Real-time imaging assessment of pulmonary vascular responses

Proceedings of the American Thoracic Society

Volumn 8, Issue 6, 2011, Pages 458-465

  Kuebler, Wolfgang M ^a,b,c,d  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

Endothelial; Imaging; Intravital microscopy; Lung; Vascular

Indexed keywords

CALCIUM ION; FLUORESCEIN ISOTHIOCYANATE DEXTRAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD VESSEL DIAMETER; BLOOD VESSEL REACTIVITY; CALCIUM SIGNALING; CELL ORGANELLE; CONFERENCE PAPER; ENDOTHELIUM CELL; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; FLUORESCENCE RESONANCE ENERGY TRANSFER; GAS EXCHANGE; IMAGING; LUNG; LUNG CIRCULATION; MICROSCOPY; MICROVASCULATURE; MOUSE; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; OXYGEN SATURATION; REAL TIME IMAGING;

ANIMALS; COMPUTER SYSTEMS; DIAGNOSTIC IMAGING; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; LUNG; MICROCIRCULATION; MODELS, ANIMAL; OXYGEN;

EID: 80655128326     PISSN: 15463222     EISSN: 19435665     Source Type: Journal    
DOI: 10.1513/pats.201101-005MW     Document Type: Conference Paper

References (54)

1. Uhlig S, Lindner K. Novel mechanisms of endothelial cell permeability in the lung: lessons from studies with intact lungs and animals. In: Tooke J, Shore A, Whatmore J, editors. The microcirculation and vascular biology. Bologna, Italy: Monduzzi Editore; 2002. pp. 221-234.
2. Malpighi M. De pulmonibus [translation by J. Young]. Proc R Soc Med 1929;23:1-11.
3. Hall HL. A study of the pulmonary circulation by the trans-illumination method. Am J Physiol 1925;72:446-457.
4. Wearn JT, Ernstene AC, Bromer AW, Barr JW, German WJ, Zschiesche LJ. The normal behavior of the pulmonary blood vessels with observations on the intermittence of the flow of blood in arterioles and capillaries. Am J Physiol 1934;109:236-256.
5. Meltzer SJ, Auer J. Continuous respiration without respiratory movements. J Exp Med 1909;11:622-625.
6. Terry RJ. A thoracic window for observation of the lung in a living animal. Science 1939;90:43-44.
7. Wagner WW Jr. Pulmonary microcirculatory observations in vivo under physiological conditions. J Appl Physiol 1969;26:375-377.
8. Wagner WW Jr, Latham LP, Gillespie MN, Guenther JP, Capen RL. Direct measurement of pulmonary capillary transit times. Science 1982;218:379-381. (Pubitemid 12037608)
9. Okada O, Presson RG, Godbey PS, Capen RL, WagnerWWJr. Temporal capillary perfusion patterns in single alveolar walls of intact dogs. J Appl Physiol 1994;76:380-386. (Pubitemid 24048270)
10. Kuebler WM, Kuhnle GE, Groh J, Goetz AE. Leukocyte kinetics in pulmonary microcirculation: intravital fluorescence microscopic study. J Appl Physiol 1994;76:65-71. (Pubitemid 24048227)
11. McCormack DG, Mehta S, Tyml K, Scott JA, Potter R, Rohan M. Pulmonary microvascular changes during sepsis: evaluation using intravital videomicroscopy. Microvasc Res 2000;60:131-140. (Pubitemid 30667054)
12. Razavi HM, Wang LF, Weicker S, Rohan M, Law C, McCormack DG, Mehta S. Pulmonary neutrophil infiltration in murine sepsis: role of inducible nitric oxide synthase. Am J Respir Crit CareMed 2004;170:227-233. (Pubitemid 38971406)
13. Tabuchi A, Mertens M, Kuppe H, Pries AR, Kuebler WM. Intravital microscopy of the murine pulmonary microcirculation. J Appl Physiol 2008;104:338-346. (Pubitemid 351231480)
14. Groh J, Kuhnle GE, Kuebler WM, Goetz AE. An experimental model for simultaneous quantitative analysis of pulmonary micro-and macrocirculation during unilateral hypoxia in vivo. Res Exp Med (Berl) 1992;192:431-441.
