메뉴 건너뛰기




Volumn 946, Issue , 2012, Pages 113-133

Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of staphylococcal immune evasion proteins

Author keywords

C3 Convertase; Complement Inhibitors; Efb; Immune Evasion; Mechanism; SCIN; Staphylococcus aureus; Structural Biology

Indexed keywords

BACTERIAL PROTEIN; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3C; COMPLEMENT COMPONENT C3D; COMPLEMENT INHIBITOR; EFB PROTEIN; SCIN A PROTEIN; SCIN PROTEIN; UNCLASSIFIED DRUG;

EID: 80555149778     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-0106-3_7     Document Type: Article
Times cited : (31)

References (62)
  • 2
    • 0026544866 scopus 로고
    • A segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1 factor H and factor B
    • Becherer, J.D., Alsenz, J., Esparza, I., Hack, C.E., and Lambris, J.D.1992) A segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1, factor H, and factor B. Biochemistry 31, 1787-1794.
    • (1992) Biochemistry , vol.31 , pp. 1787-1794
    • Becherer, J.D.1    Alsenz, J.2    Esparza, I.3    Hack, C.E.4    Lambris, J.D.5
  • 3
    • 0026841268 scopus 로고
    • Evidence for three different fibrinogen-binding proteins with unique properties from staphylococcus aureus strain newman
    • Boden, M.K. and Flock, J.-I.1992) Evidence for three different fibrinogen-binding proteins with unique properties from Staphylococcus aureus strain Newman. Microb. Pathog. 12, 289-298.
    • (1992) Microb. Pathog. , vol.12 , pp. 289-298
    • Boden, M.K.1    Flock, J.-I.2
  • 4
    • 5444259851 scopus 로고    scopus 로고
    • The complement system in regulation of adaptive immunity
    • Carroll, M.C.2004) The complement system in regulation of adaptive immunity. Nat. Immunol. 5, 981-986.
    • (2004) Nat. Immunol. , vol.5 , pp. 981-986
    • Carroll, M.C.1
  • 5
    • 69249083586 scopus 로고    scopus 로고
    • Waves of resistance: Staphylococcus aureus in the antibiotic era
    • Chambers, H.F. and Deleo, F.R.2009) Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol. 7, 629-641.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 629-641
    • Chambers, H.F.1    Deleo, F.R.2
  • 6
    • 34548566416 scopus 로고    scopus 로고
    • The anti-inflammatory activities of Staphylococcus aureus
    • Chavakis, T., Preissner, K.T. and Herrmann, M.2007) The anti-inflammatory activities of Staphylococcus aureus. Trends Immunol. 28, 408-418.
    • (2007) Trends Immunol. , vol.28 , pp. 408-418
    • Chavakis, T.1    Preissner, K.T.2    Herrmann, M.3
  • 8
    • 0034292433 scopus 로고    scopus 로고
    • Structure-guided identification of C3d residues essential for its binding to complement receptor 2 CD21
    • Clemenza, L. and Isenman, D.E.2000) Structure-guided identification of C3d residues essential for its binding to complement receptor 2 (CD21).J. Immunol. 165, 3839-3848.
    • (2000) J. Immunol. , vol.165 , pp. 3839-3848
    • Clemenza, L.1    Isenman, D.E.2
  • 9
    • 77951620048 scopus 로고    scopus 로고
    • Community-associated meticillin- resistant staphylococcus aureus
    • Deleo, F.R., Otto, M., Kreiswirth, B.N. and Chambers, H.F.2010) Community-associated meticillin- resistant Staphylococcus aureus. Lancet 375, 1557-1568.
    • (2010) Lancet , vol.375 , pp. 1557-1568
    • Deleo, F.R.1    Otto, M.2    Kreiswirth, B.N.3    Chambers, H.F.4
  • 10
    • 78650638514 scopus 로고    scopus 로고
    • Structures of C3b in complex with factors B and D give insight into complement convertase formation
    • Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R.S., Lambris, J.D. and Gros, P.2010) Structures of C3b in complex with factors B and D give insight into complement convertase formation. Science 330, 1816-1820.
