메뉴 건너뛰기




Volumn 57, Issue 3, 2011, Pages 257-271

MicroRNA and hepatocellular carcinoma: Biology and prognostic significance

Author keywords

Carcinoma, hepatocellular; Hepatitis; MicroRNAs

Indexed keywords

CASPASE; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; MICRORNA 122; MICRORNA 199; MICRORNA 21; MICRORNA 221; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN P21; RNA; SCATTER FACTOR RECEPTOR; SOMATOMEDIN; UNCLASSIFIED DRUG;

EID: 80755130254     PISSN: 00264776     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (19)

References (76)
  • 2
    • 77953719509 scopus 로고    scopus 로고
    • Molecular approaches to treatment of hepatocellular carcinoma
    • Lachenmayer A, Alsinet C, Chang CY, Llovet JM. Molecular approaches to treatment of hepatocellular carcinoma. Dig Liver Dis 2010;42(Suppl 3):S264-72.
    • (2010) Dig Liver Dis , vol.42 , Issue.SUPPL. 3
    • Lachenmayer, A.1    Alsinet, C.2    Chang, C.Y.3    Llovet, J.M.4
  • 3
    • 27744534653 scopus 로고    scopus 로고
    • Inhibition of P13K/Akt signaling: An emerging paradigm for targeted cancer therapy
    • Chen YL, Law PY, Loh HH. Inhibition of PI3K/Akt signaling: an emerging paradigm for targeted cancer therapy. Curr Med Chem Anticancer Agents 2005;5:575-89. (Pubitemid 41601056)
    • (2005) Current Medicinal Chemistry - Anti-Cancer Agents , vol.5 , Issue.6 , pp. 575-589
    • Chen, Y.L.1    Law, P.-Y.2    Loh, H.H.3
  • 6
    • 77953743694 scopus 로고    scopus 로고
    • The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma
    • Zhou L, Huang Y, Li J, Wang Z. The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma. Med Oncol 2009;27:255-61.
    • (2009) Med Oncol , vol.27 , pp. 255-261
    • Zhou, L.1    Huang, Y.2    Li, J.3    Wang, Z.4
  • 8
    • 67449087324 scopus 로고    scopus 로고
    • Identification of novel microRNA targets based on microRNA signatures in bladder cancer
    • Ichimi T, Enokida H, Okuno Y, Kunimoto R, Chiyomaru T, Kawamoto K et al. Identification of novel microRNA targets based on microRNA signatures in bladder cancer. Int J Cancer 2009;125:345-52.
    • (2009) Int J Cancer , vol.125 , pp. 345-352
    • Ichimi, T.1    Enokida, H.2    Okuno, Y.3    Kunimoto, R.4    Chiyomaru, T.5    Kawamoto, K.6
  • 10
    • 77953773201 scopus 로고    scopus 로고
    • MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells
    • Fornari F, Milazzo M, Chieco P, Negrini M, Calin GA, Grazi GL et al. MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res 2010;70:5184-93.
    • (2010) Cancer Res , vol.70 , pp. 5184-5193
    • Fornari, F.1    Milazzo, M.2    Chieco, P.3    Negrini, M.4    Calin, G.A.5    Grazi, G.L.6
  • 11
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer
    • DOI 10.1053/j.gastro.2007.05.022, PII S0016508507010025
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K.Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007;133:647-58. (Pubitemid 47187346)
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 12
    • 70949104622 scopus 로고    scopus 로고
    • MiR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation
    • Garofalo M, Di Leva G, Romano G, Nuovo G, Suh SS, Ngankeu A et al. miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 2009;16:498-509.
    • (2009) Cancer Cell , vol.16 , pp. 498-509
    • Garofalo, M.1    Di Leva, G.2    Romano, G.3    Nuovo, G.4    Suh, S.S.5    Ngankeu, A.6
  • 14
    • 16544395386 scopus 로고    scopus 로고
    • Insulin-like growth factors and neoplasia
    • discussion 98-107, 265-108
    • Pollak MN. Insulin-like growth factors and neoplasia. Novartis Found Symp 2004;262:84-98; discussion 98-107, 265-108.
    • (2004) Novartis Found Symp , vol.262 , pp. 84-98
    • Pollak, M.N.1
  • 15
    • 78049506983 scopus 로고    scopus 로고
    • A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma
    • Zeng C, Wang R, Li D, Lin XJ, Wei QK, Yuan Y et al. A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma. Hepatology 2010;52:1702-12.