15. Kuebler WM, Kuhnle GE, Groh J, Goetz AE. Contribution of selectins to leucocyte sequestration in pulmonary microvessels by intravital microscopy in rabbits. J Physiol 1997;501:375-386. (Pubitemid 27280812)
16. Kuhnle GE, Kuebler WM, Groh J, Goetz AE. Effect of blood flow on the leukocyte-endothelium interaction in pulmonary microvessels. Am J Respir Crit Care Med 1995;152:1221-1228.
17. Lindert J, Werner J, Redlin M, Kuppe H, Habazettl H, Pries AR. OPS imaging of human microcirculation: a short technical report. J Vasc Res 2002;39:368-372. (Pubitemid 34983868)
18. Pries AR, Secomb TW, Gaehtgens P. Structure and hemodynamics of microvascular networks: heterogeneity and correlations. Am J Physiol 1995;269:H1713-H1722.
19. Kuebler WM, Borges J, Sckell A, Kuhnle GE, Bergh K, Messmer K, Goetz AE. Role of L-selectin in leukocyte sequestration in lung capillaries in a rabbit model of endotoxemia. Am J Respir Crit Care Med 2000;161:36-43. (Pubitemid 30055900)
20. Lehr HA, Leunig M, Menger MD, Nolte D, Messmer K. Dorsal skinfold chamber technique for intravital microscopy in nude mice. Am J Pathol 1993;143:1055-1062. (Pubitemid 24070548)
21. Sikora L, Johansson AC, Rao SP, Hughes GK, Broide DH, Sriramarao P. A murine model to study leukocyte rolling and intravascular trafficking in lung microvessels. Am J Pathol 2003;162:2019-2028. (Pubitemid 36613058)
22. Meissner S, Tabuchi A, Mertens M, Kuebler WM, Koch E. Virtual fourdimensional imaging of lung parenchyma by optical coherence tomography in mice. J Biomed Opt 2010;15:036016.
23. Mertens M, Tabuchi A, Meissner S, Krueger A, Schirrmann K, Kertzscher U, Pries AR, Slutsky AS, Koch E, Kuebler WM. Alveolar dynamics in acute lung injury: heterogeneous distension rather than cyclic opening and collapse. Crit Care Med 2009;37:2604-2611.
24. Kuebler WM, Kuhnle GE, Goetz AE. Leukocyte margination in alveolar capillaries: interrelationship with functional capillary geometry and microhemodynamics. J Vasc Res 1999;36:282-288. (Pubitemid 29413452)
25. Tabuchi A, KueblerWM. Endothelium-platelet interactions in inflammatory lung disease. Vascul Pharmacol 2008;49:141-150.
26. Otsu K, Das S, Houser SD, Quadri SK, Bhattacharya S, Bhattacharya J. Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells. Blood 2009;113:4197-4205.
27. Vanderkooi JM, Maniara G, Green TJ, Wilson DF. An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence. J Biol Chem 1987;262:5476-5482.
28. Styp-Rekowska B, Mecha Disassa N, Reglin B, Ulm L, Kuppe H, Secomb TW, Pries AR. An imaging spectroscopy approach for measurement of oxygen saturation and hematocrit during intravital microscopy. Microcirculation 2007;14:207-221. (Pubitemid 46552877)
29. Tabuchi A, Styp-Rekowska B, Pries AR, Kuebler WM. Imaging of oxygen saturation in murine pulmonary microcirculation [abstract]. Am J Respir Crit Care Med 2008;177:A548.
30. Kuebler WM, Parthasarathi K, Lindert J, Bhattacharya J. Real-time lung microscopy. J Appl Physiol 2007;102:1255-1264. (Pubitemid 46377053)
31. Brueckl C, Kaestle S, Kerem A, Habazettl H, Krombach F, Kuppe H, Kuebler WM. Hyperoxia-induced reactive oxygen species formation in pulmonary capillary endothelial cells in situ. Am J Respir Cell Mol Biol 2006;34:453-463.
32. 2+ signaling and cytoskeletal reorganization. Circ Res 2010;106:1103-1116.
33. Birukov KG, Birukova AA, Dudek SM, Verin AD, Crow MT, Zhan X, DePaola N, Garcia JG. Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells. Am J Respir Cell Mol Biol 2002;26:453-464. (Pubitemid 34253930)
34. Betz WJ, Bewick GS. Optical analysis of synaptic vesicle recycling at the frog neuromuscular junction. Science 1992;255:200-203.
