8-(4-Chlorophenylthio)-guanosine-3′,5′-cyclic monophosphate-Na stimulates human alveolar fluid clearance by releasing external Na + self-inhibition of epithelial Na + channels

American Journal of Respiratory Cell and Molecular Biology

Volumn 45, Issue 5, 2011, Pages 1007-1014

  Han, Dong Yun ^a   Nie, Hong Guang ^a,b   Su, Xue Feng ^a   Shi, Xue Mei ^a   Bhattarai, Deepa ^a   Zhao, Meimi ^a   Zhao, Run Zhen ^a   Landers, Katlin ^a   Tang, Hua ^a   Zhang, Lin ^b   Ji, Hong Long ^a  

^a UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Amiloride sensitive sodium channel; CPT cGMP; ENaC self inhibition; Lung fluid reabsorption

Indexed keywords

8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; ALPHABETAGAMMA SODIUM CHANNEL; DELTABETAGAMMA SODIUM CHANNEL; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG MECHANISM; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS; LUNG ALVEOLUS EPITHELIUM; LUNG FLUID; LUNG PARENCHYMA; OOCYTE; PROTEIN EXPRESSION;

CYCLIC GMP; EPITHELIAL SODIUM CHANNEL; HUMANS; LUNG; MUTATION; OOCYTES; SODIUM;

EID: 80555143024     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0004OC     Document Type: Article

References (65)

