Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K + channel inactivation pathway

Journal of Biological Chemistry

Volumn 286, Issue 45, 2011, Pages 39091-39099

  Ferrer, Tania ^a   Cordero Morales, Julio F ^b   Arias, Marcelo ^a   Ficker, Eckhard ^c   Medovoy, David ^d   Perozo, Eduardo ^d   Tristani Firouzi, Martin ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE-SCANNING MUTAGENESIS; AMINO ACID SUBSTITUTION; ELECTRICAL STABILITY; HELIX RESIDUES; INACTIVATION GATING; INACTIVATION PATHWAY; INACTIVATION PROCESS; INTERACTION ENERGIES; ION SELECTIVITY; MOLECULAR COUPLING; MOLECULAR DYNAMIC SIMULATIONS; MOLECULAR MECHANISM; TETRAMERS; VAN DER WAALS;

AMINO ACIDS; COMPUTER SIMULATION; ETHERS; GENES; MOLECULAR DYNAMICS; OLIGOMERS; VAN DER WAALS FORCES;

ORGANIC COMPOUNDS;

HUMAN ETHER A GO GO RELATED GENE 1 POTASSIUM CHANNEL; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KV1.2; POTASSIUM CHANNEL KV1.5; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; MOLECULAR COUPLING; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

AMINO ACID SUBSTITUTION; ANIMALS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; MODELS, MOLECULAR; MUSCLE PROTEINS; MUTAGENESIS; MUTATION, MISSENSE; MYOCARDIUM; PROTEIN STRUCTURE, SECONDARY; XENOPUS LAEVIS;

EID: 80655125019     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.292060     Document Type: Article

References (41)