    • (2010) Science , vol.330 , pp. 1816-1820
    • Forneris, F.1    Ricklin, D.2    Wu, J.3    Tzekou, A.4    Wallace, R.S.5    Lambris, J.D.6    Gros, P.7
  • 11
    • 30544444128 scopus 로고    scopus 로고
    • Immune evasion by staphylococci
    • Foster, T.J.2005) Immune evasion by Staphylococci. Nat. Rev. Microbiol. 3, 948-958.
    • (2005) Nat. Rev. Microbiol. , vol.3 , pp. 948-958
    • Foster, T.J.1
  • 12
    • 0035661477 scopus 로고    scopus 로고
    • Annihilating host defense
    • Frank, M.M.2001) Annihilating host defense. Nat. Med. 7, 1285-1286.
    • (2001) Nat. Med. , vol.7 , pp. 1285-1286
    • Frank, M.M.1
  • 13
    • 77956180132 scopus 로고    scopus 로고
    • Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor SCIN bound to C3c and C3b
    • Garcia, B.L., Ramyar, K.X., Tzekou, A., Ricklin, D., McWhorter, W.J., Lambris, J.D. and Geisbrecht, B.V.2010) Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b J. Mol. Biol. 402, 17-29.
    • (2010) J. Mol. Biol. , vol.402 , pp. 17-29
    • Garcia, B.L.1    Ramyar, K.X.2    Tzekou, A.3    Ricklin, D.4    McWhorter, W.J.5    Lambris, J.D.6    Geisbrecht, B.V.7
  • 14
    • 58149334961 scopus 로고    scopus 로고
    • Staphylococcal complement inhibitors: Biological functions recognition of complement components and potential therapeutic implications
    • Geisbrecht, B.V.2008) Staphylococcal complement inhibitors: biological functions, recognition of complement components, and potential therapeutic implications. Adv. Exp. Med. Biol. 632, 221-236.
    • (2008) Adv. Exp. Med. Biol. , vol.632 , pp. 221-236
    • Geisbrecht, B.V.1
  • 17
    • 0026544866 scopus 로고
    • A segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1 factor H and factor B
    • Becherer, J.D., Alsenz, J., Esparza, I., Hack, C.E., and Lambris, J.D.1992) A segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1, factor H, and factor B. Biochemistry 31, 1787-1794.
    • (1992) Biochemistry , vol.31 , pp. 1787-1794
    • Becherer, J.D.1    Alsenz, J.2    Esparza, I.3    Hack, C.E.4    Lambris, J.D.5
  • 18
    • 0026841268 scopus 로고
    • Evidence for three different fibrinogen-binding proteins with unique properties from Staphylococcus aureus strain newman
    • Boden, M.K. and Flock, J.-I.1992) Evidence for three different fibrinogen-binding proteins with unique properties from Staphylococcus aureus strain Newman. Microb. Pathog. 12, 289-298.
    • (1992) Microb. Pathog. , vol.12 , pp. 289-298
    • Boden, M.K.1    Flock, J.-I.2
  • 19
    • 5444259851 scopus 로고    scopus 로고
    • The complement system in regulation of adaptive immunity
    • Carroll, M.C.2004) The complement system in regulation of adaptive immunity. Nat. Immunol. 5, 981-986.
    • (2004) Nat. Immunol. , vol.5 , pp. 981-986
    • Carroll, M.C.1
  • 20
    • 69249083586 scopus 로고    scopus 로고
    • Waves of resistance: Staphylococcus aureus in the antibiotic era
    • Chambers, H.F. and Deleo, F.R.2009) Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol. 7, 629-641.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 629-641
    • Chambers, H.F.1    Deleo, F.R.2
  • 21
    • 34548566416 scopus 로고    scopus 로고
    • The anti-inflammatory activities of staphylococcus aureus
    • Chavakis, T., Preissner, K.T. and Herrmann, M.2007) The anti-inflammatory activities of Staphylococcus aureus. Trends Immunol. 28, 408-418.