35. Kuebler WM, Ying X, Singh B, Issekutz AC, Bhattacharya J. Pressure is proinflammatory in lung venular capillaries. J Clin Invest 1999;104:495-502. (Pubitemid 29534333)
36. Kuebler WM. Effects of pressure and flow on the pulmonary endothelium. In: Voelkel N, Rounds S, editors. The pulmonary endothelium, Hoboken, NJ: John Wiley & Sons Inc.; 2009. pp. 309-326.
37. Kuebler WM, Ying X, Bhattacharya J. Pressure-induced endothelial Ca21 oscillations in lung capillaries. Am J Physiol Lung Cell Mol Physiol 2002;282:L917-L923. (Pubitemid 34654607)
38. Pries AR, Kuebler WM. Normal endothelium. Handb Exp Pharmacol 2006;176:1-40.
39. Kuebler WM, Parthasarathi K, Wang PM, Bhattacharya J. A novel signaling mechanism between gas and blood compartments of the lung. J Clin Invest 2000;105:905-913. (Pubitemid 30203063)
40. 1G T-type calcium channel selectively regulates P-selectin surface expression in pulmonary capillary endothelium. Am J Physiol Lung Cell Mol Physiol 2010;299:L86-L97.
41. Kuebler WM, Uhlig U, Goldmann T, Schael G, Kerem A, Exner K, Martin C, Vollmer E, Uhlig S. Stretch activates nitric oxide production in pulmonary vascular endothelial cells in situ. Am J Respir Crit Care Med 2003;168:1391-1398. (Pubitemid 37492903)
42. Kuebler WM, Yang Y, Samapati R, Uhlig S. Vascular barrier regulation by PAF, ceramide, caveolae, and NO: an intricate signaling network with discrepant effects in the pulmonary and systemic vasculature. Cell Physiol Biochem 2010;26:29-40.
43. Yang Y, Yin J, Baumgartner W, Samapati R, Solymosi EA, Reppien E, Kuebler WM, Uhlig S. Platelet-activating factor reduces endothelial nitric oxide production: role of acid sphingomyelinase. Eur Respir J 2010;36:417-427.
44. Yin J, Kuebler WM. Mechanotransduction by TRP channels: general concepts and specific role in the vasculature. Cell Biochem Biophys 2010;56:1-18.
45. Yin J, Hoffmann J, Kaestle SM, Neye N, Wang L, Baeurle J, Liedtke W, Wu S, Kuppe H, Pries AR, et al. Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. Circ Res 2008;102: 966-974. (Pubitemid 351591552)
46. Kaestle SM, Reich CA, Yin N, Habazettl H, Weimann J, Kuebler WM. Nitric oxide-dependent inhibition of alveolar fluid clearance in hydrostatic lung edema. Am J Physiol Lung Cell Mol Physiol 2007;293:L859-L869. (Pubitemid 47572234)
47. Kaestle S, Kuppe H, Kuebler WM. Compartmentalisation of the inflammatory response. In: Gullo A, editor. Proceedings of the 18th Postgraduate Course in Critical Care Medicine. Milano, Berlin, Heidelberg, New York, Hong Kong, London, Paris, Tokyo: Springer; 2003. pp. 639-654.
48. St Croix CM, Bauer WM. Use of spectral fluorescence resonance energy transfer to detect nitric oxide-based signaling events in isolated perfused lung. Curr Protoc Cytom 2008; Chapter 12:Unit 12.
49. 2+-dependent proinflammatory responses in lung capillaries. J Clin Invest 2006;116:2193-2200.
50. BAC GCaMP2 transgenic mice. Circ Res 2007;101:1300-1309.
51. Fingar VH, Taber SW, Wieman TJ. A new model for the study of pulmonary microcirculation: determination of pulmonary edema in rats. J Surg Res 1994;57:385-393. (Pubitemid 24283592)
52. Cypel M, Yeung JC, Hirayama S, Rubacha M, Fischer S, Anraku M, Sato M, Harwood S, Pierre A, Waddell TK, et al. Technique for prolonged normothermic ex vivo lung perfusion. J Heart Lung Transplant 2008;27:1319-1325.
53. CypelM, Liu M, RubachaM, Yeung JC, Hirayama S, Anraku M, Sato M, Medin J, Davidson BL, de Perrot M, et al. Functional repair of human donor lungs by IL-10 gene therapy. Sci Transl Med 2009;1:4ra9.
54. Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE. Reconstituting organ-level lung functions on a chip. Science 2010;328:1662-1668.