    • (2010) Hepatology , vol.52 , pp. 1702-1712
    • Zeng, C.1    Wang, R.2    Li, D.3    Lin, X.J.4    Wei, Q.K.5    Yuan, Y.6
  • 17
    • 0035743304 scopus 로고    scopus 로고
    • Expression of p57/Kip2 protein in hepatocellular carcinoma
    • DOI 10.1159/000055378
    • Ito Y, Takeda T, Sakon M, Tsujimoto M, Monden M, Matsuura N. Expression of p57/Kip2 protein in hepatocellular carcinoma. Oncology 2001;61:221-5. (Pubitemid 34701537)
    • (2001) Oncology , vol.61 , Issue.3 , pp. 221-225
    • Ito, Y.1    Takeda, T.2    Sakon, M.3    Tsujimoto, M.4    Monden, M.5    Matsuura, N.6
  • 18
    • 0036549097 scopus 로고    scopus 로고
    • Expression of p57(KIP2) in hepatocellular carcinoma: Relationship between tumor differentiation and patient survival
    • Nakai S, Masaki T, Shiratori Y, Ohgi T, Morishita A, Kurokohchi K et al. Expression of p57(KIP2) in hepatocellular carcinoma: relationship between tumor differentiation and patient survival. Int J Oncol 2002;20:769-75.
    • (2002) Int J Oncol , vol.20 , pp. 769-775
    • Nakai, S.1    Masaki, T.2    Shiratori, Y.3    Ohgi, T.4    Morishita, A.5    Kurokohchi, K.6
  • 20
    • 77953676683 scopus 로고    scopus 로고
    • Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma
    • Csepregi A, Ebert MP, Rocken C, Schneider-Stock R, Hoffmann J, Schulz HU et al. Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma. BMC Cancer 2010;10:317.
    • (2010) BMC Cancer , vol.10 , pp. 317
    • Csepregi, A.1    Ebert, M.P.2    Rocken, C.3    Schneider-Stock, R.4    Hoffmann, J.5    Schulz, H.U.6
  • 26
    • 34548168073 scopus 로고    scopus 로고
    • MiR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kipl
    • Galardi S, Mercatelli N, Giorda E, Massalini S, Frajese GV, Ciafre SA et al. miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kipl. J Biol Chem 2007;282:23716-4.
    • (2007) J Biol Chem , vol.282 , pp. 23716-23724
    • Galardi, S.1    Mercatelli, N.2    Giorda, E.3    Massalini, S.4    Frajese, G.V.5    Ciafre, S.A.6
  • 28
    • 34548268220 scopus 로고    scopus 로고
    • Kip1 by miRNA 221/222 in glioblastoma
    • Gillies JK, Lorimer IA. Regulation of p27Kip1 by miRNA 221/222 in glioblastoma. Cell Cycle 2007;6:2005-9. (Pubitemid 47327888)
    • (2007) Cell Cycle , vol.6 , Issue.16 , pp. 2005-2009
    • Gillies, J.K.1    Lorimer, I.A.J.2
  • 30
    • 52949127316 scopus 로고    scopus 로고
    • MiR-221 controls CDKNlC/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
    • Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA et al. MiR-221 controls CDKNlC/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene 2008;27:5651-61.
    • (2008) Oncogene , vol.27 , pp. 5651-5661
    • Fornari, F.1    Gramantieri, L.2    Ferracin, M.3    Veronese, A.4    Sabbioni, S.5    Calin, G.A.6
  • 33
    • 67651007766 scopus 로고    scopus 로고
    • MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells
    • Fornari F, Gramantieri L, Giovannini C, Veronese A, Ferracin M, Sabbioni S et al. MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res 2009;69:5761-7.
    • (2009) Cancer Res , vol.69 , pp. 5761-5767
    • Fornari, F.1    Gramantieri, L.2    Giovannini, C.3    Veronese, A.4    Ferracin, M.5    Sabbioni, S.6
  • 34
  • 35
    • 67651154718 scopus 로고    scopus 로고
    • MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells
    • Xu T, Zhu Y, Xiong Y, Ge YY, Yun JP, Zhuang SM. MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. Hepatology 2009;50:113-21.