    • (2007) Trends Immunol. , vol.28 , pp. 408-418
    • Chavakis, T.1    Preissner, K.T.2    Herrmann, M.3
  • 23
    • 0034292433 scopus 로고    scopus 로고
    • Structure-guided identification of C3d residues essential for its binding to complement receptor 2 CD21
    • Clemenza, L. and Isenman, D.E.2000) Structure-guided identification of C3d residues essential for its binding to complement receptor 2 (CD21).J. Immunol. 165, 3839-3848.
    • (2000) J. Immunol. , vol.165 , pp. 3839-3848
    • Clemenza, L.1    Isenman, D.E.2
  • 24
    • 77951620048 scopus 로고    scopus 로고
    • Community-associated meticillin- resistant staphylococcus aureus
    • Deleo, F.R., Otto, M., Kreiswirth, B.N. and Chambers, H.F.2010) Community-associated meticillin- resistant Staphylococcus aureus. Lancet 375, 1557-1568.
    • (2010) Lancet , vol.375 , pp. 1557-1568
    • Deleo, F.R.1    Otto, M.2    Kreiswirth, B.N.3    Chambers, H.F.4
  • 25
    • 78650638514 scopus 로고    scopus 로고
    • Structures of C3b in complex with factors B and D give insight into complement convertase formation
    • Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R.S., Lambris, J.D. and Gros, P.2010) Structures of C3b in complex with factors B and D give insight into complement convertase formation. Science 330, 1816-1820.
    • (2010) Science , vol.330 , pp. 1816-1820
    • Forneris, F.1    Ricklin, D.2    Wu, J.3    Tzekou, A.4    Wallace, R.S.5    Lambris, J.D.6    Gros, P.7
  • 26
    • 30544444128 scopus 로고    scopus 로고
    • Immune evasion by staphylococci
    • Foster, T.J.2005) Immune evasion by Staphylococci. Nat. Rev. Microbiol. 3, 948-958.
    • (2005) Nat. Rev. Microbiol. , vol.3 , pp. 948-958
    • Foster, T.J.1
  • 27
    • 0035661477 scopus 로고    scopus 로고
    • Annihilating host defense
    • Frank, M.M.2001) Annihilating host defense. Nat. Med. 7, 1285-1286.
    • (2001) Nat. Med. , vol.7 , pp. 1285-1286
    • Frank, M.M.1
  • 28
    • 77956180132 scopus 로고    scopus 로고
    • Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor SCIN bound to C3c and C3b
    • Garcia, B.L., Ramyar, K.X., Tzekou, A., Ricklin, D., McWhorter, W.J., Lambris, J.D. and Geisbrecht, B.V.2010) Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b J. Mol. Biol. 402, 17-29.
    • (2010) J. Mol. Biol. , vol.402 , pp. 17-29
    • Garcia, B.L.1    Ramyar, K.X.2    Tzekou, A.3    Ricklin, D.4    McWhorter, W.J.5    Lambris, J.D.6    Geisbrecht, B.V.7
  • 29
    • 58149334961 scopus 로고    scopus 로고
    • Staphylococcal complement inhibitors: Biological functions recognition of complement components and potential therapeutic implications
    • Geisbrecht, B.V.2008) Staphylococcal complement inhibitors: biological functions, recognition of complement components, and potential therapeutic implications. Adv. Exp. Med. Biol. 632, 221-236.
    • (2008) Adv. Exp. Med. Biol. , vol.632 , pp. 221-236
    • Geisbrecht, B.V.1
  • 31
    • 84859000255 scopus 로고    scopus 로고
    • Meticillin resistant staphylococcus aureus in the hospital
    • preva-Kluytmans, J. and Struelens, M.2009) Meticillin resistant Staphylococcus aureus in the hospital. BMJ 338, b364.
    • (2009) BMJ , vol.338
    • Preva-Kluytmans, J.1    Struelens, M.2
  • 32
    • 77951207010 scopus 로고    scopus 로고
    • Complement inhibition by gram-positive pathogens: Molecular mechanisms and therapeutic implications
    • Laarman, A., Milder, F., van Strijp, J. and Rooijakkers, S.2010) Complement inhibition by gram-positive pathogens: molecular mechanisms and therapeutic implications. J. Mol. Med. 88, 115-120.
