Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing-remitting or chronic EAE

Journal of Neuroimmunology

Volumn 225, Issue 1-2, 2010, Pages 100-111

  Aharoni, Rina ^a   Eilam, Raya ^a   Stock, Ariel ^a   Vainshtein, Anya ^a   Shezen, Elias ^a   Gal, Hilah ^a   Friedman, Nir ^a   Arnon, Ruth ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Experimental autoimmune encephalomyelitis; Glatiramer acetate; Immunomodulation; Interleukin 17; Multiple sclerosis; T regulatory cells

Indexed keywords

GLATIRAMER; INTERLEUKIN 17; MYELIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DISEASE COURSE; DISEASE EXACERBATION; DRUG MECHANISM; FEMALE; IMMUNOMODULATION; MICROGLIA; MOUSE; NERVE CELL STIMULATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REMISSION; TH17 CELL; THERAPY EFFECT;

ANIMALS; CENTRAL NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-17; MICE; MICE, INBRED C57BL; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; MYELIN PROTEOLIPID PROTEIN; PEPTIDE FRAGMENTS; PEPTIDES; SPINAL CORD; STATISTICS AS TOPIC; T-LYMPHOCYTES, REGULATORY;

EID: 77955658134     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.04.022     Document Type: Article

References (34)

1. Aharoni R., Teitelbaum D., Sela M., Arnon R. Copolymer 1 induces T cells of the T helper type 2 that cross react with myelin basic protein and suppress experimental autoimmune encephalomyelitis. Proc. Natl Acad. Sci. USA 1997, 94:10821-10826.
2. Aharoni R., Teitelbaum D., Arnon R., Sela M. Copolymer 1 acts against the immunodominanat epitope 82-100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking. Proc. Natl Acad. Sci. USA 1999, 96:634-639.
3. Aharoni R., Teitelbaum D., Leitner O., Meshorer A., Sela M., Arnon R. Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1. Proc. Natl Acad. Sci. USA 2000, 97:11472-11477.
4. Aharoni R., Kayhan B., Eilam R., Sela M., Arnon R. Glatiramer acetate-specific T cells in the brain express T helper 2/3 cytokines and brain-derived neurotrophic factor in situ. Proc. Natl Acad. Sci. USA 2003, 100:14157-14162.
5. Aharoni R., Arnon R., Eilam R. Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis. J. Neurosci. 2005, 25:8217-8228.
6. Aharoni R., Eylam R., Domev H., Labunsky G., Sela M., Arnon R. The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice. Proc. Natl Acad. Sci. USA 2005, 102:19045-19050.
7. Aharoni R., Herschkovitz A., Eilam R., Blumberg-Hazan M., Sela M., Bruck W., Arnon R. Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis. Proc. Natl Acad. Sci. USA 2008, 105:11358-11363.
8. Aranami T., Yamamaura T. Th17 cells and autoimmune encephalomyelitis (EAE/MS). Allergol. Int. 2008, 57:115-120.
9. Arnon R., Sela M. Immunomodulation by the copolymer glatiramer acetate. J. Mol. Recognit. 2003, 16:412-421.
10. Afzali B., Mitchell P., Lechler R.I., John S., Lombardi G. Translational induction of interleukin-17 production by regulatory cells. Clinical and Experimental Immunology, Mini-review Series on Th17 cells 2009, 1-9.
11. Begum-Haque S., Sharma A., Kasper I., Foureau D.M., Mielcarz D.W., Haque A., Kasper L.H. Downregulation of IL-17 and IL-6 in the central nervous system by glatiramer acetate in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2008, 204:58-65.
12. Behi M.E., Dubucquoi S., Lefranc D., Zephir H., De Seze J., Vermersch P., Prin L. New insights into cell responses involved in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Lett. 2005, 96:11-26.
13. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells. Nature 2006, 44:235-238.
14. Bettelli E., Oukka M., Kuchroo V.K. Th-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 2007, 8:345-350.