1. + channel. Physiol Rev 1988;68:309-373.
2. + channel by aldosterone: open questions and emerging answers. Kidney Int 2000;57:1270-1276.
3. Rossier BC, Pradervand S, Schild L, Hummler E. Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors. Annu Rev Physiol 2002;64:877-897. (Pubitemid 34259252)
4. Horisberger JD, Chraibi A. Epithelial sodium channel: a ligand-gated channel? Nephron, Physiol 2004;96:37-41.
5. Lingueglia E, Deval E, Lazdunski M. Fmrfamide-gated sodium channel and asic channels: a new class of ionotropic receptors for fmrfamide and related peptides. Peptides 2006;27:1138-1152.
6. Chraibi A, Horisberger JD. Na self inhibition of human epithelial Na channel: temperature dependence and effect of extracellular proteases. J Gen Physiol 2002;120:133-145. (Pubitemid 34857964)
7. + self-inhibition. J Biol Chem 2004;279:31687-31696.
8. Li JH, Kau ST. Bumetanide stimulation of sodium permeability of the apical membrane of toad urinary bladder. J Pharmacol Exp Ther 1988;246:980-985.
9. 2+ on Xenopus and rat ENaCs expressed in Xenopus oocytes. Am J Physiol Cell Physiol 2005;289:C946-C958.
10. +. J Membr Biol 2003;194:33-45.
11. Chraibi A, Horisberger JD. Stimulation of epithelial sodium channel activity by the sulfonylurea glibenclamide. J Pharmacol Exp Ther 1999;290:341-347. (Pubitemid 29302341)
12. Chraibi A, Schnizler M, Clauss W, Horisberger JD. Effects of 8-cpt-cAMP on the epithelial sodium channel expressed in Xenopus oocytes. J Membr Biol 2001;183:15-23. (Pubitemid 32835813)
13. + self-inhibition. J Biol Chem 2009;284:792-798.
14. Lu M, Echeverri F, Kalabat D, Laita B, Dahan DS, Smith RD, Xu H, Staszewski L, Yamamoto J, Ling J, et al. Small molecule activator of the human epithelial sodium channel. J Biol Chem 2008;283: 11981-11994.
15. Ji HL, Benos DJ. Degenerin sites mediate proton activation of deltabetagamma-epithelial sodium channel. J Biol Chem 2004;279: 26939-26947. (Pubitemid 38812529)
16. Molina R, Han DY, Su XF, Zhao RZ, Zhao M, Sharp GM, Chang Y, Ji HL. Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition. Biochim Biophys Acta 2011; 1808:1818-1826.
17. Collier DM, Snyder PM. Extracellular chloride regulates the epithelial sodium channel. J Biol Chem 2009;284:29320-29325.
18. + channel activities in cultured human alveolar epithelial cells. Mol Pharmacol 2006;69:1755-1762.
19. Nie HG, Zhang W, Han DY, Li QN, Li J, Zhao RZ, Su XF, Peng JB, Ji HL. 8-pCPT-cGMP stimulates alphabetagamma-ENaC activity in oocytes as an external ligand requiring specific nucleotide moieties. Am J Physiol Renal Physiol 2010;298:F323-F334.
20. + self-inhibition. J Biol Chem 2003;278:28418-28426.
21. + self-inhibition. J Biol Chem 2007;282:20180-20190.
22. Sheng S, Perry CJ, Kleyman TR. External nickel inhibits epithelial sodium channel by binding to histidine residues within the extracellular domains of alpha and gamma subunits and reducing channel open probability. J Biol Chem 2002;277:50098-50111. (Pubitemid 36014463)
23. Maarouf AB, Sheng N, Chen J, Winarski KL, Okumura S, Carattino MD, Boyd CR, Kleyman TR, Sheng S. Novel determinants of epithelial sodium channel gating within extracellular thumb domains. J Biol Chem 2009;284:7756-7765.
24. + selfinhibition. Am J Physiol Renal Physiol 2006;290:F1488-F1496.
25. Huber R, Krueger B, Diakov A, Korbmacher J, Haerteis S, Einsiedel J, Gmeiner P, Azad AK, Cuppens H, Cassiman JJ, et al. Functional characterization of a partial loss-of-function mutation of the epithelial sodium channel (ENaC) associated with atypical cystic fibrosis. Cell Physiol Biochem 2010;25:145-158.
26. Nie HG, Chen L, Han DY, Li J, Song WF, Wei SP, Fang XH, Gu X, Matalon S, Ji HL. Regulation of epithelial sodium channels by cGMP/PKGII. J Physiol 2009;587:2663-2676.
27. Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson G, et al. Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Crit Care Med 2006;34:676-681.
28. Sakuma T, Gu X, Sugita M, Sagawa M, Sakuda M, Toga H. Catecholamine clearance from alveolar spaces of rat and human lungs. Respiration 2005;72:189-196. (Pubitemid 40591533)
29. + channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport. Respir Res 2010;11:65.
30. + channel. A new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Lett 1993;318:95-99.
31. Ji HL, Parker S, Langloh AL, Fuller CM, Benos DJ. Point mutations in the post-M2 region of human alpha-ENaC regulate cation selectivity. Am J Physiol Cell Physiol 2001;281:C64-C74.
32. Ji HL, Su XF, Kedar S, Li J, Barbry P, Smith PR, Matalon S, Benos DJ. Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction. J Biol Chem 2006;281:8233-8241. (Pubitemid 43847444)
33. +channel 3 and cystic fibrosis transmembrane conductance regulator. J Biol Chem 2006;281:36960-36968.
34. Jain L, Chen XJ, Brown LA, Eaton DC. Nitric oxide inhibits lung sodium transport through a cGMP-mediated inhibition of epithelial cation channels. Am J Physiol 1998;274:L475-L484.
35. Chen L, Bosworth CA, Pico T, Collawn JF, Varga K, Gao Z, Clancy JP, Fontenberry JA, Lancaster JR Jr, Matalon S. Detano and nitrated lipids increase chloride secretion across lung airway cells. Am J Respir Cell Mol Biol 2008;39:50-62.
36. Bangel-Ruland N, Sobczak K, Christmann T, Kentrup D, Langhorst H, Kusche-Vihrog K, Weber WM. Characterization of the epithelial sodium channel delta-subunit in human nasal epithelium. Am J Respir Cell Mol Biol 2010;42:498-505.
