Regulation of prohormone convertase 1. (PC1) by thyroid hormone

American Journal of Physiology - Endocrinology and Metabolism

Volumn 280, Issue 1 43-1, 2001, Pages

  Li, Qiao Ling ^a,b   Jansen, Erik ^d   Brent, Gregory A ^c   Friedman, Theodore C ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Hypothyroidism; Negative thyroid response element; Pituitary; Posttranslational processing; Processing enzyme; Regulation; Triiodo L thyronine

Indexed keywords

FURIN; LIOTHYRONINE; MESSENGER RNA; OLIGONUCLEOTIDE; PROHORMONE CONVERTASE 1; PROPYLTHIOURACIL; RETINOID X RECEPTOR; RETINOID X RECEPTOR BETA; THYROID HORMONE; THYROID HORMONE RECEPTOR; THYROID HORMONE RECEPTOR ALPHA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; ENZYME REGULATION; HORMONE ACTION; HORMONE BINDING; HORMONE INHIBITION; HUMAN; HUMAN CELL; HYPERTHYROIDISM; MALE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; RAT; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EID: 0035019510     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2001.280.1.e160     Document Type: Article

References (55)

1. Hypothyroidism increases substance P concentrations in the heterotopic anterior pituitary
2. Coordinate regulation of mRNA levels of pro-opiomelanocortin and the candidate processing enzymes PC2 and PC3, but not furin, in the rat pituitary intermediate lobe
3. Prohormone-converting enzymes: Regulation and evaluation of function using antisense RNA
4. Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor
5. Thyroid hormone regulation of the rat glycoprotein hormone alpha-subunit gene promoter activity
6. Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary
7. Preparation of extracts from higher eukaryotes
8. Ligand (T3) dependent and independent effects of thyroid hormone receptors upon human TRH gene transcription in neuroblastoma cells
9. Homodimer and heterodimer DNA binding and transcriptional responsiveness to triiodothyronine (T3) and 9-cis-retinoic acid are determined by the number and order of high affinity half-sites in a T3 response element
10. Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2
11. Isolation of two complementary deoxyribonucleic acid clones from a rat insulinoma cell line based on similarities to Kex2 and furin sequences and the specific localization of each transcript to endocrine and neuroendocrine tissues in rats
12. Transactivation by the thyroid hormone receptor is dependent on the spacer sequence in hormone response elements containing directly repeated half-sites
13. The thyroid gland
14. Identification of a thyroid hormone receptor that is pituitary-specific
15. Regulation of anterior pituitary galanin gene expression by thyroid hormone
16. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
17. Neuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements
18. Cell type-specific protein-DNA interactions at the cAMP response elements of the prohormone convertase 1 promoter. Evidence for additional transactivators distinct from CREB/ATF family members
19. Regulation of human prohormone convertase 2 promoter activity by the transcription factor EGR-1
20. Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates
21. PACE4: A subtilisin-like endoprotease prevalent in the anterior pituitary and regulated by thyroid status
22. Evidence for neuropeptide Y synthesis in the rat anterior pituitary and the influence of thyroid hormone status: Comparison with vasoactive intestinal peptide, substance P, and neurotensin
23. Ligand-dependent heterodimerization of thyroid hormone receptor and retinoid X receptor
24. Thyroid hormone receptor coactivators and corepressors
25. Vasoactive intestinal peptide in the anterior pituitary is increased in hypothyroidism
26. A unique role of the beta-2 thyroid hormone receptor isoform in negative regulation by thyroid hormone. Mapping of a novel amino-terminal domain important for ligand-independent activation
27. Thyroid hormone receptors: Multiple forms, multiple possibilities
28. An activator protein-1 (AP-1) response element on pro alpha1(l) collagen gene is necessary for thyroid hormone-induced inhibition of promoter activity in cardiac fibroblasts
29. Assignment of the beta-thyroid hormone receptor to 3,5,3′-triiodothyronine-dependent inhibition of transcription from the thyrotropin-releasing hormone promoter in chick hypothalamic neurons
30. Interactions between the prohormone convertase 2 (PC2) promoter and the thyroid hormone receptor
31. Reversal of TR-T3 inhibition of the hTRH gene by excess TR ligand-binding domain: Evidence for novel accessory protein
32. Regulation of the human TRH (hTRH) gene by human thyroid hormone receptor beta 1 (hTR beta 1) mutants
33. Regulation of prohormone convertase 1 (PC1) by gp130-related cytokines
34. Leukemia inhibitory factor (LIF) modulates pro-opiomelanocortin (POMC) gene regulation in stably-transfected AtT-20 cells over-expressing LIF
35. Expression and hormonal regulation of coactivator and corepressor genes
36. Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues
37. The molecular basis of thyroid hormone actions
38. Brief report: Impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function
39. Thyroid hormone regulation of peptidylglycine alpha-amidating monooxygenase expression in anterior pituitary gland
40. Negative regulation of the gene for the preprothyrotropin-releasing hormone from the mouse by thyroid hormone requires additional factors in conjunction with thyroid hormone receptors
41. Interactions of estrogen- and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: A comparison with the vitellogenin A2 consensus ERE
42. The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1
43. Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides
44. Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, furin, and Kex2: Distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2
45. The pituitary in hypothyroidism
46. The pituitary in thyrotoxicosis
47. A novel natural mutation in the thyroid hormone receptor defines a dual functional domain that exchanges nuclear receptor corepressors and coactivators
48. Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1
49. Localization of prohormone convertases 1/3 and 2 in the human pituitary gland and pituitary adenomas: Analysis by immunohistochemistry, immunoelectron microscopy, and laser scanning microscopy
50. A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene
51. Stimulation of prohormone convertase-1 mRNA expression by second messenger signaling systems
52. T3 receptor suppression of Sp1-dependent transcription from the epidermal growth factor receptor promoter via overlapping DNA-binding sites
53. Roles of 3,5,3′-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation
54. Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity
55. Proteolytic processing in the secretory pathway