Dynamic structural changes during complement C3 activation analyzed by hydrogen/deuterium exchange mass spectrometry

Molecular Immunology

Volumn 45, Issue 11, 2008, Pages 3142-3151

  Schuster, Michael C ^a   Ricklin, Daniel ^a   Papp, Krisztián ^a   Molnar, Kathleen S ^b   Coales, Stephen J ^b   Hamuro, Yoshitomo ^b   Sfyroera, Georgia ^a   Chen, Hui ^a   Winters, Michael S ^a   Lambris, John D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ExSAR Corporation   (United States)

Author keywords

Activation; C3; C3b; Complement; Hydrogen deuterium exchange; Mass spectrometry

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3B; DEUTERIUM; HYDROGEN;

ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTROSPRAY; HUMAN; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; COMPLEMENT ACTIVATION; COMPLEMENT C3; COMPLEMENT C3B; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE MAPPING; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 43449131563     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.03.010     Document Type: Article

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