37. Song W, Matalon S. Modulation of alveolar fluid clearance by reactive oxygen-nitrogen intermediates. Am J Physiol Lung Cell Mol Physiol 2007;293:L855-L858. (Pubitemid 47572233)
38. Matalon S, Hardiman KM, Jain L, Eaton DC, Kotlikoff M, Eu JP, Sun J, Meissner G, Stamler JS. Regulation of ion channel structure and function by reactive oxygen-nitrogen species. Am J Physiol Lung Cell Mol Physiol 2003;285:L1184-L1189. (Pubitemid 37448787)
39. + absorption across cultured alveolar type II monolayers. Am J Physiol 1998;274:L369-L377.
40. Goodman BE, Brown SE, Crandall ED. Regulation of transport across pulmonary alveolar epithelial cell monolayers. J Appl Physiol 1984;57:703-710. (Pubitemid 14048787)
41. + transport and fluid absorption in the distal lung. J Physiol 2002;544:537-548.
42. Schwiebert EM, Potter ED, Hwang TH, Woo JS, Ding C, Qiu W, Guggino WB, Levine MA, Guggino SE. cGMP stimulates sodium and chloride currents in rat tracheal airway epithelia. Am J Physiol 1997;272:C911-C922.
43. +conductance of adult rat alveolar type II pneumocytes: evidence for the involvement of cGMP-activated cation channels. J Physiol 2001;536:693-701.
44. Xu W, Leung S, Wright J, Guggino SE. Expression of cyclic nucleotidegated cation channels in airway epithelial cells. J Membr Biol 1999;171:117-126. (Pubitemid 29461509)
45. Kamosinska B, Radomski A, Man SF, Radomski MW, Duszyk M. Role of inducible nitric-oxide synthase in regulation of whole-cell current in lung epithelial cells. J Pharmacol Exp Ther 2000;295:500-505.
46. Lazrak A, Samanta A, Matalon S. Biophysical properties and molecular characterization of amiloride-sensitive sodium channels in A549 cells. Am J Physiol Lung Cell Mol Physiol 2000;278:L848-L857. (Pubitemid 30220047)
47. + channels in urinary bladder cells of Japanese tree frog, Hyla Japonica. J Comp Physiol B 2007;177:503-508.
48. Yamada T, Matsuda K, Uchiyama M. Frog anp increases the amiloride-sensitive Na(+) channel activity in urinary bladder cells of Japanese tree frog, Hyla Japonica. Gen Comp Endocrinol 2007;152:286-288. (Pubitemid 46935135)
49. +conductance. Am J Physiol 1993;265:C630-C640.
50. Jain L, Chen XJ, Ramosevac S, Brown LA, Eaton DC. Expression of highly selective sodium channels in alveolar type II cells is determined by culture conditions. Am J Physiol Lung Cell Mol Physiol 2001;280: L646-L658.
51. Norlin A, Lu LN, Guggino SE, Matthay MA, Folkesson HG. Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats. J Appl Physiol 2001;90:1489-1496. (Pubitemid 32220936)
52. Junor RW, Benjamin AR, Alexandrou D, Guggino SE, Walters DV. Lack of a role for cyclic nucleotide gated cation channels in lung liquid absorption in fetal sheep. J Physiol 2000;523:493-502. (Pubitemid 30137655)
53. Schutte H, Witzenrath M, Mayer K, Rosseau S, Seeger W, Grimminger F. Short-term "preconditioning" with inhaled nitric oxide protects rabbit lungs against ischemia-reperfusion injury. Transplantation 2001;72:1363-1370. (Pubitemid 33015759)
54. Sakuma T, Zhao Y, Sugita M, Sagawa M, Toga H, Ishibashi T, Nishio M, Matthay MA. Malnutrition impairs alveolar fluid clearance in rat lungs. Am J Physiol Lung Cell Mol Physiol 2004;286:L1268-L1274. (Pubitemid 38656664)
55. Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA. Contribution of CFTR to apicalbasolateral fluid transport in cultured human alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol 2006;290:L242-L249.
56. Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA. Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol 2002;119:199-207. (Pubitemid 34522236)
57. French PJ, Bijman J, Edixhoven M, Vaandrager AB, Scholte BJ, Lohmann SM, Nairn AC, de Jonge HR. Isotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP dependent protein kinase II. J Biol Chem 1995;270:26626-26631.
58. Golin-Bisello F, Bradbury N, Ameen N. Sta and cGMP stimulate CFTR translocation to the surface of villus enterocytes in rat jejunum and is regulated by protein kinase G. Am J Physiol Cell Physiol 2005;289:C708-C716. (Pubitemid 41192680)
59. Gamm DM, Francis SH, Angelotti TP, Corbin JD, Uhler MD. The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J Biol Chem 1995;270:27380-27388.
60. Sager G, Ravna AW. Cellular efflux of cAMP and cGMP: a question about selectivity. Mini Rev Med Chem 2009;9:1009-1013.
61. Sager G. Cyclic gmp transporters. Neurochem Int 2004;45:865-873. (Pubitemid 39108059)
62. Goette-Di Marco P, Talha S, Enache I, Weiller MA, Charloux A, Massard G, Kessler R, Piquard F, Geny B. Endocrine heart after lung transplantation: increased brain natriuretic peptide is related to right ventricular function. Transpl Int 2010;23:728-735.
63. Arias-Diaz J, Vara E, Torres-Melero J, Garcia C, Baki W, Ramirez- Armengol JA, Balibrea JL. Nitrite/nitrate and cytokine levels in bronchoalveolar lavage fluid of lung cancer patients. Cancer 1994;74:1546-1551. (Pubitemid 24302973)
64. Sandera P, Hillinger S, Stammberger U, Schoedon G, Zalunardo M, Weder W, Schmid RA. 8-Br-cyclic GMP given during reperfusion improves post-transplant lung edema and free radical injury. J Heart Lung Transplant 2000;19:173-178. (Pubitemid 30088989)
65. Hillinger S, Schmid RA, Sandera P, Stammberger U, Schneiter D, Schoedon G, Weder W. 8-Br-cGMP is superior to prostaglandin E1 for lung preservation. Ann Thorac Surg 1999;68:1138-1142, discussion 1143.