    • (2009) Hepatology , vol.50 , pp. 113-121
    • Xu, T.1    Zhu, Y.2    Xiong, Y.3    Ge, Y.Y.4    Yun, J.P.5    Zhuang, S.M.6
  • 36
    • 34247602670 scopus 로고    scopus 로고
    • Survival and apoptosis: A dysregulated balance in liver cancer
    • DOI 10.1111/j.1478-3231.2006.01409.x
    • Fabregat I, Roncero C, Fernandez M. Survival and apoptosis: a dysregulated balance in liver cancer. Liver Int 2007;27:155-62. (Pubitemid 46680718)
    • (2007) Liver International , vol.27 , Issue.2 , pp. 155-162
    • Fabregat, I.1    Roncero, C.2    Fernandez, M.3
  • 37
    • 0036898067 scopus 로고    scopus 로고
    • Effect of bax, bcl-2 and bcl-xL on regulating apoptosis in tissues of normal liver and hepatocellular carcinoma
    • Guo XZ, Shao XD, Liu MP, Xu JH, Ren LN, Zhao JJ et al. Effect of bax, bcl-2 and bcl-xL on regulating apoptosis in tissues of normal liver and hepatocellular carcinoma. World J Gastroenterol 2002;8:1059-62.
    • (2002) World J Gastroenterol , vol.8 , pp. 1059-1062
    • Guo, X.Z.1    Shao, X.D.2    Liu, M.P.3    Xu, J.H.4    Ren, L.N.5    Zhao, J.J.6
  • 39
    • 0035823238 scopus 로고    scopus 로고
    • Bmf: A proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
    • DOI 10.1126/science.1062257
    • Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE et al. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 2001;293:1829-32. (Pubitemid 32845780)
    • (2001) Science , vol.293 , Issue.5536 , pp. 1829-1832
    • Puthalakath, H.1    Villunger, A.2    O'Reilly, L.A.3    Beaumont, J.G.4    Coultas, L.5    Cheney, R.E.6    Huang, D.C.S.7    Strasser, A.8
  • 42
    • 78649950629 scopus 로고    scopus 로고
    • PUMA is a novel target of miR-221/222 in human epithelial cancers
    • Zhang C, Zhang J, Zhang A, Wang Y, Han L, You Y, et al. PUMA is a novel target of miR-221/222 in human epithelial cancers. Int J Oncol 2010;37:1621-1626.
    • (2010) Int J Oncol , vol.37 , pp. 1621-1626
    • Zhang, C.1    Zhang, J.2    Zhang, A.3    Wang, Y.4    Han, L.5    You, Y.6
  • 43
    • 50849115468 scopus 로고    scopus 로고
    • MiR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines
    • Lin CJ, Gong HY, Tseng HC, Wang WL, Wu JL. miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines. Biochem Biophys Res Commun 2008;375:315-320.
    • (2008) Biochem Biophys Res Commun , vol.375 , pp. 315-320
    • Lin, C.J.1    Gong, H.Y.2    Tseng, H.C.3    Wang, W.L.4    Wu, J.L.5
  • 44
    • 77950602604 scopus 로고    scopus 로고
    • Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma
    • Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH et at. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 2010;51:836-45.
    • (2010) Hepatology , vol.51 , pp. 836-845
    • Xiong, Y.1    Fang, J.H.2    Yun, J.P.3    Yang, J.4    Zhang, Y.5    Jia, W.H.6
  • 45
    • 59149098054 scopus 로고    scopus 로고
    • MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity
    • Su H, Yang JR, Xu T, Huang J, Xu L, Yuan Y et al. MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer Res 2009;69:1135-42.
    • (2009) Cancer Res , vol.69 , pp. 1135-1142
    • Su, H.1    Yang, J.R.2    Xu, T.3    Huang, J.4    Xu, L.5    Yuan, Y.6
  • 47
    • 34848855124 scopus 로고    scopus 로고
    • The MET receptor tyrosine kinase in invasion and metastasis
    • DOI 10.1002/jcp.21183
    • Benvenuti S, Comoglio PM. The MET receptor tyrosine kinase in invasion and metastasis. J Cell Physiol 2007;213:316-25. (Pubitemid 47509708)
    • (2007) Journal of Cellular Physiology , vol.213 , Issue.2 , pp. 316-325
    • Benvenuti, S.1    Comoglio, P.M.2
  • 48
    • 0036217866 scopus 로고    scopus 로고
    • Invasive growth: From development to metastasis
    • DOI 10.1172/JCI200215392
    • Comoglio PM, Trusolino L. Invasive growth: from development to metastasis. J Clin Invest 2002;109:857-62. (Pubitemid 34275105)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.7 , pp. 857-862
    • Comoglio, P.M.1    Trusolino, L.2
  • 49
    • 7444231680 scopus 로고    scopus 로고
    • RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival
    • DOI 10.1158/0008-5472.CAN-04-1043
    • Shinomiya N, Gao CF, Xie Q, Gustafson M, Waters DJ, Zhang YW et al. RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival. Cancer Res 2004;64:7962-70. (Pubitemid 39446930)
    • (2004) Cancer Research , vol.64 , Issue.21 , pp. 7962-7970
    • Shinomiya, N.1    Chong, F.G.2    Xie, Q.3    Gustafson, M.4    Waters, D.J.5    Zhang, Y.-W.6    Vande, W.G.F.7
  • 50
    • 33745220780 scopus 로고    scopus 로고
    • Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    • Kaposi-Novak P, Lee JS, Gomez-Quiroz L, Coulouarn C, Factor VM, Thorgeirsson SS. Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest 2006;116:1582-95.