1. Warmke, J. W., and Ganetzky, B. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 3438-3442
2. Huffaker, S. J., Chen, J., Nicodemus, K. K., Sambataro, F., Yang, F., Mattay, V., Lipska, B. K., Hyde, T. M., Song, J., Rujescu, D., Giegling, I., Mayilyan, K., Proust, M. J., Soghoyan, A., Caforio, G., Callicott, J. H., Bertolino, A., Meyer-Lindenberg, A., Chang, J., Ji, Y., Egan, M. F., Goldberg, T. E., Kleinman, J. E., Lu, B., and Weinberger, D. R. (2009) Nat. Med. 15, 509-518
3. Sanguinetti, M. C., Jiang, C., Curran, M. E., and Keating, M. T. (1995) Cell 81, 299-307
4. Wang, H., Zhang, Y., Cao, L., Han, H., Wang, J., Yang, B., Nattel, S., and Wang, Z. (2002) Cancer Res. 62, 4843-4848
5. Trudeau, M. C., Warmke, J. W., Ganetzky, B., and Robertson, G. A. (1995) Science 269, 92-95
6. Sanguinetti, M. C., and Tristani-Firouzi, M. (2006) Nature 440, 463-469
7. Perrin, M. J., Kuchel, P. W., Campbell, T. J., and Vandenberg, J. I. (2008) Mol. Pharmacol. 74, 1443-1452
8. Hoshi, T., Zagotta, W. N., and Aldrich, R. W. (1991) Neuron 7, 547-556
9. Cordero-Morales, J. F., Cuello, L. G., Zhao, Y., Jogini, V., Cortes, D. M., Roux, B., and Perozo, E. (2006) Nat. Struct. Mol. Biol. 13, 311-318
10. Cordero-Morales, J. F., Cuello, L. G., and Perozo, E. (2006) Nat. Struct. Mol. Biol. 13, 319-322
11. Cuello, L. G., Jogini, V., Cortes, D. M., and Perozo, E. (2010) Nature 466, 203-208
12. Cuello, L. G., Jogini, V., Cortes, D. M., Pan, A. C., Gagnon, D. G., Dalmas, O., Cordero-Morales, J. F., Chakrapani, S., Roux, B., and Perozo, E. (2010) Nature 466, 272-275
13. Schonherr, R., and Heinemann, S. H. (1996) J. Physiol. 493.3, 635-642
14. Smith, P. L., Baukrowitz, T., and Yellen, G. (1996) Nature 379, 833-836
15. Rasmusson, R. L., Morales, M. J., Wang, S., Liu, S., Campbell, D. L., Brahmajothi, M. V., and Strauss, H. C. (1998) Circ. Res. 82, 739-750
16. Spector, P. S., Curran, M. E., Zou, A., Keating, M. T., and Sanguinetti, M. C. (1996) J. Gen. Physiol. 107, 611-619
17. Zhang, M., Liu, J., and Tseng, G. N. (2004) J. Gen. Physiol. 124, 703-718
18. Tristani-Firouzi, M., Chen, J., and Sanguinetti, M. C. (2002) J. Biol. Chem. 277, 18994-19000
19. Stühmer, W. (1992) Methods Enzymol. 207, 319-339
20. Stefani, E., and Bezanilla, F. (1998) in Methods in Enzymology (Conn, P. N., ed) pp. 300-318, Academic Press, San Diego, CA
21. Piper, D. R., Varghese, A., Sanguinetti, M. C., and Tristani-Firouzi, M. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 10534-10539
22. Armstrong, C. M., and Bezanilla, F. (1977) J. Gen. Physiol. 70, 567-590
23. Piper, D. R., Hinz, W. A., Tallurri, C. K., Sanguinetti, M. C., and Tristani-Firouzi, M. (2005) J. Biol. Chem. 280, 7206-7217
24. Piper, D. R., Rupp, J., Sachse, F. B., Sanguinetti, M. C., and Tristani-Firouzi, M. (2008) Cell. Physiol. Biochem. 21, 37-46
25. Jogini, V., and Roux, B. (2007) Biophys. J. 93, 3070-3082
26. Phillips, J. C., Braun, R., Wang, W., Gumbart, J., Tajkhorshid, E., Villa, E., Chipot, C., Skeel, R. D., Kalé, L., and Schulten, K. (2005) J. Comput. Chem. 26, 1781-1802
27. Humphrey, W., Dalke, A., and Schulten, K. (1996) J. Mol. Graph. 14, 33-38, 27-38
28. Gajewski, C., Dagcan, A., Roux, B., and Deutsch, C. (2011) Proc. Natl. Acad. Sci. U.S.A. 108, 3240-3245
29. Ju, P., Pages, G., Riek, R. P., Chen, P. C., Torres, A. M., Bansal, P. S., Kuyucak, S., Kuchel, P. W., and Vandenberg, J. I. (2009) J. Biol. Chem. 284, 1000-1008
30. Panyi, G., and Deutsch, C. (2006) J. Gen. Physiol. 128, 547-559
31. Yifrach, O., and MacKinnon, R. (2002) Cell 111, 231-239
32. Clarke, C. E., Hill, A. P., Zhao, J., Kondo, M., Subbiah, R. N., Campbell, T. J., and Vandenberg, J. I. (2006) J. Physiol. 573, 291-304
33. Jiang, M., Zhang, M., Maslennikov, I. V., Liu, J., Wu, D. M., Korolkova, Y. V., Arseniev, A. S., Grishin, E. V., and Tseng, G. N. (2005) J. Physiol. 569, 75-89
34. Liu, J., Zhang, M., Jiang, M., and Tseng, G. N. (2002) J. Gen. Physiol. 120, 723-737
35. Torres, A. M., Bansal, P. S., Sunde, M., Clarke, C. E., Bursill, J. A., Smith, D. J., Bauskin, A., Breit, S. N., Campbell, T. J., Alewood, P. F., Kuchel, P. W., and Vandenberg, J. I. (2003) J. Biol. Chem. 278, 42136-42148
36. Wang, D. T., Hill, A. P., Mann, S. A., Tan, P. S., and Vandenberg, J. I. (2010) Nat. Struct. Mol. Biol. 18, 35-41
37. Long, S. B., Tao, X., Campbell, E. B., and MacKinnon, R. (2007) Nature 450, 376-382
38. Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B. T., and MacKinnon, R. (2003) Nature 423, 33-41
39. Doyle, D. A., Morais Cabral, J., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., and MacKinnon, R. (1998) Science 280, 69-77
40. Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B. T., and MacKinnon, R. (2002) Nature 417, 515-522
41. Zhou, Z., Gong, Q., Epstein, M. L., and January, C. T. (1998) J. Biol. Chem. 273, 21061-21066