The novel small molecule α9α10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesic

European Journal of Pharmacology

Volumn 670, Issue 2-3, 2011, Pages 500-508

  Holtman, Joseph R ^a   Dwoskin, Linda P ^b   Dowell, Cheryl ^c   Wala, Elzbieta P ^e   Zhang, Zhenfa ^b   Crooks, Peter A ^b   McIntosh, J Michael ^c,d  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b University of Kentucky   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alpha9alpha10; Analgesia; Nicotinic acetylcholine receptor; Pain

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; 5,5',5'',5''' (1,2,4,5 BENZENETETRAYL)TETRAKIS [1 (3 PHENYLPYRIDINIUM) 4 PENTYNE]TETRABROMIDE; ANALGESIC AGENT; BUNGAROTOXIN RECEPTOR; FORMALDEHYDE; MU OPIATE RECEPTOR; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA1BETA1DELTA EPSILON; NICOTINIC RECEPTOR ALPHA2BETA4; NICOTINIC RECEPTOR ALPHA3BETA2; NICOTINIC RECEPTOR ALPHA3BETA2BETA3; NICOTINIC RECEPTOR ALPHA3BETA4; NICOTINIC RECEPTOR ALPHA4BETA2; NICOTINIC RECEPTOR ALPHA4BETA4; NICOTINIC RECEPTOR ALPHA6; NICOTINIC RECEPTOR ALPHA9ALPHA10; NICOTINIC RECEPTOR BLOCKING AGENT; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG; ZZ 204G;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; FEMALE; HYPERALGESIA; IC 50; IN VIVO STUDY; INFLAMMATORY PAIN; MECHANICAL STIMULATION; MOLECULAR CLONING; MOTOR COORDINATION; MOTOR PERFORMANCE; NERVE COMPRESSION; NEUROPATHIC PAIN; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; OOCYTE; PAIN; PAW FLINCH; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR AFFINITY; ROTAROD TEST; TAIL FLICK TEST; XENOPUS;

ALKYNES; ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; BENZENE; CONSTRICTION, PATHOLOGIC; FEASIBILITY STUDIES; FORMALDEHYDE; HYPERALGESIA; MOTOR ACTIVITY; NEURALGIA; NICOTINIC ANTAGONISTS; PROTEIN SUBUNITS; PYRIDINIUM COMPOUNDS; RATS; RECEPTORS, NICOTINIC;

EID: 80755128339     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.08.053     Document Type: Article

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