    • (2006) J Clin Invest , vol.116 , pp. 1582-1595
    • Kaposi-Novak, P.1    Lee, J.S.2    Gomez-Quiroz, L.3    Coulouarn, C.4    Factor, V.M.5    Thorgeirsson, S.S.6
  • 51
    • 0031044486 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor and its receptor c-met proto- oncogene in hepatocellular carcinoma
    • DOI 10.1002/hep.510250413
    • Ueki T, Fujimoto J, Suzuki T, Yamamoto H, Okamoto E. Expression of hepatocyte growth factor and its receptor c-met proto-oncogene in hepatocellular carcinoma. Hepatology 1997;25:862-6. (Pubitemid 27157127)
    • (1997) Hepatology , vol.25 , Issue.4 , pp. 862-866
    • Ueki, T.1    Fujimoto, J.2    Suzuki, T.3    Yamamoto, H.4    Okamoto, E.5
  • 52
    • 48849095238 scopus 로고    scopus 로고
    • MicroRNA miR-199a*regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2)
    • Kim S, Lee UJ, Kim MN, Lee EJ, Kim JY, Lee MY et al. MicroRNA miR-199a*regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2). J Biol Chem 2008;283:18158-66.
    • (2008) J Biol Chem , vol.283 , pp. 18158-18166
    • Kim, S.1    Lee, U.J.2    Kim, M.N.3    Lee, E.J.4    Kim, J.Y.5    Lee, M.Y.6
  • 53
  • 54
    • 58549114916 scopus 로고    scopus 로고
    • MiR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells
    • Li N, Fu H, Tie Y, Hu Z, Kong W, Wu Y et al. miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells. Cancer Lett 2009;275:44-53.
    • (2009) Cancer Lett , vol.275 , pp. 44-53
    • Li, N.1    Fu, H.2    Tie, Y.3    Hu, Z.4    Kong, W.5    Wu, Y.6
  • 55
    • 65549097632 scopus 로고    scopus 로고
    • MicroRNA-23b mediates urokinase and c-met downmodulation and a decreased migration of human hepatocellular carcinoma cells
    • Salvi A, Sabelli C, Moncini S, Venturin M, Arici B, Riva P et al. MicroRNA-23b mediates urokinase and c-met downmodulation and a decreased migration of human hepatocellular carcinoma cells. Febs J 2009;276:2966-82.
    • (2009) Febs J , vol.276 , pp. 2966-2982
    • Salvi, A.1    Sabelli, C.2    Moncini, S.3    Venturin, M.4    Arici, B.5    Riva, P.6
  • 58
    • 77950095763 scopus 로고    scopus 로고
    • TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3
    • Wang B, Hsu SH, Majumder S, Kutay H, Huang W, Jacob ST et al. TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene 2010;29:1787-97.
    • (2010) Oncogene , vol.29 , pp. 1787-1797
    • Wang, B.1    Hsu, S.H.2    Majumder, S.3    Kutay, H.4    Huang, W.5    Jacob, S.T.6
  • 60
    • 70349976819 scopus 로고    scopus 로고
    • Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
    • Coulouarn C, Factor VM, Andersen JB, Durkin ME, Thorgeirsson SS. Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene 2009;28:3526-36.
    • (2009) Oncogene , vol.28 , pp. 3526-3536
    • Coulouarn, C.1    Factor, V.M.2    Andersen, J.B.3    Durkin, M.E.4    Thorgeirsson, S.S.5
  • 61
    • 66149114383 scopus 로고    scopus 로고
    • MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma
    • Tsai WC, Hsu PW, Lai TC, Chau GY, Lin CW, Chen CM et al. MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. Hepatology 2009;49:1571-82.