    • (2010) J. Mol. Med. , vol.88 , pp. 115-120
    • Laarman, A.1    Milder, F.2    Van Strijp, J.3    Rooijakkers, S.4
  • 33
    • 0019984714 scopus 로고
    • Breakdown of C3 after complement activation identification of a new fragment C3g using monoclonal antibodies
    • Lachmann, P.J., Pangburn, M.K., and Oldroyd, R.G.1982) Breakdown of C3 after complement activation. Identification of a new fragment, C3g, using monoclonal antibodies. J. Exp. Med. 156, 205-216.
    • (1982) J. Exp. Med. , vol.156 , pp. 205-216
    • Lachmann, P.J.1    Pangburn, M.K.2    Oldroyd, R.G.3
  • 34
    • 0023796341 scopus 로고
    • The multifunctional role of C3 the third component of complement
    • Lambris, J.D.1988) The multifunctional role of C3, the third component of complement. Immunol. Today 9, 387-393.
    • (1988) Immunol. Today , vol.9 , pp. 387-393
    • Lambris, J.D.1
  • 35
    • 0009247302 scopus 로고
    • Mapping of the C3d receptor CR2-binding site and a neoantigenic site in the C3d domain of the third component of complement
    • U.S.A.
    • Lambris, J.D., Ganu, V.S., Hirani, S., and Muller-Eberhard, H.J.1985) Mapping of the C3d receptor (CR2)-binding site and a neoantigenic site in the C3d domain of the third component of complement. Proc. Natl. Acad. Sci. U.S.A. 82, 4235-4239.
    • (1985) Proc. Natl. Acad. Sci. , vol.82 , pp. 4235-4239
    • Lambris, J.D.1    Ganu, V.S.2    Hirani, S.3    Muller-Eberhard, H.J.4
  • 38
    • 10944229082 scopus 로고    scopus 로고
    • Identification and characterization of the C3 binding domain of the Staphylococcus aureus extracellular fibrinogen-binding protein Efb
    • Lee, L.Y.L., Liang, X., Hook, M. and Brown, E.L.2004b) Identification and characterization of the C3 binding domain of the Staphylococcus aureus extracellular fibrinogen-binding protein (Efb).J. Biol. Chem. 279, 50710-50716.
    • (2004) J. Biol. Chem. , vol.279 , pp. 50710-50716
    • Lee, L.Y.L.1    Liang, X.2    Hook, M.3    Brown, E.L.4
  • 39
    • 0028171792 scopus 로고
    • Vaccination with staphylococcus aureus fibrinogenbinding proteins FgBPs reduces colonisation of S aureus in a mouse mastitis model
    • Mamo, W., Boden, M., and Flock, J.-I.1994) Vaccination with Staphylococcus aureus fibrinogenbinding proteins (FgBPs) reduces colonisation of S. aureus in a mouse mastitis model. FEMS Immunol. Med. Microbiol. 10, 47-53.
    • (1994) FEMS Immunol. Med. Microbiol. , vol.10 , pp. 47-53
    • Mamo, W.1    Boden, M.2    Flock, J.-I.3
  • 41
    • 0023217090 scopus 로고
    • Production of mouse monoclonal antibodies that detect distinct neoantigenic epitopes on bound C3b and iC3b but not on the corresponding soluble fragments
    • Nilsson, B., Svensson, K.E., Borwell, P., and Nilsson, U.R.1987) Production of mouse monoclonal antibodies that detect distinct neoantigenic epitopes on bound C3b and iC3b but not on the corresponding soluble fragments. Mol. Immunol. 24, 487-494.
