Adrenomedullin inhibits IL-1β-induced rheumatoid synovial fibroblast proliferation and MMPs, COX-2 and PGE2 production

Inflammation

Volumn 34, Issue 5, 2011, Pages 335-343

  Lee, Eun Gyeong ^a   Lee, Sang Il ^b   Chae, Han Jung ^a   Park, Seoung Ju ^a   Lee, Yong Chul ^a   Yoo, Wan Hee ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

Author keywords

Adrenomedulin; COX; MAPK signalings; MMPs; Rheumatoid arthritis

Indexed keywords

ADRENOMEDULLIN; CHOLECYSTOKININ OCTAPEPTIDE; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E2; PROTEIN INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; FATTY ACID SYNTHESIS; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INTRACELLULAR SIGNALING; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIUM;

ADRENOMEDULLIN; ARTHRITIS, RHEUMATOID; CELL PROLIFERATION; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; FIBROBLASTS; GENE EXPRESSION; HUMANS; INTERLEUKIN-1BETA; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASES; RNA, MESSENGER; SYNOVIAL MEMBRANE; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 80655126779     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-010-9239-7     Document Type: Article

References (20)

1. Cawston, T.E. 1995. Proteinase and connective tissue breakdown. In Mechanisms and models in rheumatoid arthritis, ed. B. Henderson, J.C.W Edwards, and E.R. Pettipher. London: Academic.
2. Han, M.K., J.S. Kim, B.H. Park, et al. 2003. NF-kappa B-depend-ent lymphocyte hyperadhesiveness to synovial fibroblasts by hypoxia and reoxygenation: Potential role in rheumatoid arthritis. Journal of Leukocyte Biology 73: 525-529.
3. Pratt, A.G., J.D. Isaacs, and D.L. Mattey. 2009. Current concepts in the pathogenesis of early rheumatoid arthritis. Best Practice & Research. Clinical Rheumatology23: 37-48.
4. Choy E.H., and G.S. Panayi. 2001. Cytokine pathways andjoint inflammation in rheumatoid arthritis. The New England Journal of Medicine 344: 907-916. (Pubitemid 32224400)
5. Firestein, G.S. 1997. Etiology and pathogenesis of rheumatoid arthritis. In Textbook ofrheumatology, 5th ed, ed. WN. Kelley, E. D. Harris Jr., S. Ruddy and C.B. Sledge, 851-897. Philadelphia: WB Saunders.
6. Matsushita, T., N. Matsui, S. Yoshiya, H. Fujioka, and M. Kurosaka 2004. Production of adrenomedullin from synovial cells in rheumatoid arthritis patients. Rheumatology International 24: 20-24. (Pubitemid 38168109)
7. Chosa, E., H. Hamada, K. Kitamura, T. Eto, and N. Tajima. 2003. Increased plasma andjoint tissue adrenomedullin concentrations in patients with rheumatoid arthritis compared to those with osteo-arthritis. The Journal of Rheumatology 30: 2553-2556. (Pubitemid 37549329)
8. Gonzalez-Rey, E., A. Chorny F. O'Valle, and M. Delgado. 2007. Adrenomedullin protects from experimental arthritis by down-regulating inflammation and Th1 response and inducing regulatory Tcells. The American Journal of Pathology 170: 263-271. (Pubitemid 47339205)
9. Arnett, F.C., S.M. Edworthy DA. Bloch, et al. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis and Rheumatism 31: 315-324. (Pubitemid 18091653)
10. Lee, H.Y, H.S. Jeon, E.K. Song, et al. 2006. CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL-mediated osteo-clastogenesis: Evidence of NF-kappa B-dependent, CD40-mediated bone destruction in rheumatoid arthritis. Arthritis and Rheumatism 54: 1747-1758.
11. Yun, HJ., E.G. Lee, S.I. Lee, H.J. Chae, and WH. Yoo. 2009. Adrenomedullin inhibits MAPK pathway-dependent rheumatoid synovial fibroblast-mediated osteoclastogenesis by IL-1 and TNF-alpha. Rheumatology International 29(10): 1161-1168.
12. Nakagawa, T., M. Takahashi, T. Ozaki, K.K. Watanabe, S. Todo, H. Mizuguchi, T. Hayakawa, and A. Nakagawara. 2002. Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter Molecular and Cellular Biology 22: 2575-2585. (Pubitemid 34262980)
13. Hodgkin, P.D., L.C. Yamashita, R.L. Coffman, and M.R. Kehry 1990. Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines. The Journal of Immunology 145: 2025-2034. (Pubitemid 20343361)
14. Nanke, Y, S. Kotake, K. Yonemoto, S. Saito, T. Tomatsu, and N. Kamatani. 2003. Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes. Annals of the Rheumatic Diseases 62: 82-83. (Pubitemid 36005804)
15. Genovese, M.C., and J.M. Kremer. 2004. Treatment of rheumatoid arthritis with etanercept. Rheumatic Diseases Clinics of North America 30(2): 311-328. (Pubitemid 38692564)
16. Caramaschi, P., D. Biasi, M. Colombatti, et al. 2006. Anti-TNFalpha therapy in rheumatoid arthritis and autoimmunity. Rheumatology International 26(3): 209-214. (Pubitemid 41830977)
17. Nagaya, N., T. Satoh, T. Nishikimi, et al. 2000. Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure. Circulation 101: 498-503. (Pubitemid 30080863)
18. Han, Z., D.L. Boyle, L. Chang, et al. 2001. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. Journal of Clinical Investigation 108: 73-81. (Pubitemid 32634924)
19. Badger, A.M., D.E. Griswold, R. Kapadia, et al. 2000. Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis. Arthritis and Rheumatism 43: 175-183. (Pubitemid 30368227)
20. Nishikawa, M., A. Myoui, T. Tomita, K. Takahi, A. Nampei, and H. Yoshikawa. 2003. Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653. Arthritis and Rheu-matism 48: 2670-2681. (Pubitemid 37129445)