    • (2009) Hepatology , vol.49 , pp. 1571-1582
    • Tsai, W.C.1    Hsu, P.W.2    Lai, T.C.3    Chau, G.Y.4    Lin, C.W.5    Chen, C.M.6
  • 64
    • 79551507191 scopus 로고    scopus 로고
    • MicroRNA profile predicts recurrence after resection in patients with hepatocellular carcinoma within the Milan Criteria
    • Sato F, Hatano E, Kitamura K, Myomoto A, Fujiwara T, Takizawa S et al. MicroRNA profile predicts recurrence after resection in patients with hepatocellular carcinoma within the Milan Criteria. PLoS One 2011;6:e16435.
    • (2011) PLoS One , vol.6
    • Sato, F.1    Hatano, E.2    Kitamura, K.3    Myomoto, A.4    Fujiwara, T.5    Takizawa, S.6
  • 65
    • 23844523406 scopus 로고    scopus 로고
    • miR-122, a mammalian liver-specific microRNA, is processed from her mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1
    • Chang J, Nicolas E, Marks D, Sander C, Lerro A, Buendia MA et al. miR-122, a mammalian liver-specific microRNA, is processed from her mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1. RNA Biol 2004;1:106-13.
    • (2004) RNA Biol , vol.1 , pp. 106-113
    • Chang, J.1    Nicolas, E.2    Marks, D.3    Sander, C.4    Lerro, A.5    Buendia, M.A.6
  • 66
    • 24644483623 scopus 로고    scopus 로고
    • Molecular biology: Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
    • DOI 10.1126/science.1113329
    • Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 2005;309:1577-81. (Pubitemid 41266486)
    • (2005) Science , vol.309 , Issue.5740 , pp. 1577-1581
    • Jopling, C.L.1    Yi, M.2    Lancaster, A.M.3    Lemon, S.M.4    Sarnow, P.5
  • 67
    • 77955078117 scopus 로고    scopus 로고
    • Targeting viral infection by microRNA inhibition
    • Roberts AP, Jopling CL. Targeting viral infection by microRNA inhibition. Genome Biol 2010;11:201.
    • (2010) Genome Biol , vol.11 , pp. 201
    • Roberts, A.P.1    Jopling, C.L.2
  • 69
    • 46249083024 scopus 로고    scopus 로고
    • MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations
    • DOI 10.1002/hep.22256
    • Ladeiro Y, Couchy G, Balabaud C, Bioulac-Sage P, Pelletier L, Rebouissou S et al. MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 2008;47:1955-63. (Pubitemid 351952843)
    • (2008) Hepatology , vol.47 , Issue.6 , pp. 1955-1963
    • Ladeiro, Y.1    Couchy, G.2    Balabaud, C.3    Bioulac-Sage, P.4    Pelletier, L.5    Rebouissou, S.6    Zucman-Rossi, J.7
  • 71
    • 33646157967 scopus 로고    scopus 로고
    • Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
    • Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T et al. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 2006;25:2537-45.
    • (2006) Oncogene , vol.25 , pp. 2537-2545
    • Murakami, Y.1    Yasuda, T.2    Saigo, K.3    Urashima, T.4    Toyoda, H.5    Okanoue, T.6
  • 72
    • 77955970127 scopus 로고    scopus 로고
    • Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion
    • Shen Q, Cicinnati VR, Zhang X, Iacob S, Weber F, Sotiropoulos GC et al. Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion. Mol Cancer 2010;9:227.
    • (2010) Mol Cancer , vol.9 , pp. 227
    • Shen, Q.1    Cicinnati, V.R.2    Zhang, X.3    Iacob, S.4    Weber, F.5    Sotiropoulos, G.C.6
  • 73
    • 55549120234 scopus 로고    scopus 로고
    • MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis
    • Yan LX, Huang XF, Shao Q, Huang MY, Deng L, Wu QL et al. MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. Rna 2008;14:2348-60.
    • (2008) Rna , vol.14 , pp. 2348-2360
    • Yan, L.X.1    Huang, X.F.2    Shao, Q.3    Huang, M.Y.4    Deng, L.5    Wu, Q.L.6
  • 75
    • 43749113595 scopus 로고    scopus 로고
    • Modulation of miRNA activity in human cancer: A new paradigm for cancer gene therapy?
    • DOI 10.1038/cgt.2008.8, PII CGT20088
    • Tong AW, Nemunaitis J. Modulation of miRNA activity in human cancer: a new paradigm for cancer gene therapy? Cancer Gene Ther 2008;15:341-55. (Pubitemid 351693228)
    • (2008) Cancer Gene Therapy , vol.15 , Issue.6 , pp. 341-355
    • Tong, A.W.1    Nemunaitis, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.