Cancer suicide gene therapy with TK.007: Superior killing efficiency and bystander effect

Journal of Molecular Medicine

Volumn 89, Issue 11, 2011, Pages 1113-1124

  Preu, Ellen ^a,b   Muik, Alexander ^c,d   Weber, Kristoffer ^a   Otte, Jürgen ^b   Von Laer, Dorothee ^d   Fehse, Boris ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b Frankfurter Stiftung für Krebskranke Kinder   (Germany)

^c INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Bystander effect; Cancer gene therapy; HSVtk; Suicide gene

Indexed keywords

ANTINEOPLASTIC AGENT; GANCICLOVIR; HERPESVIRUS VECTOR; LENTIVIRUS VECTOR; THYMIDINE KINASE; TK 007; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BYSTANDER EFFECT; CANCER CELL CULTURE; CANCER GENE THERAPY; CANCER INHIBITION; CANCER REGRESSION; CANCER SURVIVAL; COLON CANCER; CONTROLLED STUDY; DRUG EFFECT; GENETIC TRANSDUCTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; LUNG CANCER; MELANOMA CELL; MOUSE; NONHUMAN; SUICIDE GENE; SUICIDE GENE THERAPY; TARGET CELL DESTRUCTION; TUMOR CELL DESTRUCTION; VIRAL GENE THERAPY;

ANIMALS; ANTIVIRAL AGENTS; BYSTANDER EFFECT; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GANCICLOVIR; GENE THERAPY; GENES, TRANSGENIC, SUICIDE; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASM TRANSPLANTATION; NEOPLASMS; SIMPLEXVIRUS; THYMIDINE KINASE; TRANSPLANTATION, HETEROLOGOUS; VIRAL PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80755132075     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-011-0777-8     Document Type: Article

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