Nuclear localization of Merkel cell polyomavirus large T antigen in Merkel cell carcinoma

Virology

Volumn 398, Issue 2, 2010, Pages 273-279

  Nakamura, Tomoyuki ^a   Sato, Yuko ^a   Watanabe, Daisuke ^b   Ito, Hideki ^c   Shimonohara, Nozomi ^a   Tsuji, Takahiro ^a   Nakajima, Noriko ^a   Suzuki, Yoshio ^d   Matsuo, Koma ^c   Nakagawa, Hidemi ^c   Sata, Tetsutaro ^a   Katano, Harutaka ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

^c JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d ASAHI GENERAL HOSPITAL   (Japan)

Author keywords

Large T antigen; Merkel cell carcinoma; Merkel cell polyomavirus; Mutation; Nuclear localization signal

Indexed keywords

ARGININE; LYSINE; VIRUS LARGE T ANTIGEN;

AMINO ACID SEQUENCE; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DELETION MUTANT; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MERKEL CELL; MERKEL CELL TUMOR; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; POLYOMA VIRUS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STOP CODON; VIRUS STRAIN;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; BLOTTING, WESTERN; CARCINOMA, MERKEL CELL; CELL LINE; CELL NUCLEUS; GENE EXPRESSION REGULATION, VIRAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR LOCALIZATION SIGNALS; POLYMERASE CHAIN REACTION; POLYOMAVIRUS; POLYOMAVIRUS INFECTIONS; RABBITS; SEQUENCE ALIGNMENT; SEQUENCE DELETION; SKIN NEOPLASMS; TUMOR VIRUS INFECTIONS;

ORYCTOLAGUS CUNICULUS; POLYOMAVIRUS;

EID: 75849121694     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.12.024     Document Type: Article

References (22)

1. Asahi-Ozaki Y., Sato Y., Kanno T., Sata T., and Katano H. Quantitative analysis of Kaposi sarcoma-associated herpesvirus (KSHV) in KSHV-associated diseases. J. Infect. Dis. 193 (2006) 773-782
2. Becker J.C., Houben R., Ugurel S., Trefzer U., Pfohler C., and Schrama D. MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. J. Invest. Dermatol. 129 (2009) 248-250
3. DeCaprio J.A. How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40. Virology 384 (2009) 274-284
4. Duncavage E.J., Zehnbauer B.A., and Pfeifer J.D. Prevalence of Merkel cell polyomavirus in Merkel cell carcinoma. Mod. Pathol. 22 (2009) 516-521
5. Feng H., Shuda M., Chang Y., and Moore P.S. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319 (2008) 1096-1100
6. Foulongne V., Kluger N., Dereure O., Brieu N., Guillot B., and Segondy M. Merkel cell polyomavirus and Merkel cell carcinoma, France. Emerg. Infect. Dis. 14 (2008) 1491-1493
7. Garneski K.M., Warcola A.H., Feng Q., Kiviat N.B., Leonard J.H., and Nghiem P. Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. J. Invest. Dermatol. 129 (2009) 246-248
8. Jarvis D.L., Lanford R.E., and Butel J.S. Structural comparisons of wild-type and nuclear transport-defective simian virus 40 large tumor antigens. Virology 134 (1984) 168-176
9. Kalderon D., Roberts B.L., Richardson W.D., and Smith A.E. A short amino acid sequence able to specify nuclear location. Cell 39 (1984) 499-509
10. Kassem A., Schopflin A., Diaz C., Weyers W., Stickeler E., Werner M., and Zur Hausen A. Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res. 68 (2008) 5009-5013
11. Katano H., Sato Y., Kurata T., Mori S., and Sata T. High expression of HHV-8-encoded ORF73 protein in spindle-shaped cells of Kaposi's sarcoma. Am. J. Pathol. 155 (1999) 47-52
12. Katano H., Ogawa-Goto K., Hasegawa H., Kurata T., and Sata T. Human-herpesvirus-8-encoded K8 protein colocalizes with the promyelocytic leukemia protein (PML) bodies and recruits p53 to the PML bodies. Virology 286 (2001) 446-455
13. Katano H., Ito H., Suzuki Y., Nakamura T., Sato Y., Tsuji T., Matsuo K., Nakagawa H., and Sata T. Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcoma. J. Med. Virol. 81 (2009) 1951-1958
14. Kean J.M., Rao S., Wang M., and Garcea R.L. Seroepidemiology of human polyomaviruses. PLoS Pathog. 5 (2009) e1000363
15. Kuramochi H., Hayashi K., Uchida K., Miyakura S., Shimizu D., Vallbohmer D., Park S., Danenberg K.D., Takasaki K., and Danenberg P.V. Vascular endothelial growth factor messenger RNA expression level is preserved in liver metastases compared with corresponding primary colorectal cancer. Clin. Cancer Res. 12 (2006) 29-33
16. Levine A.J. The common mechanisms of transformation by the small DNA tumor viruses: the inactivation of tumor suppressor gene products: p53. Virology 384 (2009) 285-293
17. Niwa H., Yamamura K., and Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108 (1991) 193-199
18. Pipas J.M. SV40: cell transformation and tumorigenesis. Virology 384 (2009) 294-303
19. Sastre-Garau X., Peter M., Avril M.F., Laude H., Couturier J., Rozenberg F., Almeida A., Boitier F., Carlotti A., Couturaud B., and Dupin N. Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis. J. Pathol. 218 (2009) 48-56
20. Shuda M., Feng H., Kwun H.J., Rosen S.T., Gjoerup O., Moore P.S., and Chang Y. T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 16272-16277
21. Shuda M., Arora R., Kwun H.J., Feng H., Sarid R., Fernandez-Figueras M.T., Tolstov Y., Gjoerup O., Mansukhani M.M., Swerdlow S.H., Chaudhary P.M., Kirkwood J.M., Nalesnik M.A., Kant J.A., Weiss L.M., Moore P.S., and Chang Y. Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int. J. Cancer (2009) Electronic Publication
22. Smith D.B., and Johnson K.S. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67 (1988) 31-40