Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 23, 2011, Pages 6982-6988

  Ciocoiu, Calin C ^a   Ravna, Aina W ^b   Sylte, Ingebrigt ^b   Rustan, Arild C ^a   Hansen, Trond Vidar ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Agonist; Fluorine; GW 501516; PPAR ; PPAR

Indexed keywords

2 FLUORO 2 (2 ETHYL 4 ((4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL)THIAZOL 5 YL)METHYLTHIO)PHENOXY)ACETIC ACID; 2 FLUORO 2 (2 ISOPROPYL 4 ((4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL)THIAZOL 5 YL)METHYLTHIO)PHENOXY)ACETIC ACID; 2 FLUORO 2 (2 METHYL 4 ((4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL)THIAZOL 5 YL)METHYLTHIO)PHENOXY)ACETIC ACID; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ARGININE; CYSTEINE; ETHYL 2 FLUORO 2 (2 ISOPROPYL 4 ((4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL)THIAZOL 5 YL)METHYLTHIO)PHENOXY)ACETIC ACID; ETHYL 2 FLUORO 2 (2 METHYL 4 ((4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL)THIAZOL 5 YL)METHYLTHIO)PHENOXY)ACETIC ACID; FLUORINE; HISTIDINE; OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; ROSIGLITAZONE; THREONINE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG OXIDATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR MODEL; MYOTUBE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SKELETAL MUSCLE;

CELLS, CULTURED; HUMANS; HYDROCARBONS, FLUORINATED; MODELS, MOLECULAR; MUSCLE CELLS; MUSCLE, SKELETAL; PPAR ALPHA; PROTEIN BINDING; THIAZOLES;

EID: 80655146733     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.020     Document Type: Article

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