, E.3    Ransohoff, R.M.4    Yu, M.5    Tuohy, V.K.6
  • 47
    • 0012315645 scopus 로고    scopus 로고
    • Neurotrophin secretion: current facts and future prospect
    • Lessman V., Gottmann K., Malcangio M. Neurotrophin secretion: current facts and future prospect. Prog Neurobiol 2003, 69:341-374.
    • (2003) Prog Neurobiol , vol.69 , pp. 341-374
    • Lessman, V.1    Gottmann, K.2    Malcangio, M.3
  • 48
    • 0035239020 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
    • Murer M.G., Yan O., Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prop Neurobiol 2001, 63:71-124.
    • (2001) Prop Neurobiol , vol.63 , pp. 71-124
    • Murer, M.G.1    Yan, O.2    Raisman-Vozari, R.3
  • 49
    • 0033569751 scopus 로고    scopus 로고
    • Understanding CNS remyelination: clues from developmental and regeneration biology
    • Franklin R.J., Hinks G.L. Understanding CNS remyelination: clues from developmental and regeneration biology. J Neurosci Res 1999, 15:207-213.
    • (1999) J Neurosci Res , vol.15 , pp. 207-213
    • Franklin, R.J.1    Hinks, G.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.