    • (1987) Mol. Immunol. , vol.24 , pp. 487-494
    • Nilsson, B.1    Svensson, K.E.2    Borwell, P.3    Nilsson, U.R.4
  • 42
    • 0020420067 scopus 로고
    • Analogous antigenic alterations elicited in C3 by physiologic binding and by denaturation in the presence of sodium dodecylsulfate
    • Nilsson, U.R., and Nilsson, B.1982) Analogous antigenic alterations elicited in C3 by physiologic binding and by denaturation in the presence of sodium dodecylsulfate. J. Immunol. 129, 2594-2597.
    • (1982) J. Immunol. , vol.129 , pp. 2594-2597
    • Nilsson, U.R.1    Nilsson, B.2
  • 43
    • 33845961542 scopus 로고    scopus 로고
    • Structural transitions of complement component C3 and its activation products
    • U.S.A.
    • Nishida, N., Walz, T. and Springer, T.A.2006) Structural transitions of complement component C3 and its activation products. Proc. Nat. Acad. Sci. U.S.A. 103, 19737-19742.
    • (2006) Proc. Nat. Acad. Sci. , vol.103 , pp. 19737-19742
    • Nishida, N.1    Walz, T.2    Springer, T.A.3
  • 44
    • 0029843565 scopus 로고    scopus 로고
    • Lack of the extracellular 19-kilodalton fibrinogen-binding protein from Staphylococcus aureus decreases virulence in experimental wound infection
    • Palma, M., Nozohoor, S., Schennings, T., Heimdahl, A., and Flock, J.-I.1996) Lack of the extracellular 19-kilodalton fibrinogen-binding protein from Staphylococcus aureus decreases virulence in experimental wound infection. Infect. Immun. 64, 5284-5289.
    • (1996) Infect. Immun. , vol.64 , pp. 5284-5289
    • Palma, M.1    Nozohoor, S.2    Schennings, T.3    Heimdahl, A.4    Flock, J.-I.5
  • 45
    • 0035943662 scopus 로고    scopus 로고
    • Extracellular fibrinogenbinding protein Efb from staphylococcus aureus blocks platelet aggregation due to its binding the alpha-chain
    • Palma, M., Shannon, O., Quezada, H.C., Berg, A., and Flock, J.-I.2001) Extracellular fibrinogenbinding protein, Efb, from Staphylococcus aureus blocks platelet aggregation due to its binding the alpha-chain. J. Biol. Chem. 276, 31691-31697.
    • (2001) J. Biol. Chem. , vol.276 , pp. 31691-31697
    • Palma, M.1    Shannon, O.2    Quezada, H.C.3    Berg, A.4    Flock, J.-I.5
  • 46
    • 0032557528 scopus 로고    scopus 로고
    • Multiple binding sites in the interaction between an extracellular fibrinogen-binding protein from Staphylococcus aureus and fibrinogen
    • Palma, M., Wade, D., Flock, M., and Flock, J.-I.1998) Multiple binding sites in the interaction between an extracellular fibrinogen-binding protein from Staphylococcus aureus and fibrinogen. J. Biol. Chem. 273, 13177-13181.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13177-13181
    • Palma, M.1    Wade, D.2    Flock, M.3    Flock, J.-I.4
  • 47
    • 0022521480 scopus 로고
    • The C3 convertase of the alternative pathway of human complement enzymic properties of the biomolecular proteinase
    • Pangburn, M.K. and Muller-Eberhard, H.J.1986) The C3 convertase of the alternative pathway of human complement. Enzymic properties of the biomolecular proteinase. Biochem. J. 235, 723-730.
    • (1986) Biochem. J. , vol.235 , pp. 723-730
    • Pangburn, M.K.1    Muller-Eberhard, H.J.2
  • 48
    • 1842816463 scopus 로고    scopus 로고
    • Structural analysis of engineered Bb fragment of complement factor B: Insights into the activation mechanism of the alternative pathway C3-convertase
    • Ponnuraj, K., Xu, Y., Macon, K., Moore, D., Volanakis, J.E. and Narayana, S.V.2004) Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase. Mol. Cell 14, 17-28.