15. Bjartmar C., Wujek J.R., Trapp B.D. Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J. Neurol. Sci. 2003, 15:165-171.
16. Fridkis-Hareli M., Teitelbaum D., Gurevich E., et al. Direct binding of myelin basic protein and synthetic copolymer 1 class II major histocompatibility complex molecules on living antigen presenting cells-specificity and promiscuity. Proc. Natl Acad. Sci. USA 1994, 91:4872-4876.
17. Farina C., Weber M.S., Meinl E., Wekerle H., Hohlfeld R. Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action. Neurol 2005, 4:567-575.
18. Gilgum-Sherki Y., Panet H., Holdengreber V., Mosberg-Galili R., Offen D. Axonal damage is reduced following glatiramer acetate treatment in C57/bl mice with chronic-induced experimental autoimmune encephalomyelitis. Neurosci. Res. 2003, 47:201-207.
19. Haas J., Korporal M., Balint B., Fritzsching B., Schwarz A., Wildemann B. Glatiramer acetate improves regulatory T-cell function by expansion of naïve CD4+CD25+Focp3+ T-cells in patients with MS. J. Neuroimmunol. 2009.
20. Hellings N., Raus J., Stinissen P. Insights into the immunopathogenesis of multiple sclerosis. Immunol. Res. 2002, 25:27-51.
21. Hobom M., Storch M.K., Weissert R., Maier K., Radhakrishnan A., Kramer B., Bahr M., Diem R. Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis. Brain Pathol. 2004, 14:148-157.
22. Hohlfeld R., Wekerle H. Autoimmune concepts of MS as a basis for selective immunotherapy: from the pipe dreams to therapeutic pipelines. Proc. Natl Acad. Sci. USA 2004, 101:14599-14606.
23. Hong J., Li N., Zhang X., Zheng B., Zhang Z. Induction of CD4+CD25+ regulatory T cells by copolymer-1 through activation of transcription factor Foxp3. Proc. Natl Acad. Sci. USA 2005, 102:6449-6454.
24. Jee Y., Piao W.H., Liu R., Bai X.F., Rhodes S., Rodenbaugh R., Campagnolo D.I., Shi F.D., Volmer T.L. CD4+CD25+ regulatory T cells contribute to the therapeutic effects of glatiramer acetate in experimental autoimmune encephalomyelitis. Clin. Immunol. 2007, 125:34-42.
25. Kawanokuchi J., Shimizu K., Nitta A., Yamada K., Mizuno T., Takeuch H., Suzumura A. Production and function of IL-17 in microglia. J. Neuroimmunol. 2008, 194:54-61.
26. Lalancette-Hebert M., Gowing G., Simard A., Wemg A.S., Kriz J. Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J. Neurosci. 2007, 27:2596-2605.
27. Prendergast C.T., Anderton S.M. Immune cell entry to central nervous system - current understanding and prospective therapeutic targets. Endoc. Metab. Immune Disorder Drug Target 2009, 9:315-327.
28. Reichert F., Rotshenker S. Gelatin-3/MAC-2 in experimental allergic encephalomyelitis. Exp. Neurol. 1999, 160:508-514.
29. Traugott U. Detailed analysis of early immunopathologic events during lesion formation in acute experimental autoimmune encephalomyelitis. Cell. Immunol. 1989, 119:114-129.
30. Vila J., Isaacs J.D., Anderson A.E. Regulatory T cells and autoimmunity. Curr. Opin. Hematol. 2009, 16:274-279.
31. Weber M.S., Prod'homme T., Youssef S., Dunn S.E., Rundle C.D., Lee L., Patarroyo J.C., Stüve O., Sobel R.A., Steinman L., Zamvil S.S. Type II monocytes modulate T cell-mediated central nervous system autoimmune disease. Nat. Med. 2007, 13(8):935-943.
32. Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., Armitage R.J. Human IL-17: a novel cytokine derived from T-cells. J. Immunol. 1995, 15(155):5483-5486.
33. Zamvil S.S., Steinman L. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 1990, 8:579-621.
34. Zhou X., Baliley-Bucktrout S., Jeker L.T., Bluestone J.A. Plasticity of CD4+ Foxp3+ T cells. Curr. Opin. Immunol. 2009, 21:281-285.