    • (2004) Mol. Cell , vol.14 , pp. 17-28
    • Ponnuraj, K.1    Xu, Y.2    MacOn, K.3    Moore, D.4    Volanakis, J.E.5    Narayana, S.V.6
  • 49
    • 77955883153 scopus 로고    scopus 로고
    • Complement: A key system for immune surveillance and homeostasis
    • Ricklin, D., Hajishengallis, G., Yang, K. and Lambris, J.D.2010) Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11, 785-797.
    • (2010) Nat. Immunol. , vol.11 , pp. 785-797
    • Ricklin, D.1    Hajishengallis, G.2    Yang, K.3    Lambris, J.D.4
  • 50
    • 36048937343 scopus 로고    scopus 로고
    • Complement-targeted therapeutics
    • Ricklin, D. and Lambris, J.D.2007) Complement-targeted therapeutics. Nat. Biotechnol. 25, 1265-1275.
    • (2007) Nat. Biotechnol. , vol.25 , pp. 1265-1275
    • Ricklin, D.1    Lambris, J.D.2
  • 51
    • 71849115185 scopus 로고    scopus 로고
    • Cutting edge: Members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2
    • Ricklin, D., Ricklin-Lichtsteiner, S.K., Markiewski, M.M., Geisbrecht, B.V. and Lambris, J.D (2008) Cutting edge: members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2. J. Immunol. 181, 7463-7467.
    • (2008) J. Immunol. , vol.181 , pp. 7463-7467
    • Ricklin, D.1    Ricklin-Lichtsteiner, S.K.2    Markiewski, M.M.3    Geisbrecht, B.V.4    Lambris, J.D.5
  • 57
    • 77952813339 scopus 로고    scopus 로고
    • Molecular mechanisms of complement evasion: Learning from staphylococci and meningococci
    • Serruto, D., Rappuoli, R., Scarselli, M., Gros, P. and van Strijp, J.A.2010) Molecular mechanisms of complement evasion: learning from staphylococci and meningococci. Nat. Rev. Microbiol.8, 393-399.
    • (2010) Nat. Rev. Microbiol. , vol.8 , pp. 393-399
    • Serruto, D.1    Rappuoli, R.2    Scarselli, M.3    Gros, P.4    Van Strijp, J.A.5
  • 58
    • 0022383497 scopus 로고
    • Detection of a neoantigen on human C3bi and C3d by monoclonal antibody
    • Tamerius, J.D., Pangburn, M.K., and Muller-Eberhard, H.J.1985) Detection of a neoantigen on human C3bi and C3d by monoclonal antibody. J. Immunol. 135, 2015-2019.
    • (1985) J. Immunol. , vol.135 , pp. 2015-2019
    • Tamerius, J.D.1    Pangburn, M.K.2    Muller-Eberhard, H.J.3
  • 59
    • 60649109828 scopus 로고    scopus 로고
    • Protein allostery signal transmission and dynamics: A classification scheme of allosteric mechanisms
    • Tsai, C.J., Del Sol, A. and Nussinov, R.2009) Protein allostery, signal transmission, and dynamics: a classification scheme of allosteric mechanisms. Mol. Biosyst. 5, 207-216.
    • (2009) Mol. Biosyst. , vol.5 , pp. 207-216
    • Tsai, C.J.1    Del Sol, A.2    Nussinov, R.3
  • 61
    • 67649230210 scopus 로고    scopus 로고
    • Structure of complement fragment C3b-factor H and implications for host protection by complement regulators
    • Wu, J., Wu, Y.Q., Ricklin, D., Janssen, B.J., Lambris, J.D. and Gros, P.2009) Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat. Immunol. 10, 728-733.
    • (2009) Nat. Immunol. , vol.10 , pp. 728-733
    • Wu, J.1    Wu, Y.Q.2    Ricklin, D.3    Janssen, B.J.4    Lambris, J.D.5    Gros, P.6
  • 62
    • 70349437186 scopus 로고    scopus 로고
    • Complement regulators and inhibitory proteins
    • Zipfel, P.F. and Skerka, C.2009) Complement regulators and inhibitory proteins. Nat. Rev. Immunol. 9, 729-740.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 729-740
    • Zipfel, P.F.1    Skerka, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.